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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:FGFR2_BICC1

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: FGFR2_BICC1
KinaseFusionDB ID: KFG2327
FusionGDB2.0 ID: KFG2327
HgeneTgene
Gene symbol

FGFR2

BICC1

Gene ID

2263

80114

Gene namefibroblast growth factor receptor 2BicC family RNA binding protein 1
SynonymsBBDS|BEK|BFR-1|CD332|CEK3|CFD1|ECT1|JWS|K-SAM|KGFR|TK14|TK25BICC|CYSRD
Cytomap

10q26.13

10q21.1

Type of geneprotein-codingprotein-coding
Descriptionfibroblast growth factor receptor 2BEK fibroblast growth factor receptorbacteria-expressed kinasekeratinocyte growth factor receptorprotein tyrosine kinase, receptor like 14protein bicaudal C homolog 1FGFR2-BICC1 fusion kinase proteinbicaudal C homolog 1
Modification date2024041620240305
UniProtAcc

P21802

Q9H694

Ensembl transtripts involved in fusion geneENST idsENST00000346997, ENST00000351936, 
ENST00000356226, ENST00000357555, 
ENST00000358487, ENST00000360144, 
ENST00000369056, ENST00000369059, 
ENST00000369060, ENST00000369061, 
ENST00000457416, ENST00000478859, 
ENST00000359354, ENST00000490349, 
ENST00000263103, ENST00000476684, 
ENST00000373886, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: FGFR2 [Title/Abstract] AND BICC1 [Title/Abstract] AND fusion [Title/Abstract]

Identification of Targetable FGFR Gene Fusions in Diverse Cancers (pmid: 23558953)
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)FGFR2(123243212)-BICC1(60461834), # samples:6
BICC1(60563002)-FGFR2(123239535), # samples:2
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFGFR2

GO:0008284

positive regulation of cell population proliferation

8663044

HgeneFGFR2

GO:0008543

fibroblast growth factor receptor signaling pathway

8663044|15629145

HgeneFGFR2

GO:0018108

peptidyl-tyrosine phosphorylation

15629145|16844695

HgeneFGFR2

GO:0046777

protein autophosphorylation

15629145

TgeneBICC1

GO:0090090

negative regulation of canonical Wnt signaling pathway

21922595


check buttonKinase Fusion gene breakpoints across FGFR2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonKinase Fusion gene breakpoints across BICC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChimerDB4TCGA-ED-A7PXFGFR2chr10

123243211

BICC1chr10

60461833

ChimerDB4TCGA-ZH-A8Y5-01AFGFR2chr10

123243212

BICC1chr10

60461834

ChimerDB4TCGA-ZH-A8Y5-01AFGFR2chr10

123243213

BICC1chr10

60461831

ChiTaRS5.0AB821310FGFR2chr10

123243212

BICC1chr10

60461832

ChimerDB4TCGA-W5-AA2W-01AFGFR2chr10

123243212

BICC1chr10

60566344

ChimerDB4TCGA-W5-AA2WFGFR2chr10

123243211

BICC1chr10

60566343



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)
ENST00000369061ENST00000373886FGFR2chr10123243212BICC1chr10605663445403936
ENST00000369061ENST00000373886FGFR2chr10123243212BICC1chr106046183473471584
ENST00000369061ENST00000373886FGFR2chr10123243211BICC1chr10605663435403936
ENST00000369061ENST00000373886FGFR2chr10123243211BICC1chr106046183373471584
ENST00000369061ENST00000373886FGFR2chr10123243213BICC1chr106046183173471584
ENST00000369061ENST00000373886FGFR2chr10123243212BICC1chr106046183273471584

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

>ENST00000369061_ENST00000373886_FGFR2_chr10_123243212_BICC1_chr10_60566344_length(amino acids)=936
MKALRVVHARRGSVQMGLTSTWRYGRGPGIGTVTMVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGE
SLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSE
NSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE
YGSINHTYHLDVVAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSM
NSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDL
SDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLA
SQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIP
VEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEAFDYEQKKLLATKAMLKKPVVTEVRTPTNTW
SGLGFSKSMPAETIKELRRANHVSYKPTMTTTYEGSSMSLSRSNSREHLGGGSESDNWRDRNGIGPGSHSEFAASIGSPKRKQNKSTEHY
LSSSNYMDCISSLTGSNGCNLNSSFKGSDLPELFSKLGLGKYTDVFQQQEIDLQTFLTLTDQDLKELGITTFGARRKMLLAISELNKNRR

--------------------------------------------------------------

>ENST00000369061_ENST00000373886_FGFR2_chr10_123243212_BICC1_chr10_60461834_length(amino acids)=1584
MKALRVVHARRGSVQMGLTSTWRYGRGPGIGTVTMVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGE
SLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSE
NSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE
YGSINHTYHLDVVAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSM
NSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDL
SDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLA
SQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIP
VEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEIMEETNTQIAWPSKLKIGAKSKKDPHIKVSG
KKEDVKEAKEMIMSVLDTKSNRVTLKMDVSHTEHSHVIGKGGNNIKKVMEETGCHIHFPDSNRNNQAEKSNQVSIAGQPAGVESARVRIR
ELLPLVLMFELPIAGILQPVPDPNSPSIQHISQTYNISVSFKQRSRMYGATVIVRGSQNNTSAVKEGTAMLLEHLAGSLASAIPVSTQLD
IAAQHHLFMMGRNGSNIKHIMQRTGAQIHFPDPSNPQKKSTVYLQGTIESVCLARQYLMGCLPLVLMFDMKEEIEVDPQFIAQLMEQLDV
FISIKPKPKQPSKSVIVKSVERNALNMYEARKCLLGLESSGVTIATSPSPASCPAGLACPSLDILASAGLGLTGLGLLGPTTLSLNTSTT
PNSLLNALNSSVSPLQSPSSGTPSPTLWAPPLANTSSATGFSAIPHLMIPSTAQATLTNILLSGVPTYGHTAPSPPPGLTPVDVHINSMQ
TEGKKISAALNGHAQSPDIKYGAISTSSLGEKVLSANHGDPSIQTSGSEQTSPKSSPTEGCNDAFVEVGMPRSPSHSGNAGDLKQMMCPS
KVSCAKRQTVELLQGTKNSHLHSTDRLLSDPELSATESPLADKKAPGSERAAERAAAAQQNSERAHLAPRSSYVNMQAFDYEQKKLLATK
AMLKKPVVTEVRTPTNTWSGLGFSKSMPAETIKELRRANHVSYKPTMTTTYEGSSMSLSRSNSREHLGGGSESDNWRDRNGIGPGSHSEF
AASIGSPKRKQNKSTEHYLSSSNYMDCISSLTGSNGCNLNSSFKGSDLPELFSKLGLGKYTDVFQQQEIDLQTFLTLTDQDLKELGITTF

--------------------------------------------------------------

>ENST00000369061_ENST00000373886_FGFR2_chr10_123243211_BICC1_chr10_60566343_length(amino acids)=936
MKALRVVHARRGSVQMGLTSTWRYGRGPGIGTVTMVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGE
SLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSE
NSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE
YGSINHTYHLDVVAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSM
NSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDL
SDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLA
SQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIP
VEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEAFDYEQKKLLATKAMLKKPVVTEVRTPTNTW
SGLGFSKSMPAETIKELRRANHVSYKPTMTTTYEGSSMSLSRSNSREHLGGGSESDNWRDRNGIGPGSHSEFAASIGSPKRKQNKSTEHY
LSSSNYMDCISSLTGSNGCNLNSSFKGSDLPELFSKLGLGKYTDVFQQQEIDLQTFLTLTDQDLKELGITTFGARRKMLLAISELNKNRR

--------------------------------------------------------------

>ENST00000369061_ENST00000373886_FGFR2_chr10_123243211_BICC1_chr10_60461833_length(amino acids)=1584
MKALRVVHARRGSVQMGLTSTWRYGRGPGIGTVTMVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGE
SLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSE
NSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE
YGSINHTYHLDVVAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSM
NSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDL
SDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLA
SQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIP
VEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEIMEETNTQIAWPSKLKIGAKSKKDPHIKVSG
KKEDVKEAKEMIMSVLDTKSNRVTLKMDVSHTEHSHVIGKGGNNIKKVMEETGCHIHFPDSNRNNQAEKSNQVSIAGQPAGVESARVRIR
ELLPLVLMFELPIAGILQPVPDPNSPSIQHISQTYNISVSFKQRSRMYGATVIVRGSQNNTSAVKEGTAMLLEHLAGSLASAIPVSTQLD
IAAQHHLFMMGRNGSNIKHIMQRTGAQIHFPDPSNPQKKSTVYLQGTIESVCLARQYLMGCLPLVLMFDMKEEIEVDPQFIAQLMEQLDV
FISIKPKPKQPSKSVIVKSVERNALNMYEARKCLLGLESSGVTIATSPSPASCPAGLACPSLDILASAGLGLTGLGLLGPTTLSLNTSTT
PNSLLNALNSSVSPLQSPSSGTPSPTLWAPPLANTSSATGFSAIPHLMIPSTAQATLTNILLSGVPTYGHTAPSPPPGLTPVDVHINSMQ
TEGKKISAALNGHAQSPDIKYGAISTSSLGEKVLSANHGDPSIQTSGSEQTSPKSSPTEGCNDAFVEVGMPRSPSHSGNAGDLKQMMCPS
KVSCAKRQTVELLQGTKNSHLHSTDRLLSDPELSATESPLADKKAPGSERAAERAAAAQQNSERAHLAPRSSYVNMQAFDYEQKKLLATK
AMLKKPVVTEVRTPTNTWSGLGFSKSMPAETIKELRRANHVSYKPTMTTTYEGSSMSLSRSNSREHLGGGSESDNWRDRNGIGPGSHSEF
AASIGSPKRKQNKSTEHYLSSSNYMDCISSLTGSNGCNLNSSFKGSDLPELFSKLGLGKYTDVFQQQEIDLQTFLTLTDQDLKELGITTF

--------------------------------------------------------------

>ENST00000369061_ENST00000373886_FGFR2_chr10_123243213_BICC1_chr10_60461831_length(amino acids)=1584
MKALRVVHARRGSVQMGLTSTWRYGRGPGIGTVTMVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGE
SLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSE
NSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE
YGSINHTYHLDVVAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSM
NSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDL
SDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLA
SQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIP
VEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEIMEETNTQIAWPSKLKIGAKSKKDPHIKVSG
KKEDVKEAKEMIMSVLDTKSNRVTLKMDVSHTEHSHVIGKGGNNIKKVMEETGCHIHFPDSNRNNQAEKSNQVSIAGQPAGVESARVRIR
ELLPLVLMFELPIAGILQPVPDPNSPSIQHISQTYNISVSFKQRSRMYGATVIVRGSQNNTSAVKEGTAMLLEHLAGSLASAIPVSTQLD
IAAQHHLFMMGRNGSNIKHIMQRTGAQIHFPDPSNPQKKSTVYLQGTIESVCLARQYLMGCLPLVLMFDMKEEIEVDPQFIAQLMEQLDV
FISIKPKPKQPSKSVIVKSVERNALNMYEARKCLLGLESSGVTIATSPSPASCPAGLACPSLDILASAGLGLTGLGLLGPTTLSLNTSTT
PNSLLNALNSSVSPLQSPSSGTPSPTLWAPPLANTSSATGFSAIPHLMIPSTAQATLTNILLSGVPTYGHTAPSPPPGLTPVDVHINSMQ
TEGKKISAALNGHAQSPDIKYGAISTSSLGEKVLSANHGDPSIQTSGSEQTSPKSSPTEGCNDAFVEVGMPRSPSHSGNAGDLKQMMCPS
KVSCAKRQTVELLQGTKNSHLHSTDRLLSDPELSATESPLADKKAPGSERAAERAAAAQQNSERAHLAPRSSYVNMQAFDYEQKKLLATK
AMLKKPVVTEVRTPTNTWSGLGFSKSMPAETIKELRRANHVSYKPTMTTTYEGSSMSLSRSNSREHLGGGSESDNWRDRNGIGPGSHSEF
AASIGSPKRKQNKSTEHYLSSSNYMDCISSLTGSNGCNLNSSFKGSDLPELFSKLGLGKYTDVFQQQEIDLQTFLTLTDQDLKELGITTF

--------------------------------------------------------------

>ENST00000369061_ENST00000373886_FGFR2_chr10_123243212_BICC1_chr10_60461832_length(amino acids)=1584
MKALRVVHARRGSVQMGLTSTWRYGRGPGIGTVTMVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGE
SLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSE
NSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE
YGSINHTYHLDVVAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSM
NSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDL
SDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLA
SQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIP
VEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEIMEETNTQIAWPSKLKIGAKSKKDPHIKVSG
KKEDVKEAKEMIMSVLDTKSNRVTLKMDVSHTEHSHVIGKGGNNIKKVMEETGCHIHFPDSNRNNQAEKSNQVSIAGQPAGVESARVRIR
ELLPLVLMFELPIAGILQPVPDPNSPSIQHISQTYNISVSFKQRSRMYGATVIVRGSQNNTSAVKEGTAMLLEHLAGSLASAIPVSTQLD
IAAQHHLFMMGRNGSNIKHIMQRTGAQIHFPDPSNPQKKSTVYLQGTIESVCLARQYLMGCLPLVLMFDMKEEIEVDPQFIAQLMEQLDV
FISIKPKPKQPSKSVIVKSVERNALNMYEARKCLLGLESSGVTIATSPSPASCPAGLACPSLDILASAGLGLTGLGLLGPTTLSLNTSTT
PNSLLNALNSSVSPLQSPSSGTPSPTLWAPPLANTSSATGFSAIPHLMIPSTAQATLTNILLSGVPTYGHTAPSPPPGLTPVDVHINSMQ
TEGKKISAALNGHAQSPDIKYGAISTSSLGEKVLSANHGDPSIQTSGSEQTSPKSSPTEGCNDAFVEVGMPRSPSHSGNAGDLKQMMCPS
KVSCAKRQTVELLQGTKNSHLHSTDRLLSDPELSATESPLADKKAPGSERAAERAAAAQQNSERAHLAPRSSYVNMQAFDYEQKKLLATK
AMLKKPVVTEVRTPTNTWSGLGFSKSMPAETIKELRRANHVSYKPTMTTTYEGSSMSLSRSNSREHLGGGSESDNWRDRNGIGPGSHSEF
AASIGSPKRKQNKSTEHYLSSSNYMDCISSLTGSNGCNLNSSFKGSDLPELFSKLGLGKYTDVFQQQEIDLQTFLTLTDQDLKELGITTF

--------------------------------------------------------------

Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:123243212/chr10:60461834)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FGFR2

P21802

BICC1

Q9H694

FUNCTION: Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1. {ECO:0000269|PubMed:12529371, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:15629145, ECO:0000269|PubMed:16384934, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19103595, ECO:0000269|PubMed:19387476, ECO:0000269|PubMed:19410646, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:8663044}.FUNCTION: Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development. {ECO:0000269|PubMed:21922595}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
655650651678679765768765767768655650651678679765768765767768655650651678679765768765767768655650651678679765768765767768655650651678679765768765767768655650651678679765768765767768655650651678679765768765767768655650651678679765768765767768655650651678679765768765767768655650651678679765768765767768655650651678679765768765767768655650651678679765768765767768655650651678679765768765767768655650651678679765768765767768655650651678679765768765767768655650651678679765768765767768655650651678679765768765767768655650651678679765768765767768768767768768767768768767768768767768768767768768767768
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote
HgeneFGFR2123243211BICC160461833ENST00000369061141525_1251710DomainNote=Ig-like C2-type 1
HgeneFGFR2123243211BICC160461833ENST00000369061151625_1251705DomainNote=Ig-like C2-type 1
HgeneFGFR2123243211BICC160461833ENST00000369061151625_1251706DomainNote=Ig-like C2-type 1
HgeneFGFR2123243211BICC160461833ENST00000369061161725_1251708DomainNote=Ig-like C2-type 1
HgeneFGFR2123243211BICC160461833ENST00000369061161725_1251681DomainNote=Ig-like C2-type 1
HgeneFGFR2123243211BICC160461833ENST00000369061161725_1251820DomainNote=Ig-like C2-type 1
HgeneFGFR2123243211BICC160461833ENST00000369061161725_1251770DomainNote=Ig-like C2-type 1
HgeneFGFR2123243211BICC160461833ENST00000369061171825_1251786DomainNote=Ig-like C2-type 1
HgeneFGFR2123243211BICC160461833ENST00000369061171825_1251822DomainNote=Ig-like C2-type 1
HgeneFGFR2123243211BICC160461833ENST00000369061171825_1251823DomainNote=Ig-like C2-type 1
HgeneFGFR2123243211BICC160566343ENST00000369061141525_1251710DomainNote=Ig-like C2-type 1
HgeneFGFR2123243211BICC160566343ENST00000369061151625_1251705DomainNote=Ig-like C2-type 1
HgeneFGFR2123243211BICC160566343ENST00000369061151625_1251706DomainNote=Ig-like C2-type 1
HgeneFGFR2123243211BICC160566343ENST00000369061161725_1251708DomainNote=Ig-like C2-type 1
HgeneFGFR2123243211BICC160566343ENST00000369061161725_1251681DomainNote=Ig-like C2-type 1
HgeneFGFR2123243211BICC160566343ENST00000369061161725_1251820DomainNote=Ig-like C2-type 1
HgeneFGFR2123243211BICC160566343ENST00000369061161725_1251770DomainNote=Ig-like C2-type 1
HgeneFGFR2123243211BICC160566343ENST00000369061171825_1251786DomainNote=Ig-like C2-type 1
HgeneFGFR2123243211BICC160566343ENST00000369061171825_1251822DomainNote=Ig-like C2-type 1
HgeneFGFR2123243211BICC160566343ENST00000369061171825_1251823DomainNote=Ig-like C2-type 1
HgeneFGFR2123243212BICC160461832ENST00000369061141525_1251710DomainNote=Ig-like C2-type 1
HgeneFGFR2123243212BICC160461832ENST00000369061151625_1251705DomainNote=Ig-like C2-type 1
HgeneFGFR2123243212BICC160461832ENST00000369061151625_1251706DomainNote=Ig-like C2-type 1
HgeneFGFR2123243212BICC160461832ENST00000369061161725_1251708DomainNote=Ig-like C2-type 1
HgeneFGFR2123243212BICC160461832ENST00000369061161725_1251681DomainNote=Ig-like C2-type 1
HgeneFGFR2123243212BICC160461832ENST00000369061161725_1251820DomainNote=Ig-like C2-type 1
HgeneFGFR2123243212BICC160461832ENST00000369061161725_1251770DomainNote=Ig-like C2-type 1
HgeneFGFR2123243212BICC160461832ENST00000369061171825_1251786DomainNote=Ig-like C2-type 1
HgeneFGFR2123243212BICC160461832ENST00000369061171825_1251822DomainNote=Ig-like C2-type 1
HgeneFGFR2123243212BICC160461832ENST00000369061171825_1251823DomainNote=Ig-like C2-type 1
HgeneFGFR2123243212BICC160461834ENST00000369061141525_1251710DomainNote=Ig-like C2-type 1
HgeneFGFR2123243212BICC160461834ENST00000369061151625_1251705DomainNote=Ig-like C2-type 1
HgeneFGFR2123243212BICC160461834ENST00000369061151625_1251706DomainNote=Ig-like C2-type 1
HgeneFGFR2123243212BICC160461834ENST00000369061161725_1251708DomainNote=Ig-like C2-type 1
HgeneFGFR2123243212BICC160461834ENST00000369061161725_1251681DomainNote=Ig-like C2-type 1
HgeneFGFR2123243212BICC160461834ENST00000369061161725_1251820DomainNote=Ig-like C2-type 1
HgeneFGFR2123243212BICC160461834ENST00000369061161725_1251770DomainNote=Ig-like C2-type 1
HgeneFGFR2123243212BICC160461834ENST00000369061171825_1251786DomainNote=Ig-like C2-type 1
HgeneFGFR2123243212BICC160461834ENST00000369061171825_1251822DomainNote=Ig-like C2-type 1
HgeneFGFR2123243212BICC160461834ENST00000369061171825_1251823DomainNote=Ig-like C2-type 1
HgeneFGFR2123243212BICC160566344ENST00000369061141525_1251710DomainNote=Ig-like C2-type 1
HgeneFGFR2123243212BICC160566344ENST00000369061151625_1251705DomainNote=Ig-like C2-type 1
HgeneFGFR2123243212BICC160566344ENST00000369061151625_1251706DomainNote=Ig-like C2-type 1
HgeneFGFR2123243212BICC160566344ENST00000369061161725_1251708DomainNote=Ig-like C2-type 1
HgeneFGFR2123243212BICC160566344ENST00000369061161725_1251681DomainNote=Ig-like C2-type 1
HgeneFGFR2123243212BICC160566344ENST00000369061161725_1251820DomainNote=Ig-like C2-type 1
HgeneFGFR2123243212BICC160566344ENST00000369061161725_1251770DomainNote=Ig-like C2-type 1
HgeneFGFR2123243212BICC160566344ENST00000369061171825_1251786DomainNote=Ig-like C2-type 1
HgeneFGFR2123243212BICC160566344ENST00000369061171825_1251822DomainNote=Ig-like C2-type 1
HgeneFGFR2123243212BICC160566344ENST00000369061171825_1251823DomainNote=Ig-like C2-type 1
HgeneFGFR2123243213BICC160461831ENST00000369061141525_1251710DomainNote=Ig-like C2-type 1
HgeneFGFR2123243213BICC160461831ENST00000369061151625_1251705DomainNote=Ig-like C2-type 1
HgeneFGFR2123243213BICC160461831ENST00000369061151625_1251706DomainNote=Ig-like C2-type 1
HgeneFGFR2123243213BICC160461831ENST00000369061161725_1251708DomainNote=Ig-like C2-type 1
HgeneFGFR2123243213BICC160461831ENST00000369061161725_1251681DomainNote=Ig-like C2-type 1
HgeneFGFR2123243213BICC160461831ENST00000369061161725_1251820DomainNote=Ig-like C2-type 1
HgeneFGFR2123243213BICC160461831ENST00000369061161725_1251770DomainNote=Ig-like C2-type 1
HgeneFGFR2123243213BICC160461831ENST00000369061171825_1251786DomainNote=Ig-like C2-type 1
HgeneFGFR2123243213BICC160461831ENST00000369061171825_1251822DomainNote=Ig-like C2-type 1
HgeneFGFR2123243213BICC160461831ENST00000369061171825_1251823DomainNote=Ig-like C2-type 1
HgeneFGFR2123243211BICC160461833ENST000003690611415154_2471710DomainNote=Ig-like C2-type 2
HgeneFGFR2123243211BICC160461833ENST000003690611516154_2471705DomainNote=Ig-like C2-type 2
HgeneFGFR2123243211BICC160461833ENST000003690611516154_2471706DomainNote=Ig-like C2-type 2
HgeneFGFR2123243211BICC160461833ENST000003690611617154_2471708DomainNote=Ig-like C2-type 2
HgeneFGFR2123243211BICC160461833ENST000003690611617154_2471681DomainNote=Ig-like C2-type 2
HgeneFGFR2123243211BICC160461833ENST000003690611617154_2471820DomainNote=Ig-like C2-type 2
HgeneFGFR2123243211BICC160461833ENST000003690611617154_2471770DomainNote=Ig-like C2-type 2
HgeneFGFR2123243211BICC160461833ENST000003690611718154_2471786DomainNote=Ig-like C2-type 2
HgeneFGFR2123243211BICC160461833ENST000003690611718154_2471822DomainNote=Ig-like C2-type 2
HgeneFGFR2123243211BICC160461833ENST000003690611718154_2471823DomainNote=Ig-like C2-type 2
HgeneFGFR2123243211BICC160566343ENST000003690611415154_2471710DomainNote=Ig-like C2-type 2
HgeneFGFR2123243211BICC160566343ENST000003690611516154_2471705DomainNote=Ig-like C2-type 2
HgeneFGFR2123243211BICC160566343ENST000003690611516154_2471706DomainNote=Ig-like C2-type 2
HgeneFGFR2123243211BICC160566343ENST000003690611617154_2471708DomainNote=Ig-like C2-type 2
HgeneFGFR2123243211BICC160566343ENST000003690611617154_2471681DomainNote=Ig-like C2-type 2
HgeneFGFR2123243211BICC160566343ENST000003690611617154_2471820DomainNote=Ig-like C2-type 2
HgeneFGFR2123243211BICC160566343ENST000003690611617154_2471770DomainNote=Ig-like C2-type 2
HgeneFGFR2123243211BICC160566343ENST000003690611718154_2471786DomainNote=Ig-like C2-type 2
HgeneFGFR2123243211BICC160566343ENST000003690611718154_2471822DomainNote=Ig-like C2-type 2
HgeneFGFR2123243211BICC160566343ENST000003690611718154_2471823DomainNote=Ig-like C2-type 2
HgeneFGFR2123243212BICC160461832ENST000003690611415154_2471710DomainNote=Ig-like C2-type 2
HgeneFGFR2123243212BICC160461832ENST000003690611516154_2471705DomainNote=Ig-like C2-type 2
HgeneFGFR2123243212BICC160461832ENST000003690611516154_2471706DomainNote=Ig-like C2-type 2
HgeneFGFR2123243212BICC160461832ENST000003690611617154_2471708DomainNote=Ig-like C2-type 2
HgeneFGFR2123243212BICC160461832ENST000003690611617154_2471681DomainNote=Ig-like C2-type 2
HgeneFGFR2123243212BICC160461832ENST000003690611617154_2471820DomainNote=Ig-like C2-type 2
HgeneFGFR2123243212BICC160461832ENST000003690611617154_2471770DomainNote=Ig-like C2-type 2
HgeneFGFR2123243212BICC160461832ENST000003690611718154_2471786DomainNote=Ig-like C2-type 2
HgeneFGFR2123243212BICC160461832ENST000003690611718154_2471822DomainNote=Ig-like C2-type 2
HgeneFGFR2123243212BICC160461832ENST000003690611718154_2471823DomainNote=Ig-like C2-type 2
HgeneFGFR2123243212BICC160461834ENST000003690611415154_2471710DomainNote=Ig-like C2-type 2
HgeneFGFR2123243212BICC160461834ENST000003690611516154_2471705DomainNote=Ig-like C2-type 2
HgeneFGFR2123243212BICC160461834ENST000003690611516154_2471706DomainNote=Ig-like C2-type 2
HgeneFGFR2123243212BICC160461834ENST000003690611617154_2471708DomainNote=Ig-like C2-type 2
HgeneFGFR2123243212BICC160461834ENST000003690611617154_2471681DomainNote=Ig-like C2-type 2
HgeneFGFR2123243212BICC160461834ENST000003690611617154_2471820DomainNote=Ig-like C2-type 2
HgeneFGFR2123243212BICC160461834ENST000003690611617154_2471770DomainNote=Ig-like C2-type 2
HgeneFGFR2123243212BICC160461834ENST000003690611718154_2471786DomainNote=Ig-like C2-type 2
HgeneFGFR2123243212BICC160461834ENST000003690611718154_2471822DomainNote=Ig-like C2-type 2
HgeneFGFR2123243212BICC160461834ENST000003690611718154_2471823DomainNote=Ig-like C2-type 2
HgeneFGFR2123243212BICC160566344ENST000003690611415154_2471710DomainNote=Ig-like C2-type 2
HgeneFGFR2123243212BICC160566344ENST000003690611516154_2471705DomainNote=Ig-like C2-type 2
HgeneFGFR2123243212BICC160566344ENST000003690611516154_2471706DomainNote=Ig-like C2-type 2
HgeneFGFR2123243212BICC160566344ENST000003690611617154_2471708DomainNote=Ig-like C2-type 2
HgeneFGFR2123243212BICC160566344ENST000003690611617154_2471681DomainNote=Ig-like C2-type 2
HgeneFGFR2123243212BICC160566344ENST000003690611617154_2471820DomainNote=Ig-like C2-type 2
HgeneFGFR2123243212BICC160566344ENST000003690611617154_2471770DomainNote=Ig-like C2-type 2
HgeneFGFR2123243212BICC160566344ENST000003690611718154_2471786DomainNote=Ig-like C2-type 2
HgeneFGFR2123243212BICC160566344ENST000003690611718154_2471822DomainNote=Ig-like C2-type 2
HgeneFGFR2123243212BICC160566344ENST000003690611718154_2471823DomainNote=Ig-like C2-type 2
HgeneFGFR2123243213BICC160461831ENST000003690611415154_2471710DomainNote=Ig-like C2-type 2
HgeneFGFR2123243213BICC160461831ENST000003690611516154_2471705DomainNote=Ig-like C2-type 2
HgeneFGFR2123243213BICC160461831ENST000003690611516154_2471706DomainNote=Ig-like C2-type 2
HgeneFGFR2123243213BICC160461831ENST000003690611617154_2471708DomainNote=Ig-like C2-type 2
HgeneFGFR2123243213BICC160461831ENST000003690611617154_2471681DomainNote=Ig-like C2-type 2
HgeneFGFR2123243213BICC160461831ENST000003690611617154_2471820DomainNote=Ig-like C2-type 2
HgeneFGFR2123243213BICC160461831ENST000003690611617154_2471770DomainNote=Ig-like C2-type 2
HgeneFGFR2123243213BICC160461831ENST000003690611718154_2471786DomainNote=Ig-like C2-type 2
HgeneFGFR2123243213BICC160461831ENST000003690611718154_2471822DomainNote=Ig-like C2-type 2
HgeneFGFR2123243213BICC160461831ENST000003690611718154_2471823DomainNote=Ig-like C2-type 2
HgeneFGFR2123243211BICC160461833ENST000003690611415256_3581710DomainNote=Ig-like C2-type 3
HgeneFGFR2123243211BICC160461833ENST000003690611516256_3581705DomainNote=Ig-like C2-type 3
HgeneFGFR2123243211BICC160461833ENST000003690611516256_3581706DomainNote=Ig-like C2-type 3
HgeneFGFR2123243211BICC160461833ENST000003690611617256_3581708DomainNote=Ig-like C2-type 3
HgeneFGFR2123243211BICC160461833ENST000003690611617256_3581681DomainNote=Ig-like C2-type 3
HgeneFGFR2123243211BICC160461833ENST000003690611617256_3581820DomainNote=Ig-like C2-type 3
HgeneFGFR2123243211BICC160461833ENST000003690611617256_3581770DomainNote=Ig-like C2-type 3
HgeneFGFR2123243211BICC160461833ENST000003690611718256_3581786DomainNote=Ig-like C2-type 3
HgeneFGFR2123243211BICC160461833ENST000003690611718256_3581822DomainNote=Ig-like C2-type 3
HgeneFGFR2123243211BICC160461833ENST000003690611718256_3581823DomainNote=Ig-like C2-type 3
HgeneFGFR2123243211BICC160566343ENST000003690611415256_3581710DomainNote=Ig-like C2-type 3
HgeneFGFR2123243211BICC160566343ENST000003690611516256_3581705DomainNote=Ig-like C2-type 3
HgeneFGFR2123243211BICC160566343ENST000003690611516256_3581706DomainNote=Ig-like C2-type 3
HgeneFGFR2123243211BICC160566343ENST000003690611617256_3581708DomainNote=Ig-like C2-type 3
HgeneFGFR2123243211BICC160566343ENST000003690611617256_3581681DomainNote=Ig-like C2-type 3
HgeneFGFR2123243211BICC160566343ENST000003690611617256_3581820DomainNote=Ig-like C2-type 3
HgeneFGFR2123243211BICC160566343ENST000003690611617256_3581770DomainNote=Ig-like C2-type 3
HgeneFGFR2123243211BICC160566343ENST000003690611718256_3581786DomainNote=Ig-like C2-type 3
HgeneFGFR2123243211BICC160566343ENST000003690611718256_3581822DomainNote=Ig-like C2-type 3
HgeneFGFR2123243211BICC160566343ENST000003690611718256_3581823DomainNote=Ig-like C2-type 3
HgeneFGFR2123243212BICC160461832ENST000003690611415256_3581710DomainNote=Ig-like C2-type 3
HgeneFGFR2123243212BICC160461832ENST000003690611516256_3581705DomainNote=Ig-like C2-type 3
HgeneFGFR2123243212BICC160461832ENST000003690611516256_3581706DomainNote=Ig-like C2-type 3
HgeneFGFR2123243212BICC160461832ENST000003690611617256_3581708DomainNote=Ig-like C2-type 3
HgeneFGFR2123243212BICC160461832ENST000003690611617256_3581681DomainNote=Ig-like C2-type 3
HgeneFGFR2123243212BICC160461832ENST000003690611617256_3581820DomainNote=Ig-like C2-type 3
HgeneFGFR2123243212BICC160461832ENST000003690611617256_3581770DomainNote=Ig-like C2-type 3
HgeneFGFR2123243212BICC160461832ENST000003690611718256_3581786DomainNote=Ig-like C2-type 3
HgeneFGFR2123243212BICC160461832ENST000003690611718256_3581822DomainNote=Ig-like C2-type 3
HgeneFGFR2123243212BICC160461832ENST000003690611718256_3581823DomainNote=Ig-like C2-type 3
HgeneFGFR2123243212BICC160461834ENST000003690611415256_3581710DomainNote=Ig-like C2-type 3
HgeneFGFR2123243212BICC160461834ENST000003690611516256_3581705DomainNote=Ig-like C2-type 3
HgeneFGFR2123243212BICC160461834ENST000003690611516256_3581706DomainNote=Ig-like C2-type 3
HgeneFGFR2123243212BICC160461834ENST000003690611617256_3581708DomainNote=Ig-like C2-type 3
HgeneFGFR2123243212BICC160461834ENST000003690611617256_3581681DomainNote=Ig-like C2-type 3
HgeneFGFR2123243212BICC160461834ENST000003690611617256_3581820DomainNote=Ig-like C2-type 3
HgeneFGFR2123243212BICC160461834ENST000003690611617256_3581770DomainNote=Ig-like C2-type 3
HgeneFGFR2123243212BICC160461834ENST000003690611718256_3581786DomainNote=Ig-like C2-type 3
HgeneFGFR2123243212BICC160461834ENST000003690611718256_3581822DomainNote=Ig-like C2-type 3
HgeneFGFR2123243212BICC160461834ENST000003690611718256_3581823DomainNote=Ig-like C2-type 3
HgeneFGFR2123243212BICC160566344ENST000003690611415256_3581710DomainNote=Ig-like C2-type 3
HgeneFGFR2123243212BICC160566344ENST000003690611516256_3581705DomainNote=Ig-like C2-type 3
HgeneFGFR2123243212BICC160566344ENST000003690611516256_3581706DomainNote=Ig-like C2-type 3
HgeneFGFR2123243212BICC160566344ENST000003690611617256_3581708DomainNote=Ig-like C2-type 3
HgeneFGFR2123243212BICC160566344ENST000003690611617256_3581681DomainNote=Ig-like C2-type 3
HgeneFGFR2123243212BICC160566344ENST000003690611617256_3581820DomainNote=Ig-like C2-type 3
HgeneFGFR2123243212BICC160566344ENST000003690611617256_3581770DomainNote=Ig-like C2-type 3
HgeneFGFR2123243212BICC160566344ENST000003690611718256_3581786DomainNote=Ig-like C2-type 3
HgeneFGFR2123243212BICC160566344ENST000003690611718256_3581822DomainNote=Ig-like C2-type 3
HgeneFGFR2123243212BICC160566344ENST000003690611718256_3581823DomainNote=Ig-like C2-type 3
HgeneFGFR2123243213BICC160461831ENST000003690611415256_3581710DomainNote=Ig-like C2-type 3
HgeneFGFR2123243213BICC160461831ENST000003690611516256_3581705DomainNote=Ig-like C2-type 3
HgeneFGFR2123243213BICC160461831ENST000003690611516256_3581706DomainNote=Ig-like C2-type 3
HgeneFGFR2123243213BICC160461831ENST000003690611617256_3581708DomainNote=Ig-like C2-type 3
HgeneFGFR2123243213BICC160461831ENST000003690611617256_3581681DomainNote=Ig-like C2-type 3
HgeneFGFR2123243213BICC160461831ENST000003690611617256_3581820DomainNote=Ig-like C2-type 3
HgeneFGFR2123243213BICC160461831ENST000003690611617256_3581770DomainNote=Ig-like C2-type 3
HgeneFGFR2123243213BICC160461831ENST000003690611718256_3581786DomainNote=Ig-like C2-type 3
HgeneFGFR2123243213BICC160461831ENST000003690611718256_3581822DomainNote=Ig-like C2-type 3
HgeneFGFR2123243213BICC160461831ENST000003690611718256_3581823DomainNote=Ig-like C2-type 3
HgeneFGFR2123243211BICC160461833ENST000003690611617481_7701770DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
HgeneFGFR2123243211BICC160461833ENST000003690611718481_7701822DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
HgeneFGFR2123243211BICC160461833ENST000003690611718481_7701823DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
HgeneFGFR2123243211BICC160566343ENST000003690611617481_7701770DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
HgeneFGFR2123243211BICC160566343ENST000003690611718481_7701822DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
HgeneFGFR2123243211BICC160566343ENST000003690611718481_7701823DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
HgeneFGFR2123243212BICC160461832ENST000003690611617481_7701770DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
HgeneFGFR2123243212BICC160461832ENST000003690611718481_7701822DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
HgeneFGFR2123243212BICC160461832ENST000003690611718481_7701823DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
HgeneFGFR2123243212BICC160461834ENST000003690611617481_7701770DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
HgeneFGFR2123243212BICC160461834ENST000003690611718481_7701822DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
HgeneFGFR2123243212BICC160461834ENST000003690611718481_7701823DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
HgeneFGFR2123243212BICC160566344ENST000003690611617481_7701770DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
HgeneFGFR2123243212BICC160566344ENST000003690611718481_7701822DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
HgeneFGFR2123243212BICC160566344ENST000003690611718481_7701823DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
HgeneFGFR2123243213BICC160461831ENST000003690611617481_7701770DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
HgeneFGFR2123243213BICC160461831ENST000003690611718481_7701822DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
HgeneFGFR2123243213BICC160461831ENST000003690611718481_7701823DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


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Kinase Fusion Protein Structures

check button CIF files of the predicted kinase fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Kinase Fusion protein CIF link (fusion AA seq ID in KinaseFusionDB)HenstTenstHgeneHchrHbpTgeneTchrTbpAA seqLen(AA seq)
PDB file >>>104_FGFR2_BICC1ENST00000369061ENST00000373886FGFR2chr10123243212BICC1chr1060461832
MKALRVVHARRGSVQMGLTSTWRYGRGPGIGTVTMVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGE
SLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSE
NSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE
YGSINHTYHLDVVAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSM
NSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDL
SDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLA
SQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIP
VEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEIMEETNTQIAWPSKLKIGAKSKKDPHIKVSG
KKEDVKEAKEMIMSVLDTKSNRVTLKMDVSHTEHSHVIGKGGNNIKKVMEETGCHIHFPDSNRNNQAEKSNQVSIAGQPAGVESARVRIR
ELLPLVLMFELPIAGILQPVPDPNSPSIQHISQTYNISVSFKQRSRMYGATVIVRGSQNNTSAVKEGTAMLLEHLAGSLASAIPVSTQLD
IAAQHHLFMMGRNGSNIKHIMQRTGAQIHFPDPSNPQKKSTVYLQGTIESVCLARQYLMGCLPLVLMFDMKEEIEVDPQFIAQLMEQLDV
FISIKPKPKQPSKSVIVKSVERNALNMYEARKCLLGLESSGVTIATSPSPASCPAGLACPSLDILASAGLGLTGLGLLGPTTLSLNTSTT
PNSLLNALNSSVSPLQSPSSGTPSPTLWAPPLANTSSATGFSAIPHLMIPSTAQATLTNILLSGVPTYGHTAPSPPPGLTPVDVHINSMQ
TEGKKISAALNGHAQSPDIKYGAISTSSLGEKVLSANHGDPSIQTSGSEQTSPKSSPTEGCNDAFVEVGMPRSPSHSGNAGDLKQMMCPS
KVSCAKRQTVELLQGTKNSHLHSTDRLLSDPELSATESPLADKKAPGSERAAERAAAAQQNSERAHLAPRSSYVNMQAFDYEQKKLLATK
AMLKKPVVTEVRTPTNTWSGLGFSKSMPAETIKELRRANHVSYKPTMTTTYEGSSMSLSRSNSREHLGGGSESDNWRDRNGIGPGSHSEF
AASIGSPKRKQNKSTEHYLSSSNYMDCISSLTGSNGCNLNSSFKGSDLPELFSKLGLGKYTDVFQQQEIDLQTFLTLTDQDLKELGITTF
1584
3D view using mol* of 104_FGFR2_BICC1
PDB file >>>HKFP_146_FGFR2_BICC1ENST00000369061ENST00000373886FGFR2chr10123243212BICC1chr1060566344
MKALRVVHARRGSVQMGLTSTWRYGRGPGIGTVTMVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGE
SLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSE
NSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE
YGSINHTYHLDVVAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSM
NSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDL
SDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLA
SQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIP
VEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEAFDYEQKKLLATKAMLKKPVVTEVRTPTNTW
SGLGFSKSMPAETIKELRRANHVSYKPTMTTTYEGSSMSLSRSNSREHLGGGSESDNWRDRNGIGPGSHSEFAASIGSPKRKQNKSTEHY
LSSSNYMDCISSLTGSNGCNLNSSFKGSDLPELFSKLGLGKYTDVFQQQEIDLQTFLTLTDQDLKELGITTFGARRKMLLAISELNKNRR
936_FGFR2_BICC1
PDB file >>>HKFP_147_FGFR2_BICC1ENST00000369061ENST00000373886FGFR2chr10123243212BICC1chr1060461834
MKALRVVHARRGSVQMGLTSTWRYGRGPGIGTVTMVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGE
SLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSE
NSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE
YGSINHTYHLDVVAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSM
NSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDL
SDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLA
SQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIP
VEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEIMEETNTQIAWPSKLKIGAKSKKDPHIKVSG
KKEDVKEAKEMIMSVLDTKSNRVTLKMDVSHTEHSHVIGKGGNNIKKVMEETGCHIHFPDSNRNNQAEKSNQVSIAGQPAGVESARVRIR
ELLPLVLMFELPIAGILQPVPDPNSPSIQHISQTYNISVSFKQRSRMYGATVIVRGSQNNTSAVKEGTAMLLEHLAGSLASAIPVSTQLD
IAAQHHLFMMGRNGSNIKHIMQRTGAQIHFPDPSNPQKKSTVYLQGTIESVCLARQYLMGCLPLVLMFDMKEEIEVDPQFIAQLMEQLDV
FISIKPKPKQPSKSVIVKSVERNALNMYEARKCLLGLESSGVTIATSPSPASCPAGLACPSLDILASAGLGLTGLGLLGPTTLSLNTSTT
PNSLLNALNSSVSPLQSPSSGTPSPTLWAPPLANTSSATGFSAIPHLMIPSTAQATLTNILLSGVPTYGHTAPSPPPGLTPVDVHINSMQ
TEGKKISAALNGHAQSPDIKYGAISTSSLGEKVLSANHGDPSIQTSGSEQTSPKSSPTEGCNDAFVEVGMPRSPSHSGNAGDLKQMMCPS
KVSCAKRQTVELLQGTKNSHLHSTDRLLSDPELSATESPLADKKAPGSERAAERAAAAQQNSERAHLAPRSSYVNMQAFDYEQKKLLATK
AMLKKPVVTEVRTPTNTWSGLGFSKSMPAETIKELRRANHVSYKPTMTTTYEGSSMSLSRSNSREHLGGGSESDNWRDRNGIGPGSHSEF
AASIGSPKRKQNKSTEHYLSSSNYMDCISSLTGSNGCNLNSSFKGSDLPELFSKLGLGKYTDVFQQQEIDLQTFLTLTDQDLKELGITTF
1584_FGFR2_BICC1
3D view using mol* of HKFP_147_FGFR2_BICC1
PDB file >>>HKFP_148_FGFR2_BICC1ENST00000369061ENST00000373886FGFR2chr10123243211BICC1chr1060566343
MKALRVVHARRGSVQMGLTSTWRYGRGPGIGTVTMVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGE
SLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSE
NSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE
YGSINHTYHLDVVAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSM
NSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDL
SDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLA
SQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIP
VEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEAFDYEQKKLLATKAMLKKPVVTEVRTPTNTW
SGLGFSKSMPAETIKELRRANHVSYKPTMTTTYEGSSMSLSRSNSREHLGGGSESDNWRDRNGIGPGSHSEFAASIGSPKRKQNKSTEHY
LSSSNYMDCISSLTGSNGCNLNSSFKGSDLPELFSKLGLGKYTDVFQQQEIDLQTFLTLTDQDLKELGITTFGARRKMLLAISELNKNRR
936_FGFR2_BICC1
PDB file >>>HKFP_149_FGFR2_BICC1ENST00000369061ENST00000373886FGFR2chr10123243211BICC1chr1060461833
MKALRVVHARRGSVQMGLTSTWRYGRGPGIGTVTMVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGE
SLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSE
NSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE
YGSINHTYHLDVVAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSM
NSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDL
SDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLA
SQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIP
VEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEIMEETNTQIAWPSKLKIGAKSKKDPHIKVSG
KKEDVKEAKEMIMSVLDTKSNRVTLKMDVSHTEHSHVIGKGGNNIKKVMEETGCHIHFPDSNRNNQAEKSNQVSIAGQPAGVESARVRIR
ELLPLVLMFELPIAGILQPVPDPNSPSIQHISQTYNISVSFKQRSRMYGATVIVRGSQNNTSAVKEGTAMLLEHLAGSLASAIPVSTQLD
IAAQHHLFMMGRNGSNIKHIMQRTGAQIHFPDPSNPQKKSTVYLQGTIESVCLARQYLMGCLPLVLMFDMKEEIEVDPQFIAQLMEQLDV
FISIKPKPKQPSKSVIVKSVERNALNMYEARKCLLGLESSGVTIATSPSPASCPAGLACPSLDILASAGLGLTGLGLLGPTTLSLNTSTT
PNSLLNALNSSVSPLQSPSSGTPSPTLWAPPLANTSSATGFSAIPHLMIPSTAQATLTNILLSGVPTYGHTAPSPPPGLTPVDVHINSMQ
TEGKKISAALNGHAQSPDIKYGAISTSSLGEKVLSANHGDPSIQTSGSEQTSPKSSPTEGCNDAFVEVGMPRSPSHSGNAGDLKQMMCPS
KVSCAKRQTVELLQGTKNSHLHSTDRLLSDPELSATESPLADKKAPGSERAAERAAAAQQNSERAHLAPRSSYVNMQAFDYEQKKLLATK
AMLKKPVVTEVRTPTNTWSGLGFSKSMPAETIKELRRANHVSYKPTMTTTYEGSSMSLSRSNSREHLGGGSESDNWRDRNGIGPGSHSEF
AASIGSPKRKQNKSTEHYLSSSNYMDCISSLTGSNGCNLNSSFKGSDLPELFSKLGLGKYTDVFQQQEIDLQTFLTLTDQDLKELGITTF
1584_FGFR2_BICC1
PDB file >>>HKFP_150_FGFR2_BICC1ENST00000369061ENST00000373886FGFR2chr10123243213BICC1chr1060461831
MKALRVVHARRGSVQMGLTSTWRYGRGPGIGTVTMVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGE
SLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSE
NSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE
YGSINHTYHLDVVAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSM
NSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDL
SDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLA
SQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIP
VEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEIMEETNTQIAWPSKLKIGAKSKKDPHIKVSG
KKEDVKEAKEMIMSVLDTKSNRVTLKMDVSHTEHSHVIGKGGNNIKKVMEETGCHIHFPDSNRNNQAEKSNQVSIAGQPAGVESARVRIR
ELLPLVLMFELPIAGILQPVPDPNSPSIQHISQTYNISVSFKQRSRMYGATVIVRGSQNNTSAVKEGTAMLLEHLAGSLASAIPVSTQLD
IAAQHHLFMMGRNGSNIKHIMQRTGAQIHFPDPSNPQKKSTVYLQGTIESVCLARQYLMGCLPLVLMFDMKEEIEVDPQFIAQLMEQLDV
FISIKPKPKQPSKSVIVKSVERNALNMYEARKCLLGLESSGVTIATSPSPASCPAGLACPSLDILASAGLGLTGLGLLGPTTLSLNTSTT
PNSLLNALNSSVSPLQSPSSGTPSPTLWAPPLANTSSATGFSAIPHLMIPSTAQATLTNILLSGVPTYGHTAPSPPPGLTPVDVHINSMQ
TEGKKISAALNGHAQSPDIKYGAISTSSLGEKVLSANHGDPSIQTSGSEQTSPKSSPTEGCNDAFVEVGMPRSPSHSGNAGDLKQMMCPS
KVSCAKRQTVELLQGTKNSHLHSTDRLLSDPELSATESPLADKKAPGSERAAERAAAAQQNSERAHLAPRSSYVNMQAFDYEQKKLLATK
AMLKKPVVTEVRTPTNTWSGLGFSKSMPAETIKELRRANHVSYKPTMTTTYEGSSMSLSRSNSREHLGGGSESDNWRDRNGIGPGSHSEF
AASIGSPKRKQNKSTEHYLSSSNYMDCISSLTGSNGCNLNSSFKGSDLPELFSKLGLGKYTDVFQQQEIDLQTFLTLTDQDLKELGITTF
1584_FGFR2_BICC1
PDB file >>>HKFP_151_FGFR2_BICC1ENST00000369061ENST00000373886FGFR2chr10123243212BICC1chr1060461832
MKALRVVHARRGSVQMGLTSTWRYGRGPGIGTVTMVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGE
SLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSE
NSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENE
YGSINHTYHLDVVAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSM
NSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDL
SDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLA
SQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIP
VEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEIMEETNTQIAWPSKLKIGAKSKKDPHIKVSG
KKEDVKEAKEMIMSVLDTKSNRVTLKMDVSHTEHSHVIGKGGNNIKKVMEETGCHIHFPDSNRNNQAEKSNQVSIAGQPAGVESARVRIR
ELLPLVLMFELPIAGILQPVPDPNSPSIQHISQTYNISVSFKQRSRMYGATVIVRGSQNNTSAVKEGTAMLLEHLAGSLASAIPVSTQLD
IAAQHHLFMMGRNGSNIKHIMQRTGAQIHFPDPSNPQKKSTVYLQGTIESVCLARQYLMGCLPLVLMFDMKEEIEVDPQFIAQLMEQLDV
FISIKPKPKQPSKSVIVKSVERNALNMYEARKCLLGLESSGVTIATSPSPASCPAGLACPSLDILASAGLGLTGLGLLGPTTLSLNTSTT
PNSLLNALNSSVSPLQSPSSGTPSPTLWAPPLANTSSATGFSAIPHLMIPSTAQATLTNILLSGVPTYGHTAPSPPPGLTPVDVHINSMQ
TEGKKISAALNGHAQSPDIKYGAISTSSLGEKVLSANHGDPSIQTSGSEQTSPKSSPTEGCNDAFVEVGMPRSPSHSGNAGDLKQMMCPS
KVSCAKRQTVELLQGTKNSHLHSTDRLLSDPELSATESPLADKKAPGSERAAERAAAAQQNSERAHLAPRSSYVNMQAFDYEQKKLLATK
AMLKKPVVTEVRTPTNTWSGLGFSKSMPAETIKELRRANHVSYKPTMTTTYEGSSMSLSRSNSREHLGGGSESDNWRDRNGIGPGSHSEF
AASIGSPKRKQNKSTEHYLSSSNYMDCISSLTGSNGCNLNSSFKGSDLPELFSKLGLGKYTDVFQQQEIDLQTFLTLTDQDLKELGITTF
1584_FGFR2_BICC1


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Comparison of Fusion Protein Isoforms

check button Superimpose the 3D Structures Among All Fusion Protein Isoforms
* Download the pdb file and open it from the molstar online viewer.
3D view using mol* of viewer/superimpose_isoforms/HKFP_146_FGFR2_BICC1_vs_HKFP_147_FGFR2_BICC1_superimposed.pdb.html

check button Comparison of the Secondary Structures of Fusion Protein Isoforms
./secondary_str/HKFP_146_FGFR2_BICC1_vs_HKFP_147_FGFR2_BICC1.png
secondary structure of ./secondary_str/HKFP_146_FGFR2_BICC1_vs_HKFP_147_FGFR2_BICC1.png

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

FGFR2_BICC1 does not have any known PDB structures.

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pLDDT score distribution

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
* The blue color at the bottom marks the best active site residues.
104_FGFR2_BICC1.png
all structure sitemap plddt 104_FGFR2_BICC1.png
104_FGFR2_BICC1.png
all structure sitemap plddt2 104_FGFR2_BICC1.png
HKFP_147_FGFR2_BICC1.png
all structure sitemap plddt HKFP_147_FGFR2_BICC1.png


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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Kinase Fusion AA seq ID in KinaseFusionDBSite scoreSizeDscoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
HKFP_147_FGFR2_BICC11.0574231.0871390.5220.4970.7510.9971.0410.9321.1170.836Chain A: 364,365,366,367,368,369,388,390,391,393,4
07,409,410,411,412,413,414,415,416,417,437,439,440
,441,447,448,449,450,451,452,453,454,455,456,457,4
58,459,460,461,462,463,470,477,486,487,488,489,492
,493,542,543,544,547,548,552,553,555,565,566,567,5
68,569,571,572,575,576,577,578,579,580,582,583,584
,585,586,587,588,592,596,597,598,599,600,601,602

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Ramachandran Plot of Kinase Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

104_FGFR2_BICC1_ramachandran.png
all structure FGFR2-BICC1
HKFP_147_FGFR2_BICC1_ramachandran.png
all structure FGFR2-BICC1

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Virtual Screening Results


check button Distribution of the average docking score across all approved kinase inhibitors.
Distribution of the number of occurrence across all approved kinase inhibitors.
5'-kinase fusion protein case
all structure FGFR2-BICC1
3'-kinase fusion protein case

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check button Drug information from DrugBank of the top 20 interacting small molecules.
* The detailed information of individual kinase inhibitors are available in the download page.
Fusion gene name infoDrugDocking scoreGlide g scoreGlide energy
HKFP_147_FGFR2_BICC1_vsw_4-DOCK_HTVS_1-001Pexidartinib-6.4787-6.6955-38.7802
HKFP_147_FGFR2_BICC1_vsw_4-DOCK_HTVS_1-001Pexidartinib-6.4787-6.6955-38.7802
HKFP_147_FGFR2_BICC1_vsw_4-DOCK_HTVS_1-001Midostaurin-6.24849-6.24849-19.3955
HKFP_147_FGFR2_BICC1_vsw_4-DOCK_HTVS_1-001Larotrectinib-6.09518-6.09518-45.8099
HKFP_147_FGFR2_BICC1_vsw_4-DOCK_HTVS_1-001Midostaurin-5.93047-5.93047-53.1946
HKFP_147_FGFR2_BICC1_vsw_4-DOCK_HTVS_1-001Dasatinib-5.8627699999999985-6.3486699999999985-55.5584
HKFP_147_FGFR2_BICC1_vsw_4-DOCK_HTVS_1-001Dasatinib-5.8627699999999985-6.3486699999999985-55.5584
HKFP_147_FGFR2_BICC1_vsw_4-DOCK_HTVS_1-001Dasatinib-5.8627699999999985-6.3486699999999985-55.5584
HKFP_147_FGFR2_BICC1_vsw_4-DOCK_HTVS_1-001Pralsetinib-5.71813-5.80963-55.6256
HKFP_147_FGFR2_BICC1_vsw_4-DOCK_HTVS_1-001Regorafenib-5.65364-5.65364-48.76600000000001
HKFP_147_FGFR2_BICC1_vsw_4-DOCK_HTVS_1-001Lenvatinib-5.6517800000000005-5.6517800000000005-33.9098
HKFP_147_FGFR2_BICC1_vsw_4-DOCK_HTVS_1-001Pralsetinib-5.64012-5.73162-51.4959
HKFP_147_FGFR2_BICC1_vsw_4-DOCK_HTVS_1-001Belumosudil-5.47384-5.48154-52.3571
HKFP_147_FGFR2_BICC1_vsw_4-DOCK_HTVS_1-001Sorafenib-5.459969999999998-5.47207-48.4533
HKFP_147_FGFR2_BICC1_vsw_4-DOCK_HTVS_1-001Sorafenib-5.459969999999998-5.47207-48.4533
HKFP_147_FGFR2_BICC1_vsw_4-DOCK_HTVS_1-001Axitinib-5.45734-5.46054-37.6318
HKFP_147_FGFR2_BICC1_vsw_4-DOCK_HTVS_1-001Pralsetinib-5.38919-6.54139-56.9709
HKFP_147_FGFR2_BICC1_vsw_4-DOCK_HTVS_1-001Selumetinib-5.3799199999999985-5.38862-46.265
HKFP_147_FGFR2_BICC1_vsw_4-DOCK_HTVS_1-001Selumetinib-5.3799199999999985-5.38862-46.265
HKFP_147_FGFR2_BICC1_vsw_4-DOCK_HTVS_1-001Mobocertinib-5.3217300000000005-5.32943-52.378
104_FGFR2_BICC1-DOCK_HTVS_1-001Lapatinib-6.68215-6.77095-59.6959
104_FGFR2_BICC1-DOCK_HTVS_1-001Netarsudil-6.56122-6.5723199999999995-49.6384
104_FGFR2_BICC1-DOCK_HTVS_1-001Netarsudil-6.56122-6.5723199999999995-49.6384
104_FGFR2_BICC1-DOCK_HTVS_1-001Larotrectinib-6.278580000000001-6.278580000000001-50.4099
104_FGFR2_BICC1-DOCK_HTVS_1-001Netarsudil-6.19704-6.20814-54.9219
104_FGFR2_BICC1-DOCK_HTVS_1-001Netarsudil-6.19704-6.20814-54.9219
104_FGFR2_BICC1-DOCK_HTVS_1-001Lapatinib-6.17165-6.26045-55.6953
104_FGFR2_BICC1-DOCK_HTVS_1-001Pralsetinib-6.05569-6.14719-42.7377
104_FGFR2_BICC1-DOCK_HTVS_1-001Larotrectinib-5.95535-5.95535-51.0727
104_FGFR2_BICC1-DOCK_HTVS_1-001Cabozantinib-5.94025-5.98525-55.9493
104_FGFR2_BICC1-DOCK_HTVS_1-001Cabozantinib-5.94025-5.98525-55.9493
104_FGFR2_BICC1-DOCK_HTVS_1-001Neratinib-5.7366-5.9225-50.1515
104_FGFR2_BICC1-DOCK_HTVS_1-001Pazopanib-5.63767-5.64457-41.0676
104_FGFR2_BICC1-DOCK_HTVS_1-001Pazopanib-5.63767-5.64457-41.0676
104_FGFR2_BICC1-DOCK_HTVS_1-001Larotrectinib-5.53718-5.53718-49.4987
104_FGFR2_BICC1-DOCK_HTVS_1-001Neratinib-5.43219-5.61449-49.788000000000004
104_FGFR2_BICC1-DOCK_HTVS_1-001Neratinib-5.43219-5.61449-49.788000000000004
104_FGFR2_BICC1-DOCK_HTVS_1-001Ibrutinib-5.2706-5.2706-37.1413
104_FGFR2_BICC1-DOCK_HTVS_1-001Abrocitinib-5.26269-5.27379-39.5986
104_FGFR2_BICC1-DOCK_HTVS_1-001Abrocitinib-5.26269-5.27379-39.5986

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Kinase-Substrate Information of FGFR2_BICC1


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
FGFR2P21802humanFGFR2P21802Y769TLTTNEEyLDLSQPL
FGFR2P21802humanCTNNB1P35222Y142AVVNLINyQDDAELA
FGFR2P21802humanPTENP60484Y240RREDKFMyFEFPQPLPTEN_C2
FGFR2P21802humanGLO1Q04760Y136GIAVPDVysACkRFEGlyoxalase
FGFR2P21802humanTFRCP02786Y20FGGEPLsytRFsLAR
FGFR2P21802humanGRB2P62993Y160QVPQQPtyVQALFDF


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
FGFR2IDDescription0.00e+00
FGFR2GO:0008543fibroblast growth factor receptor signaling pathway7.81e-04
FGFR2GO:0030316osteoclast differentiation7.81e-04
FGFR2GO:0044344cellular response to fibroblast growth factor stimulus7.81e-04
FGFR2GO:0060742epithelial cell differentiation involved in prostate gland development7.81e-04
FGFR2GO:0021761limbic system development7.81e-04
FGFR2GO:0071774response to fibroblast growth factor7.81e-04
FGFR2GO:0001704formation of primary germ layer7.81e-04
FGFR2GO:0060670branching involved in labyrinthine layer morphogenesis7.81e-04
FGFR2GO:0060572morphogenesis of an epithelial bud9.34e-04
FGFR2GO:0097091synaptic vesicle clustering9.61e-04
FGFR2GO:0048660regulation of smooth muscle cell proliferation1.18e-03
FGFR2GO:0048659smooth muscle cell proliferation1.18e-03
FGFR2GO:0001837epithelial to mesenchymal transition1.18e-03
FGFR2GO:0061138morphogenesis of a branching epithelium1.23e-03
FGFR2GO:0060713labyrinthine layer morphogenesis1.23e-03
FGFR2GO:0007369gastrulation1.26e-03
FGFR2GO:0060571morphogenesis of an epithelial fold1.26e-03
FGFR2GO:0001763morphogenesis of a branching structure1.26e-03
FGFR2GO:0002053positive regulation of mesenchymal cell proliferation1.26e-03
FGFR2GO:0060669embryonic placenta morphogenesis1.40e-03
FGFR2GO:0060441epithelial tube branching involved in lung morphogenesis1.61e-03
FGFR2GO:0002573myeloid leukocyte differentiation1.61e-03
FGFR2GO:0051091positive regulation of DNA-binding transcription factor activity1.62e-03
FGFR2GO:0010464regulation of mesenchymal cell proliferation1.62e-03
FGFR2GO:0033002muscle cell proliferation1.62e-03
FGFR2GO:0031069hair follicle morphogenesis1.62e-03
FGFR2GO:0048762mesenchymal cell differentiation1.80e-03
FGFR2GO:0010092specification of animal organ identity1.80e-03
FGFR2GO:0048730epidermis morphogenesis1.83e-03
FGFR2GO:0010463mesenchymal cell proliferation2.43e-03
FGFR2GO:0060428lung epithelium development2.43e-03
FGFR2GO:0060711labyrinthine layer development2.58e-03
FGFR2GO:0060070canonical Wnt signaling pathway2.59e-03
FGFR2GO:0035987endodermal cell differentiation2.62e-03
FGFR2GO:0048546digestive tract morphogenesis2.62e-03
FGFR2GO:0060485mesenchyme development2.62e-03
FGFR2GO:0030850prostate gland development2.64e-03
FGFR2GO:0060688regulation of morphogenesis of a branching structure2.78e-03
FGFR2GO:0060425lung morphogenesis2.85e-03
FGFR2GO:0097479synaptic vesicle localization2.85e-03
FGFR2GO:0001706endoderm formation3.21e-03
FGFR2GO:0001701in utero embryonic development3.84e-03
FGFR2GO:0045453bone resorption3.84e-03
FGFR2GO:0001655urogenital system development3.84e-03
FGFR2GO:0048645animal organ formation3.84e-03
FGFR2GO:0051090regulation of DNA-binding transcription factor activity3.84e-03
FGFR2GO:0030900forebrain development3.84e-03
FGFR2GO:0051347positive regulation of transferase activity3.96e-03
FGFR2GO:1904888cranial skeletal system development4.12e-03

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Related Drugs to FGFR2_BICC1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning FGFR2-BICC1 and kinase inhibitors the PubMed Abstract (04-01-2024)
all structure sitemap plddt FGFR2-BICC1

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title
FGFR2-BICC1 AND Sorafenib 318070102019-1110.2147/ott.s218796FGFR2-BICC1: A Subtype Of FGFR2 Oncogenic Fusion Variant In Cholangiocarcinoma And The Response To Sorafenib.
FGFR2-BICC1 AND Pemigatinib 361891362022-910.1016/j.aace.2022.07.001Hyperphosphatemic Tumoral Calcinosis With Pemigatinib Use.

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Related Diseases to FGFR2_BICC1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFGFR2C2931196Craniofacial dysostosis type 123CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneFGFR2C0220658Pfeiffer Syndrome21CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneFGFR2C0001193Apert syndrome19CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneFGFR2C0795998JACKSON-WEISS SYNDROME10CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneFGFR2C0175699Saethre-Chotzen Syndrome8CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneFGFR2C1852406Cutis Gyrata Syndrome of Beare And Stevenson8CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneFGFR2C2936791Antley-Bixler Syndrome, Autosomal Dominant7CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneFGFR2C1510455Acrocephalosyndactylia6CTD_human;ORPHANET
HgeneFGFR2C0265269Lacrimoauriculodentodigital syndrome5CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneFGFR2C0010278Craniosynostosis4CTD_human;GENOMICS_ENGLAND
HgeneFGFR2C1863389Apert-Crouzon Disease4CTD_human
HgeneFGFR2C1865070SCAPHOCEPHALY, MAXILLARY RETRUSION, AND MENTAL RETARDATION4CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneFGFR2C0006142Malignant neoplasm of breast3CTD_human;UNIPROT
HgeneFGFR2C0030044Acrocephaly3CTD_human
HgeneFGFR2C0036341Schizophrenia3PSYGENET
HgeneFGFR2C0221356Brachycephaly3CTD_human
HgeneFGFR2C0265534Scaphycephaly3CTD_human
HgeneFGFR2C0265535Trigonocephaly3CTD_human
HgeneFGFR2C0376634Craniofacial Abnormalities3CTD_human
HgeneFGFR2C0678222Breast Carcinoma3CTD_human
HgeneFGFR2C1257931Mammary Neoplasms, Human3CTD_human
HgeneFGFR2C1458155Mammary Neoplasms3CTD_human
HgeneFGFR2C1833340Synostotic Posterior Plagiocephaly3CTD_human
HgeneFGFR2C1860819Metopic synostosis3CTD_human
HgeneFGFR2C2931150Synostotic Anterior Plagiocephaly3CTD_human
HgeneFGFR2C3281247BENT BONE DYSPLASIA SYNDROME3CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneFGFR2C4551902Craniosynostosis, Type 13CTD_human
HgeneFGFR2C4704874Mammary Carcinoma, Human3CTD_human
HgeneFGFR2C0008925Cleft Palate2CTD_human
HgeneFGFR2C0011570Mental Depression2PSYGENET
HgeneFGFR2C0011581Depressive disorder2PSYGENET
HgeneFGFR2C0024623Malignant neoplasm of stomach2CGI;CTD_human
HgeneFGFR2C0038356Stomach Neoplasms2CGI;CTD_human
HgeneFGFR2C1708349Hereditary Diffuse Gastric Cancer2CTD_human
HgeneFGFR2C1837218Cleft palate, isolated2CTD_human


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate