| UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY |
|
|||||||
|
Kinase Fusion Gene:FLT1_ATG10 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: FLT1_ATG10 | KinaseFusionDB ID: KFG2388 | FusionGDB2.0 ID: KFG2388 | Hgene | Tgene | Gene symbol | FLT1 | ATG10 | Gene ID | 2321 | 83734 | |
| Gene name | fms related receptor tyrosine kinase 1 | autophagy related 10 | ||||||||||
| Synonyms | FLT|FLT-1|VEGFR-1|VEGFR1 | APG10|APG10L|pp12616 | ||||||||||
| Cytomap | 13q12.3 | 5q14.1-q14.2 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | vascular endothelial growth factor receptor 1fms related tyrosine kinase 1fms-like tyrosine kinase 1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)tyrosine-protein kinase FRTtyrosine-protein ki | ubiquitin-like-conjugating enzyme ATG10APG10 autophagy 10-likeATG10 autophagy related 10 homologautophagy-related protein 10 | ||||||||||
| Modification date | 20240411 | 20240411 | ||||||||||
| UniProtAcc | P17948 | Q9H0Y0 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000282397, ENST00000539099, ENST00000540678, ENST00000541932, ENST00000543394, | ENST00000282185, ENST00000355178, ENST00000458350, ENST00000513443, ENST00000513634, ENST00000514253, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: FLT1 [Title/Abstract] AND ATG10 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | FLT1(28995889)-ATG10(81471544), # samples:1 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | FLT1 | GO:0002548 | monocyte chemotaxis | 8605350|18079407 |
| Hgene | FLT1 | GO:0018108 | peptidyl-tyrosine phosphorylation | 9299537|11513746 |
| Hgene | FLT1 | GO:0030335 | positive regulation of cell migration | 8605350 |
| Hgene | FLT1 | GO:0035924 | cellular response to vascular endothelial growth factor stimulus | 8605350 |
| Hgene | FLT1 | GO:0036323 | vascular endothelial growth factor receptor-1 signaling pathway | 15952180 |
| Hgene | FLT1 | GO:0043406 | positive regulation of MAP kinase activity | 9299537 |
| Hgene | FLT1 | GO:0043410 | positive regulation of MAPK cascade | 9299537 |
| Hgene | FLT1 | GO:0046777 | protein autophosphorylation | 9299537|11513746 |
| Hgene | FLT1 | GO:0048010 | vascular endothelial growth factor receptor signaling pathway | 1312256|9299537 |
| Tgene | ATG10 | GO:0000045 | autophagosome assembly | 16963840 |
| Tgene | ATG10 | GO:0032446 | protein modification by small protein conjugation | 16963840 |
| Kinase Fusion gene breakpoints across FLT1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across ATG10 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Top |
Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChiTaRS5.0 | AY516568 | FLT1 | chr13 | 28995889 | ATG10 | chr5 | 81471544 |
Top |
Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
Top |
Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
Top |
Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:28995889/:81471544) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| FLT1 | ATG10 |
| FUNCTION: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. Acts as a positive regulator of postnatal retinal hyaloid vessel regression (By similarity). May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes phosphorylation of PTK2/FAK1 (PubMed:16685275). {ECO:0000250|UniProtKB:P35969, ECO:0000269|PubMed:11141500, ECO:0000269|PubMed:11312102, ECO:0000269|PubMed:11811792, ECO:0000269|PubMed:12796773, ECO:0000269|PubMed:14633857, ECO:0000269|PubMed:15735759, ECO:0000269|PubMed:16685275, ECO:0000269|PubMed:18079407, ECO:0000269|PubMed:18515749, ECO:0000269|PubMed:18583712, ECO:0000269|PubMed:18593464, ECO:0000269|PubMed:20512933, ECO:0000269|PubMed:20551949, ECO:0000269|PubMed:21752276, ECO:0000269|PubMed:7824266, ECO:0000269|PubMed:8248162, ECO:0000269|PubMed:8605350, ECO:0000269|PubMed:9299537, ECO:0000269|Ref.11}.; FUNCTION: [Isoform 1]: Phosphorylates PLCG. {ECO:0000269|PubMed:9299537}.; FUNCTION: [Isoform 2]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 3]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 4]: May function as decoy receptor for VEGFA. {ECO:0000269|PubMed:21752276}.; FUNCTION: [Isoform 7]: Has a truncated kinase domain; it increases phosphorylation of SRC at 'Tyr-418' by unknown means and promotes tumor cell invasion. {ECO:0000269|PubMed:20512933}. | FUNCTION: E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3 (By similarity). Plays a role in adenovirus-mediated cell lysis. {ECO:0000250, ECO:0000269|PubMed:21367888}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
Top |
Kinase-Substrate Information of FLT1_ATG10 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| FLT1 | P17948 | human | FLT1 | P17948 | Y1327 | CCSPPPDyNSVVLyS | |
| FLT1 | P17948 | human | FLT1 | P17948 | Y1213 | GsSDDVRyVNAFKFM | |
| FLT1 | P17948 | human | GLO1 | Q04760 | Y136 | GIAVPDVysACkRFE | Glyoxalase |
| FLT1 | P17948 | human | FLT1 | P17948 | Y1169 | VQQDGKDyIPINAIL | |
| FLT1 | P17948 | human | FLT1 | P17948 | Y1333 | DyNSVVLySTPPI__ | |
| FLT1 | P17948 | human | FLT1 | P17948 | Y1242 | ATSMFDDyQGDSSTL |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| FLT1 | ID | Description | 0.00e+00 |
| FLT1 | GO:0060033 | anatomical structure regression | 2.48e-02 |
| FLT1 | GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity | 2.48e-02 |
| FLT1 | GO:1905563 | negative regulation of vascular endothelial cell proliferation | 2.48e-02 |
| FLT1 | GO:0090218 | positive regulation of lipid kinase activity | 2.48e-02 |
| FLT1 | GO:0010863 | positive regulation of phospholipase C activity | 2.48e-02 |
| FLT1 | GO:0043550 | regulation of lipid kinase activity | 2.48e-02 |
| FLT1 | GO:1900274 | regulation of phospholipase C activity | 2.48e-02 |
| FLT1 | GO:0010518 | positive regulation of phospholipase activity | 2.48e-02 |
| FLT1 | GO:0038084 | vascular endothelial growth factor signaling pathway | 2.48e-02 |
| FLT1 | GO:0101023 | vascular endothelial cell proliferation | 2.48e-02 |
| FLT1 | GO:1905562 | regulation of vascular endothelial cell proliferation | 2.48e-02 |
| FLT1 | GO:0006749 | glutathione metabolic process | 2.48e-02 |
| FLT1 | GO:0010517 | regulation of phospholipase activity | 2.48e-02 |
| FLT1 | GO:0060193 | positive regulation of lipase activity | 2.48e-02 |
| FLT1 | GO:0048010 | vascular endothelial growth factor receptor signaling pathway | 2.48e-02 |
| FLT1 | GO:0006081 | cellular aldehyde metabolic process | 2.48e-02 |
| FLT1 | GO:0002548 | monocyte chemotaxis | 2.48e-02 |
| FLT1 | GO:0035924 | cellular response to vascular endothelial growth factor stimulus | 2.48e-02 |
| FLT1 | GO:0001937 | negative regulation of endothelial cell proliferation | 2.48e-02 |
| FLT1 | GO:0060191 | regulation of lipase activity | 2.48e-02 |
| FLT1 | GO:0043406 | positive regulation of MAP kinase activity | 2.66e-02 |
| FLT1 | GO:0030316 | osteoclast differentiation | 3.06e-02 |
| FLT1 | GO:0071902 | positive regulation of protein serine/threonine kinase activity | 3.67e-02 |
| FLT1 | GO:0043405 | regulation of MAP kinase activity | 3.67e-02 |
| FLT1 | GO:0045834 | positive regulation of lipid metabolic process | 3.67e-02 |
| FLT1 | GO:0051897 | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | 3.90e-02 |
| FLT1 | GO:0050680 | negative regulation of epithelial cell proliferation | 3.90e-02 |
| FLT1 | GO:0001936 | regulation of endothelial cell proliferation | 3.90e-02 |
| FLT1 | GO:0045766 | positive regulation of angiogenesis | 3.90e-02 |
| FLT1 | GO:1904018 | positive regulation of vasculature development | 3.90e-02 |
| FLT1 | GO:0046777 | protein autophosphorylation | 3.97e-02 |
| FLT1 | GO:0001935 | endothelial cell proliferation | 3.97e-02 |
| FLT1 | GO:0071674 | mononuclear cell migration | 3.97e-02 |
| FLT1 | GO:0042180 | cellular ketone metabolic process | 4.12e-02 |
| FLT1 | GO:0002573 | myeloid leukocyte differentiation | 4.12e-02 |
| FLT1 | GO:0030595 | leukocyte chemotaxis | 4.12e-02 |
| FLT1 | GO:0097529 | myeloid leukocyte migration | 4.12e-02 |
| FLT1 | GO:0051896 | regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | 4.12e-02 |
| FLT1 | GO:0018108 | peptidyl-tyrosine phosphorylation | 4.26e-02 |
| FLT1 | GO:0018212 | peptidyl-tyrosine modification | 4.26e-02 |
| FLT1 | GO:0045860 | positive regulation of protein kinase activity | 4.26e-02 |
| FLT1 | GO:0071900 | regulation of protein serine/threonine kinase activity | 4.26e-02 |
| FLT1 | GO:0043491 | phosphatidylinositol 3-kinase/protein kinase B signal transduction | 4.26e-02 |
| FLT1 | GO:0060326 | cell chemotaxis | 4.55e-02 |
| FLT1 | GO:0033674 | positive regulation of kinase activity | 4.55e-02 |
| FLT1 | GO:0019216 | regulation of lipid metabolic process | 4.55e-02 |
| FLT1 | GO:0043010 | camera-type eye development | 4.55e-02 |
| FLT1 | GO:0045765 | regulation of angiogenesis | 4.55e-02 |
| FLT1 | GO:1901342 | regulation of vasculature development | 4.55e-02 |
Top |
Related Drugs to FLT1_ATG10 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning FLT1-ATG10 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
Top |
Related Diseases to FLT1_ATG10 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Top |
Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
Copyright 2024-Present -The University of Texas Health Science Center at Houston
Web File Viewing | Emergency Information |Campus Carry|Site Policies |