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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:AKT1_ANKS1A

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: AKT1_ANKS1A
KinaseFusionDB ID: KFG259
FusionGDB2.0 ID: KFG259
HgeneTgene
Gene symbol

AKT1

ANKS1A

Gene ID

207

23294

Gene nameAKT serine/threonine kinase 1ankyrin repeat and sterile alpha motif domain containing 1A
SynonymsAKT|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHAANKS1
Cytomap

14q32.33

6p21.31

Type of geneprotein-codingprotein-coding
DescriptionRAC-alpha serine/threonine-protein kinaseAKT1mPKB alphaRAC-PK-alphaprotein kinase B alphaproto-oncogene c-Aktrac protein kinase alphaserine-threonine protein kinasev-akt murine thymoma viral oncogene homolog 1v-akt murine thymoma viral oncogene-lankyrin repeat and SAM domain-containing protein 1AOdinankyrin repeat and SAM domain containing 1
Modification date2024041620240407
UniProtAcc

P31749

Q92625

Ensembl transtripts involved in fusion geneENST idsENST00000349310, ENST00000402615, 
ENST00000407796, ENST00000554581, 
ENST00000544168, ENST00000554192, 
ENST00000554585, ENST00000554848, 
ENST00000555458, ENST00000555528, 
ENST00000360359, ENST00000470698, 
ENST00000535627, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: AKT1 [Title/Abstract] AND ANKS1A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)AKT1(105235689)-ANKS1A(34977682), # samples:1
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAKT1

GO:0001934

positive regulation of protein phosphorylation

19057511

HgeneAKT1

GO:0006468

protein phosphorylation

14749367

HgeneAKT1

GO:0006468

protein phosphorylation

11994271|23431171

HgeneAKT1

GO:0007173

epidermal growth factor receptor signaling pathway

20878056

HgeneAKT1

GO:0016310

phosphorylation

20333297

HgeneAKT1

GO:0018105

peptidyl-serine phosphorylation

16139227|32322062

HgeneAKT1

GO:0018107

peptidyl-threonine phosphorylation

20605787

HgeneAKT1

GO:0019049

virus-mediated perturbation of host defense response

14749367

HgeneAKT1

GO:0030307

positive regulation of cell growth

19203586

HgeneAKT1

GO:0032079

positive regulation of endodeoxyribonuclease activity

20605787

HgeneAKT1

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

23512198

HgeneAKT1

GO:0032869

cellular response to insulin stimulus

12172553|17386266|24529379

HgeneAKT1

GO:0033138

positive regulation of peptidyl-serine phosphorylation

19667065

HgeneAKT1

GO:0035556

intracellular signal transduction

14749367

HgeneAKT1

GO:0035655

interleukin-18-mediated signaling pathway

21321938

HgeneAKT1

GO:0043066

negative regulation of apoptotic process

19203586

HgeneAKT1

GO:0043491

phosphatidylinositol 3-kinase/protein kinase B signal transduction

21321938|28147277

HgeneAKT1

GO:0043536

positive regulation of blood vessel endothelial cell migration

20011604

HgeneAKT1

GO:0046889

positive regulation of lipid biosynthetic process

32322062

HgeneAKT1

GO:0048661

positive regulation of smooth muscle cell proliferation

21321938

HgeneAKT1

GO:0051091

positive regulation of DNA-binding transcription factor activity

19057511

HgeneAKT1

GO:0070141

response to UV-A

18483258

HgeneAKT1

GO:0070848

response to growth factor

33505021

HgeneAKT1

GO:0071364

cellular response to epidermal growth factor stimulus

30514904

HgeneAKT1

GO:0110002

regulation of tRNA methylation

15861136

HgeneAKT1

GO:0150033

negative regulation of protein localization to lysosome

24529379

HgeneAKT1

GO:0160049

negative regulation of cGAS/STING signaling pathway

26440888

HgeneAKT1

GO:1902018

negative regulation of cilium assembly

31204173

HgeneAKT1

GO:1904263

positive regulation of TORC1 signaling

12172553|17386266|24529379|30514904|31548394|33594058

HgeneAKT1

GO:1905552

positive regulation of protein localization to endoplasmic reticulum

32322062


check buttonKinase Fusion gene breakpoints across AKT1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonKinase Fusion gene breakpoints across ANKS1A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChimerDB4TCGA-FD-A3SR-01AAKT1chr14

105235689

ANKS1Achr6

34977682



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:105235689/:34977682)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AKT1

P31749

ANKS1A

Q92625

FUNCTION: AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis (PubMed:15861136, PubMed:15526160, PubMed:11882383, PubMed:21620960, PubMed:21432781, PubMed:31204173). This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates (PubMed:15526160, PubMed:11882383, PubMed:21620960, PubMed:21432781, PubMed:31204173). Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported (PubMed:15526160, PubMed:11882383, PubMed:21620960, PubMed:21432781). AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface (By similarity). Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling (By similarity). Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport (PubMed:11994271). AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity (By similarity). Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven (By similarity). AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase) (PubMed:11154276). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis (PubMed:11154276). AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating the mTORC1 signaling pathway, and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1 (PubMed:12150915, PubMed:12172553). Also regulates the mTORC1 signaling pathway by catalyzing phosphorylation of CASTOR1 and DEPDC5 (PubMed:31548394, PubMed:33594058). AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization (PubMed:10358075). In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319' (PubMed:10358075). FOXO3 and FOXO4 are phosphorylated on equivalent sites (PubMed:10358075). AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein) (PubMed:9829964). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1 (PubMed:9829964). AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis (By similarity). Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis (By similarity). Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity (By similarity). The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth (By similarity). AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I) (PubMed:12176338, PubMed:12964941). AKT mediates the antiapoptotic effects of IGF-I (By similarity). Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly (PubMed:19934221). May be involved in the regulation of the placental development (By similarity). Phosphorylates STK4/MST1 at 'Thr-120' and 'Thr-387' leading to inhibition of its: kinase activity, nuclear translocation, autophosphorylation and ability to phosphorylate FOXO3 (PubMed:17726016). Phosphorylates STK3/MST2 at 'Thr-117' and 'Thr-384' leading to inhibition of its: cleavage, kinase activity, autophosphorylation at Thr-180, binding to RASSF1 and nuclear translocation (PubMed:20086174, PubMed:20231902). Phosphorylates SRPK2 and enhances its kinase activity towards SRSF2 and ACIN1 and promotes its nuclear translocation (PubMed:19592491). Phosphorylates RAF1 at 'Ser-259' and negatively regulates its activity (PubMed:10576742). Phosphorylation of BAD stimulates its pro-apoptotic activity (PubMed:10926925). Phosphorylates KAT6A at 'Thr-369' and this phosphorylation inhibits the interaction of KAT6A with PML and negatively regulates its acetylation activity towards p53/TP53 (PubMed:23431171). Phosphorylates palladin (PALLD), modulating cytoskeletal organization and cell motility (PubMed:20471940). Phosphorylates prohibitin (PHB), playing an important role in cell metabolism and proliferation (PubMed:18507042). Phosphorylates CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization (PubMed:16982699). These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation (PubMed:16139227). Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation (PubMed:20682768). Phosphorylates PCK1 at 'Ser-90', reducing the binding affinity of PCK1 to oxaloacetate and changing PCK1 into an atypical protein kinase activity using GTP as donor (PubMed:32322062). Also acts as an activator of TMEM175 potassium channel activity in response to growth factors: forms the lysoK(GF) complex together with TMEM175 and acts by promoting TMEM175 channel activation, independently of its protein kinase activity (PubMed:32228865). Acts as an inhibitor of tRNA methylation by mediating phosphorylation of the N-terminus of METTL1, thereby inhibiting METTL1 methyltransferase activity (PubMed:15861136). In response to LPAR1 receptor pathway activation, phosphorylates Rabin8/RAB3IP which alters its activity and phosphorylates WDR44 which induces WDR44 binding to Rab11, thereby switching Rab11 vesicular function from preciliary trafficking to endocytic recycling (PubMed:31204173). {ECO:0000250|UniProtKB:P31750, ECO:0000250|UniProtKB:P47196, ECO:0000269|PubMed:10358075, ECO:0000269|PubMed:10576742, ECO:0000269|PubMed:10926925, ECO:0000269|PubMed:11154276, ECO:0000269|PubMed:11994271, ECO:0000269|PubMed:12150915, ECO:0000269|PubMed:12172553, ECO:0000269|PubMed:12176338, ECO:0000269|PubMed:12964941, ECO:0000269|PubMed:15861136, ECO:0000269|PubMed:16139227, ECO:0000269|PubMed:16982699, ECO:0000269|PubMed:17726016, ECO:0000269|PubMed:18507042, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:19934221, ECO:0000269|PubMed:20086174, ECO:0000269|PubMed:20231902, ECO:0000269|PubMed:20471940, ECO:0000269|PubMed:20682768, ECO:0000269|PubMed:23431171, ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:31548394, ECO:0000269|PubMed:32228865, ECO:0000269|PubMed:32322062, ECO:0000269|PubMed:33594058, ECO:0000269|PubMed:9829964, ECO:0000303|PubMed:11882383, ECO:0000303|PubMed:15526160, ECO:0000303|PubMed:21432781, ECO:0000303|PubMed:21620960}.FUNCTION: Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity). {ECO:0000250, ECO:0000269|PubMed:17875921}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


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Kinase-Substrate Information of AKT1_ANKS1A


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
AKT1P31749humanDIABLOQ9NR28S67AQkSEPHsLSSEALMSmac_DIABLO
AKT1P31749humanBCL2L11O43521S87FIFMRRSsLLSRSss
AKT1P31749humanPKMP14618S222AVDLPAVsEkDIQDLPK
AKT1P31749humanTFEBP19484S467KASsRRssFsMEEGDDUF3371
AKT1P31749humanPLCG1P19174S1248HGrAREGsFEsRyQQ
AKT1P31749humanMAP3K11Q16584S674PGRERGEsPTtPPTP
AKT1P31749humanTBC1D4O60343S318EFRsRCssVtGVQRRPID
AKT1P31749humanRALGAPA2Q2PPJ7T715PMRFRsAttSGAPGV
AKT1P31749humanSIK1P57059S435VFRPRPVsPsSLLDT
AKT1P31749humanPHB1P35232T258LSRSRNItyLPAGQs
AKT1P31749humanPCK1P35558S90RDVARIEsktVIVTQPEPCK_N
AKT1P31749humanSTK4Q13043T183DtMAkRNtVIGTPFWPkinase
AKT1P31749humanPRKAA1Q13131S494GtAtPQRsGsVsNyRAdenylateSensor
AKT1P31749humanNF2P35240S315MRRRKADsLEVQQMkFERM_C
AKT1P31749humanTOPBP1Q92547S1159EERARLAsNLQWPSC
AKT1P31749humanTWIST1Q15672T121NVRERQRtQsLNEAFHLH
AKT1P31749humanSLC9A1P19634S703MsRARIGsDPLAyEP
AKT1P31749humanEGFRP00533S229rCrGKSPsDCCHNQCFurin-like
AKT1P31749humanCABLES1Q8TDN4T415AFGARRNtIDstSsF
AKT1P31749humanCDKN1AP38936S146GRkRRQtsMTDFyHs
AKT1P31749humanBTKQ06187S51FERGRRGsKKGsIDVPH
AKT1P31749humanMITFO75030S516KtssRRssMSMEETEDUF3371
AKT1P31749humanIRAK1P51617T100LRARDIItAWHPPAPDeath
AKT1P31749humanPPP1CAP62136T320NPGGRPItPPRNsAK
AKT1P31749humanPANK4Q9NVE7T406AQRARsGtFDLLEMD
AKT1P31749humanSKIP12755T458QPRKRKLtVDTPGAP
AKT1P31749humanCARD11Q9BXL7S652LERPFRPsVtsVGHV
AKT1P31749humanTWIST1Q15672S42GGRkRRSsRRsAGGG
AKT1P31749humanSTK4Q13043T120IIRLRNktLTEDEIAPkinase
AKT1P31749humanFOXO4P98177S262TFRPRSssNAsSVsT
AKT1P31749humanRARAP10276S96FVCQDKSsGYHYGVSzf-C4
AKT1P31749humanTP53RKQ96S44S250RLRGRKRsMVG____
AKT1P31749humanKRT19P08727S35GVAFrAPsIHGGsGG
AKT1P31749humanYWHAZP63104S58VVGARRssWRVVssI14-3-3
AKT1P31749humanCBY1Q9Y3M2S20TPPRKsAsLSNLHsLChibby
AKT1P31749humanCELF1Q92879S28GQVPrtWsEkDLRELRRM_1
AKT1P31749humanPDCD4Q53EL6S67kRRLRKNssRDsGrG
AKT1P31749humanCDKN1CP49918T310GVGsVEQtPRKRLR_
AKT1P31749humanPHF20Q9BVI0S265RKRGRPPsIAPTAVDDUF3776
AKT1P31749humanHSF1Q00613S230PkYSRQFsLEHVHGS
AKT1P31749humanBMI1P35226S316ANRPRKssVNGSSAT
AKT1P31749humanCLK2P49760S34HKRRRSRsWSSSSDR
AKT1P31749humanMTORP42345S2448RsRtRtDsysAGQsV
AKT1P31749humanPYGO2Q9BRQ0S48PEKKRRKsNtQGPAY
AKT1P31749humanACLYP53396S455PAPsRtAsFsEsRAD
AKT1P31749humanPFKFB2O60825S466PVRMRRNsFtPLssS
AKT1P31749humanNUAK1O60285S600PARQRIRsCVsAENF
AKT1P31749humanAURKBQ96GD4T73DILTRHFtIDDFEIG
AKT1P31749humanADARP55265T1033RLGERLRtMSCSDKIA_deamin
AKT1P31749humanINVSQ9Y283T866ARRLEtstLSEDFQV
AKT1P31749humanHSF1Q00613T527PPKAkDPtVS_____Vert_HS_TF
AKT1P31749humanDEPDC5O75140S1530QQRRRRNstSSTNQNDEPDC5_CTD
AKT1P31749humanCDKN1BP46527T157GIRkrPAtDDSSTQN
AKT1P31749humanSRSF3P84103S128FsRsRsRsLsRDRRR
AKT1P31749humanSTK3Q13188T384GtMKRNAtsPQVQRP
AKT1P31749humanBRCA1P38398S694QTSKRHDsDTFPELk
AKT1P31749humanKMT2DO14686-3S1331RGRARLKsTASSIET
AKT1P31749humanSUMO1P63165T76QrIADNHtPkELGMERad60-SLD
AKT1P31749humanZFP36L1Q07352S92RFRDRsFsEGGERLLTis11B_N
AKT1P31749humanRNF11Q9Y3C5T135DWLMRSFtCPSCMEPzf-RING_2
AKT1P31749humanSRSF3P84103S130RsRsRsLsRDRRRER
AKT1P31749humanFLNCQ14315S2233LGRERLGsFGsItRQFilamin
AKT1P31749humanACAP1Q15027S554sIRPRPGsLRSkPEP
AKT1P31749humanPHF20Q9BVI0S291ELRRRKIsKGCEVPL
AKT1P31749humanUSP4Q13107S445NHRLRNDsVIVDTFHUCH
AKT1P31749humanLONP1P36776S181NESDVVEsLDEIyHTLON_substr_bdg
AKT1P31749humanSP1P08047S42FsQARSSsTGsSSSt
AKT1P31749humanRUNX2Q13950S196GRSGRGKsFtLtITVRunt
AKT1P31749humanCDKN1CP49918S282FFAkRKRsAPEKSSG
AKT1P31749humanNQO1P15559T128FIGEFAytyAAMyDkFlavodoxin_2
AKT1P31749humanFOXO4P98177T32QsRPRsCtWPLPRPE
AKT1P31749humanMXD1Q05195S145IERIRMDsIGSTVSS
AKT1P31749humanBECN1Q14457S295FRLGRLPsVPVEWNEAPG6
AKT1P31749humanRBM8AQ9Y5S9S168GGRRRsRsPDRRRR_
AKT1P31749humanYBX1P67809S102NPRKyLrsVGDGEtVCSD
AKT1P31749humanMDM2Q00987S186RQRkRHksDsIsLsF
AKT1P31749humanSOX2P48431T116KYRPRRktktLMkKDSOXp
AKT1P31749humanPRKAA1Q13131S496AtPQRsGsVsNyRSCAdenylateSensor
AKT1P31749humanKDM5AP29375S1255CLTERAMsWQDRARQ
AKT1P31749humanGATA2P23769S401QTRNRKMsNKSKKSK
AKT1P31749humanCCNFP41002S577TKRKRENsLQEDRGS
AKT1P31749humanPTK2Q05397S695EERMRMEsRRQAtVs
AKT1P31749humanADRB2P07550S346LLCLRRssLKAyGNG
AKT1P31749humanUSP14P54578S432THQGRSSsSGHyVSWUCH
AKT1P31749humanNR3C1P04150S134ANLNRstsVPENPkSGCR
AKT1P31749humanPKMP14618S97NVrtAtEsFAsDPILPK
AKT1P31749humanHES5Q5TA89S35RRDRINssIEQLKLLHLH
AKT1P31749humanPDCD4Q53EL6S457RGRKRFVsEGDGGRL
AKT1P31749humanRPL13P26373S106DPrRRNkstEsLQANRibosomal_L13e
AKT1P31749humanVCPP55072S352AAtNRPNsIDPALRRAAA
AKT1P31749humanCREBBPQ92793T1871LMRRRMAtMNtRNVP
AKT1P31749humanRUNX2Q13950T198SGRGKsFtLtITVFTRunt
AKT1P31749humanZNF322Q6U7Q0S224EKSYRHRsAFIVHKRzf-C2H2
AKT1P31749humanCOPS6Q7L5N1S60DHWIRMRsQEGRPVQJAB
AKT1P31749humanEDC3Q96F86S161sFRRRHNsWssssRHEdc3_linker
AKT1P31749humanPIK3R6Q5UE93T607SHRPREVtVsLRAtGPI3K_1B_p101
AKT1P31749humanITCHQ96J02S257PsRPPRPsRPPPPTP
AKT1P31749humanPANK2Q9BZ23S189TRRDRLGsysGPtsV
AKT1P31749humanTKTP29401T382GCATRNRtVPFCsTFTransket_pyr
AKT1P31749humanFANCAO15360S1149CLRSRDPsLMVDFIL
AKT1P31749humanCDCA7Q9BWT1T163SRRPRRRtFPGVASR
AKT1P31749humanH2BC11P06899S36RKRSRkEsysIyVykHistone
AKT1P31749humanTERF1P54274T358KKESRRAtESRIPVS
AKT1P31749humanEP300Q09472S1834MLRRRMAsMQRTGVV
AKT1P31749humanALYREFQ86V81T219GGGtrRGtRGGARGRFoP_duplication
AKT1P31749humanPHB2Q99623S91RARPRkIssPTGSkDBand_7
AKT1P31749humanMETTL1Q9UBP6S27YYRQrAHsNPMADHT
AKT1P31749humanBCL10O95999S231PLRsRtVsRQ_____
AKT1P31749humanGJA1P17302S373RAssRAssRPRPDDL
AKT1P31749humanRAF1P04049S259sQRQRststPNVHMV
AKT1P31749humanTSC2P49815S981AFRCRSIsVSEHVVR
AKT1P31749humanFOXO1Q12778S256sPrRrAAsMDNNskF
AKT1P31749humanSSH1Q8WYL5T826AGLVRKHtKELERLK
AKT1P31749humanCHUKO15111T23EMRERLGtGGFGNVCPkinase
AKT1P31749humanCABLES1Q8TDN4T309APLRRCRtLsGsPRP
AKT1P31749humanINVSQ9Y283T864SGARRLEtstLSEDF
AKT1P31749humanNGEFQ8N5V2S18KTRRKsAsDQWNTDN
AKT1P31749humanTERF1P54274T273sKRTRtItSQDKPSG
AKT1P31749humanAGAP2Q99490-2S472RNLARALsTDCTPSG
AKT1P31749humanSIRT6Q8N6T7S338PKRERPtsPAPHRPP
AKT1P31749humanPHB2Q99623S176TERAKDFsLILDDVABand_7
AKT1P31749humanACLYP53396T447NAsGststPAPsRtA
AKT1P31749humanSTK4Q13043T387tMKRRDEtMQPAKPs
AKT1P31749humanTBC1D4O60343S570AKRsLtssLENIFsr
AKT1P31749humanYAP1P46937S127PQHVRAHssPAsLQL
AKT1P31749humanBABAM1Q9NWV8S29EPRPRtRsNPEGAED
AKT1P31749humanADARB1P78563T553LQGERLLtMSCSDKIA_deamin
AKT1P31749humanTBC1D1Q86TI0T596AFRRRANtLsHFPIE
AKT1P31749humanVCPP55072S746AMRFARRsVsDNDIrVps4_C
AKT1P31749humanACLYP53396S451ststPAPsRtAsFsE
AKT1P31749humanMAP2K4P45985S80IERLRtHsIESSGkL
AKT1P31749humanTIFAQ96CG3T9tSFEDADtEEtVTCL
AKT1P31749humanTERTO14746S824AVRIRGKsYVQCQGIRVT_1
AKT1P31749humanNF2P35240S518DTDMKRLsMEIEKEKERM_C
AKT1P31749humanRARGP13631S371YARRRRPsQPYMFPRHormone_recep
AKT1P31749humanARP10275S215SGRAREAsGAPtsSKAndrogen_recep
AKT1P31749humanDLC1Q96QB1S766VTRTRsLsACNKRVG
AKT1P31749humanPFKFB3Q16875S461NPLMRRNsVtPLAsP
AKT1P31749humanUBE2IP63279T35PTKNPDGtMNLMNWEUQ_con
AKT1P31749humanCDKN1AP38936T145QGRkRRQtsMTDFyH
AKT1P31749humanEPHA2P29317S897RVsIRLPstsGsEGV
AKT1P31749humanMDM2Q00987S188RkRHksDsIsLsFDE
AKT1P31749humanPTK2Q05397T700MEsRRQAtVsWDsGG
AKT1P31749humanRPS3AP61247T10VGKNKRLtKGGKKGA
AKT1P31749humanCFLARO15519S273LLRDTFTsLGYEVQKPeptidase_C14
AKT1P31749humanH2BC3P33778S36RKRsRkEsysIyVykHistone
AKT1P31749humanFOXO1Q12778T24LPRPRsCtWPLPRPE
AKT1P31749humanDNMT1P26358S143RtPRRsksDGEAkPE
AKT1P31749humanSCYL1Q96KG9T469sTRHRVLtSAFSRAT
AKT1P31749humanCYTH2Q99418T276LGGGRVKtWKRRWFIPH
AKT1P31749humanEYA1Q99502S299SDRLRRGsDGKsRGR
AKT1P31749humanTAL1P17542T90EARHRVPttELCRPP
AKT1P31749humanBADQ92934S99PFrGrsRsAPPNLWABcl-2_BAD
AKT1P31749humanPFKFB2O60825S483IRRPRNysVGsRPLK
AKT1P31749humanNIBAN1Q9BZQ8S602AsPARRAsAILPGVL
AKT1P31749humanAGAP2Q99490-2S629THLSRVRsLDLDDWPArfGap
AKT1P31749humanHNRNPA1P09651S199sQrGrsGsGNFGGGr
AKT1P31749humanSMAD3P84022T179PQSNIPEtPPPGYLS
AKT1P31749humanPTPN1P18031S50RNRyRDVsPFDHsRIY_phosphatase
AKT1P31749humanAKT1P31749S246LSRERVFsEDRARFYPkinase
AKT1P31749humanNCLP19338T641EIDGNkVtLDWAkPKRRM_1
AKT1P31749humanRPL7AP62424T106AHkYRPEtkQEKKQR
AKT1P31749humanNCF1P14598S304GAPPRRssIRNAHsINECFESHC
AKT1P31749humanNR4A1P22736S351GRRGRLPsKPKQPPD
AKT1P31749humanHTTP42858S419GGRsRsGsIVELIAG
AKT1P31749humanVCPP55072S748RFARRsVsDNDIrkyVps4_C
AKT1P31749humanFBXW7Q969H0S227QQRRRITsVQPPTGL
AKT1P31749humanMST1RQ04912S1394VRRPRPLsEPPRPT_
AKT1P31749humanVDAC2P45880S48DVKtksCsGVEFStsPorin_3
AKT1P31749humanRAC1P63000S71yDRLRPLsYPQTDVFRas
AKT1P31749humanGSK3AP49840S21sGrARtssFAEPGGG
AKT1P31749humanNSD2O96028S172ARRNRKRsIKyDsLL
AKT1P31749humanHSPB1P04792S82RALsRQLssGVsEIr
AKT1P31749humanPPATQ06203T397DSIVRGNtIsPIIkLPribosyltran
AKT1P31749humanUSP35Q9P2H5S613CRRRRLGsVMRPTEDUCH
AKT1P31749humanTTC3P53804S378AYTPRsLsAPIFTTS
AKT1P31749humanPLD2O14939T175NyLNRLLtMSFyRNYPX
AKT1P31749humanMDM4O15151S367PDCRRtIsAPVVRPk
AKT1P31749humanCARD11Q9BXL7S558MQPPRsRssIMsITA
AKT1P31749humanARHGAP22Q7Z5H3S16ARRARsKsLVMGEQS
AKT1P31749humanSLC9A1P19634S648KTRQRLRsYNRHtLVNEXCaM_BD
AKT1P31749humanBTKQ06187T495EMRHRFQtQQLLEMCPK_Tyr_Ser-Thr
AKT1P31749humanNOS3P29474S615SYKIRFNsISCSDPLFlavodoxin_1
AKT1P31749humanHK2P52789T473QHRARQktLEHLQLSHexokinase_1
AKT1P31749humanALYREFQ86V81S34RGRGrAGsQGGrGGG
AKT1P31749humanSKP2Q13309S72PPRkRLkskGsDkDF
AKT1P31749humanAKT1P31749T72tERPRPNtFIIRCLQPH
AKT1P31749humanKDM5AP29375S287RQRKGtLsVNFVDLY
AKT1P31749humanTSC2P49815T1462GLrPrGytISDsAPs
AKT1P31749humanTARBP2Q15633S283ILSLRsCsLGsLGAL
AKT1P31749humanPKMP14618S37MCRLDIDsPPItARN
AKT1P31749humanLMNAP02545S404RsRGRAssHssQtQG
AKT1P31749humanBRCA1P38398T509LKRKRRPtsGLHPED
AKT1P31749humanCASP9P55211S196kLRRRFssLHFMVEVPeptidase_C14
AKT1P31749humanCCDC88AQ3V6T2S1417INRERQksLtLtPTR
AKT1P31749humanMTORP42345T2446NKRsRtRtDsysAGQ
AKT1P31749humanFLIIQ13045S436RLRRRKDsAQDDQAK
AKT1P31749humanSLC9A1P19634S796QRIQRCLsDPGPHPE
AKT1P31749humanZRANB1Q9UGI0S78SARPRVksSYSMENA
AKT1P31749humanMAP3K5Q99683S83ATRGRGssVGGGSrR
AKT1P31749humanHTRA2O43464S212RVRVRLLsGDTYEAVTrypsin_2; Peptidase_M50
AKT1P31749humanNDRG2Q9UN36T348GNRsRsRtLsQssEs
AKT1P31749humanBCL10O95999S218EEGTCANsSEMFLPL
AKT1P31749humanUSP33Q8TEY7T185ELRARGLtGLKNIGN
AKT1P31749humanNOS3P29474S1177TSRIRtQsFsLQERQ
AKT1P31749humanCREB1P16220S119EILsRRPsyRkILNDpKID
AKT1P31749humanNCOR1O75376S1450tVRSRHtsVVsSGPs
AKT1P31749humanRAB3IPQ96QF0S165LSRLRsPsVLEVREK
AKT1P31749humanPCGF2P35227T334TSRGRKMtVNGAPVP
AKT1P31749humanITGB3P05106T779LyKEAtstFTNItyRIntegrin_b_cyt
AKT1P31749humanWT1P19544-7S67GRRsRGAsGsEPQQM
AKT1P31749humanXIAPP98170S87VGRHRKVsPNCRFINBIR
AKT1P31749humanTSC2P49815S939sFRARstsLNERPKs
AKT1P31749humanSP1P08047S698CPkRFMRsDHLskHIzf-C2H2
AKT1P31749humanMAP3K11Q16584T477HVRRRRGtFKRSKLR
AKT1P31749humanGSK3BP49841S9SGRPRttsFAEsCkP
AKT1P31749humanRPS3P23396T70GrrIrELtAVVQkRFKH_2
AKT1P31749humanZBTB33Q86T24T606yLSDRSStIPAMkDD
AKT1P31749humanZRANB1Q9UGI0T117QRRTRsPtESPQSSG
AKT1P31749humanNDRG2Q9UN36S332LsRsRtAsLtsAAsV
AKT1P31749humanRPS3AP61247S112LTRDkMCsMVKKWQTRibosomal_S3Ae
AKT1P31749humanRANBP3Q9H6Z4S126VKRERtssLtQFPPs
AKT1P31749humanTBC1D4O60343S751EGRKRtsstCsNEsL
AKT1P31749humanNF2P35240T230AIRNKKGtELLLGVDFERM_C
AKT1P31749humanEZH2Q15910S21CWRKRVKsEyMRLRQ
AKT1P31749humanTMIGD2Q96BF3S220GKDQRGQsIyStSFP
AKT1P31749humanARP10275S792CVRMRHLsQEFGWLQHormone_recep
AKT1P31749humanNGEFQ8N5V2S16LEKTRRKsAsDQWNT
AKT1P31749humanMDM2Q00987S166SsRRRAIsEtEENsD
AKT1P31749humanAKT1S1Q96B36T246LPRPRLNtsDFQkLKPRAS
AKT1P31749humanRUNX2Q13950T200RGKsFtLtITVFTNPRunt
AKT1P31749humanARHGAP19Q14CB8S422QkRARsRsFsGLIkR
AKT1P31749humanIWS1Q96ST2T721QRRRMNstGGQtPRR
AKT1P31749humanFBXO31Q5XUX0S33AETAAADsEPDtDPE
AKT1P31749humanSLC7A11Q9UPY5S26NVNGRLPsLGNkEPP
AKT1P31749humanFOXO3O43524T32QsRPRsCtWPLQRPE
AKT1P31749humanCYCSP99999Y47ktGQAPGysytAANkCytochrom_C
AKT1P31749humanBECN1Q14457S234AQyQREysEFkRQQLAPG6_N
AKT1P31749humanBAXQ07812S184VAGVLTAsLtIWKKMTM
AKT1P31749humanUPF1Q92900T151FCNGRGNtSGSHIVNUPF1_Zn_bind
AKT1P31749humanTBC1D4O60343S341QPRRRHAsAPsHVQPPID
AKT1P31749humanCDKN1BP46527T198PGLRRRQt_______
AKT1P31749humanKAT6AQ92794T369RGRKRKItLSSQSAS
AKT1P31749humanKDM5AP29375T285QMRQRKGtLsVNFVD
AKT1P31749humanACOT4Q8N9L9S392GGEPRAHskAQEDAWBAAT_C
AKT1P31749humanSIK1P57059T182kSGEPLStWCGSPPYPkinase
AKT1P31749humanACIN1Q9UKV3S1180GPRsRsRsRDRRRKERSB_motif
AKT1P31749humanYBX1P67809S209YGrrPQysNPPVQGE
AKT1P31749humanLONP1P36776S173VFLKRDDsNESDVVELON_substr_bdg
AKT1P31749humanFOXO4P98177S197APRRRAAsMDsSSKL
AKT1P31749humanZNF322Q6U7Q0T262IVHQRVHtGEkPYKC
AKT1P31749humanSTK3Q13188T117IIRLRNktLIEDEIAPkinase
AKT1P31749humanESR1P03372S167GGRERLAsTNDkGSMOest_recep
AKT1P31749humanFOXO1Q12778S319TFRPRtssNAstIsG
AKT1P31749humanMASTLQ96GX5T299QsRKRLAtSSAsSQS
AKT1P31749humanCDK2P24941T39LkKIRLDtETEGVPsPkinase
AKT1P31749humanFOXG1P55316T279KLRRRsttsRAKLAF
AKT1P31749humanBRAFP15056S365GQRDRsssAPNVHIN
AKT1P31749humanCARHSP1Q9Y2V2S52tRRtrtFsAtVRAsQ
AKT1P31749humanNHERF1O14745T156ELRPRLCtMKKGPsGPDZ
AKT1P31749humanARFIP2P53365S260GTRGRLEsAQATFQAArfaptin
AKT1P31749humanTENT2Q6PIY7S116LsGERRYsMPPLFHT
AKT1P31749humanTBC1D7Q9P0N9S124GkLPRsPsFPLEPDD
AKT1P31749humanRPS6P62753S236AKRRRLssLRAstsK
AKT1P31749humanCHEK1O14757S280AKRPRVtsGGVsEsP
AKT1P31749humanSH3BP4Q9P0V3S246FRsKRsYsLsELsVL
AKT1P31749humanGAB2Q9UQC2S159LLRERKSsAPSHsSQ
AKT1P31749humanDNM1LO00429S616PIPIMPAsPQKGHAV
AKT1P31749humanZFP36L1Q07352S203PRLQHsFsFAGFPSA
AKT1P31749humanATXN1P54253S775AtRKRRWsAPESRKL
AKT1P31749humanLARP6Q9BRS8S451QEKsPGtsPLLsRKM
AKT1P31749humanPKMP14618S202tEVENGGsLGskkGVPK
AKT1P31749humanWNK1Q9H4A3T60EYRRRRHtMDKDSrG
AKT1P31749humanLTB4R2Q9NPC1T324GGRSREGtMELRTTPTM
AKT1P31749humanRPS6KA3P51812T115KVRDRVRtKMERDIL
AKT1P31749humanFLNAP21333S2152tRRRRAPsVANVGsHFilamin
AKT1P31749humanTBC1D4O60343T642QFRRRAHtFsHPPss
AKT1P31749humanINVSQ9Y283S865GARRLEtstLSEDFQ
AKT1P31749humanWEE1P30291S642KKMNRSVsLtIy___
AKT1P31749humanBRAFP15056S429PQRERKsssssEDRN
AKT1P31749humanNF2P35240S10GAIASRMsFSsLkRK
AKT1P31749humanCCT2P78371S260GsRVRVDstAkVAEICpn60_TCP1
AKT1P31749humanMAP3K8P41279S400EDQPRCQsLDSALLE
AKT1P31749humanDLC1Q96QB1S735MVRKRsVsNstQtSS
AKT1P31749humanKDM5AP29375T1225SRRPRLEtILSLLVS
AKT1P31749humanPARK7Q99497T125GFGSKVTtHPLAkDkDJ-1_PfpI
AKT1P31749humanSP1P08047T679ELQRHKRtHtGEkkFzf-C2H2
AKT1P31749humanVIMP08670S39ttstrtysLGsALrPFilament_head
AKT1P31749humanCARD11Q9BXL7S644NLMFRKFsLERPFRP
AKT1P31749humanPANK2Q9BZ23S169PLRRRAssAsVPAVG
AKT1P31749humanUBE2SQ16763T152AARARLLtEIHGGAGUQ_con
AKT1P31749humanTBC1D4O60343T568NKAKRsLtssLENIF
AKT1P31749humanNCF1P14598S328QDAYRRNsVRFLQQRNECFESHC
AKT1P31749humanSRSF3P84103S122SPRRRsFsRsRsRsL
AKT1P31749humanSSBP05455T389VKRAREEtDkEEPAS
AKT1P31749humanZNF322Q6U7Q0T150LVHQRSHtGEKPYLC
AKT1P31749humanBCL3P20749S41kRPLRAPsPEPAAPR
AKT1P31749humanTBC1D4O60343S588RMRGRLGsVDsFERs
AKT1P31749humanHSPA1BP0DMV8S631AQGPkGGsGsGPtIE
AKT1P31749humanCDKN1BP46527S10NVRVSNGsPsLErMD
AKT1P31749humanCCNFP41002T31RRRPRNLtILSLPED
AKT1P31749humanMAPKAP1Q9BPZ7T86GIRRRsNtAQRLERLSIN1
AKT1P31749humanMVDP53602S96LARKRRNsRDGDPLP
AKT1P31749humanSRSF3P84103S138RDRRRERsLsRERNH
AKT1P31749humanCBX3Q13185T89AGkEkDGtKRksLsD
AKT1P31749humanDLC1Q96QB1S1004RHRLRWHsFQSSHRP
AKT1P31749humanTKTP29401S387NRtVPFCsTFAAFFTTransket_pyr
AKT1P31749humanKDM5AP29375S225TRRVkTQsESGDVSR
AKT1P31749humanZYXQ15942S142PQPREKVssIDLEId
AKT1P31749humanFAF1Q9UNN5S582kLRIRtPsGEFLERRUBX
AKT1P31749humanCBX3Q13185T55FLkWkGFtDADNtWEChromo
AKT1P31749humanRALGAPA2Q2PPJ7S486SsWGRTYsFtSAMsR
AKT1P31749humanTBC1D4O60343S666GRAQGVRsPLLRQSS
AKT1P31749humanRGCCQ9H4X1-2S45ERMKRRSsAsVSDSSRGCC
AKT1P31749humanNPM1P06748S48QLsLrTVsLGAGAkDNucleoplasmin
AKT1P31749humanKHSRPQ92945S193GLPERsVsLtGAPEsKH_1
AKT1P31749humanPIP5K1CO60331S555RYRRRtQssGQDGRP
AKT1P31749humanCLK2P49760T127RRRRRSRtFSRSSSQ
AKT1P31749humanHES5Q5TA89S34MRRDRINssIEQLKLHLH
AKT1P31749humanILF3Q12906S647rGrGRGGsIRGRGRG
AKT1P31749humanSYTL1Q8IYJ3S241RMLsSSSsVSSLNSS
AKT1P31749humanELAVL1Q15717S100VSYARPSsEVIkDAN
AKT1P31749humanHSF1Q00613S326ssVDtLLsPTALIDsVert_HS_TF
AKT1P31749humanCTNNB1P35222S552QDtQRRtsMGGtQQQ
AKT1P31749humanTWIST1Q15672S123RERQRtQsLNEAFAAHLH
AKT1P31749humanPACS2Q86VP3S437GRRGRStsLKERQAA
AKT1P31749humanTSPYL5Q86VY4T120SERLAADtVFVGTAG
AKT1P31749humanTERTO14746S227GARRRGGsASRSLPL
AKT1P31749humanS1PR1P21453T236RTRSRRLtFRKNISK7tm_1
AKT1P31749humanNHEJ1Q9H9Q4T181LIRDRLktEPFEENS
AKT1P31749humanLMNAP02545S301QsRIRIDsLsAQLsQFilament
AKT1P31749humanPIKFYVEQ9Y2I7S318LsLDRsGsPMVPSyE
AKT1P31749humanATG4BQ9Y4P1S34WILGRKYsIFTEkDE
AKT1P31749humanSRSF3P84103S140RRRERsLsRERNHKP
AKT1P31749humanRICTORQ6R327T1135NRRIRtLtEPsVDFNRICTOR_phospho
AKT1P31749humanFOXA2Q9Y261T156KTYRRSYtHAKPPYSForkhead_N
AKT1P31749humanPALLDQ8WX93S1118VRRPRsRsRDsGDEN
AKT1P31749humanPIKFYVEQ9Y2I7S307PARNRsAsItNLsLD
AKT1P31749humanSH3RF1Q7Z6J0S304KNTKKRHsFtsLtMA
AKT1P31749humanHJURPQ8NCD3S486GLEtRRLsLPssKAK
AKT1P31749humanZNF322Q6U7Q0T234IVHKRVHtGEkPYKC
AKT1P31749humanRUNX2Q13950S28PSTsRRFsPPSssLQ
AKT1P31749humanTENT2Q6PIY7S110VNQIVPLsGERRYsM
AKT1P31749humanIRS1P35568S629VPsGRKGsGDyMPMs
AKT1P31749humanNCLP19338T707HKPQGKKtKFE____
AKT1P31749humanPDK1Q15118T346APRPRVEtsRAVPLAHATPase_c
AKT1P31749humanRPS3AP61247T88FRkFkLItEDVQGkNRibosomal_S3Ae
AKT1P31749humanH3C14Q71DI3T45PHryrPGtVALrEIRHistone
AKT1P31749humanCASTOR1Q8WTX7S14EHRVRVLsVARPGLWCastor1_N
AKT1P31749humanFOXO3O43524S253APRRRAVsMDNSNkY
AKT1P31749humanSRPK2P78362T492PSHDRSRtVsAsstG
AKT1P31749humanGATA1P15976S310QtRNRKAsGkGkkkR
AKT1P31749humanHSF1Q00613T142DsVTKLLtDVQLMKG
AKT1P31749humanH3C1P68431T45PHryrPGtVALrEIRHistone
AKT1P31749humanNLRP3Q96P20S5___MKMAsTRCKLAR
AKT1P31749humanKCNH2Q12809_VAR_014388T897SFRRRtDtDtEQPGE
AKT1P31749humanESR1P03372S305IkRSkkNsLALSLtA
AKT1P31749humanCSNK2A1P68400T13PsRARVytDVNtHRP
AKT1P31749humanNQO1P15559S40kGWEVVEsDLyAMNFFlavodoxin_2
AKT1P31749humanDOCK6Q96HP0S1194GQRsRLAsMLDSDTE
AKT1P31749humanKRT8P05787S432sAyGGLtsPGLsysL
AKT1P31749humanIWS1Q96ST2S720PQRRRMNstGGQtPR
AKT1P31749humanEPRS1P07814S999NQGGGLsssGAGEGQ
AKT1P31749humanFLCNQ8NFG4S62NSRMRAHsPAEGAsV
AKT1P31749humanH2BC18Q5QNW6S36RKRsRkEsysVyVykHistone
AKT1P31749humanEMSYQ7Z589S209RKRRRtNsssssPVV
AKT1P31749humanUSP10Q14694T674VEIsRRVtLEkLPPVUCH
AKT1P31749humanPEA15Q15121S116kDIIRQPsEEEIIKL
AKT1P31749humanRPS6KA3P51812S19KMAVEsPsDSAENGQ
AKT1P31749humanDBNLQ9UJU6S269KQKERAMsttsIssP
AKT1P31749humanDBNLQ9UJU6T291PFLQkQLtQPEtHFG
AKT1P31749humanMAZP56270T385kDRLRAHtVRHEEKV
AKT1P31749humanHMOX1P09601S188LYRSRMNsLEMtPAVHeme_oxygenase
AKT1P31749humanTIAM1Q13009S231sTCQRANsLGDLYAQ


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
AKT1IDDescription0.00e+00
AKT1GO:2001233regulation of apoptotic signaling pathway3.53e-21
AKT1GO:0097191extrinsic apoptotic signaling pathway2.19e-18
AKT1GO:2001234negative regulation of apoptotic signaling pathway1.12e-15
AKT1GO:2001236regulation of extrinsic apoptotic signaling pathway3.36e-15
AKT1GO:0062197cellular response to chemical stress1.32e-14
AKT1GO:0050673epithelial cell proliferation1.86e-14
AKT1GO:0071496cellular response to external stimulus1.14e-13
AKT1GO:0050678regulation of epithelial cell proliferation1.70e-13
AKT1GO:0006913nucleocytoplasmic transport1.70e-13
AKT1GO:0051169nuclear transport1.70e-13
AKT1GO:1904019epithelial cell apoptotic process3.91e-13
AKT1GO:0070482response to oxygen levels4.05e-13
AKT1GO:2001237negative regulation of extrinsic apoptotic signaling pathway7.10e-13
AKT1GO:0031667response to nutrient levels8.77e-13
AKT1GO:0051347positive regulation of transferase activity1.16e-12
AKT1GO:0036293response to decreased oxygen levels1.91e-12
AKT1GO:0097193intrinsic apoptotic signaling pathway2.48e-12
AKT1GO:0043281regulation of cysteine-type endopeptidase activity involved in apoptotic process3.07e-12
AKT1GO:0031669cellular response to nutrient levels3.56e-12
AKT1GO:0034599cellular response to oxidative stress4.88e-12
AKT1GO:1901873regulation of post-translational protein modification7.03e-12
AKT1GO:0034504protein localization to nucleus7.13e-12
AKT1GO:1901653cellular response to peptide1.48e-11
AKT1GO:0051090regulation of DNA-binding transcription factor activity1.82e-11
AKT1GO:0001666response to hypoxia1.84e-11
AKT1GO:0031668cellular response to extracellular stimulus3.46e-11
AKT1GO:0031929TOR signaling3.64e-11
AKT1GO:0071375cellular response to peptide hormone stimulus4.13e-11
AKT1GO:1904035regulation of epithelial cell apoptotic process5.07e-11
AKT1GO:0043434response to peptide hormone6.45e-11
AKT1GO:2000116regulation of cysteine-type endopeptidase activity6.50e-11
AKT1GO:0071453cellular response to oxygen levels6.73e-11
AKT1GO:1903320regulation of protein modification by small protein conjugation or removal7.12e-11
AKT1GO:0031647regulation of protein stability1.02e-10
AKT1GO:0036294cellular response to decreased oxygen levels1.05e-10
AKT1GO:0032869cellular response to insulin stimulus1.64e-10
AKT1GO:1900180regulation of protein localization to nucleus1.83e-10
AKT1GO:0031331positive regulation of cellular catabolic process2.34e-10
AKT1GO:0016055Wnt signaling pathway2.63e-10
AKT1GO:0071456cellular response to hypoxia2.74e-10
AKT1GO:0198738cell-cell signaling by wnt2.80e-10
AKT1GO:0009266response to temperature stimulus3.67e-10
AKT1GO:0009895negative regulation of catabolic process4.09e-10
AKT1GO:0010506regulation of autophagy5.88e-10
AKT1GO:0009267cellular response to starvation7.76e-10
AKT1GO:0033674positive regulation of kinase activity1.09e-09
AKT1GO:0062012regulation of small molecule metabolic process1.09e-09
AKT1GO:0009408response to heat1.24e-09
AKT1GO:0043525positive regulation of neuron apoptotic process1.24e-09

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Related Drugs to AKT1_ANKS1A


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning AKT1-ANKS1A and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

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Related Diseases to AKT1_ANKS1A


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate