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Kinase Fusion Gene:GXYLT2_NEK3 |
Kinase Fusion Protein Summary |
Kinase Fusion gene summary |
Kinase Fusion partner gene information | Kinase Fusion gene name: GXYLT2_NEK3 | KinaseFusionDB ID: KFG2637 | FusionGDB2.0 ID: KFG2637 | Hgene | Tgene | Gene symbol | GXYLT2 | NEK3 | Gene ID | 727936 | 4752 | |
Gene name | glucoside xylosyltransferase 2 | NIMA related kinase 3 | ||||||||||
Synonyms | GLT8D4 | HSPK36 | ||||||||||
Cytomap | 3p13 | 13q14.3 | ||||||||||
Type of gene | protein-coding | protein-coding | ||||||||||
Description | glucoside xylosyltransferase 2glycosyltransferase 8 domain containing 4glycosyltransferase 8 domain-containing protein 4 | serine/threonine-protein kinase Nek3HSPK 36NIMA (never in mitosis gene a)-related kinase 3glycogen synthase A kinasehydroxyalkyl-protein kinasenever in mitosis A-related kinase 3nimA-related protein kinase 3phosphorylase B kinase kinase | ||||||||||
Modification date | 20240305 | 20240403 | ||||||||||
UniProtAcc | A0PJZ3 | P51956 | ||||||||||
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000389617, | ENST00000339406, ENST00000378101, ENST00000400357, ENST00000452082, | |||||||||
Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: GXYLT2 [Title/Abstract] AND NEK3 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | NEK3(52722550)-GXYLT2(73006380), # samples:3 GXYLT2(72971486)-NEK3(52719026), # samples:2 |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | GXYLT2 | GO:0016266 | O-glycan processing | 19940119 |
Kinase Fusion gene breakpoints across GXYLT2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Kinase Fusion gene breakpoints across NEK3 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
Kinase Fusion gene information. |
Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
ChimerDB4 | TCGA-EB-A44R-06A | GXYLT2 | chr3 | 72971486 | NEK3 | chr13 | 52719026 |
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Kinase Fusion ORF Analysis |
Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:52722550/chr13:73006380) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
GXYLT2 | NEK3 |
FUNCTION: Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose. {ECO:0000269|PubMed:19940119}. | FUNCTION: Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2. {ECO:0000269|PubMed:15618286, ECO:0000269|PubMed:17297458}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of GXYLT2_NEK3 |
Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
NEK3 | P51956 | human | NEK3 | P51956 | T165 | FACTYVGtPYYVPPE | Pkinase |
NEK3 | P51956 | human | SNAP29 | O95721 | S105 | MDQDLkIsQkHINsI | V-SNARE_C |
Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
Enriched GO biological processes of the phosphorylation target genes of the kinase |
Kinase | GOID | GO term | P.adjust |
NEK3 | ID | Description | 0.00e+00 |
NEK3 | GO:0016082 | synaptic vesicle priming | 1.98e-02 |
NEK3 | GO:0090043 | regulation of tubulin deacetylation | 1.98e-02 |
NEK3 | GO:0031629 | synaptic vesicle fusion to presynaptic active zone membrane | 1.98e-02 |
NEK3 | GO:0090042 | tubulin deacetylation | 1.98e-02 |
NEK3 | GO:0099500 | vesicle fusion to plasma membrane | 1.98e-02 |
NEK3 | GO:0048499 | synaptic vesicle membrane organization | 1.98e-02 |
NEK3 | GO:0090311 | regulation of protein deacetylation | 2.12e-02 |
NEK3 | GO:0006476 | protein deacetylation | 2.47e-02 |
NEK3 | GO:0097352 | autophagosome maturation | 2.47e-02 |
NEK3 | GO:0006903 | vesicle targeting | 2.47e-02 |
NEK3 | GO:0035601 | protein deacylation | 2.47e-02 |
NEK3 | GO:0098732 | macromolecule deacylation | 2.47e-02 |
NEK3 | GO:0140029 | exocytic process | 2.48e-02 |
NEK3 | GO:0140056 | organelle localization by membrane tethering | 2.48e-02 |
NEK3 | GO:0022406 | membrane docking | 2.54e-02 |
NEK3 | GO:0016079 | synaptic vesicle exocytosis | 2.54e-02 |
NEK3 | GO:0006906 | vesicle fusion | 2.84e-02 |
NEK3 | GO:0090174 | organelle membrane fusion | 2.84e-02 |
NEK3 | GO:0007269 | neurotransmitter secretion | 3.03e-02 |
NEK3 | GO:0099643 | signal release from synapse | 3.03e-02 |
NEK3 | GO:0030010 | establishment of cell polarity | 3.03e-02 |
NEK3 | GO:0048284 | organelle fusion | 3.03e-02 |
NEK3 | GO:0061025 | membrane fusion | 3.10e-02 |
NEK3 | GO:0001505 | regulation of neurotransmitter levels | 3.10e-02 |
NEK3 | GO:0051650 | establishment of vesicle localization | 3.10e-02 |
NEK3 | GO:0099504 | synaptic vesicle cycle | 3.10e-02 |
NEK3 | GO:0006836 | neurotransmitter transport | 3.10e-02 |
NEK3 | GO:0051648 | vesicle localization | 3.10e-02 |
NEK3 | GO:0099003 | vesicle-mediated transport in synapse | 3.10e-02 |
NEK3 | GO:0045055 | regulated exocytosis | 3.10e-02 |
NEK3 | GO:0007163 | establishment or maintenance of cell polarity | 3.10e-02 |
NEK3 | GO:0032984 | protein-containing complex disassembly | 3.22e-02 |
NEK3 | GO:0016236 | macroautophagy | 4.22e-02 |
NEK3 | GO:0006887 | exocytosis | 4.31e-02 |
NEK3 | GO:0016050 | vesicle organization | 4.39e-02 |
NEK3 | GO:0060271 | cilium assembly | 4.41e-02 |
NEK3 | GO:0044782 | cilium organization | 4.61e-02 |
NEK3 | GO:0051656 | establishment of organelle localization | 5.17e-02 |
NEK3 | GO:0023061 | signal release | 5.19e-02 |
NEK3 | GO:0022411 | cellular component disassembly | 5.20e-02 |
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Related Drugs to GXYLT2_NEK3 |
Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
Distribution of the number of studies mentioning GXYLT2-NEK3 and kinase inhibitors the PubMed Abstract (04-01-2024) |
Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to GXYLT2_NEK3 |
Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
MeSH ID | MeSH term |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
Clinical Trials from clinicaltrials.gov (06-17-2024) |
Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |