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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:IGF1R_MAN2B1

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: IGF1R_MAN2B1
KinaseFusionDB ID: KFG2815
FusionGDB2.0 ID: KFG2815
HgeneTgene
Gene symbol

IGF1R

MAN2B1

Gene ID

3480

4125

Gene nameinsulin like growth factor 1 receptormannosidase alpha class 2B member 1
SynonymsCD221|IGFIR|IGFR|JTK13LAMAN|MANB
Cytomap

15q26.3

19p13.13

Type of geneprotein-codingprotein-coding
Descriptioninsulin-like growth factor 1 receptorIGF-I receptorlysosomal alpha-mannosidaselysosomal acid alpha-mannosidasemannosidase alpha-Bmannosidase, alpha B, lysosomal
Modification date2024041120240403
UniProtAcc

P08069

O00754

Ensembl transtripts involved in fusion geneENST idsENST00000268035, ENST00000558762, 
ENST00000560432, 		ENST00000221363, 
ENST00000456935, ENST00000495617, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: IGF1R [Title/Abstract] AND MAN2B1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)IGF1R(99259243)-MAN2B1(12777526), # samples:1
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIGF1R

GO:0043066

negative regulation of apoptotic process

12556535

HgeneIGF1R

GO:0043409

negative regulation of MAPK cascade

12556535

HgeneIGF1R

GO:0046328

regulation of JNK cascade

12556535

HgeneIGF1R

GO:0046777

protein autophosphorylation

1846292|7679099|11162456

HgeneIGF1R

GO:0048009

insulin-like growth factor receptor signaling pathway

7679099|7692086

HgeneIGF1R

GO:0051897

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

7692086

TgeneMAN2B1

GO:0036211

protein modification process

8910458


check buttonKinase Fusion gene breakpoints across IGF1R (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonKinase Fusion gene breakpoints across MAN2B1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChiTaRS5.0BM149772IGF1Rchr15

99259243

MAN2B1chr19

12777526



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:99259243/:12777526)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IGF1R

P08069

MAN2B1

O00754


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


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Kinase-Substrate Information of IGF1R_MAN2B1


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
IGF1RP08069humanIRS1P35568Y989VPssRGDyMTMQMSC
IGF1RP08069humanPDPK1O15530Y376DEDCyGNyDNLLSQF
IGF1RP08069humanPTH1RQ03431Y494ARsGsssySyGPMVS
IGF1RP08069humanIRS1P35568Y632GRKGsGDyMPMsPKs
IGF1RP08069humanANXA2P07355Y24HstPPsAyGsVkAyt
IGF1RP08069humanPCNAP12004Y250DMGHLkYyLAPkIEDPCNA_C
IGF1RP08069humanIRS1P35568Y941EEtGtEEyMKMDLGP
IGF1RP08069humanIRS4O14654Y921EADSSsDyVNMDFTk
IGF1RP08069humanIRS1P35568Y662QRVDPNGyMMMsPsG
IGF1RP08069humanIRS1P35568Y896EPKsPGEyVNIEFGS
IGF1RP08069humanESR1P03372Y219sIQGHNDyMCPATNQzf-C4
IGF1RP08069humanIGF1RP08069Y1161FGMTRDIyEtDyyRkPK_Tyr_Ser-Thr
IGF1RP08069humanIRS4O14654Y828GQNDNsEyVPMLPGk
IGF1RP08069humanIRS1P35568Y1179GLENGLNyIDLDLVk
IGF1RP08069humanPCNAP12004Y60RSEGFDTyrCDRNLAPCNA_N
IGF1RP08069humanIGF1RP08069Y1281FREVsFyySEENKLP
IGF1RP08069humanSIRPAP78324Y470AsEDtLtyADLDMVH
IGF1RP08069humanPDPK1O15530Y373sEDDEDCyGNyDNLL
IGF1RP08069humanIGF1RP08069S982SVNPEyFsAADVYVP
IGF1RP08069humanIRS4O14654Y847GLDkEVSyNWDPKDA
IGF1RP08069humanH3C1P68431Y41GVkkPHryrPGtVALHistone
IGF1RP08069humanIGF1RP08069Y980yASVNPEyFsAADVY
IGF1RP08069humanPCNAP12004Y133LGIPEQEysCVVkMPPCNA_C
IGF1RP08069humanIRS4O14654Y656SGGRFRLyFCVDrGA
IGF1RP08069humanIGF1RP08069Y1165RDIyEtDyyRkGGkGPK_Tyr_Ser-Thr
IGF1RP08069humanIRS1P35568Y732LLPCTGDyMNMSPVG
IGF1RP08069humanIGF1RP08069Y1280GFREVsFyySEENKL
IGF1RP08069humanIGF1RP08069Y1166DIyEtDyyRkGGkGLPK_Tyr_Ser-Thr
IGF1RP08069humanSIRPAP78324Y496PEPSFsEyASVQVPR


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
IGF1RIDDescription0.00e+00
IGF1RGO:0008286insulin receptor signaling pathway2.93e-04
IGF1RGO:0048009insulin-like growth factor receptor signaling pathway7.18e-04
IGF1RGO:0032869cellular response to insulin stimulus7.18e-04
IGF1RGO:0042698ovulation cycle1.18e-03
IGF1RGO:0032868response to insulin1.24e-03
IGF1RGO:0071375cellular response to peptide hormone stimulus1.81e-03
IGF1RGO:0032355response to estradiol2.07e-03
IGF1RGO:1904035regulation of epithelial cell apoptotic process2.07e-03
IGF1RGO:0044849estrous cycle2.07e-03
IGF1RGO:1902065response to L-glutamate2.07e-03
IGF1RGO:1901653cellular response to peptide2.07e-03
IGF1RGO:0051347positive regulation of transferase activity2.81e-03
IGF1RGO:0043434response to peptide hormone2.81e-03
IGF1RGO:1904019epithelial cell apoptotic process2.81e-03
IGF1RGO:0034121regulation of toll-like receptor signaling pathway6.09e-03
IGF1RGO:0071392cellular response to estradiol stimulus8.54e-03
IGF1RGO:0071548response to dexamethasone8.54e-03
IGF1RGO:0010518positive regulation of phospholipase activity1.26e-02
IGF1RGO:0010656negative regulation of muscle cell apoptotic process1.26e-02
IGF1RGO:0043491phosphatidylinositol 3-kinase/protein kinase B signal transduction1.44e-02
IGF1RGO:0048511rhythmic process1.44e-02
IGF1RGO:0010517regulation of phospholipase activity1.44e-02
IGF1RGO:0007249canonical NF-kappaB signal transduction1.44e-02
IGF1RGO:0060193positive regulation of lipase activity1.44e-02
IGF1RGO:1904036negative regulation of epithelial cell apoptotic process1.57e-02
IGF1RGO:0070301cellular response to hydrogen peroxide1.65e-02
IGF1RGO:0048545response to steroid hormone1.68e-02
IGF1RGO:0033674positive regulation of kinase activity1.73e-02
IGF1RGO:0002224toll-like receptor signaling pathway1.79e-02
IGF1RGO:0045806negative regulation of endocytosis1.79e-02
IGF1RGO:0060191regulation of lipase activity1.88e-02
IGF1RGO:0045913positive regulation of carbohydrate metabolic process1.96e-02
IGF1RGO:0010660regulation of muscle cell apoptotic process2.04e-02
IGF1RGO:0010657muscle cell apoptotic process2.27e-02
IGF1RGO:0042542response to hydrogen peroxide2.78e-02
IGF1RGO:0043255regulation of carbohydrate biosynthetic process2.92e-02
IGF1RGO:0007200phospholipase C-activating G protein-coupled receptor signaling pathway3.28e-02
IGF1RGO:0051051negative regulation of transport3.31e-02
IGF1RGO:0043200response to amino acid3.82e-02
IGF1RGO:0051384response to glucocorticoid3.82e-02
IGF1RGO:0046328regulation of JNK cascade4.02e-02
IGF1RGO:0001101response to acid chemical4.47e-02
IGF1RGO:0045834positive regulation of lipid metabolic process4.51e-02
IGF1RGO:0062207regulation of pattern recognition receptor signaling pathway4.51e-02
IGF1RGO:0062013positive regulation of small molecule metabolic process4.53e-02
IGF1RGO:0031960response to corticosteroid4.55e-02
IGF1RGO:0034614cellular response to reactive oxygen species4.71e-02
IGF1RGO:0045807positive regulation of endocytosis4.71e-02
IGF1RGO:0007254JNK cascade5.10e-02

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Related Drugs to IGF1R_MAN2B1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning IGF1R-MAN2B1 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

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Related Diseases to IGF1R_MAN2B1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate