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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:HMGA2_TBK1

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: HMGA2_TBK1
KinaseFusionDB ID: KFG2728
FusionGDB2.0 ID: KFG2728
HgeneTgene
Gene symbol

HMGA2

TBK1

Gene ID

8091

29110

Gene namehigh mobility group AT-hook 2TANK binding kinase 1
SynonymsBABL|HMGI-C|HMGIC|LIPO|SRS5|STQTL9FTDALS4|IIAE8|NAK|T2K
Cytomap

12q14.3

12q14.2

Type of geneprotein-codingprotein-coding
Descriptionhigh mobility group protein HMGI-CHMGA2/KRT121P fusionserine/threonine-protein kinase TBK1NF-kB-activating kinaseNF-kappa-B-activating kinase
Modification date2024040720240413
UniProtAcc

P52926

Q9UHD2

Ensembl transtripts involved in fusion geneENST idsENST00000403681, ENST00000541363, 
ENST00000393577, ENST00000393578, 
ENST00000425208, ENST00000536545, 
ENST00000354636, 		ENST00000331710, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: HMGA2 [Title/Abstract] AND TBK1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHMGA2

GO:0000122

negative regulation of transcription by RNA polymerase II

14627817

HgeneHMGA2

GO:0002062

chondrocyte differentiation

21484705

HgeneHMGA2

GO:0006284

base-excision repair

19465398

HgeneHMGA2

GO:0010564

regulation of cell cycle process

14645522

HgeneHMGA2

GO:0010628

positive regulation of gene expression

18832382

HgeneHMGA2

GO:0031507

heterochromatin formation

16901784

HgeneHMGA2

GO:0035556

intracellular signal transduction

16061642

HgeneHMGA2

GO:0035988

chondrocyte proliferation

21484705

HgeneHMGA2

GO:0043066

negative regulation of apoptotic process

19465398

HgeneHMGA2

GO:0043392

negative regulation of DNA binding

14645522

HgeneHMGA2

GO:0043922

negative regulation by host of viral transcription

17005673

HgeneHMGA2

GO:0045869

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

17005673

HgeneHMGA2

GO:0045892

negative regulation of DNA-templated transcription

18832382

HgeneHMGA2

GO:0045893

positive regulation of DNA-templated transcription

15225648|15755872|17005673|17324944|17426251

HgeneHMGA2

GO:0045944

positive regulation of transcription by RNA polymerase II

14645522|18832382

HgeneHMGA2

GO:0071902

positive regulation of protein serine/threonine kinase activity

19549901

HgeneHMGA2

GO:0090402

oncogene-induced cell senescence

16901784

HgeneHMGA2

GO:2000648

positive regulation of stem cell proliferation

21484705

HgeneHMGA2

GO:2001033

negative regulation of double-strand break repair via nonhomologous end joining

19549901

TgeneTBK1

GO:0002218

activation of innate immune response

25636800

TgeneTBK1

GO:0002753

cytoplasmic pattern recognition receptor signaling pathway

29441066

TgeneTBK1

GO:0006468

protein phosphorylation

27103069

TgeneTBK1

GO:0010508

positive regulation of autophagy

28871090

TgeneTBK1

GO:0016239

positive regulation of macroautophagy

27103069

TgeneTBK1

GO:0018105

peptidyl-serine phosphorylation

25636800|25803835|27103069

TgeneTBK1

GO:0018107

peptidyl-threonine phosphorylation

25636800|27103069

TgeneTBK1

GO:0032479

regulation of type I interferon production

25636800

TgeneTBK1

GO:0032481

positive regulation of type I interferon production

14703513|22394562|25636800|29441066

TgeneTBK1

GO:0032727

positive regulation of interferon-alpha production

16127453

TgeneTBK1

GO:0032728

positive regulation of interferon-beta production

16127453

TgeneTBK1

GO:0034142

toll-like receptor 4 signaling pathway

28747347

TgeneTBK1

GO:0045087

innate immune response

25636800

TgeneTBK1

GO:0045944

positive regulation of transcription by RNA polymerase II

16127453

TgeneTBK1

GO:0140374

antiviral innate immune response

14703513|22394562

TgeneTBK1

GO:1904262

negative regulation of TORC1 signaling

31530866

TgeneTBK1

GO:1904263

positive regulation of TORC1 signaling

29150432


check buttonKinase Fusion gene breakpoints across HMGA2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonKinase Fusion gene breakpoints across TBK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
CCLEDMS 114HMGA2chr12

66232349

TBK1chr12

64860681

CCLEDMS 114HMGA2chr12

66232349

TBK1chr12

64868010



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)
ENST00000403681ENST00000331710HMGA2chr1266232349TBK1chr12648680103766632

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

>ENST00000403681_ENST00000331710_HMGA2_chr12_66232349_TBK1_chr12_64868010_length(amino acids)=632
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWHPDMYER
AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLL
TPVLANILEADQEKCWGFDQFFAETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLVLEPGRLA
QHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITGVVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNET
VHKKTEVVITLDFCIRNIEKTVKVYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQEGTHPKDR
NVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTHFTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQC
FDIEEEVSKYQEYTNELQETLPQKMFTASSGIKHTMTPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMDGGLRNVD

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Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:/chr12:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HMGA2

P52926

TBK1

Q9UHD2

FUNCTION: Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation (By similarity). Positively regulates IGF2 expression through PLAG1 and in a PLAG1-independent manner (PubMed:28796236). {ECO:0000250|UniProtKB:P52927, ECO:0000269|PubMed:14645522, ECO:0000269|PubMed:28796236}.FUNCTION: Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents (PubMed:12692549, PubMed:14703513, PubMed:18583960, PubMed:12702806, PubMed:15367631, PubMed:10581243, PubMed:11839743, PubMed:15485837, PubMed:21138416, PubMed:25636800, PubMed:23453971, PubMed:23453972, PubMed:23746807, PubMed:26611359, PubMed:32404352). Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X (PubMed:12692549, PubMed:14703513, PubMed:18583960, PubMed:12702806, PubMed:15367631, PubMed:25636800). This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB (PubMed:12702806, PubMed:15367631, PubMed:25636800, PubMed:32972995). In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli (PubMed:23453971, PubMed:23453972, PubMed:23746807). Plays a key role in IRF3 activation: acts by first phosphorylating innate adapter proteins MAVS, STING1 and TICAM1 on their pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1 (PubMed:25636800, PubMed:30842653). Phosphorylated IRF3 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce expression of interferons (PubMed:25636800). Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes (PubMed:21931631). Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus (PubMed:10783893, PubMed:15489227). Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy (PubMed:21617041). Phosphorylates SMCR8 component of the C9orf72-SMCR8 complex, promoting autophagosome maturation (PubMed:27103069). Phosphorylates ATG8 proteins MAP1LC3C and GABARAPL2, thereby preventing their delipidation and premature removal from nascent autophagosomes (PubMed:31709703). Phosphorylates and activates AKT1 (PubMed:21464307). Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity (By similarity). Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C (PubMed:21270402). Phosphorylates Borna disease virus (BDV) P protein (PubMed:16155125). Plays an essential role in the TLR3- and IFN-dependent control of herpes virus HSV-1 and HSV-2 infections in the central nervous system (PubMed:22851595). Acts both as a positive and negative regulator of the mTORC1 complex, depending on the context: activates mTORC1 in response to growth factors by catalyzing phosphorylation of MTOR, while it limits the mTORC1 complex by promoting phosphorylation of RPTOR (PubMed:29150432, PubMed:31530866). {ECO:0000250|UniProtKB:Q9WUN2, ECO:0000269|PubMed:10581243, ECO:0000269|PubMed:10783893, ECO:0000269|PubMed:11839743, ECO:0000269|PubMed:12692549, ECO:0000269|PubMed:12702806, ECO:0000269|PubMed:14703513, ECO:0000269|PubMed:15367631, ECO:0000269|PubMed:15485837, ECO:0000269|PubMed:15489227, ECO:0000269|PubMed:16155125, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:21270402, ECO:0000269|PubMed:21464307, ECO:0000269|PubMed:21617041, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:22851595, ECO:0000269|PubMed:23453971, ECO:0000269|PubMed:23453972, ECO:0000269|PubMed:23746807, ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:26611359, ECO:0000269|PubMed:27103069, ECO:0000269|PubMed:29150432, ECO:0000269|PubMed:30842653, ECO:0000269|PubMed:31530866, ECO:0000269|PubMed:31709703, ECO:0000269|PubMed:32972995}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote
TgeneHMGA266232349TBK164868010ENST00000403681421309_385180730DomainNote=Ubiquitin-like


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Kinase Fusion Protein Structures

check button CIF files of the predicted kinase fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Kinase Fusion protein CIF link (fusion AA seq ID in KinaseFusionDB)HenstTenstHgeneHchrHbpTgeneTchrTbpAA seqLen(AA seq)
PDB file >>>TKFP_411_HMGA2_TBK1ENST00000403681ENST00000331710HMGA2chr1266232349TBK1chr1264868010
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWHPDMYER
AVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLL
TPVLANILEADQEKCWGFDQFFAETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLVLEPGRLA
QHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITGVVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNET
VHKKTEVVITLDFCIRNIEKTVKVYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQEGTHPKDR
NVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTHFTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQC
FDIEEEVSKYQEYTNELQETLPQKMFTASSGIKHTMTPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMDGGLRNVD
632_HMGA2_TBK1


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Comparison of Fusion Protein Isoforms

check button Superimpose the 3D Structures Among All Fusion Protein Isoforms
* Download the pdb file and open it from the molstar online viewer.

check button Comparison of the Secondary Structures of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

HMGA2_TBK1 does not have any known PDB structures.

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pLDDT score distribution

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
* The blue color at the bottom marks the best active site residues.


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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Kinase Fusion AA seq ID in KinaseFusionDBSite scoreSizeDscoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues

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Ramachandran Plot of Kinase Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

233_HMGA2_TBK1_ramachandran.png
all structure HMGA2-TBK1

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Virtual Screening Results


check button Distribution of the average docking score across all approved kinase inhibitors.
Distribution of the number of occurrence across all approved kinase inhibitors.
5'-kinase fusion protein case
3'-kinase fusion protein case

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check button Drug information from DrugBank of the top 20 interacting small molecules.
* The detailed information of individual kinase inhibitors are available in the download page.
Fusion gene name infoDrugDocking scoreGlide g scoreGlide energy

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Kinase-Substrate Information of HMGA2_TBK1


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
TBK1Q9UHD2humanPELI1Q96FA3T80DQHsIsYtLsRAQtVPellino
TBK1Q9UHD2humanSQSTM1Q13501S403ESLSQMLsMGFsDEGUBA_5
TBK1Q9UHD2humanPRPS1P60891T228DMADtCGtICHAADkPribosyl_synth
TBK1Q9UHD2humanLMO7Q8WWI1-3S417KWKDRRKsYTSDLQKDUF4757
TBK1Q9UHD2humanOPTNQ96CV9S177ssGssEDsFVEIRMA
TBK1Q9UHD2humanGABARAPL2P60520S88DKTVPQssLTMGQLYATG8
TBK1Q9UHD2humanDDAH2O95865S253QEALQKLsDVTLVPV
TBK1Q9UHD2humanTNIP1Q15025S123PPSSGTssEFEVVTP
TBK1Q9UHD2humanTRIP12Q14669S312STKkRsEsPPAELPs
TBK1Q9UHD2humanRPS6KB1P23443S447GsPRtPVsPVkFsPG
TBK1Q9UHD2humanASB8Q9H765S17QSIQSKYsLSERLIR
TBK1Q9UHD2humanOPTNQ96CV9S473AQMEVYCsDFHAERACC2-LZ
TBK1Q9UHD2humanSMCR8Q8TEV9T796AsPAGAGtLHALSRY
TBK1Q9UHD2humanGABARAPL2P60520S87VDKTVPQssLTMGQLATG8
TBK1Q9UHD2humanSTING1Q86WV6S366QEPELLIsGMEkPLP
TBK1Q9UHD2humanMAPTP10636-8S198sGDRsGyssPGsPGt
TBK1Q9UHD2humanIRF3Q14653T404NsHPLsLtsDQYKAY
TBK1Q9UHD2humanIRF3Q14653S386ARVGGAssLENtVDL
TBK1Q9UHD2humanMAP1LC3CQ9BXW4S96VNNKsLVsMSATMAEATG8
TBK1Q9UHD2humanDDAH2O95865T203VRAMAVLtDHPyASL
TBK1Q9UHD2humanE2F1Q01094S332TDSATIVsPPPSsPP
TBK1Q9UHD2humanPELI1Q96FA3T288QCPVGFNtLAFPsMkPellino
TBK1Q9UHD2humanMAPTP10636-8S214GsRsRtPsLPtPPtR
TBK1Q9UHD2humanHTTP42858S13kLMkAFEsLksFQQQ
TBK1Q9UHD2humanIRF7Q92985S477VssLDSSsLsLCLsS
TBK1Q9UHD2humanIRF3Q14653S396NtVDLHIsNsHPLsL
TBK1Q9UHD2humanMAPTP10636-8S356rVQskIGsLDNItHVTubulin-binding
TBK1Q9UHD2humanMAPTP10636-8S285INkkLDLsNVQskCGTubulin-binding
TBK1Q9UHD2humanIRF7Q92985S471GTQREGVssLDSSsL
TBK1Q9UHD2humanSIKE1Q9BRV8S185kELRELLsIssEsLQSIKE
TBK1Q9UHD2humanDDAH2O95865S245GGGDLPNsQEALQKL
TBK1Q9UHD2humanAKT1P31749S473RPHFPQFsysAsGtAPkinase_C
TBK1Q9UHD2humanTRIM56Q9BRZ2T442LEEDRAQtPHEDGGP
TBK1Q9UHD2humanSTAT6P42226S407PIQLQALsLPLVVIVSTAT_bind
TBK1Q9UHD2humanPRPS2P11908T228DMADtCGtICHAADkPribosyl_synth
TBK1Q9UHD2humanSTX17P56962S202SQQEKIDsIADHVNSSNARE
TBK1Q9UHD2humanMTORP42345S2159RIQsIAPsLQVItSk
TBK1Q9UHD2humanMAPTP10636-8T30RKDQGGytMHQDQEG
TBK1Q9UHD2humanTBK1Q9UHD2S172EDDEQFVsLyGTEEyPkinase
TBK1Q9UHD2humanIRF7Q92985S472TQREGVssLDSSsLs
TBK1Q9UHD2humanRPTORQ8N122S877HIHQAGGsPPAssts
TBK1Q9UHD2humanSMCR8Q8TEV9S402QDRPPsSsLEECPIP
TBK1Q9UHD2humanSIKE1Q9BRV8S198LQARkENsMDTASQA
TBK1Q9UHD2humanRPS6KB1P23443T444RFIGsPRtPVsPVkF
TBK1Q9UHD2humanIRF3Q14653S398VDLHIsNsHPLsLts
TBK1Q9UHD2humanIRF5Q13568S293VELFGPIsLEQVRFPIRF-3
TBK1Q9UHD2humanMAPTP10636-8S324kVTskCGsLGNIHHkTubulin-binding
TBK1Q9UHD2humanMAPTP10636-8S289LDLsNVQskCGsKDNTubulin-binding
TBK1Q9UHD2humanHDAC3O15379S424DHDNDKEsDVEI___
TBK1Q9UHD2humanPELI1Q96FA3S293FNtLAFPsMkRkDVVPellino
TBK1Q9UHD2humanSIKE1Q9BRV8S188RELLsIssEsLQARk
TBK1Q9UHD2humanXIAPP98170S430QDESSQtsLQkEIst
TBK1Q9UHD2humanTICAM1Q8IUC6S210LAsNLEIsQsPTMPF
TBK1Q9UHD2humanSIKE1Q9BRV8S133PVLkAHQsHSAEIESSIKE
TBK1Q9UHD2humanPBXIP1Q96AQ6S147REEGRCsssDDDtDV
TBK1Q9UHD2humanRELAQ04206S536sGDEDFSsIADMDFS
TBK1Q9UHD2humanMETTL3Q86U44S67GPKPSTAsAVPELAT
TBK1Q9UHD2humanCTNNB1P35222S552QDtQRRtsMGGtQQQ
TBK1Q9UHD2humanMAVSQ7Z434S442CFEDLAIsASTSLGM
TBK1Q9UHD2humanMAPTP10636-8S191ssGEPPKsGDRsGys
TBK1Q9UHD2humanIRF7Q92985S479sLDSSsLsLCLsSAN
TBK1Q9UHD2humanPELI1Q96FA3S76IsNKDQHsIsYtLsRPellino
TBK1Q9UHD2humanHTTP42858S16kAFEsLksFQQQQQQ
TBK1Q9UHD2humanIRF3Q14653S402IsNsHPLsLtsDQYK
TBK1Q9UHD2humanOPTNQ96CV9S513FEDGGRQsLMEMQsR
TBK1Q9UHD2humanMAP1LC3CQ9BXW4S93YLLVNNKsLVsMSATATG8
TBK1Q9UHD2humanIRF3Q14653S385MARVGGAssLENtVD
TBK1Q9UHD2humanPEBP1P30086S109VLsDyVGsGPPkGTGPBP
TBK1Q9UHD2humanIRF3Q14653S175PQPLRsPsLDNPtPF
TBK1Q9UHD2humanSTAT2P52630T404IWDFGYLtLVEQRSGSTAT_bind
TBK1Q9UHD2humanESR1P03372S305IkRSkkNsLALSLtA
TBK1Q9UHD2humanSTING1Q86WV6S358VPStstMsQEPELLI
TBK1Q9UHD2humanIRF3Q14653S173PCPQPLRsPsLDNPt
TBK1Q9UHD2humanTNIP1Q15025S122KPPSSGTssEFEVVT
TBK1Q9UHD2humanSIKE1Q9BRV8S187LRELLsIssEsLQARSIKE
TBK1Q9UHD2humanSQSTM1Q13501S366PEsEGPssLDPsQEG
TBK1Q9UHD2humanSIKE1Q9BRV8S190LLsIssEsLQARkEN
TBK1Q9UHD2humanIRF5Q13568S158QRMLPSLsLTEDVKW
TBK1Q9UHD2humanMAPTP10636-8S305kHVPGGGsVQIVykPTubulin-binding
TBK1Q9UHD2humanIRF3Q14653S405sHPLsLtsDQYKAYL
TBK1Q9UHD2humanAKT1P31749T308kDGAtMKtFCGtPEyPkinase
TBK1Q9UHD2humanDDAH2O95865T211DHPyASLtLPDDAAA


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
TBK1IDDescription0.00e+00
TBK1GO:0045088regulation of innate immune response4.50e-12
TBK1GO:0032728positive regulation of interferon-beta production9.51e-12
TBK1GO:0007249canonical NF-kappaB signal transduction9.51e-12
TBK1GO:0032481positive regulation of type I interferon production9.51e-12
TBK1GO:0060338regulation of type I interferon-mediated signaling pathway1.00e-11
TBK1GO:0043122regulation of canonical NF-kappaB signal transduction4.11e-11
TBK1GO:0032608interferon-beta production7.66e-11
TBK1GO:0032648regulation of interferon-beta production7.66e-11
TBK1GO:0002221pattern recognition receptor signaling pathway2.44e-10
TBK1GO:0060340positive regulation of type I interferon-mediated signaling pathway3.81e-10
TBK1GO:0002758innate immune response-activating signaling pathway3.90e-10
TBK1GO:0045089positive regulation of innate immune response3.90e-10
TBK1GO:0032479regulation of type I interferon production3.90e-10
TBK1GO:0032606type I interferon production3.90e-10
TBK1GO:0060337type I interferon-mediated signaling pathway6.35e-10
TBK1GO:0071357cellular response to type I interferon6.57e-10
TBK1GO:0002218activation of innate immune response6.81e-10
TBK1GO:0002833positive regulation of response to biotic stimulus6.81e-10
TBK1GO:0031349positive regulation of defense response7.16e-10
TBK1GO:0034340response to type I interferon9.34e-10
TBK1GO:0002753cytosolic pattern recognition receptor signaling pathway1.24e-09
TBK1GO:0140888interferon-mediated signaling pathway3.71e-09
TBK1GO:0016236macroautophagy3.71e-09
TBK1GO:0001959regulation of cytokine-mediated signaling pathway4.49e-09
TBK1GO:0010506regulation of autophagy7.22e-09
TBK1GO:0060759regulation of response to cytokine stimulus7.61e-09
TBK1GO:0051607defense response to virus7.53e-08
TBK1GO:0140546defense response to symbiont7.53e-08
TBK1GO:0032727positive regulation of interferon-alpha production7.93e-08
TBK1GO:1903320regulation of protein modification by small protein conjugation or removal8.16e-08
TBK1GO:0030522intracellular receptor signaling pathway1.13e-07
TBK1GO:0002757immune response-activating signaling pathway1.17e-07
TBK1GO:0001961positive regulation of cytokine-mediated signaling pathway1.40e-07
TBK1GO:0001819positive regulation of cytokine production1.91e-07
TBK1GO:0002764immune response-regulating signaling pathway1.91e-07
TBK1GO:0032607interferon-alpha production2.06e-07
TBK1GO:0032647regulation of interferon-alpha production2.06e-07
TBK1GO:0060760positive regulation of response to cytokine stimulus2.40e-07
TBK1GO:1901873regulation of post-translational protein modification2.46e-07
TBK1GO:0031331positive regulation of cellular catabolic process2.58e-07
TBK1GO:0043123positive regulation of canonical NF-kappaB signal transduction2.58e-07
TBK1GO:0032008positive regulation of TOR signaling2.60e-07
TBK1GO:0009615response to virus6.12e-07
TBK1GO:0010508positive regulation of autophagy9.48e-07
TBK1GO:0016241regulation of macroautophagy1.39e-06
TBK1GO:0061912selective autophagy1.77e-06
TBK1GO:0031929TOR signaling1.86e-06
TBK1GO:0038202TORC1 signaling2.04e-06
TBK1GO:0043331response to dsRNA4.40e-06

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Related Drugs to HMGA2_TBK1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning HMGA2-TBK1 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

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Related Diseases to HMGA2_TBK1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneHMGA2C1519176Salivary Gland Pleomorphic Adenoma2ORPHANET


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate