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Kinase Fusion Gene:KCNQ5_MAP3K11 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: KCNQ5_MAP3K11 | KinaseFusionDB ID: KFG2988 | FusionGDB2.0 ID: KFG2988 | Hgene | Tgene | Gene symbol | KCNQ5 | MAP3K11 | Gene ID | 56479 | 4296 | |
| Gene name | potassium voltage-gated channel subfamily Q member 5 | mitogen-activated protein kinase kinase kinase 11 | ||||||||||
| Synonyms | Kv7.5|MRD46 | MEKK11|MLK-3|MLK3|PTK1|SPRK | ||||||||||
| Cytomap | 6q13 | 11q13.1 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | potassium voltage-gated channel subfamily KQT member 5KQT-like 5potassium channel proteinpotassium channel subunit alpha KvLQT5potassium channel, voltage gated KQT-like subfamily Q, member 5voltage-gated potassium channel subunit Kv7.5 | mitogen-activated protein kinase kinase kinase 11SH3 domain-containing proline-rich kinasemixed lineage kinase 3protein-tyrosine kinase PTK1src-homology 3 domain-containing proline-rich kinase | ||||||||||
| Modification date | 20240411 | 20240305 | ||||||||||
| UniProtAcc | Q9NR82 | Q16584 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000342056, ENST00000355194, ENST00000370398, ENST00000370392, ENST00000355635, ENST00000414165, ENST00000402622, ENST00000403813, | ENST00000309100, ENST00000532507, ENST00000530153, ENST00000534432, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: KCNQ5 [Title/Abstract] AND MAP3K11 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | ||||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | KCNQ5 | GO:0071805 | potassium ion transmembrane transport | 10787416|11159685 |
| Tgene | MAP3K11 | GO:0006468 | protein phosphorylation | 11053428 |
| Tgene | MAP3K11 | GO:0046777 | protein autophosphorylation | 8195146 |
| Kinase Fusion gene breakpoints across KCNQ5 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across MAP3K11 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| CCLE | S462 | KCNQ5 | chr6 | 73843364 | MAP3K11 | chr11 | 65367239 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:/chr11:) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KCNQ5 | MAP3K11 |
| FUNCTION: Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Therefore, it is important in the regulation of neuronal excitability. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. As the native M-channel, the potassium channel composed of KCNQ3 and KCNQ5 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1. {ECO:0000269|PubMed:10787416, ECO:0000269|PubMed:11159685, ECO:0000269|PubMed:28669405}. | FUNCTION: Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. {ECO:0000269|PubMed:12529434, ECO:0000269|PubMed:15258589, ECO:0000269|PubMed:8195146, ECO:0000269|PubMed:9003778}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of KCNQ5_MAP3K11 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| MAP3K11 | Q16584 | human | GLI1 | P08151 | S1089 | NMAVGNMsVLLRSLP | |
| MAP3K11 | Q16584 | human | PIN1 | Q13526 | S138 | QkPFEDAsFALrTGE | Rotamase |
| MAP3K11 | Q16584 | human | PRKAA1 | Q13131 | T183 | sDGEFLRtsCGsPNy | Pkinase |
| MAP3K11 | Q16584 | human | MAP3K11 | Q16584 | T277 | LAREWHKtTQMsAAG | PK_Tyr_Ser-Thr |
| MAP3K11 | Q16584 | human | PAK1 | Q13153 | S204 | tKsVyTRsVIEPLPV | |
| MAP3K11 | Q16584 | human | PAK1 | Q13153 | S133 | DVLEFyNsKKtsNsQ | |
| MAP3K11 | Q16584 | human | MAP2K4 | P45985 | S257 | ISGQLVDsIAKtRDA | Pkinase |
| MAP3K11 | Q16584 | human | MAP3K11 | Q16584 | S281 | WHKtTQMsAAGTYAW | PK_Tyr_Ser-Thr |
| MAP3K11 | Q16584 | human | MAP2K3 | P46734 | S218 | IsGyLVDsVAKtMDA | Pkinase |
| MAP3K11 | Q16584 | human | GLI1 | P08151 | T394 | HGPDAHVtKRHRGDG | |
| MAP3K11 | Q16584 | human | MAP2K3 | P46734 | T222 | LVDsVAKtMDAGCKP | Pkinase |
| MAP3K11 | Q16584 | human | MAP2K4 | P45985 | T261 | LVDsIAKtRDAGCRP | Pkinase |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| MAP3K11 | ID | Description | 0.00e+00 |
| MAP3K11 | GO:0051347 | positive regulation of transferase activity | 2.10e-03 |
| MAP3K11 | GO:0043410 | positive regulation of MAPK cascade | 2.10e-03 |
| MAP3K11 | GO:0051770 | positive regulation of nitric-oxide synthase biosynthetic process | 2.10e-03 |
| MAP3K11 | GO:0071322 | cellular response to carbohydrate stimulus | 2.10e-03 |
| MAP3K11 | GO:0051767 | nitric-oxide synthase biosynthetic process | 2.10e-03 |
| MAP3K11 | GO:0051769 | regulation of nitric-oxide synthase biosynthetic process | 2.10e-03 |
| MAP3K11 | GO:0043507 | positive regulation of JUN kinase activity | 3.76e-03 |
| MAP3K11 | GO:0009743 | response to carbohydrate | 3.76e-03 |
| MAP3K11 | GO:0051403 | stress-activated MAPK cascade | 3.76e-03 |
| MAP3K11 | GO:0031098 | stress-activated protein kinase signaling cascade | 3.76e-03 |
| MAP3K11 | GO:0045740 | positive regulation of DNA replication | 4.22e-03 |
| MAP3K11 | GO:0045860 | positive regulation of protein kinase activity | 4.80e-03 |
| MAP3K11 | GO:0043506 | regulation of JUN kinase activity | 4.80e-03 |
| MAP3K11 | GO:0038093 | Fc receptor signaling pathway | 6.59e-03 |
| MAP3K11 | GO:0043525 | positive regulation of neuron apoptotic process | 6.59e-03 |
| MAP3K11 | GO:0033674 | positive regulation of kinase activity | 6.59e-03 |
| MAP3K11 | GO:0060537 | muscle tissue development | 1.21e-02 |
| MAP3K11 | GO:0043406 | positive regulation of MAP kinase activity | 1.21e-02 |
| MAP3K11 | GO:0046330 | positive regulation of JNK cascade | 1.21e-02 |
| MAP3K11 | GO:0055017 | cardiac muscle tissue growth | 1.21e-02 |
| MAP3K11 | GO:0016055 | Wnt signaling pathway | 1.21e-02 |
| MAP3K11 | GO:0198738 | cell-cell signaling by wnt | 1.21e-02 |
| MAP3K11 | GO:0060419 | heart growth | 1.32e-02 |
| MAP3K11 | GO:0090398 | cellular senescence | 1.63e-02 |
| MAP3K11 | GO:0032874 | positive regulation of stress-activated MAPK cascade | 1.84e-02 |
| MAP3K11 | GO:0006275 | regulation of DNA replication | 1.84e-02 |
| MAP3K11 | GO:0070304 | positive regulation of stress-activated protein kinase signaling cascade | 1.84e-02 |
| MAP3K11 | GO:0046328 | regulation of JNK cascade | 2.00e-02 |
| MAP3K11 | GO:0033135 | regulation of peptidyl-serine phosphorylation | 2.09e-02 |
| MAP3K11 | GO:0071902 | positive regulation of protein serine/threonine kinase activity | 2.09e-02 |
| MAP3K11 | GO:0043405 | regulation of MAP kinase activity | 2.09e-02 |
| MAP3K11 | GO:0034614 | cellular response to reactive oxygen species | 2.38e-02 |
| MAP3K11 | GO:0070507 | regulation of microtubule cytoskeleton organization | 2.51e-02 |
| MAP3K11 | GO:0007254 | JNK cascade | 2.51e-02 |
| MAP3K11 | GO:0035265 | organ growth | 2.87e-02 |
| MAP3K11 | GO:0032872 | regulation of stress-activated MAPK cascade | 3.07e-02 |
| MAP3K11 | GO:0070302 | regulation of stress-activated protein kinase signaling cascade | 3.08e-02 |
| MAP3K11 | GO:0046777 | protein autophosphorylation | 3.33e-02 |
| MAP3K11 | GO:0000302 | response to reactive oxygen species | 3.43e-02 |
| MAP3K11 | GO:0043523 | regulation of neuron apoptotic process | 3.92e-02 |
| MAP3K11 | GO:0048738 | cardiac muscle tissue development | 3.92e-02 |
| MAP3K11 | GO:0034599 | cellular response to oxidative stress | 3.92e-02 |
| MAP3K11 | GO:0045542 | positive regulation of cholesterol biosynthetic process | 3.92e-02 |
| MAP3K11 | GO:0060245 | detection of cell density | 3.92e-02 |
| MAP3K11 | GO:0106120 | positive regulation of sterol biosynthetic process | 3.92e-02 |
| MAP3K11 | GO:1903943 | regulation of hepatocyte apoptotic process | 3.92e-02 |
| MAP3K11 | GO:1904179 | positive regulation of adipose tissue development | 3.92e-02 |
| MAP3K11 | GO:0032886 | regulation of microtubule-based process | 3.92e-02 |
| MAP3K11 | GO:0060828 | regulation of canonical Wnt signaling pathway | 3.92e-02 |
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Related Drugs to KCNQ5_MAP3K11 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning KCNQ5-MAP3K11 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to KCNQ5_MAP3K11 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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