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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:KHDRBS1_LCK

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: KHDRBS1_LCK
KinaseFusionDB ID: KFG3005
FusionGDB2.0 ID: KFG3005
HgeneTgene
Gene symbol

KHDRBS1

LCK

Gene ID

10657

3932

Gene nameKH RNA binding domain containing, signal transduction associated 1LCK proto-oncogene, Src family tyrosine kinase
SynonymsSam68|p62|p68IMD22|LSK|YT16|p56lck|pp58lck
Cytomap

1p35.2

1p35.2

Type of geneprotein-codingprotein-coding
DescriptionKH domain-containing, RNA-binding, signal transduction-associated protein 1GAP-associated tyrosine phosphoprotein p62 (Sam68)KH domain containing, RNA binding, signal transduction associated 1p21 Ras GTPase-activating protein-associated p62src-associatyrosine-protein kinase LckT-lymphocyte specific protein tyrosine kinase p56lckleukocyte C-terminal Src kinaselymphocyte cell-specific protein-tyrosine kinasep56(LSTRA) protein-tyrosine kinaseproto-oncogene tyrosine-protein kinase LCKt cell-specific
Modification date2024040720240411
UniProtAcc

Q07666

P06239

Ensembl transtripts involved in fusion geneENST idsENST00000307714, ENST00000327300, 
ENST00000492989, 		ENST00000333070, 
ENST00000336890, ENST00000373564, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: KHDRBS1 [Title/Abstract] AND LCK [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)KHDRBS1(32505174)-LCK(32739926), # samples:2
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKHDRBS1

GO:0000381

regulation of alternative mRNA splicing, via spliceosome

24514149

HgeneKHDRBS1

GO:0031647

regulation of protein stability

21613532

HgeneKHDRBS1

GO:0045948

positive regulation of translational initiation

21613532

HgeneKHDRBS1

GO:0046833

positive regulation of RNA export from nucleus

21613532

HgeneKHDRBS1

GO:0050852

T cell receptor signaling pathway

9045636

TgeneLCK

GO:0006468

protein phosphorylation

214242

TgeneLCK

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

16116473

TgeneLCK

GO:0009410

response to xenobiotic stimulus

16116473

TgeneLCK

GO:0035556

intracellular signal transduction

8681956

TgeneLCK

GO:0038083

peptidyl-tyrosine autophosphorylation

8478617

TgeneLCK

GO:0038094

Fc-gamma receptor signaling pathway

8478617

TgeneLCK

GO:0050870

positive regulation of T cell activation

8943371


check buttonKinase Fusion gene breakpoints across KHDRBS1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonKinase Fusion gene breakpoints across LCK (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChimerDB4TCGA-VQ-A8PE-01AKHDRBS1chr1

32505174

LCKchr1

32739926

ChimerDB4TCGA-VQ-A8PEKHDRBS1chr1

32505174

LCKchr1

32739925



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:32505174/:32739926)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KHDRBS1

Q07666

LCK

P06239


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


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Kinase-Substrate Information of KHDRBS1_LCK


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
LCKP06239humanPRDX1Q06830Y194DVQkSkEyFskQK__1-cysPrx_C
LCKP06239humanCD5P06127Y453AsHVDNEysQPPRNs
LCKP06239humanPLCG2P16885Y753ERDINSLyDVsRMyV
LCKP06239humanIL2RBP14784Y418LSGEDDAyCTFPSRD
LCKP06239humanCD247P20963Y142GkGHDGLyQGLstAtITAM
LCKP06239humanCHN2P52757Y153KMTTNPIyEHIGyAt
LCKP06239humanZAP70P43403Y315MPMDtsVyEsPysDP
LCKP06239humanPTPN6P29350Y564sKHkEDVyENLHTkN
LCKP06239humanSHC1P29353-2Y239EEPPDHQyyNDFPGK
LCKP06239humanVAV1P15498Y142SVGDEDIySGLSDQI
LCKP06239humanZAP70P43403Y474VLLVNRHyAkISDFGPK_Tyr_Ser-Thr
LCKP06239humanSTAP2Q9UGK3Y250PFLLDEDyEKVLGyV
LCKP06239humanIL2RBP14784Y384ACQVyFTyDPySEED
LCKP06239humanSH2D2AQ9NP31Y280PKPSNPIyNEPDEPI
LCKP06239humanVAV1P15498Y174EAEGDEIyEDLMRsE
LCKP06239humanBTLAQ7Z6A9Y257ENKPGIVyASLNHsV
LCKP06239humanSTAT2P52630Y690NLQERRKyLKHRLIV
LCKP06239humanSTAT5AP42229Y694LAkAVDGyVkPQIkQ
LCKP06239humanSLAMF1Q13291Y307QDPCTTIyVAATEPV
LCKP06239humanADAM15Q13444Y715LVMLGASyWYRARLHTM
LCKP06239humanPLCG2P16885Y1197LESEEELySSCRQLR
LCKP06239humanITGB2P05107Y735HLSDLREyRRFEkEKIntegrin_b_cyt
LCKP06239humanZAP70P43403Y319tsVyEsPysDPEELk
LCKP06239humanDGKAP23743Y335ILPPSSIyPSVLASG
LCKP06239humanSHC1P29353-2Y240EPPDHQyyNDFPGKE
LCKP06239humanSH2D2AQ9NP31Y305GEAPsNIyVEVEDEG
LCKP06239humanPTENP60484Y240RREDKFMyFEFPQPLPTEN_C2
LCKP06239humanSOCS3O14543Y221IREFLDQyDAPL___
LCKP06239humanPPP2CAP67775Y307VTRRtPDyFl_____
LCKP06239humanSIGLEC10Q96LC7Y597RHstILDyINVVPTA
LCKP06239humanSH2D2AQ9NP31Y260PQLPPEVytIPVPRH
LCKP06239humanIL2RBP14784Y381EIEACQVyFTyDPyS
LCKP06239humanTHEMISQ8N1K5Y429EAALLPLyMEGGFVECABIT
LCKP06239humanCBLP22681Y774sENEDDGyDVPKPPV
LCKP06239humanTHEMISQ8N1K5Y540EEITEEQyyMMRRYE
LCKP06239humanLAX1Q8IWV1Y373SNEDSSDyENVLTAKLAX
LCKP06239humanITKQ08881Y512RFVLDDQytsstGtkPK_Tyr_Ser-Thr
LCKP06239humanTBK1Q9UHD2Y354SSNQELIyEGRRLVLTBK1_ULD
LCKP06239humanLCKP06239Y394RLIEDNEytAREGAkPK_Tyr_Ser-Thr
LCKP06239humanZAP70P43403Y69ERQLNGTyAIAGGkASH2
LCKP06239humanTHEMISQ8N1K5Y95IVADkTPyLTMEEITCABIT
LCKP06239humanLCP2Q13094Y128DGEDDGDyEsPNEEE
LCKP06239humanSLC25A4P12235Y195RAAyFGVyDtAkGMLTM; Mito_carr
LCKP06239humanLAX1Q8IWV1Y193SSEDSHDyVNVPTAELAX
LCKP06239humanSH2D2AQ9NP31Y290PDEPIAFyAMGrGsP
LCKP06239humanMED28Q9H204Y64ASLVSQDyVNGTDQEMed28
LCKP06239humanSHC1P29353-2Y317ELFDDPSyVNVQNLD
LCKP06239humanSSBP3Q9BWW4Y25EkLALyVyEYLLHVG
LCKP06239humanCD33P20138Y340EMDEELHyASLNFHG
LCKP06239humanCCDC50Q8IVM0Y304SSHkGFHyKH_____
LCKP06239humanZAP70P43403Y493LGADDsyytARsAGkPK_Tyr_Ser-Thr
LCKP06239humanLCKP06239Y505FTAtEGQyQPQP___
LCKP06239humanLAX1Q8IWV1Y268SSQISNDyVNMTGLDLAX
LCKP06239humanVAV1P15498Y160VEEDEDLyDCVENEE
LCKP06239humanIL2RBP14784Y536LPLNTDAyLSLQELQ
LCKP06239humanPLCG2P16885Y759LyDVsRMyVDPsEIN
LCKP06239humanLCP2Q13094Y145PVEDDADyEPPPSND
LCKP06239humanZAP70P43403Y178EEAERkLysGAQTDGSH2
LCKP06239humanBTLAQ7Z6A9Y226LLSETGIyDNDPDLC
LCKP06239humanPECAM1P16284Y713KKDtEtVysEVRKAV
LCKP06239humanSSBP3Q9BWW4Y23AREkLALyVyEYLLH
LCKP06239humanTHEMISQ8N1K5Y541EITEEQyyMMRRYES
LCKP06239humanMAPK14Q16539Y323DEPVADPyDQsFESR
LCKP06239humanZAP70P43403Y492ALGADDsyytARsAGPK_Tyr_Ser-Thr
LCKP06239humanPTPN6P29350Y536QkGQEsEyGNItyPP
LCKP06239humanIL2RBP14784Y387VyFTyDPySEEDPDE
LCKP06239humanCBLP22681Y700EGEEDtEyMtPssRP
LCKP06239humanPTENP60484Y315RADNDKEyLVLtLtKPTEN_C2
LCKP06239humanPRKCQQ04759Y90SETTVELySLAERCR
LCKP06239humanSENP1Q9P0U3Y270EQLSHSVySLSSYTP
LCKP06239humanCD5P06127Y487DNssDsDyDLHGAQR
LCKP06239humanACP1P24666Y132QLIIEDPyyGNDsDFLMWPc
LCKP06239humanESR1P03372Y537CKNVVPLyDLLLEML
LCKP06239humanSIGLEC10Q96LC7Y667ESQEELHyATLNFPG
LCKP06239humanTIGITQ495A1Y225DCAELHDyFNVLSYR
LCKP06239humanTHEMISQ8N1K5Y174LsQEGEFyECEDERICABIT
LCKP06239humanNFKBIAP25963Y42DsMkDEEyEQMVkEL
LCKP06239humanBTLAQ7Z6A9Y282VKEAPtEyASICVRS
LCKP06239humanG3BP1Q13283Y56GkPADAVyGQkEIHRNTF2
LCKP06239humanCCDC50Q8IVM0Y279tDGEDADytHFtNQQ
LCKP06239humanBTLAQ7Z6A9Y243MQEGSEVySNPCLEE
LCKP06239humanLAX1Q8IWV1Y294AFQCCRDyENVPAADLAX
LCKP06239humanCCDC50Q8IVM0Y217MAEEkKAykkAkERE
LCKP06239humanSOCS3O14543Y204VNGHLDSyEkVTQLP
LCKP06239humanCBLP22681Y731QQIDSCTyEAMyNIQ
LCKP06239humanZAP70P43403Y126RDAMVRDyVRQTWkL
LCKP06239humanZAP70P43403Y292DtLNsDGytPEPARI
LCKP06239humanEZRP15311Y146kEVHksGyLSsERLIFERM_M
LCKP06239humanSIGLEC10Q96LC7Y691PKGTQADyAEVKFQ_
LCKP06239humanWASP42768Y291AEtsKLIyDFIEDQGPBD
LCKP06239humanLCP2Q13094Y113ssFEEDDyESPNDDQ
LCKP06239humanACP1P24666Y133LIIEDPyyGNDsDFELMWPc
LCKP06239humanTBK1Q9UHD2Y394LNTIGLIyEkISLPkTBK1_ULD
LCKP06239humanTHEMISQ8N1K5Y353PREFPTAyDLEIAkSCABIT
LCKP06239humanDAPP1Q9UN19Y139kVEEPsIyEsVRVHT
LCKP06239humanPLCG2P16885Y1217LNNQLFLyDtHQNLR
LCKP06239humanFOXP3Q9BZS1Y342NMRPPFTyATLIRWAForkhead


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
LCKIDDescription0.00e+00
LCKGO:0002764immune response-regulating signaling pathway2.84e-15
LCKGO:0002768immune response-regulating cell surface receptor signaling pathway1.70e-12
LCKGO:0002757immune response-activating signaling pathway5.29e-12
LCKGO:0050851antigen receptor-mediated signaling pathway2.33e-11
LCKGO:0002429immune response-activating cell surface receptor signaling pathway1.45e-10
LCKGO:0050852T cell receptor signaling pathway4.44e-10
LCKGO:0007159leukocyte cell-cell adhesion3.35e-09
LCKGO:1903037regulation of leukocyte cell-cell adhesion2.89e-07
LCKGO:0022407regulation of cell-cell adhesion2.89e-07
LCKGO:1903039positive regulation of leukocyte cell-cell adhesion2.77e-06
LCKGO:0018108peptidyl-tyrosine phosphorylation2.77e-06
LCKGO:0018212peptidyl-tyrosine modification2.77e-06
LCKGO:0050863regulation of T cell activation2.78e-06
LCKGO:0030168platelet activation3.79e-06
LCKGO:0007596blood coagulation6.86e-06
LCKGO:0030098lymphocyte differentiation6.86e-06
LCKGO:0022409positive regulation of cell-cell adhesion6.86e-06
LCKGO:0050817coagulation6.86e-06
LCKGO:0007599hemostasis6.95e-06
LCKGO:0002443leukocyte mediated immunity1.19e-05
LCKGO:0050870positive regulation of T cell activation1.19e-05
LCKGO:1903131mononuclear cell differentiation1.45e-05
LCKGO:0050878regulation of body fluid levels1.48e-05
LCKGO:0038093Fc receptor signaling pathway1.69e-05
LCKGO:0002696positive regulation of leukocyte activation1.91e-05
LCKGO:0050867positive regulation of cell activation2.60e-05
LCKGO:0042060wound healing4.34e-05
LCKGO:0051251positive regulation of lymphocyte activation6.96e-05
LCKGO:0050853B cell receptor signaling pathway6.96e-05
LCKGO:0050730regulation of peptidyl-tyrosine phosphorylation7.56e-05
LCKGO:0002274myeloid leukocyte activation9.70e-05
LCKGO:0045785positive regulation of cell adhesion1.08e-04
LCKGO:0002703regulation of leukocyte mediated immunity1.13e-04
LCKGO:0043368positive T cell selection1.31e-04
LCKGO:0001819positive regulation of cytokine production1.31e-04
LCKGO:0002275myeloid cell activation involved in immune response1.85e-04
LCKGO:0046631alpha-beta T cell activation2.23e-04
LCKGO:0031295T cell costimulation2.47e-04
LCKGO:0050732negative regulation of peptidyl-tyrosine phosphorylation2.62e-04
LCKGO:0031294lymphocyte costimulation2.77e-04
LCKGO:0045088regulation of innate immune response3.03e-04
LCKGO:0050727regulation of inflammatory response3.03e-04
LCKGO:0002366leukocyte activation involved in immune response3.03e-04
LCKGO:0045058T cell selection3.15e-04
LCKGO:0002263cell activation involved in immune response3.15e-04
LCKGO:0030217T cell differentiation3.22e-04
LCKGO:0032943mononuclear cell proliferation3.65e-04
LCKGO:0042098T cell proliferation4.36e-04
LCKGO:0032623interleukin-2 production5.60e-04

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Related Drugs to KHDRBS1_LCK


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning KHDRBS1-LCK and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

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Related Diseases to KHDRBS1_LCK


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate