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Kinase Fusion Gene:GTF2IRD1_IKBKB |
Kinase Fusion Protein Summary |
Kinase Fusion gene summary |
Kinase Fusion partner gene information | Kinase Fusion gene name: GTF2IRD1_IKBKB | KinaseFusionDB ID: KFG2626 | FusionGDB2.0 ID: KFG2626 | Hgene | Tgene | Gene symbol | GTF2IRD1 | IKBKB | Gene ID | 9569 | 3551 | |
Gene name | GTF2I repeat domain containing 1 | inhibitor of nuclear factor kappa B kinase subunit beta | ||||||||||
Synonyms | BEN|CREAM1|GTF3|MUSTRD1|RBAP2|WBS|WBSCR11|WBSCR12|hMusTRD1alpha1 | IKK-2|IKK-beta|IKK2|IKKB|IMD15|IMD15A|IMD15B|NFKBIKB | ||||||||||
Cytomap | 7q11.23 | 8p11.21 | ||||||||||
Type of gene | protein-coding | protein-coding | ||||||||||
Description | general transcription factor II-I repeat domain-containing protein 1USE B1-binding proteinWilliams-Beuren syndrome chromosome region 11binding factor for early enhancergeneral transcription factor 3general transcription factor IIImuscle TFII-I repea | inhibitor of nuclear factor kappa-B kinase subunit betaI-kappa-B kinase 2I-kappa-B-kinase betainhibitor of kappa light polypeptide gene enhancer in B-cells, kinase betanuclear factor NF-kappa-B inhibitor kinase betanuclear factor kappa B kinase subun | ||||||||||
Modification date | 20240403 | 20240407 | ||||||||||
UniProtAcc | Q9UHL9 | O14920 | ||||||||||
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000265755, ENST00000455841, ENST00000424337, ENST00000476977, ENST00000489094, | ENST00000520810, ENST00000416505, ENST00000519735, ENST00000520835, ENST00000379708, ENST00000518983, ENST00000522147, ENST00000522785, | |||||||||
Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: GTF2IRD1 [Title/Abstract] AND IKBKB [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | GTF2IRD1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 11438732 |
Tgene | IKBKB | GO:0006468 | protein phosphorylation | 15084260|20434986 |
Tgene | IKBKB | GO:0007249 | canonical NF-kappaB signal transduction | 9346484 |
Tgene | IKBKB | GO:0018105 | peptidyl-serine phosphorylation | 21399639|25326418 |
Tgene | IKBKB | GO:0042325 | regulation of phosphorylation | 26212789 |
Tgene | IKBKB | GO:0043123 | positive regulation of canonical NF-kappaB signal transduction | 9346484 |
Tgene | IKBKB | GO:0045944 | positive regulation of transcription by RNA polymerase II | 23091055|23453807 |
Tgene | IKBKB | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 15790681 |
Tgene | IKBKB | GO:0051604 | protein maturation | 11297557 |
Tgene | IKBKB | GO:0071356 | cellular response to tumor necrosis factor | 23091055 |
Kinase Fusion gene breakpoints across GTF2IRD1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Kinase Fusion gene breakpoints across IKBKB (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
Kinase Fusion gene information. |
Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
CCLE | MCAS | GTF2IRD1 | chr7 | 73868506 | IKBKB | chr8 | 42129601 |
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Kinase Fusion ORF Analysis |
Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:/:) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
