UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine
leaf

Kinase Fusion Gene Summary

leaf

Kinase Fusion Gene Sample Information

leaf

Kinase Fusion ORF Analysis

leaf

Kinase Fusion Amino Acid Sequences

leaf

Multiple Sequence Alignment of All Fusion Protein Isoforms

leaf

Kinase Fusion Protein Functional Features

leaf

Kinase Fusion Protein Structures

leaf

Comparison of Fusion Protein Isoforms

leaf

Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

leaf

pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

leaf

Ramachandran Plot of Kinase Fusion Protein Structure

leaf

Potential Active Site Information

leaf

Virtual Screening Results

leaf

Kinase-Substrate Information

leaf

Related Drugs with This Kinase Fusion Protein

leaf

Related Disease with This Kinase Fusion Protein

leaf

Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:GRK6_DBN1

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: GRK6_DBN1
KinaseFusionDB ID: KFG2573
FusionGDB2.0 ID: KFG2573
HgeneTgene
Gene symbol

GRK6

DBN1

Gene ID

2870

1627

Gene nameG protein-coupled receptor kinase 6drebrin 1
SynonymsGPRK6D0S117E
Cytomap

5q35.3

5q35.3

Type of geneprotein-codingprotein-coding
DescriptionG protein-coupled receptor kinase 6drebrindevelopmentally-regulated brain proteindrebrin Adrebrin Edrebrin E2
Modification date2024040320240411
UniProtAcc

P43250

Q16643

Ensembl transtripts involved in fusion geneENST idsENST00000355472, ENST00000355958, 
ENST00000393576, ENST00000507633, 
ENST00000528793, 		ENST00000292385, 
ENST00000309007, ENST00000393563, 
ENST00000393565, ENST00000512501, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: GRK6 [Title/Abstract] AND DBN1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)GRK6(176862122)-DBN1(176886269), # samples:3
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDBN1

GO:0051220

cytoplasmic sequestering of protein

28966017


check buttonKinase Fusion gene breakpoints across GRK6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonKinase Fusion gene breakpoints across DBN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChimerDB4TCGA-CD-A4MHGRK6chr5

176862122

DBN1chr5

176886269



Top

Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)

Top

Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

Multiple Sequence Alignment of All Fusion Protein Isoforms



Top

Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:176862122/chr5:176886269)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GRK6

P43250

DBN1

Q16643

FUNCTION: Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). {ECO:0000250, ECO:0000269|PubMed:19801552, ECO:0000269|PubMed:20048153}.FUNCTION: Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections (PubMed:20215400). Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS (PubMed:20215400). Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines (By similarity). Involved in memory-related synaptic plasticity in the hippocampus (By similarity). {ECO:0000250|UniProtKB:Q9QXS6, ECO:0000269|PubMed:20215400}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


Top

Kinase-Substrate Information of GRK6_DBN1


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
GRK6P43250humanCXCR4P61073S324LtsVsRGssLkILsk
GRK6P43250humanGRK6P43250S484VLDIEQFstVkGVEL
GRK6P43250humanGRK6P43250T485LDIEQFstVkGVELE
GRK6P43250humanIGF1RP08069S1321LPLPDRHsGHKAENG
GRK6P43250humanADRB2P07550S355KAyGNGyssNGNtGE
GRK6P43250humanCXCR4P61073S325tsVsRGssLkILskG
GRK6P43250humanLTB4RQ15722T308VAKLLEGtGsEAsst
GRK6P43250humanADRB2P07550S356AyGNGyssNGNtGEQ
GRK6P43250humanNHERF1O14745S290PALVRsAssDtsEELEBP50_C
GRK6P43250humanOCLNQ16625S471LDDyREEsEEyMAAAOccludin_ELL


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
GRK6IDDescription0.00e+00
GRK6GO:1903036positive regulation of response to wounding1.24e-03
GRK6GO:0120162positive regulation of cold-induced thermogenesis1.40e-03
GRK6GO:0120161regulation of cold-induced thermogenesis2.35e-03
GRK6GO:0106106cold-induced thermogenesis2.35e-03
GRK6GO:1990845adaptive thermogenesis2.35e-03
GRK6GO:1903034regulation of response to wounding2.35e-03
GRK6GO:0001659temperature homeostasis2.38e-03
GRK6GO:0034764positive regulation of transmembrane transport3.47e-03
GRK6GO:0043243positive regulation of protein-containing complex disassembly4.75e-03
GRK6GO:0003018vascular process in circulatory system5.26e-03
GRK6GO:1904646cellular response to amyloid-beta5.26e-03
GRK6GO:1904645response to amyloid-beta7.34e-03
GRK6GO:0006936muscle contraction8.62e-03
GRK6GO:0090303positive regulation of wound healing8.62e-03
GRK6GO:0010959regulation of metal ion transport1.12e-02
GRK6GO:0002028regulation of sodium ion transport1.42e-02
GRK6GO:0003012muscle system process1.43e-02
GRK6GO:0007200phospholipase C-activating G protein-coupled receptor signaling pathway2.22e-02
GRK6GO:0043244regulation of protein-containing complex disassembly2.49e-02
GRK6GO:0061041regulation of wound healing2.77e-02
GRK6GO:0008277regulation of G protein-coupled receptor signaling pathway2.88e-02
GRK6GO:0030010establishment of cell polarity3.24e-02
GRK6GO:0007189adenylate cyclase-activating G protein-coupled receptor signaling pathway3.24e-02
GRK6GO:0034767positive regulation of monoatomic ion transmembrane transport3.24e-02
GRK6GO:0007009plasma membrane organization3.50e-02
GRK6GO:0009266response to temperature stimulus3.50e-02
GRK6GO:0043409negative regulation of MAPK cascade3.57e-02
GRK6GO:0050954sensory perception of mechanical stimulus3.64e-02
GRK6GO:0009612response to mechanical stimulus4.28e-02
GRK6GO:0043270positive regulation of monoatomic ion transport4.28e-02
GRK6GO:0007163establishment or maintenance of cell polarity4.28e-02
GRK6GO:0032984protein-containing complex disassembly4.28e-02
GRK6GO:0022604regulation of cell morphogenesis4.28e-02
GRK6GO:0006814sodium ion transport4.28e-02
GRK6GO:0007188adenylate cyclase-modulating G protein-coupled receptor signaling pathway4.28e-02
GRK6GO:0051896regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction4.28e-02
GRK6GO:0030643intracellular phosphate ion homeostasis4.28e-02
GRK6GO:1903943regulation of hepatocyte apoptotic process4.28e-02
GRK6GO:0010764negative regulation of fibroblast migration4.28e-02
GRK6GO:0035090maintenance of apical/basal cell polarity4.28e-02
GRK6GO:0044062regulation of excretion4.28e-02
GRK6GO:0045199maintenance of epithelial cell apical/basal polarity4.28e-02
GRK6GO:0021537telencephalon development4.28e-02
GRK6GO:0001894tissue homeostasis4.28e-02
GRK6GO:0060249anatomical structure homeostasis4.28e-02
GRK6GO:0010739positive regulation of protein kinase A signaling4.28e-02
GRK6GO:0032782bile acid secretion4.28e-02
GRK6GO:0040015negative regulation of multicellular organism growth4.28e-02
GRK6GO:0071389cellular response to mineralocorticoid stimulus4.28e-02

Top

Related Drugs to GRK6_DBN1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning GRK6-DBN1 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

Top

Related Diseases to GRK6_DBN1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


Top

Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate