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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:GSK3B_ST6GALNAC5

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: GSK3B_ST6GALNAC5
KinaseFusionDB ID: KFG2617
FusionGDB2.0 ID: KFG2617
HgeneTgene
Gene symbol

GSK3B

ST6GALNAC5

Gene ID

2932

81849

Gene nameglycogen synthase kinase 3 betaST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
Synonyms-SIAT7-E|SIAT7E|ST6GalNAcV
Cytomap

3q13.33

1p31.1

Type of geneprotein-codingprotein-coding
Descriptionglycogen synthase kinase-3 betaGSK-3 betaserine/threonine-protein kinase GSK3Balpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5GD1 alpha synthaseGalNAc alpha-2,6-sialyltransferase VST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5ST6 GalNAc alpha-2,6-sialyltr
Modification date2024041120240411
UniProtAcc

P49841

Q9BVH7

Ensembl transtripts involved in fusion geneENST idsENST00000264235, ENST00000316626, 
ENST00000473886, 		ENST00000477717, 
ENST00000496845, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: GSK3B [Title/Abstract] AND ST6GALNAC5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)GSK3B(119545067)-ST6GALNAC5(77398571), # samples:1
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGSK3B

GO:0005977

glycogen metabolic process

8638126

HgeneGSK3B

GO:0006468

protein phosphorylation

11035810|16315267|20937854

HgeneGSK3B

GO:0006983

ER overload response

14744935

HgeneGSK3B

GO:0018105

peptidyl-serine phosphorylation

11104755|14744935

HgeneGSK3B

GO:0018105

peptidyl-serine phosphorylation

8638126|11955436|17139249

HgeneGSK3B

GO:0018107

peptidyl-threonine phosphorylation

11955436|17139249|25897075

HgeneGSK3B

GO:0031175

neuron projection development

19830702

HgeneGSK3B

GO:0031334

positive regulation of protein-containing complex assembly

8638126

HgeneGSK3B

GO:0031398

positive regulation of protein ubiquitination

29142209

HgeneGSK3B

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

19364825|22660580

HgeneGSK3B

GO:0035556

intracellular signal transduction

14749367

HgeneGSK3B

GO:0043066

negative regulation of apoptotic process

14744935

HgeneGSK3B

GO:0046777

protein autophosphorylation

23184662

HgeneGSK3B

GO:0046825

regulation of protein export from nucleus

12223487

HgeneGSK3B

GO:0046827

positive regulation of protein export from nucleus

14744935

HgeneGSK3B

GO:0060070

canonical Wnt signaling pathway

16890161

HgeneGSK3B

GO:0099171

presynaptic modulation of chemical synaptic transmission

17989287

HgeneGSK3B

GO:1904886

beta-catenin destruction complex disassembly

10428961


check buttonKinase Fusion gene breakpoints across GSK3B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonKinase Fusion gene breakpoints across ST6GALNAC5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChiTaRS5.0DA572046GSK3Bchr3

119545067

ST6GALNAC5chr1

77398571



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:119545067/:77398571)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GSK3B

P49841

ST6GALNAC5

Q9BVH7


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


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Kinase-Substrate Information of GSK3B_ST6GALNAC5


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
GSK3BP49841humanSRCP12931S51AdGHRGPsAAFAPAA
GSK3BP49841humanSREBF1P36956S434PPPsDAGsPFQSsPL
GSK3BP49841humanMAPTP10636-8T231KKVAVVRtPPKsPss
GSK3BP49841humanOGTO15294S3_____MAssVGNVAD
GSK3BP49841humanGRB14Q14449S362QGRsGCSsQSIsPMR
GSK3BP49841humanPSEN1P49768S353sHLGPHRstPEsRAAPresenilin
GSK3BP49841humanAHRP35869S723ELDYPMGsFEPsPYP
GSK3BP49841humanCLASP2O75122S507QGCsREAsPsRLsVA
GSK3BP49841humanBORAQ6PGQ7S278PISsPTFsPIEFQIG
GSK3BP49841humanRXRAP19793S49GSPGQLHsPISTLSSNuc_recep-AF1
GSK3BP49841humanMAPTP10636-8S199GDRsGyssPGsPGtP
GSK3BP49841humanAHRP35869S440NGTsGkDsATTsTLS
GSK3BP49841humanMACF1Q9UPN3S7314KSAsRPGsRAGsRAG
GSK3BP49841humanJUNP05412S243PGEtPPLsPIDMEsQ
GSK3BP49841humanSUFUQ9UMX1S342LAHDRAPsRkDsLEsSUFU_C
GSK3BP49841humanAPBB1O00213T579SSSREQWtPSHVSVAPID
GSK3BP49841humanIRF3Q14653T180sPsLDNPtPFPNLGP
GSK3BP49841humanAHRP35869T697EMDsMPYtQNFISCN
GSK3BP49841humanTNKSO95271T982SLIsPAStPSCLsAA
GSK3BP49841humanERGP11308T180KDDFQRLtPSyNADISAM_PNT
GSK3BP49841humanPIAS1O75925S17MVMsLRVsELQVLLG
GSK3BP49841humanMUC1P15941S1227PPsstDRsPyEKVsA
GSK3BP49841humanCD274Q9NZQ7S184GkTtTTNsKREEKLFC2-set_2
GSK3BP49841humanMAFAQ8NHW3S61PLStPCSsVPSsPSF
GSK3BP49841humanGFI1Q99684S94EDFWRPPsPSAsPAS
GSK3BP49841humanHSPA1BP0DMV8T636GGsGsGPtIEEVD__
GSK3BP49841humanNBR1Q14596T586HNtPVDVtPCMsPLP
GSK3BP49841humanNEFHP12036S503GGEEEtKsPPAEEAA
GSK3BP49841humanDNM1LO00429S40TQSSGKSsVLEsLVGDynamin_N
GSK3BP49841humanSTK38Q15208T7_MAMtGstPCssMsN
GSK3BP49841humanGATA6Q92908S37REPStPPsPIsSSSS
GSK3BP49841humanCDC25AP30304S76SNLQRMGssEstDsG
GSK3BP49841humanDROSHAQ9NRR4S302RDNRRsPsLERSYKK
GSK3BP49841humanPIAS1O75925S13ELkQMVMsLRVsELQ
GSK3BP49841humanBAXQ07812S163GGWDGLLsYFGtPTW
GSK3BP49841humanFBXL20Q96IG2T417HAYFAPVtPPPsVGG
GSK3BP49841humanSFPQP23246T687PrGMGPGtPAGyGrG
GSK3BP49841humanEIF6P56537S235QPstIAtsMRDsLID
GSK3BP49841humanESR1P03372S104FPPLNsVsPsPLMLLOest_recep
GSK3BP49841humanAKAP11Q9UKA4T1136AKEFAPAtPPStPHN
GSK3BP49841humanHDAC4P56524S302APGsGPSsPNNSSGS
GSK3BP49841humanKAT5Q92993S86TKNGLPGsRPGsPER
GSK3BP49841humanUSF1P22415S186APRTHPYsPKsEAPR
GSK3BP49841humanPTTG1O95997S184NLLQSPssILSTLDVSecurin
GSK3BP49841humanPTENP60484S362SNPEASSsTSVtPDV
GSK3BP49841humanMACF1Q9UPN3S7222FRsRGRRsKPSsRAA
GSK3BP49841humanSTAT2P52630S393LtPEKGQsQGLIWDFSTAT_bind
GSK3BP49841humanSQLEQ14534S87WAKsPPEsENkEQLE
GSK3BP49841humanSPAG5Q96R06T978AEMsIMTtELQSLCS
GSK3BP49841humanZNF281Q9Y2X9S638PRVDLHtsGEHsELV
GSK3BP49841humanCDKN1AP38936S114EEDHVDLsLSCTLVP
GSK3BP49841humanFOXP3Q9BZS1S270kMALTkAsSVAssDK
GSK3BP49841humanRFX1P22670T124sEAsPGStAsQTGVP
GSK3BP49841humanHSP90AB1P08238S718LEGDEDAsRMEEVD_
GSK3BP49841humanMCL1Q07820S159NNtStDGsLPstPPP
GSK3BP49841humanCCNE1P24864S73AVCADPCsLIPtPDK
GSK3BP49841humanGYS1P13807S641yRyPRPAsVPPsPsLGlycogen_syn
GSK3BP49841humanCLASP2O75122S499KRsKIPRsQGCsREA
GSK3BP49841humanRASSF1Q9NS23-2S178VRPVsVPssKKPPsL
GSK3BP49841humanDESP17661S32PLGsPLssPVFPrAGFilament_head
GSK3BP49841humanCTNNB1P35222S37yLDsGIHsGATtTAP
GSK3BP49841humanRASSF1Q9NS23-2S175LKLVRPVsVPssKKP
GSK3BP49841humanVDAC1P21796T107DssFsPNtGkkNAKIPorin_3
GSK3BP49841humanPRKAA1Q13131T482RSIDDEItEAksGtAAdenylateSensor
GSK3BP49841humanPHLPP1O60346S1379GSKGLWDsLsVEEAVPP2C
GSK3BP49841humanGLE1Q53GS7S99ssAFsPAsPAtPNGT
GSK3BP49841humanFBXL20Q96IG2S251RGCHKLQsLCAsGCS
GSK3BP49841humanTNKSO95271S991SCLsAASsIDNLTGP
GSK3BP49841humanSNAI2O43623S96PPPsDTSsKDHsGSE
GSK3BP49841humanSPAG5Q96R06S974EESLAEMsIMTtELQ
GSK3BP49841humanPRKAA1Q13131S486DEItEAksGtAtPQRAdenylateSensor
GSK3BP49841humanSOX2P48431S251VksEAsssPPVVtSS
GSK3BP49841humanMAPTP10636-8S396GAEIVyKsPVVsGDt
GSK3BP49841humanTP53P04637S376LkskkGQstsRHkkL
GSK3BP49841humanFBXL20Q96IG2S255KLQsLCAsGCSNITD
GSK3BP49841humanMYBPC3Q14896S304SLLKKRDsFRtPRDs
GSK3BP49841humanE2F1Q01094T433DCDFGDLtPLDF___
GSK3BP49841humanMAPTP10636-8S404PVVsGDtsPRHLsNV
GSK3BP49841humanDNM1LO00429S44GKSsVLEsLVGRDLLDynamin_N
GSK3BP49841humanBCLAF1Q9NYF8S531KstFREEsPLRIkMITHRAP3_BCLAF1
GSK3BP49841humanMITFO75030-9S298QARAHGLsLIPSTGLDUF3371
GSK3BP49841humanMAFAQ8NHW3T57LSStPLStPCSsVPS
GSK3BP49841humanRPTORQ8N122S792DKMRRAssYSsLNSL
GSK3BP49841humanMACF1Q9UPN3S7318RPGsRAGsRAGsRAs
GSK3BP49841humanSOX9P48436T236GQSQGPPtPPtTPKT
GSK3BP49841humanPGRP06401-2S390PDSEASQsPQYsFESProg_receptor
GSK3BP49841humanCTNNB1P35222S45GATtTAPsLsGkGNP
GSK3BP49841humanMAPTP10636-8S262NVKskIGstENLkHQTubulin-binding
GSK3BP49841humanCABYRO75952T151PATPKTTtPPSsPPP
GSK3BP49841humanENDOGQ14249S288NILARAGsLkAITAG
GSK3BP49841humanCAP1Q01518S310PKPQtsPsPkRAtKk
GSK3BP49841humanCLASP2O75122S537REAsREssRDTsPVR
GSK3BP49841humanRPTORQ8N122S877HIHQAGGsPPAssts
GSK3BP49841humanGSK3BP49841Y216RGEPNVsyICsRyyRPkinase
GSK3BP49841humanGCM1Q9NP62S322NYPFPLTsWPCsFSP
GSK3BP49841humanDNMT1P26358S714DNIPEMPsPkKMHQG
GSK3BP49841humanCEBPDP49716T171PRSsPRQtPAPGPAR
GSK3BP49841humanLRP6O75581S1490AILNPPPsPAtERsH
GSK3BP49841humanKLC2Q9H0B6S608LsDSRtLssssMDLs
GSK3BP49841humanMAFAQ8NHW3S49CHRLPPGsLSStPLS
GSK3BP49841humanRICTORQ6R327T1695EAEAVLAtPPKQPIV
GSK3BP49841humanFBXL20Q96IG2S139DATCTSLskFCsKLR
GSK3BP49841humanMAPRE1Q15691S156PkkPLtssSAAPQRP
GSK3BP49841humanSNAI1O95863S119sFSsTSVsSLEAEAY
GSK3BP49841humanIKBKGQ9Y6K9S43PAMLHLPsEQGAPEt
GSK3BP49841humanMYCP01106T73kkFELLPtPPLsPsRMyc_N
GSK3BP49841humanCDX2Q99626S283RsVPEPLsPVSSLQA
GSK3BP49841humanCTPS1P17812S571RDtysDrsGsssPDs
GSK3BP49841humanDPYSL3Q14195T514tttPkGGtPAGsArG
GSK3BP49841humanATP2A2P16615S663EFDELNPsAQRDACL
GSK3BP49841humanPHLPP1O60346T1363HVQsVLLtPQDEFFIPP2C
GSK3BP49841humanUSF1P22415T153EALLGQAtPPGTGQF
GSK3BP49841humanMACF1Q9UPN3S7322RAGsRAGsRAssRRG
GSK3BP49841humanMAPTP10636-8T153DGKtKIAtPRGAAPP
GSK3BP49841humanMAPTP10636-3S199KVTSKCGsLGNIHHKTubulin-binding
GSK3BP49841humanSRCP12931S43QtPsKPAsAdGHRGP
GSK3BP49841humanPRKCEQ02156S346sEEDRsKsAPtsPCD
GSK3BP49841humanPGRP06401-2S164RQLLEDEsYDGGAGAProg_receptor
GSK3BP49841humanHRASP01112T144yGIPYIEtsAktRQGRas
GSK3BP49841humanFCARP24071S284LTFARTPsVCK____
GSK3BP49841humanNIFKQ9BYG3S230tPEKtVDsQGPtPVChNIFK_binding
GSK3BP49841humanCREB1P16220S115QKRREILsRRPsyRkpKID
GSK3BP49841humanMITFO75030-9S405PGAsKTSsRRSsMSMDUF3371
GSK3BP49841humanSTAT3P40763S727NtIDLPMsPrTLDSL
GSK3BP49841humanRBM38Q9H0Z9S195DQYPYAAsPATAASF
GSK3BP49841humanRELBQ01201S573AFGGGLLsPGPEAt_RelB_transactiv
GSK3BP49841humanMCL1Q07820S121PAADAIMsPEEELDG
GSK3BP49841humanRELAQ04206S468AVFTDLAsVDNsEFQ
GSK3BP49841humanFOXP3Q9BZS1S274TkAsSVAssDKGSCC
GSK3BP49841humanDPYSL2Q16555T509PVCEVsVtPktVtPA
GSK3BP49841humanDPYSL2Q16555T514sVtPktVtPAssAkt
GSK3BP49841humanCEBPBP17676S223VPsGSSGsLsTSSss
GSK3BP49841humanSRFP11831S224TCLNsPDsPPRsDPT
GSK3BP49841humanDESP17661S28APGFPLGsPLssPVFFilament_head
GSK3BP49841humanCCND1P24385T286EEVDLACtPtDVRDV
GSK3BP49841humanFBXL20Q96IG2S425PPPsVGGsRQRFCRC
GSK3BP49841humanBCL2L1Q07817S62PSWHLADsPAVNGAT
GSK3BP49841humanNFE2L2Q16236S347NDSDsGIsLNTsPSV
GSK3BP49841humanMYCLP12524S38KKFELVPsPPtsPPWMyc_N
GSK3BP49841humanSNAI1O95863S100DEDsGkGsQPPsPPs
GSK3BP49841humanOSBP2Q969R2S762ECSKVMHssPssPsSOxysterol_BP
GSK3BP49841humanH1-5P16401T11tAPAEtAtPAPVEks
GSK3BP49841humanAKAP11Q9UKA4T1140APAtPPStPHNSSVG
GSK3BP49841humanGYS1P13807S653PsLsRHssPHQsEDEGlycogen_syn
GSK3BP49841humanMITFO75030-9S401SSVsPGAsKTSsRRSDUF3371
GSK3BP49841humanUNGP13051S64EPGtPPssPLsAEQL
GSK3BP49841humanOGTO15294S4____MAssVGNVADS
GSK3BP49841humanPICK1Q9NRD5S342QRLVsTMsKYYNDCyArfaptin
GSK3BP49841humanAPCP25054S1501ESTPDGFsCsssLsAAPC_r
GSK3BP49841humanMACF1Q9UPN3S7226GRRsKPSsRAAsPTR
GSK3BP49841humanBMAL1O00327T21DFMsPGPtDLLSSSL
GSK3BP49841humanSTMN3Q9NZ72S60sFEVILksPSDLsPEStathmin
GSK3BP49841humanE2F1Q01094S403PEEFISLsPPHEALD
GSK3BP49841humanRFX1P22670S120SETVsEAsPGStAsQ
GSK3BP49841humanSREBF1P36956T426TEVEDTLtPPPsDAG
GSK3BP49841humanCLOCKO15516S427ALERFDHsPtPsASs
GSK3BP49841humanCCND3P30281T283QGPsQtstPtDVtAI
GSK3BP49841humanRCAN1P53805S163PDKQFLIsPPAsPPVCalcipressin
GSK3BP49841humanOSBP2Q969R2S766VMHssPssPsSDGKQOxysterol_BP
GSK3BP49841humanUNGP13051T60AGQEEPGtPPssPLs
GSK3BP49841humanADD2P35612S693SVTSGPMsPEGsPsK
GSK3BP49841humanFBXL20Q96IG2S143TSLskFCsKLRHLDLLRR_6
GSK3BP49841humanMAPTP10636-8S409DtsPRHLsNVsstGs
GSK3BP49841humanSNAI1O95863S107sQPPsPPsPAPssFS
GSK3BP49841humanIKBKGQ9Y6K9S8MNRHLWKsQLCEMVQ
GSK3BP49841humanWT1P19544-7S69RsRGAsGsEPQQMGs
GSK3BP49841humanGLE1Q53GS7T102FsPAsPAtPNGTKGk
GSK3BP49841humanPSEN1P49768S357PHRstPEsRAAVQELPresenilin
GSK3BP49841humanDROSHAQ9NRR4S300RHRDNRRsPsLERSY
GSK3BP49841humanBMAL1O00327S17STISDFMsPGPtDLL
GSK3BP49841humanNR1D1P20393S59FPPsPTGsLTQDPAR
GSK3BP49841humanSTAT3P40763T714ktKFICVtPTtCsNt
GSK3BP49841humanSTAT2P52630T385ILTsNQktLtPEKGQSTAT_bind
GSK3BP49841humanMYCLP12524S42LVPsPPtsPPWGLGPMyc_N
GSK3BP49841humanDPYSL2Q16555S518ktVtPAssAktsPAk
GSK3BP49841humanSMAD4Q13485T265ATYHHNStTTWtGSR
GSK3BP49841humanSPAG5Q96R06T111PIPQIsStPkTsEEA
GSK3BP49841humanSNCAP37840S129NEAyEMPsEEGyQDySynuclein
GSK3BP49841humanMYCNP04198T58KkFELLPtPPLsPsrMyc_N
GSK3BP49841humanIRF3Q14653S123DFSQPDTsPDTNGGG
GSK3BP49841humanXIAPP98170T180WPDYAHLtPRELASABIR
GSK3BP49841humanSP1P08047S728VGtLPLDsGAGsEGS
GSK3BP49841humanBLMP54132T171ETSksFVtPPQsHFVBLM_N
GSK3BP49841humanMAPTP10636-8S46tDAGLkEsPLQtPtE
GSK3BP49841humanFRAT1Q92837S188RLQQRRGsQPETRTGGSK-3_bind
GSK3BP49841humanMAFAQ8NHW3T53PPGsLSStPLStPCS
GSK3BP49841humanPRKAA1Q13131T490EAksGtAtPQRsGsVAdenylateSensor
GSK3BP49841humanTOP2AP11388S1361sPPKTKtsPKLsNkE
GSK3BP49841humanRPTORQ8N122S859DtssLtQsAPAsPtN
GSK3BP49841humanEIF4EBP1Q13541S65FLMECrNsPVtktPPeIF_4EBP
GSK3BP49841humanFBXL21PQ9UKT6T33FYSSLNQtHTHTVLL
GSK3BP49841humanSTK38Q15208S6__MAMtGstPCssMs
GSK3BP49841humanAHRP35869S727PMGsFEPsPYPtTSS
GSK3BP49841humanBCAMP50895S596PPGEPGLsHsGsEQP
GSK3BP49841humanMACF1Q9UPN3S7330RAssRRGsDAsDFDL
GSK3BP49841humanNFKB2Q00653S711PLPsPPTsDsDsDsE
GSK3BP49841humanFOXL2P58012S33EPEGPPPsPGKGGGG
GSK3BP49841humanMAPTP10636-8S202sGyssPGsPGtPGsR
GSK3BP49841humanTCAPO15273S157GALRRsLsRSMsQEATelethonin
GSK3BP49841humanSNAI1O95863S104GkGsQPPsPPsPAPs
GSK3BP49841humanSTAT2P52630S381RkFNILTsNQktLtPSTAT_bind
GSK3BP49841humanESR1P03372S102GGFPPLNsVsPsPLMOest_recep
GSK3BP49841humanSQLEQ14534S83IGFFWAKsPPEsENk
GSK3BP49841humanRASSF1Q9NS23-2S179RPVsVPssKKPPsLQ
GSK3BP49841humanSREBF1P36956S430DTLtPPPsDAGsPFQ
GSK3BP49841humanGRB14Q14449S358MHPYQGRsGCSsQSI
GSK3BP49841humanCEACAM1P13688S508QQPTQPTsAsPsLTA
GSK3BP49841humanESR1P03372S118LHPPPQLsPFLQPHGOest_recep
GSK3BP49841humanMAPTP10636-8S400VyKsPVVsGDtsPRH
GSK3BP49841humanTNKSO95271S978VVSASLIsPAStPSC
GSK3BP49841humanJUNBP17275T255EARsRDAtPPVsPINJun
GSK3BP49841humanSPI1P17947S41EYYPYLSsDGESHSD
GSK3BP49841humanDSPP15924S2845RsGsRsGsRRGsFDA
GSK3BP49841humanGRB14Q14449S370QSIsPMRsIsENsLVBPS
GSK3BP49841humanPTENP60484T366ASSsTSVtPDVsDNE
GSK3BP49841humanCIITAP33076S373VQARLERsSSKSLER
GSK3BP49841humanWT1P19544-7S67GRRsRGAsGsEPQQM
GSK3BP49841humanESR1P03372S106PLNsVsPsPLMLLHPOest_recep
GSK3BP49841humanHNRNPDQ14103S83DEGHsNssPRHsEAA
GSK3BP49841humanEGLN2Q96KS0S401KGVQVPVsQPPtPT_
GSK3BP49841humanGRB14Q14449S423THGsPtAsSQSSATN
GSK3BP49841humanGSK3BP49841S9SGRPRttsFAEsCkP
GSK3BP49841humanFANCLQ9NW38T178VPFCASWtPQSSLISFANCL_d2
GSK3BP49841humanPKMP14618T328GkPVICAtQMLESMIPK
GSK3BP49841humanMAPTP10636-8T217sRtPsLPtPPtREPK
GSK3BP49841humanKDM1AO60341S683NLFGHVGsTTAsRGEAmino_oxidase
GSK3BP49841humanMACF1Q9UPN3S7230KPSsRAAsPTRsssS
GSK3BP49841humanFBXL2Q9UKC9T404HAYFAPVtPPTAVAG
GSK3BP49841humanDCXO43602-2S327StPKSKQsPIStPTs
GSK3BP49841humanEIF6P56537S243MRDsLIDsLt_____
GSK3BP49841humanJUNP05412T239VPEMPGEtPPLsPIDJun
GSK3BP49841humanMAPTP10636-8S195PPKsGDRsGyssPGs
GSK3BP49841humanMAPTP10636-8S214GsRsRtPsLPtPPtR
GSK3BP49841humanSMAD1Q15797T202sPGSSSStYPHsPTS
GSK3BP49841humanUSF2Q15853T230PkIDGtRtPRDERRR
GSK3BP49841humanEIF6P56537T231LNEAQPstIAtsMRD
GSK3BP49841humanIKBKGQ9Y6K9S31QDVLGEEsPLGKPAM
GSK3BP49841humanMAPTP10636-8T50LkEsPLQtPtEDGsE
GSK3BP49841humanDPYSL5Q9BPU6T516tPLADtPtRPVTRHG
GSK3BP49841humanIL17RAQ96F46T780MVLTDPHtPYEEEQR
GSK3BP49841humanSMAD4Q13485T273TTWtGSRtAPYtPNL
GSK3BP49841humanHRASP01112T148YIEtsAktRQGVEDARas
GSK3BP49841humanEIF4EBP1Q13541T70rNsPVtktPPRDLPteIF_4EBP
GSK3BP49841humanJUNBP17275S251QTVPEARsRDAtPPVJun
GSK3BP49841humanSNAI2O43623S104KDHsGSEsPISDEEE
GSK3BP49841humanHSP90AA1P07900S726LEGDDDtsRMEEVD_
GSK3BP49841humanIKZF3Q9UKT9S378VPSERGLsPNNSGHD
GSK3BP49841humanETS1P14921S269DRLtQsWssQssFNsEts1_N_flank
GSK3BP49841humanRAB11FIP5Q9BXF6T276GPGAELLtRsPsRss
GSK3BP49841humanSP1P08047S732PLDsGAGsEGSGtAt
GSK3BP49841humanSMAD4Q13485T269HNStTTWtGSRtAPY
GSK3BP49841humanWT1P19544-7S63ERLQGRRsRGAsGsE
GSK3BP49841humanTNKSO95271S987AStPSCLsAASsIDN
GSK3BP49841humanHSP90AA1P07900T725PLEGDDDtsRMEEVD
GSK3BP49841humanMYLKQ15746S1776GRKsstGsPtsPLNA
GSK3BP49841humanNR1D1P20393S55CPTYFPPsPTGsLTQ
GSK3BP49841humanFBXO4Q9UKT5S12EPRsGtNsPPPPFSD
GSK3BP49841humanMACF1Q9UPN3S7234RAAsPTRsssSAsQs
GSK3BP49841humanAHRP35869S444GkDsATTsTLSKDSL
GSK3BP49841humanSNAI2O43623S100DTSsKDHsGSEsPIS
GSK3BP49841humanMAP3K11Q16584S789VsAGPRPsPLPsPQP
GSK3BP49841humanRPTORQ8N122S863LtQsAPAsPtNkGVH
GSK3BP49841humanMAPTP10636-8T181ktPPAPktPPssGEP
GSK3BP49841humanDNM1LO00429S616PIPIMPAsPQKGHAV
GSK3BP49841humanPICK1Q9NRD5S415kGGsWCDs_______
GSK3BP49841humanCLASP2O75122S533QGCsREAsREssRDT
GSK3BP49841humanTBK1Q9UHD2S172EDDEQFVsLyGTEEyPkinase
GSK3BP49841humanGRB14Q14449S419LRLGTHGsPtAsSQS
GSK3BP49841humanRAB11FIP5Q9BXF6S188sMKDKPRsPFsKIRD
GSK3BP49841humanCCNE1P24864T395PLPSGLLtPPQsGKK
GSK3BP49841humanNR3C1P04150S404SMRPDVSsPPSSSST
GSK3BP49841humanMCL1Q07820T163tDGsLPstPPPAEEE
GSK3BP49841humanEIF4EBP1Q13541T37PPGDysttPGGtLFseIF_4EBP
GSK3BP49841humanHSF1Q00613S303RVkEEPPsPPQsPRVVert_HS_TF
GSK3BP49841humanMAPTP10636-8T175AtRIPAktPPAPktP
GSK3BP49841humanTRAF6Q9Y4K3T266ARHLQENtQSHMRML
GSK3BP49841humanBCL2L12Q9HB09S156SESPRPCsLPIRPCY
GSK3BP49841humanOSBP2Q969R2S768HssPssPsSDGKQKTOxysterol_BP
GSK3BP49841humanHRASP01112S183ESGPGCMsCKCVLS_
GSK3BP49841humanMACF1Q9UPN3S7326RAGsRAssRRGsDAs
GSK3BP49841humanZNF322Q6U7Q0S391SEKGLELsPPHAsEA
GSK3BP49841humanSNAI1O95863S96TsLsDEDsGkGsQPP
GSK3BP49841humanMYCP01106S77LLPtPPLsPsRRsGLMyc_N
GSK3BP49841humanADD2P35612S613AKEAEtKsPLVsPsK
GSK3BP49841humanACBD5Q5T8D3-2S269DsEVYCDsMEQFGQE
GSK3BP49841humanKAT5Q92993S90LPGsRPGsPEREVPA
GSK3BP49841humanRXRAP19793S66NGMGPPFsVISSPMGNuc_recep-AF1
GSK3BP49841humanCTNNB1P35222S33QQQsyLDsGIHsGAT
GSK3BP49841humanAPCP25054S1503TPDGFsCsssLsALsAPC_r
GSK3BP49841humanMITFO75030-9S397DPLLSSVsPGAsKTSDUF3371
GSK3BP49841humanAHRP35869S436LRTKNGTsGkDsATT
GSK3BP49841humanSPI1P17947S140EEEGERQsPPLEVsD
GSK3BP49841humanWEE1P30291S211SSVkLRGssLFMDtE
GSK3BP49841humanPHLPP1O60346S1359VPRPHVQsVLLtPQDPP2C
GSK3BP49841humanMAPTP10636-8T212tPGsRsRtPsLPtPP
GSK3BP49841humanMAPRE1Q15691S155kPkkPLtssSAAPQR
GSK3BP49841humanATXN3P54252S256LRRAIQLsMQGsSRNUIM
GSK3BP49841humanCABYRO75952S155KTTtPPSsPPPTAVS
GSK3BP49841humanOSBP2Q969R2S763CSKVMHssPssPsSDOxysterol_BP
GSK3BP49841humanNFKB2Q00653S222QPIHDSKsPGASNLk
GSK3BP49841humanGFI1Q99684S98RPPsPSAsPASEKSM
GSK3BP49841humanEZH2Q15910S363GRLPNNssRPstPtI
GSK3BP49841humanSNCAIPQ9Y6H5S556AQKSEGKsLPssPssSNCAIP_SNCA_bd
GSK3BP49841humanAHRP35869S689SQEFPYKsEMDsMPY
GSK3BP49841humanIRF1P10914S184QALtPALsPCAVSST
GSK3BP49841humanNFKB2Q00653S707EPLCPLPsPPTsDsD
GSK3BP49841humanSNAI1O95863S115PAPssFSsTSVsSLE
GSK3BP49841humanCLASP2O75122S503IPRsQGCsREAsPsR
GSK3BP49841humanCTNNB1P35222T41GIHsGATtTAPsLsG
GSK3BP49841humanDNM1LO00429S693LVGQLYKsSLLDDLLGED
GSK3BP49841humanVHLP40337S68PVLRSVNsREPsQVIVHL
GSK3BP49841humanSRCP12931S493CPPECPEsLHDLMCQPK_Tyr_Ser-Thr
GSK3BP49841humanCCND2P30279T280DELDQAstPtDVRDICyclin_C
GSK3BP49841humanRICTORQ6R327S1235GIssMSssPSRETVG
GSK3BP49841humanSNAI2O43623S92RVsPPPPsDTSsKDH
GSK3BP49841humanVDAC1P21796S13TYADLGksARDVFtkPorin_3
GSK3BP49841humanDSPP15924S2849RsGsRRGsFDAtGNs
GSK3BP49841humanFOXM1Q08050-2S474PPLEEWPsPAPSFkE
GSK3BP49841humanGLE1Q53GS7S93PKsPDAssAFsPAsP
GSK3BP49841humanPPP1R2P41236T73MKIDEPstPyHSMMGIPP-2
GSK3BP49841humanPHLPP1O60346S1381KGLWDsLsVEEAVEAPP2C
GSK3BP49841humanEIF4EBP1Q13541T46GGtLFsttPGGtRIIeIF_4EBP
GSK3BP49841humanAHRP35869T731FEPsPYPtTSSLEDF
GSK3BP49841humanSPAG5Q96R06T937ADEEPEStPVPLLGs
GSK3BP49841humanEIF6P56537S239IAtsMRDsLIDsLt_
GSK3BP49841humanSRCP12931Y419RLIEDNEytARQGAkPK_Tyr_Ser-Thr
GSK3BP49841humanCEBPDP49716S167SPEPPRSsPRQtPAP
GSK3BP49841humanNIFKQ9BYG3T234tVDsQGPtPVCtPtFhNIFK_binding
GSK3BP49841humanCCNE1P24864T77DPCsLIPtPDKEDDD
GSK3BP49841humanETS1P14921T265yDsCDRLtQsWssQsEts1_N_flank
GSK3BP49841humanNFE2L2Q16236S344AEFNDSDsGIsLNTs
GSK3BP49841humanGYS1P13807S645RPAsVPPsPsLsRHsGlycogen_syn
GSK3BP49841humanNFE2L1Q14494S379SQDFLLFsPEVESLP
GSK3BP49841humanGLE1Q53GS7S92VPKsPDAssAFsPAs
GSK3BP49841humanEZH2Q15910T367NNssRPstPtINVLE
GSK3BP49841humanMAPTP10636-8T205ssPGsPGtPGsRsRt
GSK3BP49841humanFBXL20Q96IG2S421APVtPPPsVGGsRQR
GSK3BP49841humanMARK2Q7KZI7S212KLDtFCGsPPYAAPEPkinase
GSK3BP49841humanKLF5Q13887S303QATYFPPsPPSSEPG
GSK3BP49841humanGRB14Q14449S366GCSsQSIsPMRsIsE
GSK3BP49841humanDPYSL3Q14195T509PVFDLtttPkGGtPA
GSK3BP49841humanSLC6A4P31645S48GQISNGysAVPSPGA5HT_transport_N
GSK3BP49841humanIRF1P10914T180LEVEQALtPALsPCA
GSK3BP49841humanMAPTP10636-8S422GsIDMVDsPQLAtLA
GSK3BP49841humanRXRAP19793S78PMGPHSMsVPTtPTLNuc_recep-AF1
GSK3BP49841humanCD274Q9NZQ7T180QVLSGkTtTTNsKREC2-set_2
GSK3BP49841humanUSF2Q15853S155NPFSNGGsPAAEAVS
GSK3BP49841humanMAPTP10636-8S235VVRtPPKsPssAKsR
GSK3BP49841humanGLE1Q53GS7S88QPSFVPKsPDAssAF
GSK3BP49841humanENDOGQ14249T128VHAYHRAtNADYRGSEndonuclease_NS
GSK3BP49841humanIRF3Q14653S173PCPQPLRsPsLDNPt
GSK3BP49841humanCDKN1AP38936T57NFDFVtEtPLEGDFACDI
GSK3BP49841humanDPYSL3Q14195S518kGGtPAGsArGsPtR
GSK3BP49841humanAHRP35869S693PYKsEMDsMPYtQNF
GSK3BP49841humanKNSTRNQ9Y448T294VRFLEQQtLCNNQVN
GSK3BP49841humanRPTORQ8N122S722PrLrsVssyGNIRAV
GSK3BP49841humanMAP3K11Q16584S793PRPsPLPsPQPAPRR
GSK3BP49841humanIKBKGQ9Y6K9S17LCEMVQPsGGPAADQ
GSK3BP49841humanHDAC4P56524S298ACSSAPGsGPSsPNN
GSK3BP49841humanMAPTP10636-8S210PGtPGsRsRtPsLPt
GSK3BP49841humanAREL1O15033-2T783IAAPTHStLPTAHT_HECT
GSK3BP49841humanCAP1Q01518S308sAPKPQtsPsPkRAt
GSK3BP49841humanPTTG1O95997S183SNLLQSPssILSTLDSecurin
GSK3BP49841humanBORAQ6PGQ7S274TSPsPISsPTFsPIE
GSK3BP49841humanMYBPC3Q14896S133ELGESAPsPKGSSSA
GSK3BP49841humanTRIM72Q6ZMU5S255LQKILAEsPPPARLD
GSK3BP49841humanSIGIRRQ6IA17T372EPSAPPHtSGVSLGE
GSK3BP49841humanMACF1Q9UPN3S7310ADPKKSAsRPGsRAG
GSK3BP49841humanPPIFP30405S191IEsFGsksGRTSKKIPro_isomerase
GSK3BP49841humanEGLN2Q96KS0T405VPVsQPPtPT_____
GSK3BP49841humanNACAE9PAV3T2022NIQENtQtPtVQEEs
GSK3BP49841humanSNAI1O95863S111sPPsPAPssFSsTSV
GSK3BP49841humanTCAPO15273S161RsLsRSMsQEAQRG_Telethonin
GSK3BP49841-2humanGSK3BP49841-2Y216RGEPNVSyICSRYYRPkinase


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
GSK3BIDDescription0.00e+00
GSK3BGO:2000628regulation of miRNA metabolic process4.88e-19
GSK3BGO:1902893regulation of miRNA transcription4.22e-18
GSK3BGO:0061614miRNA transcription4.22e-18
GSK3BGO:0010586miRNA metabolic process9.03e-18
GSK3BGO:0140747regulation of ncRNA transcription4.04e-16
GSK3BGO:2000630positive regulation of miRNA metabolic process4.59e-16
GSK3BGO:1902895positive regulation of miRNA transcription4.59e-16
GSK3BGO:0048511rhythmic process3.17e-15
GSK3BGO:0098781ncRNA transcription1.75e-14
GSK3BGO:0007623circadian rhythm2.51e-12
GSK3BGO:0044843cell cycle G1/S phase transition8.96e-11
GSK3BGO:0030522intracellular receptor signaling pathway9.58e-10
GSK3BGO:0010212response to ionizing radiation1.19e-09
GSK3BGO:2001233regulation of apoptotic signaling pathway1.20e-09
GSK3BGO:0071214cellular response to abiotic stimulus1.97e-09
GSK3BGO:0104004cellular response to environmental stimulus1.97e-09
GSK3BGO:0062012regulation of small molecule metabolic process2.19e-09
GSK3BGO:0002065columnar/cuboidal epithelial cell differentiation2.43e-09
GSK3BGO:0097193intrinsic apoptotic signaling pathway5.65e-09
GSK3BGO:0000082G1/S transition of mitotic cell cycle6.56e-09
GSK3BGO:2001242regulation of intrinsic apoptotic signaling pathway6.97e-09
GSK3BGO:0071479cellular response to ionizing radiation9.69e-09
GSK3BGO:0042752regulation of circadian rhythm1.04e-08
GSK3BGO:0048732gland development3.92e-08
GSK3BGO:0071900regulation of protein serine/threonine kinase activity3.95e-08
GSK3BGO:0031669cellular response to nutrient levels4.18e-08
GSK3BGO:0031667response to nutrient levels4.88e-08
GSK3BGO:0051347positive regulation of transferase activity6.04e-08
GSK3BGO:1903706regulation of hemopoiesis6.65e-08
GSK3BGO:0009314response to radiation1.03e-07
GSK3BGO:0071496cellular response to external stimulus1.05e-07
GSK3BGO:0009410response to xenobiotic stimulus1.24e-07
GSK3BGO:0010332response to gamma radiation1.30e-07
GSK3BGO:0031668cellular response to extracellular stimulus1.81e-07
GSK3BGO:0048863stem cell differentiation1.92e-07
GSK3BGO:0071478cellular response to radiation2.17e-07
GSK3BGO:0022411cellular component disassembly2.19e-07
GSK3BGO:0043620regulation of DNA-templated transcription in response to stress2.75e-07
GSK3BGO:0044772mitotic cell cycle phase transition4.20e-07
GSK3BGO:0070482response to oxygen levels4.74e-07
GSK3BGO:0030099myeloid cell differentiation4.76e-07
GSK3BGO:0043434response to peptide hormone4.76e-07
GSK3BGO:0031349positive regulation of defense response5.40e-07
GSK3BGO:0050673epithelial cell proliferation5.40e-07
GSK3BGO:0002573myeloid leukocyte differentiation6.33e-07
GSK3BGO:1904029regulation of cyclin-dependent protein kinase activity6.57e-07
GSK3BGO:0035270endocrine system development7.11e-07
GSK3BGO:0036293response to decreased oxygen levels7.13e-07
GSK3BGO:0062197cellular response to chemical stress7.68e-07

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Related Drugs to GSK3B_ST6GALNAC5


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning GSK3B-ST6GALNAC5 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

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Related Diseases to GSK3B_ST6GALNAC5


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate