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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:HSP90AA1_RPS6KA3

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: HSP90AA1_RPS6KA3
KinaseFusionDB ID: KFG2759
FusionGDB2.0 ID: KFG2759
HgeneTgene
Gene symbol

HSP90AA1

RPS6KA3

Gene ID

3320

6197

Gene nameheat shock protein 90 alpha family class A member 1ribosomal protein S6 kinase A3
SynonymsEL52|HEL-S-65p|HSP86|HSP89A|HSP90A|HSP90N|HSPC1|HSPCA|HSPCAL1|HSPCAL4|HSPN|Hsp103|Hsp89|Hsp90|LAP-2|LAP2CLS|HU-3|ISPK-1|MAPKAPK1B|MRX19|RSK|RSK2|S6K-alpha3|XLID19|p90-RSK2|pp90RSK2
Cytomap

14q32.31

Xp22.12

Type of geneprotein-codingprotein-coding
Descriptionheat shock protein HSP 90-alphaHSP 86LPS-associated protein 2epididymis luminal secretory protein 52epididymis secretory sperm binding protein Li 65pheat shock 86 kDaheat shock 90kD protein 1, alphaheat shock 90kD protein 1, alpha-like 4heat shockribosomal protein S6 kinase alpha-3MAP kinase-activated protein kinase 1bMAPK-activated protein kinase 1bMAPKAP kinase 1bMAPKAPK-1bRSK-2S6K-alpha-3epididymis secretory sperm binding proteininsulin-stimulated protein kinase 1p90-RSK 3ribosomal S6
Modification date2024040720240403
UniProtAcc

P07900

P51812

Ensembl transtripts involved in fusion geneENST idsENST00000216281, ENST00000334701, 
ENST00000441629, ENST00000558600, 
ENST00000379565, ENST00000544447, 
ENST00000379548, ENST00000540702, 
ENST00000479809, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: HSP90AA1 [Title/Abstract] AND RPS6KA3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHSP90AA1

GO:0001934

positive regulation of protein phosphorylation

19363271

HgeneHSP90AA1

GO:0002218

activation of innate immune response

20628368

HgeneHSP90AA1

GO:0002230

positive regulation of defense response to virus by host

20628368

HgeneHSP90AA1

GO:0007004

telomere maintenance via telomerase

10197982

HgeneHSP90AA1

GO:0031396

regulation of protein ubiquitination

16809764

HgeneHSP90AA1

GO:0032273

positive regulation of protein polymerization

19363271

HgeneHSP90AA1

GO:0032728

positive regulation of interferon-beta production

20628368

HgeneHSP90AA1

GO:0042981

regulation of apoptotic process

25609812

HgeneHSP90AA1

GO:0045040

protein insertion into mitochondrial outer membrane

15644312

HgeneHSP90AA1

GO:0051131

chaperone-mediated protein complex assembly

15644312

HgeneHSP90AA1

GO:0051973

positive regulation of telomerase activity

10197982

HgeneHSP90AA1

GO:0098586

cellular response to virus

25609812

HgeneHSP90AA1

GO:1902949

positive regulation of tau-protein kinase activity

19363271

HgeneHSP90AA1

GO:1905323

telomerase holoenzyme complex assembly

10197982

TgeneRPS6KA3

GO:0043154

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

18402937


check buttonKinase Fusion gene breakpoints across HSP90AA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonKinase Fusion gene breakpoints across RPS6KA3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
CCLEOmm2.5HSP90AA1chr14

102605587

RPS6KA3chrX

20252932



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)
ENST00000334701ENST00000379565HSP90AA1chr14102605587RPS6KA3chrX202529328078712

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

>ENST00000334701_ENST00000379565_HSP90AA1_chr14_102605587_RPS6KA3_chrX_20252932_length(amino acids)=712
MDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKME
RDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIK
LTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSL
LRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFV
AITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIIT
LKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQL
RAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSK

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Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:/chrX:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HSP90AA1

P07900

RPS6KA3

P51812

FUNCTION: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (PubMed:11274138, PubMed:15577939, PubMed:15937123, PubMed:27353360, PubMed:29127155, PubMed:12526792). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself (PubMed:29127155). Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:27295069, PubMed:26991466). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels (PubMed:25973397). In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues(PubMed:25973397). Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment (PubMed:25973397). Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Mediates the association of TOMM70 with IRF3 or TBK1 in mitochondrial outer membrane which promotes host antiviral response (PubMed:20628368, PubMed:25609812). {ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:11276205, ECO:0000269|PubMed:12526792, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:15937123, ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:25609812, ECO:0000269|PubMed:27353360, ECO:0000269|PubMed:29127155, ECO:0000303|PubMed:25973397, ECO:0000303|PubMed:26991466, ECO:0000303|PubMed:27295069}.; FUNCTION: (Microbial infection) Seems to interfere with N.meningitidis NadA-mediated invasion of human cells. Decreasing HSP90 levels increases adhesion and entry of E.coli expressing NadA into human Chang cells; increasing its levels leads to decreased adhesion and invasion. {ECO:0000305|PubMed:22066472}.FUNCTION: Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:9770464, PubMed:16223362, PubMed:17360704, PubMed:16213824). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:9770464, PubMed:10436156). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed:16223362). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:8250835). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex (PubMed:17360704). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:18508509, PubMed:18813292). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed:18722121). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed:16213824). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:18508509, PubMed:18813292). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (By similarity). In LPS-stimulated dendritic cells, is involved in TLR4-induced macropinocytosis, and in myeloma cells, acts as effector of FGFR3-mediated transformation signaling, after direct phosphorylation at Tyr-529 by FGFR3 (By similarity). Negatively regulates EGF-induced MAPK1/3 phosphorylation via phosphorylation of SOS1 (By similarity). Phosphorylates SOS1 at 'Ser-1134' and 'Ser-1161' that create YWHAB and YWHAE binding sites and which contribute to the negative regulation of MAPK1/3 phosphorylation (By similarity). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). Acts as a regulator of osteoblast differentiation by mediating phosphorylation of ATF4, thereby promoting ATF4 transactivation activity (By similarity). {ECO:0000250|UniProtKB:P18654, ECO:0000269|PubMed:10436156, ECO:0000269|PubMed:16213824, ECO:0000269|PubMed:16223362, ECO:0000269|PubMed:17360704, ECO:0000269|PubMed:18722121, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:8250835, ECO:0000269|PubMed:9770464, ECO:0000303|PubMed:18508509, ECO:0000303|PubMed:18813292}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote
TgeneHSP90AA1102605587RPS6KA320252932ENST00000334701022328_39723741DomainNote=AGC-kinase C-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00618
TgeneHSP90AA1102605587RPS6KA320252932ENST0000033470102268_32723741DomainNote=Protein kinase 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TgeneHSP90AA1102605587RPS6KA320252932ENST00000334701022422_67923741DomainNote=Protein kinase 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159


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Kinase Fusion Protein Structures

check button CIF files of the predicted kinase fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Kinase Fusion protein CIF link (fusion AA seq ID in KinaseFusionDB)HenstTenstHgeneHchrHbpTgeneTchrTbpAA seqLen(AA seq)
PDB file >>>TKFP_421_HSP90AA1_RPS6KA3ENST00000334701ENST00000379565HSP90AA1chr14102605587RPS6KA3chrX20252932
MDEPMGEEEINPQTEEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKME
RDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIK
LTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSL
LRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFV
AITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIIT
LKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQL
RAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSK
712_HSP90AA1_RPS6KA3


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Comparison of Fusion Protein Isoforms

check button Superimpose the 3D Structures Among All Fusion Protein Isoforms
* Download the pdb file and open it from the molstar online viewer.

check button Comparison of the Secondary Structures of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

HSP90AA1_RPS6KA3 does not have any known PDB structures.

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pLDDT score distribution

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
* The blue color at the bottom marks the best active site residues.


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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Kinase Fusion AA seq ID in KinaseFusionDBSite scoreSizeDscoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues

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Ramachandran Plot of Kinase Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.


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Virtual Screening Results


check button Distribution of the average docking score across all approved kinase inhibitors.
Distribution of the number of occurrence across all approved kinase inhibitors.
5'-kinase fusion protein case
3'-kinase fusion protein case

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check button Drug information from DrugBank of the top 20 interacting small molecules.
* The detailed information of individual kinase inhibitors are available in the download page.
Fusion gene name infoDrugDocking scoreGlide g scoreGlide energy

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Kinase-Substrate Information of HSP90AA1_RPS6KA3


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
RPS6KA3P51812humanNFATC4Q14934S289PALsRRGsLGEEGsE
RPS6KA3P51812humanWWC1Q8IX03S947CRLNRsDsDSSTLSK
RPS6KA3P51812humanNFATC4Q14934S281SGTPSSAsPALsRRG
RPS6KA3P51812humanTHP07101-4S44RFIGRRQsLIEDARKTOH_N
RPS6KA3P51812humanRIOK2Q9BVS4S483QYRTRtLsItssGsA
RPS6KA3P51812humanEIF2AK2P19525T451kRtRSKGtLRyMsPEPkinase
RPS6KA3P51812humanYBX1P67809S102NPRKyLrsVGDGEtVCSD
RPS6KA3P51812humanTINF2Q9BSI4S295FPFRNLGsPtQVISk
RPS6KA3P51812humanH3C1P68431S10tkQtArkstGGkAPrHistone
RPS6KA3P51812humanRRN3Q9NYV6S649PVLYMQPsPL_____
RPS6KA3P51812humanLCP1P13796S5___MARGsVsDEEMM
RPS6KA3P51812humanMYL12AP19105S19KRPQRAtsNVFAMFD
RPS6KA3P51812humanTBX21Q9UL17S503DSKRRRVsPYPsSGD
RPS6KA3P51812humanTBX21Q9UL17S507RRVsPYPsSGDSsSP
RPS6KA3P51812humanMAP3K5Q99683T1109DRKIIATtLSKLkLEHisK-N-like
RPS6KA3P51812humanDAPK1P53355S289QALSRKAsAVNMEkF
RPS6KA3P51812humanSTAT3P40763S727NtIDLPMsPrTLDSL
RPS6KA3P51812humanSTMN1P16949S16kELEKrAsGQAFELIStathmin
RPS6KA3P51812humanEPHA2P29317S897RVsIRLPstsGsEGV
RPS6KA3P51812humanBADQ92934S99PFrGrsRsAPPNLWABcl-2_BAD
RPS6KA3P51812humanNFATC4Q14934S344QAVALPRsEEPASCN
RPS6KA3P51812humanWWC1Q8IX03T929stIIRsKtFsPGPQS
RPS6KA3P51812humanNFKBIAP25963S32LLDDRHDsGLDsMkD
RPS6KA3P51812humanGSK3AP49840S21sGrARtssFAEPGGG
RPS6KA3P51812humanPPP1R3AQ16821S65SSGTRRVsFADSFGF
RPS6KA3P51812humanNFATC4Q14934S676SNGRRKRsPTQSFRFRHD_dimer
RPS6KA3P51812humanNFATC4Q14934S285SSAsPALsRRGsLGE
RPS6KA3P51812humanSPRED2Q7Z698S168QPTRTIssPTSCEHR
RPS6KA3P51812humanMAP3K5Q99683S83ATRGRGssVGGGSrR
RPS6KA3P51812humanBADQ92934S75EIRsRHssyPAGtEDBcl-2_BAD
RPS6KA3P51812humanCASP8Q14790T263SIRDRNGtHLDAGALPeptidase_C14
RPS6KA3P51812humanCREB1P16220S119EILsRRPsyRkILNDpKID
RPS6KA3P51812humanGSK3BP49841S9SGRPRttsFAEsCkP
RPS6KA3P51812humanRANBP3Q9H6Z4S126VKRERtssLtQFPPs
RPS6KA3P51812humanESR1P03372S167GGRERLAsTNDkGSMOest_recep
RPS6KA3P51812humanH2AXP16104S16kARAkAksRSsrAGLHistone
RPS6KA3P51812humanRPS6P62753S236AKRRRLssLRAstsK
RPS6KA3P51812humanVGLL1Q99990S84PNQWRYSsPWTKPQP
RPS6KA3P51812humanRELAQ04206S276sMQLRRPsDRELsEPRHD_dimer
RPS6KA3P51812humanTINF2Q9BSI4S330ASTGKSKsPCQTLGG
RPS6KA3P51812humanTHP07101-2S67RFIGRRQsLIEDARKTOH_N
RPS6KA3P51812humanMAP3K5Q99683T1326VNGADEDtISRFLAE
RPS6KA3P51812humanTHP07101S71RFIGRRQsLIEDARKTOH_N
RPS6KA3P51812humanPPP1R3AQ16821S46PQPSRRGsDssEDIY
RPS6KA3P51812humanATF4P18848S245TrGSPNRsLPsPGVL
RPS6KA3P51812humanFOXN2P32314S369LGDsGYAsQPCAKIS
RPS6KA3P51812humanFOXN2P32314S365EDDPLGDsGYAsQPC
RPS6KA3P51812humanSPRED2Q7Z698S167EQPTRTIssPTSCEH
RPS6KA3P51812humanH2BC3P33778S32DGKkRKRsRkEsysIHistone
RPS6KA3P51812humanFGFR1P11362S789DTRSSTCsSGEDSVF
RPS6KA3P51812humanRPS6P62753S235IAKRRRLssLRAsts
RPS6KA3P51812humanSLC9A3P48764S663TMRKRLEsFKSTKLG
RPS6KA3P51812humanTHP07101-3S40RFIGRRQsLIEDARKTOH_N
RPS6KA3P51812humanCICQ96RK0S173PGKRRtQsLsALPKE
RPS6KA3P51812humanEIF2S1P05198S52MILLsELsRRRIRsIS1
RPS6KA3P51812humanKCNK3O14649S393GLMKRRssV______


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
RPS6KA3IDDescription0.00e+00
RPS6KA3GO:0071248cellular response to metal ion2.28e-04
RPS6KA3GO:0071241cellular response to inorganic substance2.28e-04
RPS6KA3GO:0097191extrinsic apoptotic signaling pathway2.28e-04
RPS6KA3GO:0010038response to metal ion2.56e-04
RPS6KA3GO:0071287cellular response to manganese ion3.40e-04
RPS6KA3GO:0034198cellular response to amino acid starvation1.04e-03
RPS6KA3GO:1990928response to amino acid starvation1.04e-03
RPS6KA3GO:0002064epithelial cell development1.04e-03
RPS6KA3GO:0010042response to manganese ion1.15e-03
RPS6KA3GO:0045862positive regulation of proteolysis1.15e-03
RPS6KA3GO:0038034signal transduction in absence of ligand1.59e-03
RPS6KA3GO:0097192extrinsic apoptotic signaling pathway in absence of ligand1.59e-03
RPS6KA3GO:1902893regulation of miRNA transcription1.71e-03
RPS6KA3GO:0061614miRNA transcription1.71e-03
RPS6KA3GO:2001233regulation of apoptotic signaling pathway1.71e-03
RPS6KA3GO:0003323type B pancreatic cell development1.71e-03
RPS6KA3GO:0010950positive regulation of endopeptidase activity1.71e-03
RPS6KA3GO:1902894negative regulation of miRNA transcription1.77e-03
RPS6KA3GO:2000629negative regulation of miRNA metabolic process1.89e-03
RPS6KA3GO:0010952positive regulation of peptidase activity2.20e-03
RPS6KA3GO:0008625extrinsic apoptotic signaling pathway via death domain receptors2.33e-03
RPS6KA3GO:2000628regulation of miRNA metabolic process2.33e-03
RPS6KA3GO:0003309type B pancreatic cell differentiation2.43e-03
RPS6KA3GO:0005979regulation of glycogen biosynthetic process2.47e-03
RPS6KA3GO:0010962regulation of glucan biosynthetic process2.47e-03
RPS6KA3GO:0140747regulation of ncRNA transcription2.57e-03
RPS6KA3GO:0006109regulation of carbohydrate metabolic process2.64e-03
RPS6KA3GO:0062197cellular response to chemical stress2.74e-03
RPS6KA3GO:0097193intrinsic apoptotic signaling pathway2.74e-03
RPS6KA3GO:0046777protein autophosphorylation3.02e-03
RPS6KA3GO:0002068glandular epithelial cell development3.02e-03
RPS6KA3GO:0071214cellular response to abiotic stimulus3.02e-03
RPS6KA3GO:0104004cellular response to environmental stimulus3.02e-03
RPS6KA3GO:0035883enteroendocrine cell differentiation3.02e-03
RPS6KA3GO:0070306lens fiber cell differentiation3.02e-03
RPS6KA3GO:0001819positive regulation of cytokine production3.02e-03
RPS6KA3GO:0010586miRNA metabolic process3.02e-03
RPS6KA3GO:0070873regulation of glycogen metabolic process3.02e-03
RPS6KA3GO:0032885regulation of polysaccharide biosynthetic process3.12e-03
RPS6KA3GO:0071496cellular response to external stimulus3.12e-03
RPS6KA3GO:0043280positive regulation of cysteine-type endopeptidase activity involved in apoptotic process3.40e-03
RPS6KA3GO:0032355response to estradiol3.56e-03
RPS6KA3GO:0005978glycogen biosynthetic process4.15e-03
RPS6KA3GO:0006984ER-nucleus signaling pathway4.15e-03
RPS6KA3GO:0009250glucan biosynthetic process4.15e-03
RPS6KA3GO:0031018endocrine pancreas development4.15e-03
RPS6KA3GO:0032881regulation of polysaccharide metabolic process4.15e-03
RPS6KA3GO:0042789mRNA transcription by RNA polymerase II4.15e-03
RPS6KA3GO:0002286T cell activation involved in immune response4.15e-03

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Related Drugs to HSP90AA1_RPS6KA3


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning HSP90AA1-RPS6KA3 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

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Related Diseases to HSP90AA1_RPS6KA3


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate