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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:FYN_COL6A3

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: FYN_COL6A3
KinaseFusionDB ID: KFG2443
FusionGDB2.0 ID: KFG2443
HgeneTgene
Gene symbol

FYN

COL6A3

Gene ID

2534

1293

Gene nameFYN proto-oncogene, Src family tyrosine kinasecollagen type VI alpha 3 chain
SynonymsSLK|SYN|p59-FYNBTHLM1|BTHLM1C|DYT27|UCMD1|UCMD1C
Cytomap

6q21

2q37.3

Type of geneprotein-codingprotein-coding
Descriptiontyrosine-protein kinase FynFYN oncogene related to SRC, FGR, YESOKT3-induced calcium influx regulatorc-syn protooncogeneproto-oncogene Synproto-oncogene c-Fynsrc-like kinasesrc/yes-related noveltyrosine kinase p59fyn(T)collagen alpha-3(VI) chaincollagen VI, alpha-3 polypeptidecollagen, type VI, alpha 3epididymis secretory sperm binding protein
Modification date2024041120240316
UniProtAcc

P06241

P12111

Ensembl transtripts involved in fusion geneENST idsENST00000229470, ENST00000229471, 
ENST00000354650, ENST00000356013, 
ENST00000368667, ENST00000368678, 
ENST00000368682, ENST00000476769, 
ENST00000538466, 		ENST00000295550, 
ENST00000346358, ENST00000347401, 
ENST00000353578, ENST00000409809, 
ENST00000472056, ENST00000392003, 
ENST00000392004, ENST00000473258, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: FYN [Title/Abstract] AND COL6A3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)FYN(111982765)-COL6A3(238277525), # samples:1
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFYN

GO:0035556

intracellular signal transduction

11606584

HgeneFYN

GO:0050852

T cell receptor signaling pathway

7722293


check buttonKinase Fusion gene breakpoints across FYN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonKinase Fusion gene breakpoints across COL6A3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChiTaRS5.0AI952526FYNchr6

111982765

COL6A3chr2

238277525



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:111982765/:238277525)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FYN

P06241

COL6A3

P12111

FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1. In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling (By similarity). {ECO:0000250|UniProtKB:P39688, ECO:0000269|PubMed:11005864, ECO:0000269|PubMed:11162638, ECO:0000269|PubMed:11536198, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:14707117, ECO:0000269|PubMed:14761972, ECO:0000269|PubMed:15536091, ECO:0000269|PubMed:15557120, ECO:0000269|PubMed:16387660, ECO:0000269|PubMed:16841086, ECO:0000269|PubMed:17194753, ECO:0000269|PubMed:18056706, ECO:0000269|PubMed:18258597, ECO:0000269|PubMed:19179337, ECO:0000269|PubMed:19652227, ECO:0000269|PubMed:20028775, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:7568038, ECO:0000269|PubMed:7822789}.FUNCTION: Collagen VI acts as a cell-binding protein.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


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Kinase-Substrate Information of FYN_COL6A3


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
FYNP06241humanGRIN2AQ12879Y1118SSPRDKIyTIDGEKENMDAR2_C
FYNP06241humanITCHQ96J02Y420QFNQRFIyGNQDLFA
FYNP06241humanNMT1P30419Y180YTLLNENyVEDDDNMNMT
FYNP06241humanDCBLD2Q96PD2Y750PAPDELVyQVPQStQ
FYNP06241humanCD5P06127Y453AsHVDNEysQPPRNs
FYNP06241humanFYB1O15117Y651LDMGDEVyDDVDTSD
FYNP06241humanFYB1O15117Y625PPPDDDIydGIEEED
FYNP06241humanPLCG2P16885Y753ERDINSLyDVsRMyV
FYNP06241humanABL1P00519Y393RLMtGDtytAHAGAkPK_Tyr_Ser-Thr
FYNP06241humanIFITM3Q01628Y20NSGQPPNyEMLkEEH
FYNP06241humanDCBLD2Q96PD2Y715PPPLVGtyNtLLsRt
FYNP06241humanCHN2P52757Y21VSSDAEEyQPPIWKS
FYNP06241humanARHGAP33O14559Y406PLLTYQLyGKFSEAMRhoGAP
FYNP06241humanGRIN2AQ12879Y1246CLRMGNLyDIDEDQMNMDAR2_C
FYNP06241humanPAG1Q9NWQ8Y317EEEIsAMyssVNKPGPAG
FYNP06241humanSKAP1Q86WV1Y232EEEKEETyDDIDGFD
FYNP06241humanDCBLD2Q96PD2Y565KKkTEGtyDLPyWDR
FYNP06241humanGRIN2AQ12879Y1105CSEVERTyLKTKSSSNMDAR2_C
FYNP06241humanDCBLD2Q96PD2S657ADLDPyNsPGQEVyH
FYNP06241humanCRMP1Q14194Y504GMyDGPVyEVPAtPK
FYNP06241humanSCN5AQ14524Y1494MTEEQKkyyNAMKKL
FYNP06241humanPECAM1P16284Y690PLNsDVQytEVQVSS
FYNP06241humanMAP2P11137-3Y67EHGSQGTySNTKENG
FYNP06241humanSTAM2O75886Y371LVNEAPVysVysKLH
FYNP06241humanAPPP05067Y757SkMQQNGyENPtykFAPP_amyloid
FYNP06241humanTGFB1I1O43294Y60SGDKDHLystVCKPRPaxillin
FYNP06241humanSLAMF1Q13291Y281EKKsLtIyAQVQKPG
FYNP06241humanCTTNQ14247Y470AyATEAVyESAEAPG
FYNP06241humanAGAP2Q99490-2Y682ESWIRAKyEQLLFLAArfGap
FYNP06241humanBSGP35613-2Y140PVTDWAWyKITDSEDIg_3
FYNP06241humanSLAMF1Q13291Y307QDPCTTIyVAATEPV
FYNP06241humanFLOT1O75955Y160DIHDDQDyLHsLGkABand_7
FYNP06241humanFYNP06241Y28sLNQssGyRyGTDPT
FYNP06241humanDCBLD2Q96PD2Y569EGtyDLPyWDRAGWW
FYNP06241humanSTAM2O75886Y291kSEPEPVyIDEDkMD
FYNP06241humanPTPRJQ12913Y1320NtTAMtIyENLAPVT
FYNP06241humanABL1P00519Y128SLEKHSWyHGPVSRNSH2
FYNP06241humanPTPRJQ12913Y1311DSkVDLIyQNtTAMt
FYNP06241humanBSGP35613-2Y183MEADPGQyRCNGTSSIg_3
FYNP06241humanFLOT2Q14254Y163DVYDkVDyLSsLGkTBand_7
FYNP06241humanH3-3AP84243S10tkQTARkstGGkAPRHistone
FYNP06241humanPXNP49023-2Y118VGEEEHVysFPNKQKPaxillin
FYNP06241humanFCGR2BP31994Y292GAENTITysLLMHPD
FYNP06241humanGRIN2AQ12879Y1267PATGEQVyQQDWAQNNMDAR2_C
FYNP06241humanRPS6KA3P51812Y483IItLkDVyDDGKyVYPkinase
FYNP06241humanDCBLD2Q96PD2Y655GyADLDPyNsPGQEV
FYNP06241humanPPP2CAP67775Y307VTRRtPDyFl_____
FYNP06241humanABL1P00519Y226KRNKPtVyGVsPNyD
FYNP06241humanSNCAP37840Y125VDPDNEAyEMPsEEGSynuclein
FYNP06241humanSCN5AQ14524Y1495TEEQKkyyNAMKKLG
FYNP06241humanFYNP06241Y39TDPTPQHyPSFGVTS
FYNP06241humanSKAP1Q86WV1Y295TRRKGVDyASyyQGL
FYNP06241humanPPP2CAP67775Y284ELDDTLkySFLQFDP
FYNP06241humanNOX4Q9NPH5Y566LSNQNNSyGTRFEYN
FYNP06241humanFYNP06241Y214KLDNGGyyITtRAQFSH2
FYNP06241humanCTTNQ14247Y446GtEPEPVysMEAADy
FYNP06241humanPLXNA2O75051Y1677sKMVSEIyLTRLLATPlexin_cytopl
FYNP06241humanCD3EP07766Y199RKGQRDLysGLNQRRITAM
FYNP06241humanABL1P00519Y115QGWVPsNyItPVNSL
FYNP06241humanSTAT3P40763Y705DPGsAAPyLktKFIC
FYNP06241humanCBLP22681Y774sENEDDGyDVPKPPV
FYNP06241humanPLEKHG1Q9ULL1Y661IDDIDHVyDNISYED
FYNP06241humanFCGR2AP12318Y288yEtADGGyMtLNPRA
FYNP06241humanABL1P00519Y215GLITTLHyPAPKRNK
FYNP06241humanABL1P00519Y70PNLFVALyDFVAsGDSH3_1
FYNP06241humanFYNP06241Y213RKLDNGGyyITtRAQSH2
FYNP06241humanRTN4Q9NQC3Y694LQETEAPyISIACDL
FYNP06241humanDCBLD2Q96PD2Y649EEGKEAGyADLDPyN
FYNP06241humanPROM1O43490Y828RMDsEDVyDDVEtIP
FYNP06241humanCLIC5Q9NZA1Y33EENESPHyDDVHEYL
FYNP06241humanAGAP2Q99490-2Y774QGRTALFyARQAGSQAnk_2
FYNP06241humanRPS6KA3P51812Y707KGAMAAtysALNRNQ
FYNP06241humanGRIN2AQ12879Y943SDkGNLMysDNRSFQNMDAR2_C
FYNP06241humanITPR1Q14643Y353NAQEKMVySLVSVPEMIR
FYNP06241humanPTPRTO14522-1Y915GYGFKEEyEALPEGQ
FYNP06241humanFYNP06241Y420RLIEDNEytARQGAkPK_Tyr_Ser-Thr
FYNP06241humanMAPTP10636-8Y18MEDHAGtyGLGDRKD
FYNP06241humanDLG4P78352Y523REDSVLSyETVTQME
FYNP06241humanCD300LBA8K4G0Y188EPGEQPIyMNFSEPL
FYNP06241humanFYB1O15117Y571TTAVEIDyDsLkLKK
FYNP06241humanSKAP1Q86WV1Y298KGVDyASyyQGLWDC
FYNP06241humanGRIN2AQ12879Y1325RLLEGNFyGSLFSVPNMDAR2_C
FYNP06241humanFYB1O15117Y771ADNDGEIyDDIAdGChSH3
FYNP06241humanPLXNA2O75051Y1605VPKQTSSyNIPASAsPlexin_cytopl
FYNP06241humanCAV1Q03135Y14VDsEGHLytVPIREQ
FYNP06241humanBCRP11274Y177ADAEKPFyVNVEFHH
FYNP06241humanCD3EP07766Y188PPVPNPDyEPIRKGQITAM
FYNP06241humanGRB10Q13322Y67NASLESLySACSMQS
FYNP06241humanFYB1O15117Y559GRTARGsyGyIKTTASH3_2
FYNP06241humanJUPP14923Y133AIVHLINyQDDAELA
FYNP06241humanNFE2L2Q16236Y576RDEDGkPysPSEYSL
FYNP06241humanPLXNA1Q9UIW2Y1679sKMVSEIyLTRLLATPlexin_cytopl
FYNP06241humanMAP2P11137-3Y50RSANGFPyREDEEGA
FYNP06241humanPLCG2P16885Y759LyDVsRMyVDPsEIN
FYNP06241humanRPS6KA3P51812Y529TITKTVEyLHAQGVVPkinase
FYNP06241humanRPS6KA3P51812Y580GLLMtPCytANFVAPPkinase
FYNP06241humanPROM1O43490Y852GYHkDHVyGIHNPVM
FYNP06241humanERBB2P04626Y877LDIDEtEyHADGGkVPK_Tyr_Ser-Thr
FYNP06241humanPECAM1P16284Y713KKDtEtVysEVRKAV
FYNP06241humanDCBLD2Q96PD2Y621LQADsAEyAQPLVGG
FYNP06241humanABL1P00519Y139VSRNAAEyLLsSGINSH2
FYNP06241humanCTTNQ14247Y486yPAEDStyDEYENDL
FYNP06241humanDCBLD2Q96PD2Y732CssAQAQyDtPKAGk
FYNP06241humanPRC1O43663Y464QTETEMLyGsAPRtPMAP65_ASE1
FYNP06241humanDCBLD2Q96PD2Y677LPITGPEyAtPIIMD
FYNP06241humanCTTNQ14247Y421rLPssPVyEDAAsFK
FYNP06241humanFYNP06241Y30NQssGyRyGTDPTPQ
FYNP06241humanRPS6KA3P51812Y470EIEILLRyGQHPNIIPkinase
FYNP06241humanSTAM2O75886Y374EAPVysVysKLHPPA
FYNP06241humanFYB1O15117Y595IEDDQEVyDDVAEQD
FYNP06241humanDCBLD2Q96PD2S618TTVLQADsAEyAQPL
FYNP06241humanPRKAA2P54646Y436EWKVVNAyHLRVRRKAdenylateSensor
FYNP06241humanPGDP52209Y481GtVSSssyNA_____
FYNP06241humanMAPK14Q16539Y323DEPVADPyDQsFESR
FYNP06241humanCD300LFQ8TDQ1Y263AEDQEPTyCNMGHLS
FYNP06241humanDCBLD2Q96PD2Y666GQEVyHAyAEPLPIT
FYNP06241humanSCN9AQ15858Y1482TEEQKkyyNAMKKLG
FYNP06241humanSLAMF1Q13291Y327ETNSITVyASVTLPE
FYNP06241humanCBLP22681Y700EGEEDtEyMtPssRP
FYNP06241humanABL1P00519Y172LRyEGRVyHyRINTASH2
FYNP06241humanCD5P06127Y487DNssDsDyDLHGAQR
FYNP06241humanPTGS2P35354Y446DQSRQMkyQSFNEYRAn_peroxidase
FYNP06241humanSIGLEC10Q96LC7Y667ESQEELHyATLNFPG
FYNP06241humanRPS6KA3P51812Y644KFSLSGGyWNSVSDTPkinase
FYNP06241humanPBKQ96KB5Y272DFDDEAYyAALGTRPPkinase
FYNP06241humanTIGITQ495A1Y225DCAELHDyFNVLSYR
FYNP06241humanGRIN2AQ12879Y1187NNDQyKLySKHFTLKNMDAR2_C
FYNP06241humanPLEKHG1Q9ULL1Y742QAVEENIyDTIGLPD
FYNP06241humanDCBLD2Q96PD2Y663NsPGQEVyHAyAEPL
FYNP06241humanPTPRTO14522-1Y1030WPDDTEVyGDIKVTLY_phosphatase
FYNP06241humanSCN9AQ15858Y1481MTEEQKkyyNAMKKL
FYNP06241humanFYB1O15117Y755CRNEEGkyGyVLRSyhSH3
FYNP06241humanFYNP06241Y185sETtkGAysLsIRDWSH2
FYNP06241humanCTTNQ14247Y453ysMEAADyREASSQQ
FYNP06241humanABL1P00519Y185TAsDGKLyVsSESRFSH2
FYNP06241humanCBLP22681Y731QQIDSCTyEAMyNIQ
FYNP06241humanRPS6KA3P51812Y488DVyDDGKyVYVVTELPkinase
FYNP06241humanFUSP35637Y526QDrrErPy_______
FYNP06241humanPTPN11Q06124Y542sKRkGHEytNIKysL
FYNP06241humanMAP2P11137Y67EHGsQGtySNTKENG
FYNP06241humanPLXNA1Q9UIW2Y1608VPKQTSAyNISNSStPlexin_cytopl
FYNP06241humanCD226Q15762Y322DDTREDIyVNyPTFs
FYNP06241humanJUPP14923Y550AAGtQQPytDGVRME
FYNP06241humanADD2P35612Y489PNQFVPLyTDPQEVL
FYNP06241humanFYB1O15117Y757NEEGkyGyVLRSyLAhSH3
FYNP06241humanCD300LFQ8TDQ1Y236VDQVEVEyVTMASLPSIT
FYNP06241humanFYB1O15117Y780DIAdGCIyDND____hSH3
FYNP06241humanIKBKGQ9Y6K9Y374PLPPAPAyLssPLAL
FYNP06241humanPRKACAP17612Y70HKETGNHyAMKILDKPkinase


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
FYNIDDescription0.00e+00
FYNGO:0002757immune response-activating signaling pathway1.90e-09
FYNGO:0018108peptidyl-tyrosine phosphorylation1.90e-09
FYNGO:0018212peptidyl-tyrosine modification1.90e-09
FYNGO:0007159leukocyte cell-cell adhesion1.90e-09
FYNGO:0050730regulation of peptidyl-tyrosine phosphorylation1.90e-09
FYNGO:0002764immune response-regulating signaling pathway1.90e-09
FYNGO:0022407regulation of cell-cell adhesion1.53e-08
FYNGO:1903037regulation of leukocyte cell-cell adhesion5.32e-08
FYNGO:0050863regulation of T cell activation5.47e-07
FYNGO:0043393regulation of protein binding9.20e-07
FYNGO:0050852T cell receptor signaling pathway9.46e-07
FYNGO:0016049cell growth1.06e-06
FYNGO:0050851antigen receptor-mediated signaling pathway1.06e-06
FYNGO:0097553calcium ion transmembrane import into cytosol1.06e-06
FYNGO:0045088regulation of innate immune response1.22e-06
FYNGO:0030100regulation of endocytosis2.15e-06
FYNGO:0050731positive regulation of peptidyl-tyrosine phosphorylation2.37e-06
FYNGO:0002274myeloid leukocyte activation3.69e-06
FYNGO:1903829positive regulation of protein localization3.69e-06
FYNGO:0031349positive regulation of defense response3.78e-06
FYNGO:0045785positive regulation of cell adhesion3.78e-06
FYNGO:0050808synapse organization3.78e-06
FYNGO:0001819positive regulation of cytokine production5.30e-06
FYNGO:0001558regulation of cell growth6.04e-06
FYNGO:1990778protein localization to cell periphery9.88e-06
FYNGO:0010038response to metal ion1.09e-05
FYNGO:0034329cell junction assembly1.09e-05
FYNGO:0007409axonogenesis1.09e-05
FYNGO:0032092positive regulation of protein binding1.09e-05
FYNGO:0002431Fc receptor mediated stimulatory signaling pathway1.15e-05
FYNGO:0045807positive regulation of endocytosis1.15e-05
FYNGO:0006909phagocytosis2.41e-05
FYNGO:0050804modulation of chemical synaptic transmission2.43e-05
FYNGO:0099177regulation of trans-synaptic signaling2.43e-05
FYNGO:0002429immune response-activating cell surface receptor signaling pathway2.63e-05
FYNGO:0022409positive regulation of cell-cell adhesion2.87e-05
FYNGO:0042326negative regulation of phosphorylation3.21e-05
FYNGO:0043254regulation of protein-containing complex assembly3.60e-05
FYNGO:0002758innate immune response-activating signaling pathway3.66e-05
FYNGO:0006898receptor-mediated endocytosis3.84e-05
FYNGO:0050727regulation of inflammatory response3.84e-05
FYNGO:0051098regulation of binding4.26e-05
FYNGO:0045089positive regulation of innate immune response4.27e-05
FYNGO:0002768immune response-regulating cell surface receptor signaling pathway4.52e-05
FYNGO:0031400negative regulation of protein modification process4.60e-05
FYNGO:0009895negative regulation of catabolic process4.68e-05
FYNGO:0070588calcium ion transmembrane transport4.95e-05
FYNGO:0006816calcium ion transport5.16e-05
FYNGO:0032388positive regulation of intracellular transport5.29e-05

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Related Drugs to FYN_COL6A3


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning FYN-COL6A3 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

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Related Diseases to FYN_COL6A3


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate