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	Kinase Fusion Gene Summary
	Kinase Fusion Gene Sample Information
	Kinase Fusion ORF Analysis
	Kinase Fusion Amino Acid Sequences
	Multiple Sequence Alignment of All Fusion Protein Isoforms
	Kinase Fusion Protein Functional Features
	Kinase Fusion Protein Structures
	Comparison of Fusion Protein Isoforms
	Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB
	pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.
	Ramachandran Plot of Kinase Fusion Protein Structure
	Potential Active Site Information
	Virtual Screening Results
	Kinase-Substrate Information
	Related Drugs with This Kinase Fusion Protein
	Related Disease with This Kinase Fusion Protein
	Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:FGFR3_ELAVL3

Kinase Fusion Protein Summary

Kinase Fusion gene summary

Kinase Fusion partner gene information	Kinase Fusion gene name: FGFR3_ELAVL3
	KinaseFusionDB ID: KFG2359
	FusionGDB2.0 ID: KFG2359
		Hgene	Tgene
	Gene symbol	FGFR3	ELAVL3
	Gene ID	2261	1995
	Gene name	fibroblast growth factor receptor 3	ELAV like RNA binding protein 3
	Synonyms	ACH\|CD333\|CEK2\|HSFGFR3EX\|JTK4	HUC\|HUCL\|PLE21
	Cytomap	4p16.3	19p13.2
	Type of gene	protein-coding	protein-coding
	Description	fibroblast growth factor receptor 3FGFR-3fibroblast growth factor receptor 3-Shydroxyaryl-protein kinasetyrosine kinase JTK4	ELAV-like protein 3ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)ELAV like neuron-specific RNA binding protein 3Hu antigen Chu-antigen Cparaneoplastic cerebellar degeneration-associated antigenparaneoplastic limbic enceph
	Modification date	20240413	20240407
	UniProtAcc	P22607	Q14576
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000260795, ENST00000340107, ENST00000352904, ENST00000412135, ENST00000440486, ENST00000481110, ENST00000474521,	ENST00000359227, ENST00000438662, ENST00000592218,
Context (manual curation of fusion genes in KinaseFusionDB)	PubMed: FGFR3 [Title/Abstract] AND ELAVL3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	FGFR3(1808661)-ELAVL3(11577642), # samples:4

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	FGFR3	GO:0008543	fibroblast growth factor receptor signaling pathway	8663044

Kinase Fusion gene breakpoints across FGFR3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Kinase Fusion gene breakpoints across ELAVL3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Kinase Fusion Gene Sample Information

Kinase Fusion gene information.

Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Sample	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
ChimerDB4	TCGA-CS-6186	FGFR3	chr4	1809011	ELAVL3	chr19	11577642
ChimerDB4	TCGA-CS-6186	FGFR3	chr4	1809107	ELAVL3	chr19	11577642
ChimerDB4	TCGA-CS-6186-01A	FGFR3	chr4	1808660	ELAVL3	chr19	11577641
ChimerDB4	TCGA-CS-6186-01A	FGFR3	chr4	1808661	ELAVL3	chr19	11577642
ChimerDB4	TCGA-CS-6186	FGFR3	chr4	1808661	ELAVL3	chr19	11577639

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Kinase Fusion ORF Analysis

Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (amino acids)
ENST00000440486	ENST00000359227	FGFR3	chr4	1808661	ELAVL3	chr19	11577642	6825	1133
ENST00000440486	ENST00000359227	FGFR3	chr4	1808661	ELAVL3	chr19	11577639	6825	1133
ENST00000440486	ENST00000359227	FGFR3	chr4	1808660	ELAVL3	chr19	11577641	6825	1133

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Kinase Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

>ENST00000440486_ENST00000359227_FGFR3_chr4_1808661_ELAVL3_chr19_11577642_length(amino acids)=1133
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSH
HSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVR
IARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMM
KMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLA
ARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKE
GHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDQILGAMESQVGGGPAGPALPNGPLLGTNGATDDSKTNLIVN
YLPQNMTQDEFKSLFGSIGDIESCKLVRDKITGQSLGYGFVNYSDPNDADKAINTLNGLKLQTKTIKVSYARPSSASIRDANLYVSGLPK
TMSQKEMEQLFSQYGRIITSRILVDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPLGAAEPITVKFANNPSQKTGQALLTHLYQSSAR
RYAGPLHHQTQRFRLDNLLNMAYGVKSPLSLIARFSPIAIDGMSGLAGVGLSGGAAGAGWCIFVYNLSPEADESVLWQLFGPFGAVTNVK

--------------------------------------------------------------

>ENST00000440486_ENST00000359227_FGFR3_chr4_1808661_ELAVL3_chr19_11577639_length(amino acids)=1133
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSH
HSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVR
IARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMM
KMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLA
ARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKE
GHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDQILGAMESQVGGGPAGPALPNGPLLGTNGATDDSKTNLIVN
YLPQNMTQDEFKSLFGSIGDIESCKLVRDKITGQSLGYGFVNYSDPNDADKAINTLNGLKLQTKTIKVSYARPSSASIRDANLYVSGLPK
TMSQKEMEQLFSQYGRIITSRILVDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPLGAAEPITVKFANNPSQKTGQALLTHLYQSSAR
RYAGPLHHQTQRFRLDNLLNMAYGVKSPLSLIARFSPIAIDGMSGLAGVGLSGGAAGAGWCIFVYNLSPEADESVLWQLFGPFGAVTNVK

--------------------------------------------------------------

>ENST00000440486_ENST00000359227_FGFR3_chr4_1808660_ELAVL3_chr19_11577641_length(amino acids)=1133
MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT
GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA
NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL
PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSH
HSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVR
IARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMM
KMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLA
ARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKE
GHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDQILGAMESQVGGGPAGPALPNGPLLGTNGATDDSKTNLIVN
YLPQNMTQDEFKSLFGSIGDIESCKLVRDKITGQSLGYGFVNYSDPNDADKAINTLNGLKLQTKTIKVSYARPSSASIRDANLYVSGLPK
TMSQKEMEQLFSQYGRIITSRILVDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPLGAAEPITVKFANNPSQKTGQALLTHLYQSSAR
RYAGPLHHQTQRFRLDNLLNMAYGVKSPLSLIARFSPIAIDGMSGLAGVGLSGGAAGAGWCIFVYNLSPEADESVLWQLFGPFGAVTNVK

--------------------------------------------------------------

Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:1808661/chr19:11577642)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FGFR3 P22607	ELAVL3 Q14576
FUNCTION: Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Plays a role in the regulation of vitamin D metabolism. Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling. Over-expressed or constitutively activated FGFR3 promotes activation of PTPN11/SHP2, STAT1, STAT5A and STAT5B. Secreted isoform 3 retains its capacity to bind FGF1 and FGF2 and hence may interfere with FGF signaling. {ECO:0000269\|PubMed:10611230, ECO:0000269\|PubMed:11294897, ECO:0000269\|PubMed:11703096, ECO:0000269\|PubMed:14534538, ECO:0000269\|PubMed:16410555, ECO:0000269\|PubMed:16597617, ECO:0000269\|PubMed:17145761, ECO:0000269\|PubMed:17311277, ECO:0000269\|PubMed:17509076, ECO:0000269\|PubMed:17561467, ECO:0000269\|PubMed:19088846, ECO:0000269\|PubMed:19286672, ECO:0000269\|PubMed:8663044}.	FUNCTION: RNA-binding protein that binds to AU-rich element (ARE) sequences of target mRNAs, including VEGF mRNA (PubMed:10710437). May also bind poly-A tracts via RRM 3 (By similarity). May be involved in neuronal differentiation and maintenance (By similarity). Plays a role in the stabilization of GAP43 mRNA and in spatial learning (By similarity). {ECO:0000250\|UniProtKB:Q60900, ECO:0000269\|PubMed:10710437}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).

646646758758760646646758758760646646758758760646646758758760646646758758760646646758758760646646758758760646646758758760646646758758760758758760758758760758758760

Partner	Hgeneene	Hbp	Tgeneene	Tbp	ENST	BPexon	TotalExon	Protein feature loci	BPloci	TotalLen	Feature	Note
Hgene	FGFR3	1808660	ELAVL3	11577641	ENST00000440486	14	15	24_126	1	695	Domain	Note=Ig-like C2-type 1
Hgene	FGFR3	1808660	ELAVL3	11577641	ENST00000440486	15	16	24_126	1	695	Domain	Note=Ig-like C2-type 1
Hgene	FGFR3	1808660	ELAVL3	11577641	ENST00000440486	16	17	24_126	1	807	Domain	Note=Ig-like C2-type 1
Hgene	FGFR3	1808660	ELAVL3	11577641	ENST00000440486	17	18	24_126	1	807	Domain	Note=Ig-like C2-type 1
Hgene	FGFR3	1808660	ELAVL3	11577641	ENST00000440486	17	18	24_126	1	809	Domain	Note=Ig-like C2-type 1
Hgene	FGFR3	1808661	ELAVL3	11577639	ENST00000440486	14	15	24_126	1	695	Domain	Note=Ig-like C2-type 1
Hgene	FGFR3	1808661	ELAVL3	11577639	ENST00000440486	15	16	24_126	1	695	Domain	Note=Ig-like C2-type 1
Hgene	FGFR3	1808661	ELAVL3	11577639	ENST00000440486	16	17	24_126	1	807	Domain	Note=Ig-like C2-type 1
Hgene	FGFR3	1808661	ELAVL3	11577639	ENST00000440486	17	18	24_126	1	807	Domain	Note=Ig-like C2-type 1
Hgene	FGFR3	1808661	ELAVL3	11577639	ENST00000440486	17	18	24_126	1	809	Domain	Note=Ig-like C2-type 1
Hgene	FGFR3	1808661	ELAVL3	11577642	ENST00000440486	14	15	24_126	1	695	Domain	Note=Ig-like C2-type 1
Hgene	FGFR3	1808661	ELAVL3	11577642	ENST00000440486	15	16	24_126	1	695	Domain	Note=Ig-like C2-type 1
Hgene	FGFR3	1808661	ELAVL3	11577642	ENST00000440486	16	17	24_126	1	807	Domain	Note=Ig-like C2-type 1
Hgene	FGFR3	1808661	ELAVL3	11577642	ENST00000440486	17	18	24_126	1	807	Domain	Note=Ig-like C2-type 1
Hgene	FGFR3	1808661	ELAVL3	11577642	ENST00000440486	17	18	24_126	1	809	Domain	Note=Ig-like C2-type 1
Hgene	FGFR3	1808660	ELAVL3	11577641	ENST00000440486	14	15	151_244	1	695	Domain	Note=Ig-like C2-type 2
Hgene	FGFR3	1808660	ELAVL3	11577641	ENST00000440486	15	16	151_244	1	695	Domain	Note=Ig-like C2-type 2
Hgene	FGFR3	1808660	ELAVL3	11577641	ENST00000440486	16	17	151_244	1	807	Domain	Note=Ig-like C2-type 2
Hgene	FGFR3	1808660	ELAVL3	11577641	ENST00000440486	17	18	151_244	1	807	Domain	Note=Ig-like C2-type 2
Hgene	FGFR3	1808660	ELAVL3	11577641	ENST00000440486	17	18	151_244	1	809	Domain	Note=Ig-like C2-type 2
Hgene	FGFR3	1808661	ELAVL3	11577639	ENST00000440486	14	15	151_244	1	695	Domain	Note=Ig-like C2-type 2
Hgene	FGFR3	1808661	ELAVL3	11577639	ENST00000440486	15	16	151_244	1	695	Domain	Note=Ig-like C2-type 2
Hgene	FGFR3	1808661	ELAVL3	11577639	ENST00000440486	16	17	151_244	1	807	Domain	Note=Ig-like C2-type 2
Hgene	FGFR3	1808661	ELAVL3	11577639	ENST00000440486	17	18	151_244	1	807	Domain	Note=Ig-like C2-type 2
Hgene	FGFR3	1808661	ELAVL3	11577639	ENST00000440486	17	18	151_244	1	809	Domain	Note=Ig-like C2-type 2
Hgene	FGFR3	1808661	ELAVL3	11577642	ENST00000440486	14	15	151_244	1	695	Domain	Note=Ig-like C2-type 2
Hgene	FGFR3	1808661	ELAVL3	11577642	ENST00000440486	15	16	151_244	1	695	Domain	Note=Ig-like C2-type 2
Hgene	FGFR3	1808661	ELAVL3	11577642	ENST00000440486	16	17	151_244	1	807	Domain	Note=Ig-like C2-type 2
Hgene	FGFR3	1808661	ELAVL3	11577642	ENST00000440486	17	18	151_244	1	807	Domain	Note=Ig-like C2-type 2
Hgene	FGFR3	1808661	ELAVL3	11577642	ENST00000440486	17	18	151_244	1	809	Domain	Note=Ig-like C2-type 2
Hgene	FGFR3	1808660	ELAVL3	11577641	ENST00000440486	14	15	253_355	1	695	Domain	Note=Ig-like C2-type 3
Hgene	FGFR3	1808660	ELAVL3	11577641	ENST00000440486	15	16	253_355	1	695	Domain	Note=Ig-like C2-type 3
Hgene	FGFR3	1808660	ELAVL3	11577641	ENST00000440486	16	17	253_355	1	807	Domain	Note=Ig-like C2-type 3
Hgene	FGFR3	1808660	ELAVL3	11577641	ENST00000440486	17	18	253_355	1	807	Domain	Note=Ig-like C2-type 3
Hgene	FGFR3	1808660	ELAVL3	11577641	ENST00000440486	17	18	253_355	1	809	Domain	Note=Ig-like C2-type 3
Hgene	FGFR3	1808661	ELAVL3	11577639	ENST00000440486	14	15	253_355	1	695	Domain	Note=Ig-like C2-type 3
Hgene	FGFR3	1808661	ELAVL3	11577639	ENST00000440486	15	16	253_355	1	695	Domain	Note=Ig-like C2-type 3
Hgene	FGFR3	1808661	ELAVL3	11577639	ENST00000440486	16	17	253_355	1	807	Domain	Note=Ig-like C2-type 3
Hgene	FGFR3	1808661	ELAVL3	11577639	ENST00000440486	17	18	253_355	1	807	Domain	Note=Ig-like C2-type 3
Hgene	FGFR3	1808661	ELAVL3	11577639	ENST00000440486	17	18	253_355	1	809	Domain	Note=Ig-like C2-type 3
Hgene	FGFR3	1808661	ELAVL3	11577642	ENST00000440486	14	15	253_355	1	695	Domain	Note=Ig-like C2-type 3
Hgene	FGFR3	1808661	ELAVL3	11577642	ENST00000440486	15	16	253_355	1	695	Domain	Note=Ig-like C2-type 3
Hgene	FGFR3	1808661	ELAVL3	11577642	ENST00000440486	16	17	253_355	1	807	Domain	Note=Ig-like C2-type 3
Hgene	FGFR3	1808661	ELAVL3	11577642	ENST00000440486	17	18	253_355	1	807	Domain	Note=Ig-like C2-type 3
Hgene	FGFR3	1808661	ELAVL3	11577642	ENST00000440486	17	18	253_355	1	809	Domain	Note=Ig-like C2-type 3
Hgene	FGFR3	1808660	ELAVL3	11577641	ENST00000440486	16	17	472_761	1	807	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Hgene	FGFR3	1808660	ELAVL3	11577641	ENST00000440486	17	18	472_761	1	807	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Hgene	FGFR3	1808660	ELAVL3	11577641	ENST00000440486	17	18	472_761	1	809	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Hgene	FGFR3	1808661	ELAVL3	11577639	ENST00000440486	16	17	472_761	1	807	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Hgene	FGFR3	1808661	ELAVL3	11577639	ENST00000440486	17	18	472_761	1	807	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Hgene	FGFR3	1808661	ELAVL3	11577639	ENST00000440486	17	18	472_761	1	809	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Hgene	FGFR3	1808661	ELAVL3	11577642	ENST00000440486	16	17	472_761	1	807	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Hgene	FGFR3	1808661	ELAVL3	11577642	ENST00000440486	17	18	472_761	1	807	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Hgene	FGFR3	1808661	ELAVL3	11577642	ENST00000440486	17	18	472_761	1	809	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159

- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).

Partner

Hgeneene

Hbp

Tgeneene

Tbp

ENST

BPexon

TotalExon

Protein feature loci

BPloci

TotalLen

Feature

Note

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Kinase Fusion Protein Structures

CIF files of the predicted kinase fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Kinase Fusion protein CIF link (fusion AA seq ID in KinaseFusionDB)	Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	AA seq	Len(AA seq)
PDB file >>>123_FGFR3_ELAVL3	ENST00000440486	ENST00000359227	FGFR3	chr4	1808660	ELAVL3	chr19	11577641	MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSH HSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVR IARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMM KMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLA ARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKE GHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDQILGAMESQVGGGPAGPALPNGPLLGTNGATDDSKTNLIVN YLPQNMTQDEFKSLFGSIGDIESCKLVRDKITGQSLGYGFVNYSDPNDADKAINTLNGLKLQTKTIKVSYARPSSASIRDANLYVSGLPK TMSQKEMEQLFSQYGRIITSRILVDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPLGAAEPITVKFANNPSQKTGQALLTHLYQSSAR RYAGPLHHQTQRFRLDNLLNMAYGVKSPLSLIARFSPIAIDGMSGLAGVGLSGGAAGAGWCIFVYNLSPEADESVLWQLFGPFGAVTNVK	1133
3D view using mol* of 123_FGFR3_ELAVL3

PDB file >>>HKFP_178_FGFR3_ELAVL3	ENST00000440486	ENST00000359227	FGFR3	chr4	1808661	ELAVL3	chr19	11577642	MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSH HSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVR IARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMM KMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLA ARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKE GHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDQILGAMESQVGGGPAGPALPNGPLLGTNGATDDSKTNLIVN YLPQNMTQDEFKSLFGSIGDIESCKLVRDKITGQSLGYGFVNYSDPNDADKAINTLNGLKLQTKTIKVSYARPSSASIRDANLYVSGLPK TMSQKEMEQLFSQYGRIITSRILVDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPLGAAEPITVKFANNPSQKTGQALLTHLYQSSAR RYAGPLHHQTQRFRLDNLLNMAYGVKSPLSLIARFSPIAIDGMSGLAGVGLSGGAAGAGWCIFVYNLSPEADESVLWQLFGPFGAVTNVK	1133_FGFR3_ELAVL3
PDB file >>>HKFP_179_FGFR3_ELAVL3	ENST00000440486	ENST00000359227	FGFR3	chr4	1808661	ELAVL3	chr19	11577639	MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSH HSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVR IARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMM KMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLA ARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKE GHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDQILGAMESQVGGGPAGPALPNGPLLGTNGATDDSKTNLIVN YLPQNMTQDEFKSLFGSIGDIESCKLVRDKITGQSLGYGFVNYSDPNDADKAINTLNGLKLQTKTIKVSYARPSSASIRDANLYVSGLPK TMSQKEMEQLFSQYGRIITSRILVDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPLGAAEPITVKFANNPSQKTGQALLTHLYQSSAR RYAGPLHHQTQRFRLDNLLNMAYGVKSPLSLIARFSPIAIDGMSGLAGVGLSGGAAGAGWCIFVYNLSPEADESVLWQLFGPFGAVTNVK	1133_FGFR3_ELAVL3
PDB file >>>HKFP_180_FGFR3_ELAVL3	ENST00000440486	ENST00000359227	FGFR3	chr4	1808660	ELAVL3	chr19	11577641	MPEDAAAPAPAMGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGT GLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAA NTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGL PANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSH HSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVR IARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMM KMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLA ARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKE GHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDQILGAMESQVGGGPAGPALPNGPLLGTNGATDDSKTNLIVN YLPQNMTQDEFKSLFGSIGDIESCKLVRDKITGQSLGYGFVNYSDPNDADKAINTLNGLKLQTKTIKVSYARPSSASIRDANLYVSGLPK TMSQKEMEQLFSQYGRIITSRILVDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPLGAAEPITVKFANNPSQKTGQALLTHLYQSSAR RYAGPLHHQTQRFRLDNLLNMAYGVKSPLSLIARFSPIAIDGMSGLAGVGLSGGAAGAGWCIFVYNLSPEADESVLWQLFGPFGAVTNVK	1133_FGFR3_ELAVL3

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Comparison of Fusion Protein Isoforms

Superimpose the 3D Structures Among All Fusion Protein Isoforms
* Download the pdb file and open it from the molstar online viewer.

Comparison of the Secondary Structures of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

FGFR3_ELAVL3 does not have any known PDB structures.

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pLDDT score distribution

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
* The blue color at the bottom marks the best active site residues.

123_FGFR3_ELAVL3.png

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Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Kinase Fusion AA seq ID in KinaseFusionDB

Site score

Size

Dscore

Volume

Exposure

Enclosure

Contact

Phobic

Philic

Balance

Don/Acc

Residues

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Ramachandran Plot of Kinase Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

123_FGFR3_ELAVL3_ramachandran.png

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Virtual Screening Results

Distribution of the average docking score across all approved kinase inhibitors.
Distribution of the number of occurrence across all approved kinase inhibitors.

5'-kinase fusion protein case

3'-kinase fusion protein case

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Drug information from DrugBank of the top 20 interacting small molecules.
* The detailed information of individual kinase inhibitors are available in the download page.

Fusion gene name info	Drug	Docking score	Glide g score	Glide energy
123_FGFR3_ELAVL3-DOCK_HTVS_1-001	Lapatinib	-7.87135	-7.96015	-55.6663
123_FGFR3_ELAVL3-DOCK_HTVS_1-001	Midostaurin	-7.748310000000001	-7.748310000000001	-37.5114
123_FGFR3_ELAVL3-DOCK_HTVS_1-001	Capmatinib	-7.5772699999999995	-7.58287	-50.4272
123_FGFR3_ELAVL3-DOCK_HTVS_1-001	Tivozanib	-7.5019800000000005	-7.5019800000000005	-51.7471
123_FGFR3_ELAVL3-DOCK_HTVS_1-001	Midostaurin	-7.49453	-7.49453	-42.071000000000005
123_FGFR3_ELAVL3-DOCK_HTVS_1-001	Belumosudil	-7.46235	-7.47005	-55.0964
123_FGFR3_ELAVL3-DOCK_HTVS_1-001	Ibrutinib	-7.4207600000000005	-7.4207600000000005	-50.5892
123_FGFR3_ELAVL3-DOCK_HTVS_1-001	Acalabrutinib	-7.34565	-7.35975	-60.5918
123_FGFR3_ELAVL3-DOCK_HTVS_1-001	Acalabrutinib	-7.34565	-7.35975	-60.5918
123_FGFR3_ELAVL3-DOCK_HTVS_1-001	Lenvatinib	-7.279710000000001	-7.279710000000001	-46.8557
123_FGFR3_ELAVL3-DOCK_HTVS_1-001	Zanubrutinib	-7.2179199999999994	-7.2179199999999994	-47.6571
123_FGFR3_ELAVL3-DOCK_HTVS_1-001	Midostaurin	-7.0762100000000006	-7.0762100000000006	-29.9916
123_FGFR3_ELAVL3-DOCK_HTVS_1-001	Belumosudil	-7.06078	-7.06848	-50.1559
123_FGFR3_ELAVL3-DOCK_HTVS_1-001	Regorafenib	-7.045210000000001	-7.045210000000001	-45.1363
123_FGFR3_ELAVL3-DOCK_HTVS_1-001	Ponatinib	-7.0428	-7.2494	-51.8888
123_FGFR3_ELAVL3-DOCK_HTVS_1-001	Ponatinib	-7.0428	-7.2494	-51.8888
123_FGFR3_ELAVL3-DOCK_HTVS_1-001	Ponatinib	-7.0428	-7.2494	-51.8888
123_FGFR3_ELAVL3-DOCK_HTVS_1-001	Midostaurin	-7.01163	-7.01163	-42.8708
123_FGFR3_ELAVL3-DOCK_HTVS_1-001	Palbociclib	-6.99587	-7.402769999999999	-45.3577
123_FGFR3_ELAVL3-DOCK_HTVS_1-001	Tepotinib	-6.961130000000001	-6.96223	-48.9456

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Kinase-Substrate Information of FGFR3_ELAVL3

Phosphorylation target of the kinase
(phosphosite, 03-17-2024)

Kinase	Kinase UniProt Acc	Kinase species	Substrate	Substrate UniProt Acc	Substrate phosphorylated residues	Substrate phosphorylated sites (+/-7AA)	Domain
FGFR3	P22607	human	FGFR3	P22607	Y724	ANCTHDLyMIMRECW	PK_Tyr_Ser-Thr
FGFR3	P22607	human	CTNNB1	P35222	Y142	AVVNLINyQDDAELA
FGFR3	P22607	human	PTEN	P60484	Y240	RREDKFMyFEFPQPL	PTEN_C2
FGFR3	P22607	human	FGFR3	P22607	Y648	DVHNLDyyKKTTNGR	PK_Tyr_Ser-Thr
FGFR3	P22607	human	FGFR3	P22607	Y647	RDVHNLDyyKKTTNG	PK_Tyr_Ser-Thr
FGFR3	P22607	human	GLO1	Q04760	Y136	GIAVPDVysACkRFE	Glyoxalase
FGFR3	P22607	human	TET2	Q6N021	Y1902	TRISLVFyQHKSMNE	Tet_JBP
FGFR3	P22607	human	RPS6KA3	P51812	Y529	TITKTVEyLHAQGVV	Pkinase
FGFR3	P22607	human	CILK1	Q9UPZ9	Y15	RQLGDGtyGsVLLGR	Pkinase
FGFR3	P22607	human	RPS6KA3	P51812	Y488	DVyDDGKyVYVVTEL	Pkinase
FGFR3	P22607	human	STAT1	P42224	Y701	DGPkGtGyIktELIs

Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

Enriched GO biological processes of the phosphorylation target genes of the kinase

Kinase	GOID	GO term	P.adjust
FGFR3	ID	Description	0.00e+00
FGFR3	GO:0003337	mesenchymal to epithelial transition involved in metanephros morphogenesis	2.21e-03
FGFR3	GO:0072182	regulation of nephron tubule epithelial cell differentiation	2.21e-03
FGFR3	GO:0072160	nephron tubule epithelial cell differentiation	2.21e-03
FGFR3	GO:0072283	metanephric renal vesicle morphogenesis	2.21e-03
FGFR3	GO:0030099	myeloid cell differentiation	2.21e-03
FGFR3	GO:0097091	synaptic vesicle clustering	2.21e-03
FGFR3	GO:2000696	regulation of epithelial cell differentiation involved in kidney development	2.21e-03
FGFR3	GO:0072077	renal vesicle morphogenesis	2.21e-03
FGFR3	GO:0072087	renal vesicle development	2.21e-03
FGFR3	GO:0060231	mesenchymal to epithelial transition	2.22e-03
FGFR3	GO:0048660	regulation of smooth muscle cell proliferation	2.56e-03
FGFR3	GO:0072202	cell differentiation involved in metanephros development	2.56e-03
FGFR3	GO:0048659	smooth muscle cell proliferation	2.56e-03
FGFR3	GO:0072273	metanephric nephron morphogenesis	2.56e-03
FGFR3	GO:0002053	positive regulation of mesenchymal cell proliferation	2.59e-03
FGFR3	GO:0003338	metanephros morphogenesis	3.77e-03
FGFR3	GO:0010464	regulation of mesenchymal cell proliferation	3.78e-03
FGFR3	GO:0033002	muscle cell proliferation	5.44e-03
FGFR3	GO:0072210	metanephric nephron development	5.58e-03
FGFR3	GO:0048762	mesenchymal cell differentiation	5.82e-03
FGFR3	GO:0010463	mesenchymal cell proliferation	5.82e-03
FGFR3	GO:0035850	epithelial cell differentiation involved in kidney development	6.35e-03
FGFR3	GO:0097479	synaptic vesicle localization	8.02e-03
FGFR3	GO:0030857	negative regulation of epithelial cell differentiation	8.23e-03
FGFR3	GO:0061005	cell differentiation involved in kidney development	8.23e-03
FGFR3	GO:0060485	mesenchyme development	8.54e-03
FGFR3	GO:0021700	developmental maturation	8.54e-03
FGFR3	GO:0072088	nephron epithelium morphogenesis	1.41e-02
FGFR3	GO:0072028	nephron morphogenesis	1.43e-02
FGFR3	GO:0051347	positive regulation of transferase activity	1.49e-02
FGFR3	GO:0008543	fibroblast growth factor receptor signaling pathway	1.51e-02
FGFR3	GO:0001656	metanephros development	1.75e-02
FGFR3	GO:0060993	kidney morphogenesis	1.84e-02
FGFR3	GO:0072080	nephron tubule development	1.86e-02
FGFR3	GO:0061326	renal tubule development	1.92e-02
FGFR3	GO:0030316	osteoclast differentiation	1.92e-02
FGFR3	GO:0048709	oligodendrocyte differentiation	1.92e-02
FGFR3	GO:0010717	regulation of epithelial to mesenchymal transition	2.05e-02
FGFR3	GO:0044344	cellular response to fibroblast growth factor stimulus	2.07e-02
FGFR3	GO:0048640	negative regulation of developmental growth	2.07e-02
FGFR3	GO:0002062	chondrocyte differentiation	2.07e-02
FGFR3	GO:0072009	nephron epithelium development	2.16e-02
FGFR3	GO:0021761	limbic system development	2.17e-02
FGFR3	GO:0071774	response to fibroblast growth factor	2.17e-02
FGFR3	GO:0042552	myelination	2.82e-02
FGFR3	GO:0007272	ensheathment of neurons	2.82e-02
FGFR3	GO:0008366	axon ensheathment	2.82e-02
FGFR3	GO:0050768	negative regulation of neurogenesis	2.82e-02
FGFR3	GO:0016525	negative regulation of angiogenesis	2.82e-02

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Related Drugs to FGFR3_ELAVL3

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Distribution of the number of studies mentioning FGFR3-ELAVL3 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1

Fusion gene - drug pair 2

PMID

Publication date

DOI

Study title

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Related Diseases to FGFR3_ELAVL3

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)

MeSH ID

MeSH term

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	FGFR3	C0001080	Achondroplasia	13	CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Hgene	FGFR3	C0410529	Hypochondroplasia (disorder)	10	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Hgene	FGFR3	C1864436	Muenke Syndrome	9	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Hgene	FGFR3	C1868678	THANATOPHORIC DYSPLASIA, TYPE I (disorder)	9	CTD_human;GENOMICS_ENGLAND;UNIPROT
Hgene	FGFR3	C2677099	CROUZON SYNDROME WITH ACANTHOSIS NIGRICANS (disorder)	7	CTD_human;GENOMICS_ENGLAND;UNIPROT
Hgene	FGFR3	C0005684	Malignant neoplasm of urinary bladder	6	CGI;CTD_human;UNIPROT
Hgene	FGFR3	C0005695	Bladder Neoplasm	4	CGI;CTD_human
Hgene	FGFR3	C1300257	Thanatophoric dysplasia, type 2	4	CTD_human;GENOMICS_ENGLAND;UNIPROT
Hgene	FGFR3	C1864852	CATSHL syndrome	4	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Hgene	FGFR3	C2674173	Achondroplasia, Severe, With Developmental Delay And Acanthosis Nigricans	3	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Hgene	FGFR3	C0265269	Lacrimoauriculodentodigital syndrome	2	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT

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Clinical Trials of the Found Drugs/Small Molecules

Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion Gene

Kinase Inhibitor

NCT ID

Study Status

Phases

Disease

# Enrolment

Date