GTF2IRD1 | IKBKB |
FUNCTION: May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow-twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8 (By similarity). {ECO:0000250, ECO:0000269|PubMed:11438732}. | FUNCTION: Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:9346484, PubMed:30337470). Acts as a part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation (PubMed:9346484). Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues (PubMed:9346484, PubMed:20434986, PubMed:20797629, PubMed:21138416). These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome (PubMed:9346484, PubMed:20434986, PubMed:20797629, PubMed:21138416). In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis (PubMed:9346484, PubMed:20434986, PubMed:20797629, PubMed:21138416). In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE (PubMed:11297557, PubMed:14673179, PubMed:20410276, PubMed:21138416). IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs (PubMed:11297557, PubMed:20410276, PubMed:21138416). Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor (PubMed:15084260). Also phosphorylates other substrates including NAA10, NCOA3, BCL10 and IRS1 (PubMed:19716809, PubMed:17213322). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates the C-terminus of IRF5, stimulating IRF5 homodimerization and translocation into the nucleus (PubMed:25326418). {ECO:0000250|UniProtKB:O88351, ECO:0000269|PubMed:11297557, ECO:0000269|PubMed:14673179, ECO:0000269|PubMed:15084260, ECO:0000269|PubMed:17213322, ECO:0000269|PubMed:19716809, ECO:0000269|PubMed:20410276, ECO:0000269|PubMed:20434986, ECO:0000269|PubMed:20797629, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:25326418, ECO:0000269|PubMed:30337470, ECO:0000269|PubMed:9346484}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of GTF2IRD1_IKBKB |
Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
IKBKB | O14920 | human | CYLD | Q9NQC7 | S432 | KMPNTNGsIGHsPLs | CYLD_phos_site |
IKBKB | O14920 | human | BBC3 | Q9BXH1 | S106 | LAEQHLEsPVPSAPG | PUMA |
IKBKB | O14920 | human | NFKB1 | P19838 | S923 | DELRDSDsVCDsGVE | |
IKBKB | O14920 | human | IRF3 | Q14653 | T404 | NsHPLsLtsDQYKAY | |
IKBKB | O14920 | human | FOS | P01100 | S308 | ADWEPLHsGSLGMGP | |
IKBKB | O14920 | human | COPS5 | Q92905 | S201 | kPPDEGPsEyQtIPL | |
IKBKB | O14920 | human | TP63 | Q9H3D4 | S43 | yRSTMSQsTQtNEFL | |
IKBKB | O14920 | human | TSC1 | Q92574 | S487 | AAIsRELsEItTAEA | Hamartin |
IKBKB | O14920 | human | BCL10 | O95999 | S138 | NNLsRsNsDEsNFsE | |
IKBKB | O14920 | human | TNFRSF1A | P19438 | S381 | FVRRLGLsDHEIDRL | Death |
IKBKB | O14920 | human | CYLD | Q9NQC7 | S439 | sIGHsPLsLsAQsVM | CYLD_phos_site |
IKBKB | O14920 | human | BBC3 | Q9BXH1 | S96 | RPDGPQPsLSLAEQH | PUMA |
IKBKB | O14920 | human | TNFAIP3 | P21580 | S381 | EPsVPQLsLMDVKCE | |
IKBKB | O14920 | human | RAPGEF2 | Q9Y4G8 | S1254 | GsWTSCSsGsHDNIQ | |
IKBKB | O14920 | human | MTURN | Q8N3F0 | S58 | GDNFHVWsESEDCLP | DUF4581 |
IKBKB | O14920 | human | CYLD | Q9NQC7 | S436 | TNGsIGHsPLsLsAQ | CYLD_phos_site |
IKBKB | O14920 | human | IRF3 | Q14653 | S398 | VDLHIsNsHPLsLts | |
IKBKB | O14920 | human | IKBKG | Q9Y6K9 | S43 | PAMLHLPsEQGAPEt | |
IKBKB | O14920 | human | IKBKG | Q9Y6K9 | S68 | LRDAIRQsNQILRER | NEMO |
IKBKB | O14920 | human | RELA | Q04206 | S536 | sGDEDFSsIADMDFS | |
IKBKB | O14920 | human | MAVS | Q7Z434 | S442 | CFEDLAIsASTSLGM | |
IKBKB | O14920 | human | RELA | Q04206 | S468 | AVFTDLAsVDNsEFQ | |
IKBKB | O14920 | human | DOK1 | Q99704 | S450 | sHNsALysQVQKSGA | |
IKBKB | O14920 | human | EDC4 | Q6P2E9 | S583 | PAPADFLsLssEtKP | |
IKBKB | O14920 | human | BCL10 | O95999 | S136 | AtNNLsRsNsDEsNF | |
IKBKB | O14920 | human | PFKFB3 | Q16875 | S269 | QGRIGGDsGLSsRGK | His_Phos_1 |
IKBKB | O14920 | human | BCL3 | P20749 | S454 | PsPAPGGs_______ | |
IKBKB | O14920 | human | ASB8 | Q9H765 | S31 | RTIAAIRsFPHDNVE | Ank_2 |
IKBKB | O14920 | human | BCL10 | O95999 | S144 | NsDEsNFsEkLRAST | |
IKBKB | O14920 | human | TSC1 | Q92574 | S511 | DsPFyRDsLPGsQRK | Hamartin |
IKBKB | O14920 | human | RPS3 | P23396 | S209 | kPLPDHVsIVEPkDE | |
IKBKB | O14920 | human | HTT | P42858 | S16 | kAFEsLksFQQQQQQ | |
IKBKB | O14920 | human | IRF3 | Q14653 | S402 | IsNsHPLsLtsDQYK | |
IKBKB | O14920 | human | IKBKB | O14920 | S258 | GTVKFsssLPyPNNL | Pkinase |
IKBKB | O14920 | human | OPTN | Q96CV9 | S513 | FEDGGRQsLMEMQsR | |
IKBKB | O14920 | human | MYC | P01106 | S82 | PLsPsRRsGLCsPSy | Myc_N |
IKBKB | O14920 | human | COPS5 | Q92905 | T205 | EGPsEyQtIPLNkIE | |
IKBKB | O14920 | human | RELA | Q04206 | S311 | RtyEtFksIMkksPF | |
IKBKB | O14920 | human | RELA | Q04206 | S42 | RYkCEGRsAGsIPGE | RHD_DNA_bind |
IKBKB | O14920 | human | NFKBIA | P25963 | S32 | LLDDRHDsGLDsMkD | |
IKBKB | O14920 | human | IKBKG | Q9Y6K9 | S85 | ELLHFQAsQREEKEF | NEMO |
IKBKB | O14920 | human | FOXO3 | O43524 | S644 | GLDFNFDsLISTQNV | FOXO-TAD |
IKBKB | O14920 | human | REL | Q04864 | S557 | SNTTVFVsQSDAFEG | |
IKBKB | O14920 | human | IRF5 | Q13568 | S446 | DsIRLQIsNPDLKDR | |
IKBKB | O14920 | human | NFKB1 | P19838 | S927 | DSDsVCDsGVETsFR | |
IKBKB | O14920 | human | DOK1 | Q99704 | S446 | sGIKsHNsALysQVQ | |
IKBKB | O14920 | human | CYLD | Q9NQC7 | S441 | GHsPLsLsAQsVMEE | CYLD_phos_site |
IKBKB | O14920 | human | RELA | Q04206 | S131 | RDLEQAIsQRIQtNN | RHD_DNA_bind |
IKBKB | O14920 | human | MYC | P01106 | S86 | sRRsGLCsPSyVAVt | Myc_N |
IKBKB | O14920 | human | RELA | Q04206 | S45 | CEGRsAGsIPGERST | RHD_DNA_bind |
IKBKB | O14920 | human | TP73 | O15350 | S471 | GEMSSSHsAQSMVSG | |
IKBKB | O14920 | human | TP63 | Q9H3D4 | S51 | TQtNEFLsPEVFQHI | |
IKBKB | O14920 | human | RELA | Q04206 | S261 | tPPYADPsLQAPVRV | RHD_dimer |
IKBKB | O14920 | human | DOK1 | Q99704 | S439 | EPGtATGsGIKsHNs | |
IKBKB | O14920 | human | NFKBIA | P25963 | S36 | RHDsGLDsMkDEEyE | |
IKBKB | O14920 | human | RELB | Q01201 | S472 | DFFSGTVsLPGLEPP | RelB_transactiv |
IKBKB | O14920 | human | TMIGD2 | Q96BF3 | S220 | GKDQRGQsIyStSFP | |
IKBKB | O14920 | human | NFKB1 | P19838 | S80 | sSEKNKKsYPQVKIC | RHD_DNA_bind |
IKBKB | O14920 | human | HTT | P42858 | S13 | kLMkAFEsLksFQQQ | |
IKBKB | O14920 | human | EDC4 | Q6P2E9 | S855 | GLQEKHKsLAFHRPP | |
IKBKB | O14920 | human | CDKN2A | P42771 | S8 | MEPAAGssMEPSADW | |
IKBKB | O14920 | human | IRF3 | Q14653 | S396 | NtVDLHIsNsHPLsL | |
IKBKB | O14920 | human | IKBKG | Q9Y6K9 | S31 | QDVLGEEsPLGKPAM | |
IKBKB | O14920 | human | CYLD | Q9NQC7 | S568 | LAFGGYLsEVVEENT | |
IKBKB | O14920 | human | EDC4 | Q6P2E9 | S107 | IVASsDssISskARG | |
IKBKB | O14920 | human | FOXO1 | Q12778 | S319 | TFRPRtssNAstIsG | |
IKBKB | O14920 | human | STAT1 | P42224 | T749 | EFDsMMNtV______ | |
IKBKB | O14920 | human | CYLD | Q9NQC7 | S444 | PLsLsAQsVMEELNT | CYLD_phos_site |
IKBKB | O14920 | human | CYLD | Q9NQC7 | S422 | RFHsLPFsLtKMPNT | CYLD_phos_site |
IKBKB | O14920 | human | BBC3 | Q9BXH1 | S10 | RARQEGSsPEPVEGL | PUMA |
IKBKB | O14920 | human | EDC4 | Q6P2E9 | S405 | PDIFSSVsVPPSLKV | Ge1_WD40 |
IKBKB | O14920 | human | BCL10 | O95999 | S141 | sRsNsDEsNFsEkLR | |
IKBKB | O14920 | human | IRS1 | P35568 | S312 | tEsItAtsPAsMVGG | |
IKBKB | O14920 | human | IKBKB | O14920 | S177 | AkELDQGsLCtsFVG | Pkinase |
IKBKB | O14920 | human | IKBKB | O14920 | S181 | DQGsLCtsFVGTLQy | Pkinase |
IKBKB | O14920 | human | IKBKG | Q9Y6K9 | S376 | PPAPAyLssPLALPs | |
IKBKB | O14920 | human | CYLD | Q9NQC7 | S418 | TTENRFHsLPFsLtK | CYLD_phos_site |
IKBKB | O14920 | human | NFKB1 | P19838 | S932 | CDsGVETsFRKLsFt | |
IKBKB | O14920 | human | HTT | P42858 | T3 | _____MAtLEkLMkA | |
IKBKB | O14920 | human | SNAP23 | O00161 | S95 | NRTkNFEsGkAykTt | SNAP-25 |
IKBKB | O14920 | human | BCL10 | O95999 | S134 | DGAtNNLsRsNsDEs | |
IKBKB | O14920 | human | DOK1 | Q99704 | S443 | ATGsGIKsHNsALys | |
IKBKB | O14920 | human | IRF3 | Q14653 | S405 | sHPLsLtsDQYKAYL |
Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
Enriched GO biological processes of the phosphorylation target genes of the kinase |
Kinase | GOID | GO term | P.adjust |
IKBKB | ID | Description | 0.00e+00 |
IKBKB | GO:0007249 | canonical NF-kappaB signal transduction | 1.34e-14 |
IKBKB | GO:0051090 | regulation of DNA-binding transcription factor activity | 4.75e-10 |
IKBKB | GO:0071356 | cellular response to tumor necrosis factor | 4.95e-10 |
IKBKB | GO:0034612 | response to tumor necrosis factor | 9.33e-10 |
IKBKB | GO:0043122 | regulation of canonical NF-kappaB signal transduction | 9.58e-10 |
IKBKB | GO:0033209 | tumor necrosis factor-mediated signaling pathway | 1.28e-08 |
IKBKB | GO:0002757 | immune response-activating signaling pathway | 1.87e-08 |
IKBKB | GO:0002764 | immune response-regulating signaling pathway | 3.11e-08 |
IKBKB | GO:0038061 | non-canonical NF-kappaB signal transduction | 8.61e-08 |
IKBKB | GO:0043123 | positive regulation of canonical NF-kappaB signal transduction | 6.12e-07 |
IKBKB | GO:0032479 | regulation of type I interferon production | 6.12e-07 |
IKBKB | GO:0032606 | type I interferon production | 6.12e-07 |
IKBKB | GO:0050851 | antigen receptor-mediated signaling pathway | 7.86e-07 |
IKBKB | GO:0009612 | response to mechanical stimulus | 9.86e-07 |
IKBKB | GO:0009615 | response to virus | 1.06e-06 |
IKBKB | GO:0002429 | immune response-activating cell surface receptor signaling pathway | 1.06e-06 |
IKBKB | GO:0002753 | cytosolic pattern recognition receptor signaling pathway | 1.43e-06 |
IKBKB | GO:0002221 | pattern recognition receptor signaling pathway | 1.70e-06 |
IKBKB | GO:0032088 | negative regulation of NF-kappaB transcription factor activity | 1.70e-06 |
IKBKB | GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 1.76e-06 |
IKBKB | GO:0031349 | positive regulation of defense response | 2.01e-06 |
IKBKB | GO:0050862 | positive regulation of T cell receptor signaling pathway | 2.42e-06 |
IKBKB | GO:0002758 | innate immune response-activating signaling pathway | 2.44e-06 |
IKBKB | GO:0002218 | activation of innate immune response | 4.31e-06 |
IKBKB | GO:2001233 | regulation of apoptotic signaling pathway | 4.68e-06 |
IKBKB | GO:0032495 | response to muramyl dipeptide | 5.13e-06 |
IKBKB | GO:0032608 | interferon-beta production | 6.80e-06 |
IKBKB | GO:0032648 | regulation of interferon-beta production | 6.80e-06 |
IKBKB | GO:0032727 | positive regulation of interferon-alpha production | 8.13e-06 |
IKBKB | GO:0035994 | response to muscle stretch | 9.29e-06 |
IKBKB | GO:2000630 | positive regulation of miRNA metabolic process | 9.29e-06 |
IKBKB | GO:0097193 | intrinsic apoptotic signaling pathway | 9.81e-06 |
IKBKB | GO:0050857 | positive regulation of antigen receptor-mediated signaling pathway | 1.17e-05 |
IKBKB | GO:0070423 | nucleotide-binding oligomerization domain containing signaling pathway | 1.33e-05 |
IKBKB | GO:0035872 | nucleotide-binding domai | 3.20e-07 |
IKBKB | GO:0045089 | positive regulation of innate immune response | 1.47e-05 |
IKBKB | GO:0032607 | interferon-alpha production | 1.55e-05 |
IKBKB | GO:0032647 | regulation of interferon-alpha production | 1.55e-05 |
IKBKB | GO:0030522 | intracellular receptor signaling pathway | 1.64e-05 |
IKBKB | GO:2001235 | positive regulation of apoptotic signaling pathway | 1.64e-05 |
IKBKB | GO:0031098 | stress-activated protein kinase signaling cascade | 1.64e-05 |
IKBKB | GO:0001819 | positive regulation of cytokine production | 1.84e-05 |
IKBKB | GO:0051091 | positive regulation of DNA-binding transcription factor activity | 1.85e-05 |
IKBKB | GO:0002237 | response to molecule of bacterial origin | 2.06e-05 |
IKBKB | GO:0002833 | positive regulation of response to biotic stimulus | 2.06e-05 |
IKBKB | GO:2000628 | regulation of miRNA metabolic process | 2.71e-05 |
IKBKB | GO:0043433 | negative regulation of DNA-binding transcription factor activity | 3.26e-05 |
IKBKB | GO:0001959 | regulation of cytokine-mediated signaling pathway | 3.67e-05 |
IKBKB | GO:0060759 | regulation of response to cytokine stimulus | 5.34e-05 |
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Related Drugs to GTF2IRD1_IKBKB |
Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
Distribution of the number of studies mentioning GTF2IRD1-IKBKB and kinase inhibitors the PubMed Abstract (04-01-2024) |
Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to GTF2IRD1_IKBKB |
Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
MeSH ID | MeSH term |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
Clinical Trials from clinicaltrials.gov (06-17-2024) |
Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |