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	Kinase Fusion Gene Summary
	Kinase Fusion Gene Sample Information
	Kinase Fusion ORF Analysis
	Kinase Fusion Amino Acid Sequences
	Multiple Sequence Alignment of All Fusion Protein Isoforms
	Kinase Fusion Protein Functional Features
	Kinase Fusion Protein Structures
	Comparison of Fusion Protein Isoforms
	Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB
	pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.
	Ramachandran Plot of Kinase Fusion Protein Structure
	Potential Active Site Information
	Virtual Screening Results
	Kinase-Substrate Information
	Related Drugs with This Kinase Fusion Protein
	Related Disease with This Kinase Fusion Protein
	Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:KIAA1549_BRAF

Kinase Fusion Protein Summary

Kinase Fusion gene summary

Kinase Fusion partner gene information	Kinase Fusion gene name: KIAA1549_BRAF
	KinaseFusionDB ID: KFG3017
	FusionGDB2.0 ID: KFG3017
		Hgene	Tgene
	Gene symbol	KIAA1549	BRAF
	Gene ID	57670	673
	Gene name	KIAA1549	B-Raf proto-oncogene, serine/threonine kinase
	Synonyms	RP86	B-RAF1\|B-raf\|BRAF-1\|BRAF1\|NS7\|RAFB1
	Cytomap	7q34	7q34
	Type of gene	protein-coding	protein-coding
	Description	UPF0606 protein KIAA1549	serine/threonine-protein kinase B-raf94 kDa B-raf proteinB-Raf proto-oncogene serine/threonine-protein kinase (p94)B-Raf serine/threonine-proteinmurine sarcoma viral (v-raf) oncogene homolog B1proto-oncogene B-Rafv-raf murine sarcoma viral oncogene
	Modification date	20240331	20240416
	UniProtAcc	Q6ZVL6	P15056
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000242365, ENST00000422774, ENST00000440172,	ENST00000288602,
Context (manual curation of fusion genes in KinaseFusionDB)	PubMed: KIAA1549 [Title/Abstract] AND BRAF [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	KIAA1549(138545884)-BRAF(140487384), # samples:2 KIAA1549(138545885)-BRAF(140481493), # samples:2 KIAA1549(138552720)-BRAF(140487384), # samples:2

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	BRAF	GO:0000165	MAPK cascade	18567582\|29433126
Tgene	BRAF	GO:0006468	protein phosphorylation	17563371
Tgene	BRAF	GO:0007173	epidermal growth factor receptor signaling pathway	18567582
Tgene	BRAF	GO:0010828	positive regulation of glucose transmembrane transport	23010278
Tgene	BRAF	GO:0033138	positive regulation of peptidyl-serine phosphorylation	19667065
Tgene	BRAF	GO:0043066	negative regulation of apoptotic process	19667065
Tgene	BRAF	GO:0070374	positive regulation of ERK1 and ERK2 cascade	22065586
Tgene	BRAF	GO:0071277	cellular response to calcium ion	18567582
Tgene	BRAF	GO:0090150	establishment of protein localization to membrane	23010278

Kinase Fusion gene breakpoints across KIAA1549 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Kinase Fusion gene breakpoints across BRAF (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Kinase Fusion Gene Sample Information

Kinase Fusion gene information.

Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Sample	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
ChimerDB4	TCGA-HT-7691-01A	KIAA1549	chr7	138545885	BRAF	chr7	140487384
ChimerKB3	.	KIAA1549	chr7	138545884	BRAF	chr7	140487384
ChimerKB3	.	KIAA1549	chr7	138545885	BRAF	chr7	140487384
ChiTaRS5.0	AM989472	KIAA1549	chr7	138545884	BRAF	chr7	140487384
ChiTaRS5.0	AM989473	KIAA1549	chr7	138545885	BRAF	chr7	140481493
ChiTaRS5.0	AM989474	KIAA1549	chr7	138552720	BRAF	chr7	140487384
ChimerDB4	AM989472	KIAA1549	chr7	138666064	BRAF	chr7	140434287
ChimerKB3	.	KIAA1549	chr7	138583965	BRAF	chr7	140434287
ChimerKB3	.	KIAA1549	chr7	138666064	BRAF	chr7	140434287
ChiTaRS5.0	FR799512	KIAA1549	chr7	138544110	BRAF	chr7	140492333
ChiTaRS5.0	FR799513	KIAA1549	chr7	138541190	BRAF	chr7	140492018
ChiTaRS5.0	FR799514	KIAA1549	chr7	138545532	BRAF	chr7	140490132
ChiTaRS5.0	FR799516	KIAA1549	chr7	138541952	BRAF	chr7	140492538
ChiTaRS5.0	FR799518	KIAA1549	chr7	138539772	BRAF	chr7	140487424
ChiTaRS5.0	FR799520	KIAA1549	chr7	138537254	BRAF	chr7	140493555
ChiTaRS5.0	FR799521	KIAA1549	chr7	138542582	BRAF	chr7	140490054
ChiTaRS5.0	FR799522	KIAA1549	chr7	138541775	BRAF	chr7	140488738
ChiTaRS5.0	FR799523	KIAA1549	chr7	138538583	BRAF	chr7	140489046
ChiTaRS5.0	FR799524	KIAA1549	chr7	138538411	BRAF	chr7	140490630
ChiTaRS5.0	FR799525	KIAA1549	chr7	138540560	BRAF	chr7	140490044
ChiTaRS5.0	FR799526	KIAA1549	chr7	138539637	BRAF	chr7	140491829
ChiTaRS5.0	FR799529	KIAA1549	chr7	138544115	BRAF	chr7	140489714
ChiTaRS5.0	FR799532	KIAA1549	chr7	138550037	BRAF	chr7	140489963
ChiTaRS5.0	FR799533	KIAA1549	chr7	138552365	BRAF	chr7	140492410
ChiTaRS5.0	FR799534	KIAA1549	chr7	138550566	BRAF	chr7	140487615
ChiTaRS5.0	FR799535	KIAA1549	chr7	138542276	BRAF	chr7	140482786
ChiTaRS5.0	FR799537	KIAA1549	chr7	138524061	BRAF	chr7	140490608
ChiTaRS5.0	FR799541	KIAA1549	chr7	138542759	BRAF	chr7	140492736
ChiTaRS5.0	FR799542	KIAA1549	chr7	138539500	BRAF	chr7	140493176
ChiTaRS5.0	FR799543	KIAA1549	chr7	138541421	BRAF	chr7	140489406
ChiTaRS5.0	FR799546	KIAA1549	chr7	138550325	BRAF	chr7	140489291
ChiTaRS5.0	FR799548	KIAA1549	chr7	138527857	BRAF	chr7	140485789
ChiTaRS5.0	FR799549	KIAA1549	chr7	138547842	BRAF	chr7	140492843
ChiTaRS5.0	FR799550	KIAA1549	chr7	138546892	BRAF	chr7	140489202
COSMIC	1161051	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1161059	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1161062	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1161063	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1161068	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1161070	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1161074	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1202088	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1202089	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1202090	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1202094	KIAA1549	chr7	138529062	BRAF	chr7	140482957
COSMIC	1202095	KIAA1549	chr7	138524878	BRAF	chr7	140487384
COSMIC	1202099	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1202110	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1202114	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1309643	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1309646	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1309647	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1309650	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1549947	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1611077	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1611078	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1611086	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1611097	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1611100	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1611103	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1611112	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1611115	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1611124	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1611132	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1611134	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1611135	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1611136	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1611137	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1611138	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1611143	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1611151	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1611155	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1611163	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1611172	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1611175	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1611190	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1611195	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1611196	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1629607	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1629608	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1629609	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1629610	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1629611	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1629612	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1629613	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1629614	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1629615	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1629616	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1629617	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1629618	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1629619	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1629620	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1629621	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1629622	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1629623	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1629624	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1629629	KIAA1549	chr7	138552721	BRAF	chr7	140481493
COSMIC	1629630	KIAA1549	chr7	138552721	BRAF	chr7	140481493
COSMIC	1629631	KIAA1549	chr7	138552721	BRAF	chr7	140481493
COSMIC	1629632	KIAA1549	chr7	138529062	BRAF	chr7	140482957
COSMIC	1674014	KIAA1549	chr7	138545885	BRAF	chr7	140482957
COSMIC	1742260	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1742261	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1742262	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1742263	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1742264	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1742265	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1742266	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1742267	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1742268	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1742269	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1742270	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1742271	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1742272	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1742273	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	IST-033	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	IST-013	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1962819	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1962820	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1962821	KIAA1549	chr7	138529062	BRAF	chr7	140482957
COSMIC	1962826	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1962845	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	1962850	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	ICGC_PA8	KIAA1549	chr7	138552687	BRAF	chr7	140482957
COSMIC	ICGC_PA9	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	ICGC_PA10	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	ICGC_PA12	KIAA1549	chr7	138529062	BRAF	chr7	140482957
COSMIC	ICGC_PA14	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	ICGC_PA21	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	ICGC_PA22	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	ICGC_PA43	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	ICGC_PA48	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	ICGC_PA59	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	ICGC_PA62	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	ICGC_PA81	KIAA1549	chr7	138529062	BRAF	chr7	140482957
COSMIC	ICGC_PA85	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	ICGC_PA86	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	ICGC_PA88	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	ICGC_PA93	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	ICGC_PA94	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	ICGC_PA95	KIAA1549	chr7	138524878	BRAF	chr7	140487384
COSMIC	ICGC_PA100	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	ICGC_PA105	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	ICGC_PA107	KIAA1549	chr7	138555903	BRAF	chr7	140487384
COSMIC	ICGC_PA162	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	2124011	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	2124032	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	2148932	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	2148933	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	2148934	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	2148935	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	2148936	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	TL049	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	TL051	KIAA1549	chr7	138552721	BRAF	chr7	140487384
COSMIC	TL003B	KIAA1549	chr7	138552721	BRAF	chr7	140487384

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Kinase Fusion ORF Analysis

Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (amino acids)
ENST00000242365	ENST00000288602	KIAA1549	chr7	138552721	BRAF	chr7	140487384	6058	1979
ENST00000242365	ENST00000288602	KIAA1549	chr7	138529062	BRAF	chr7	140482957	6544	2141
ENST00000242365	ENST00000288602	KIAA1549	chr7	138524878	BRAF	chr7	140487384	6727	2202
ENST00000242365	ENST00000288602	KIAA1549	chr7	138552721	BRAF	chr7	140481493	5884	1921
ENST00000242365	ENST00000288602	KIAA1549	chr7	138555903	BRAF	chr7	140487384	5680	1853
ENST00000242365	ENST00000288602	KIAA1549	chr7	138545885	BRAF	chr7	140487384	6376	2085
ENST00000242365	ENST00000288602	KIAA1549	chr7	138545884	BRAF	chr7	140487384	6376	2085
ENST00000242365	ENST00000288602	KIAA1549	chr7	138545885	BRAF	chr7	140481493	6202	2027
ENST00000242365	ENST00000288602	KIAA1549	chr7	138552720	BRAF	chr7	140487384	6058	1979

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Kinase Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

>ENST00000242365_ENST00000288602_KIAA1549_chr7_138552721_BRAF_chr7_140487384_length(amino acids)=1979
MHCTNPALIFLIDELSPEQHNLSLYSMELVLKKSTGHSAAQVALTETAPGSQHSSPLHVTAPPSATTFDTAFFNQGKQTKSTADPSIFVA
TYVSVTSKEVAVNDDEMDNFLPDTHWTTPRMVSPIQYITVSPPGLPREALEPMLTPSLPMVSLQDEEVTSGWQNTTRQPAAYAESASHFH
TFRSAFRTSEGIVPTPGRNLVLYPTDAYSHLSSRTLPEIVASLTEGVETTLFLSSRSLMPQPLGDGITIPLPSLGEVSQPPEEVWATSAD
RYTDVTTVLSQSLEETISPRTYPTVTASHAALAFSRTHSPLLSTPLAFASSASPTDVSSNPFLPSDSSKTSELHSNSALPGPVDNTHILS
PVSSFRPYTWCAACTVPSPQQVLATSLMEKDVGSGDGAETLCMTVLEESSISLMSSVVADFSEFEEDPQVFNTLFPSRPIVPLSSRSMEI
SETSVGISAEVDMSSVTTTQVPPAHGRLSVPASLDPTAGSLSVAETQVTPSSVTTAFFSVITSILLDSSFSVIANKNTPSLAVRDPSVFT
PYSLVPSVESSLFSDQERSSFSEHKPRGALDFASSFFSTPPLELSGSISSPSEAPASLSLMPSDLSPFTSQSFSPLVETFTLFDSSDLQS
SQLSLPSSTNLEFSQLQPSSELPLNTIMLLPSRSEVSPWSSFPSDSLEFVEASTVSLTDSEAHFTSAFIETTSYLESSLISHESAVTALV
PPGSESFDILTAGIQATSPLTTVHTTPILTESSLFSTLTPPDDQISALDGHVSVLASFSKAIPTGTVLITDAYLPSGSSFVSEATPFPLP
TELTVVGPSLTPTEVPLNTSTEVSTTSTGAATGGPLDSTLMGDAASQSPPESSAAPPLPSLRPVTAFTLEATVDTPTLATAKPPYVCDIT
VPDAYLITTVLARRAVQEYIITAIKEVLRIHFNRAVELKVYELFTDFTFLVTSGPFVYTAISVINVLINSKLVRDQTPLILSVKPSFLVP
ESRFQVQTVLQFVPPSVDTGFCNFTQRIEKGLMTALFEVRKHHQGTYNLTVQILNITISSSRVTPRRGPVNIIFAVKSTQGFLNGSEVSE
LLRNLSVVEFSFYLGYPVLQIAEPFQYPQLNLSQLLKSSWVRTVLLGVMEKQLQNEVFQAEMERKLAQLLSEVSTRRRMWRRATVAAGNS
VVQVVNVSRLEGDDNPVQLIYFVEDQDGERLSAVKSSDLINKMDLQRAAIILGYRIQGVIAQPVDRVKRPSPESQSNNLWVIVGVVIPVL
VVMVIVVILYWKLCRTDKLDFQPDTVANIQQRQKLQIPSVKGFDFAKQHLGQHNKDDILIIHEPAPLPGPLKDHTTPSENGDVPSPKSKI
PSKNVRHRGRVSPSDADSTVSEESSERDAGDKTPGAVNDGRSHRAPQSGPPLPSSGNEQHSSASIFEHVDRISRPPEASRRVPSKIQLIA
MQPIPAPPVQRPSPADRVAESNKINKEIQTALRHKSEIEHHRNKIRLRAKRRGHYEFPVVDDLSSGDTKERHRVYRRAQMQIDKILDPTA
SVPSVFIEPRKSSRIKRSPKPRRKHQVNGCPADAEKDRLITTDSDGTYRRPPGVHNSAYIGCPDLIRDQGFRGDGGSTTGLSATPPASLP
GSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQA
FKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHED
LTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPD

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>ENST00000242365_ENST00000288602_KIAA1549_chr7_138529062_BRAF_chr7_140482957_length(amino acids)=2141
MHCTNPALIFLIDELSPEQHNLSLYSMELVLKKSTGHSAAQVALTETAPGSQHSSPLHVTAPPSATTFDTAFFNQGKQTKSTADPSIFVA
TYVSVTSKEVAVNDDEMDNFLPDTHWTTPRMVSPIQYITVSPPGLPREALEPMLTPSLPMVSLQDEEVTSGWQNTTRQPAAYAESASHFH
TFRSAFRTSEGIVPTPGRNLVLYPTDAYSHLSSRTLPEIVASLTEGVETTLFLSSRSLMPQPLGDGITIPLPSLGEVSQPPEEVWATSAD
RYTDVTTVLSQSLEETISPRTYPTVTASHAALAFSRTHSPLLSTPLAFASSASPTDVSSNPFLPSDSSKTSELHSNSALPGPVDNTHILS
PVSSFRPYTWCAACTVPSPQQVLATSLMEKDVGSGDGAETLCMTVLEESSISLMSSVVADFSEFEEDPQVFNTLFPSRPIVPLSSRSMEI
SETSVGISAEVDMSSVTTTQVPPAHGRLSVPASLDPTAGSLSVAETQVTPSSVTTAFFSVITSILLDSSFSVIANKNTPSLAVRDPSVFT
PYSLVPSVESSLFSDQERSSFSEHKPRGALDFASSFFSTPPLELSGSISSPSEAPASLSLMPSDLSPFTSQSFSPLVETFTLFDSSDLQS
SQLSLPSSTNLEFSQLQPSSELPLNTIMLLPSRSEVSPWSSFPSDSLEFVEASTVSLTDSEAHFTSAFIETTSYLESSLISHESAVTALV
PPGSESFDILTAGIQATSPLTTVHTTPILTESSLFSTLTPPDDQISALDGHVSVLASFSKAIPTGTVLITDAYLPSGSSFVSEATPFPLP
TELTVVGPSLTPTEVPLNTSTEVSTTSTGAATGGPLDSTLMGDAASQSPPESSAAPPLPSLRPVTAFTLEATVDTPTLATAKPPYVCDIT
VPDAYLITTVLARRAVQEYIITAIKEVLRIHFNRAVELKVYELFTDFTFLVTSGPFVYTAISVINVLINSKLVRDQTPLILSVKPSFLVP
ESRFQVQTVLQFVPPSVDTGFCNFTQRIEKGLMTALFEVRKHHQGTYNLTVQILNITISSSRVTPRRGPVNIIFAVKSTQGFLNGSEVSE
LLRNLSVVEFSFYLGYPVLQIAEPFQYPQLNLSQLLKSSWVRTVLLGVMEKQLQNEVFQAEMERKLAQLLSEVSTRRRMWRRATVAAGNS
VVQVVNVSRLEGDDNPVQLIYFVEDQDGERLSAVKSSDLINKMDLQRAAIILGYRIQGVIAQPVDRVKRPSPESQSNNLWVIVGVVIPVL
VVMVIVVILYWKLCRTDKLDFQPDTVANIQQRQKLQIPSVKGFDFAKQHLGQHNKDDILIIHEPAPLPGPLKDHTTPSENGDVPSPKSKI
PSKNVRHRGRVSPSDADSTVSEESSERDAGDKTPGAVNDGRSHRAPQSGPPLPSSGNEQHSSASIFEHVDRISRPPEASRRVPSKIQLIA
MQPIPAPPVQRPSPADRVAESNKINKEIQTALRHKSEIEHHRNKIRLRAKRRGHYEFPVVDDLSSGDTKERHRVYRRAQMQIDKILDPTA
SVPSVFIEPRKSSRIKRSPKPRRKHQVNGCPADAEKDRLITTDSDGTYRRPPGVHNSAYIGCPSDPDLPADVQTPSSVELGRYPALPFPA
SQYIPPQPSIEEARQTMHSLLDDAFALVAPSSQPASTAGVGPGVPPGLPANSTPSQEERRATQWGSFYSPAQTANNPCSRYEDYGMTPPT
GPLPRPGFGPGLLQSTELVPPDPQQPQASAEAPFAARGIYSEEMPSVARPRPVGGTTGSTTGLSATPPASLPGSLTNVKALQKSPGPQRE
RKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILL
FMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWS
GSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAE

--------------------------------------------------------------

>ENST00000242365_ENST00000288602_KIAA1549_chr7_138524878_BRAF_chr7_140487384_length(amino acids)=2202
MHCTNPALIFLIDELSPEQHNLSLYSMELVLKKSTGHSAAQVALTETAPGSQHSSPLHVTAPPSATTFDTAFFNQGKQTKSTADPSIFVA
TYVSVTSKEVAVNDDEMDNFLPDTHWTTPRMVSPIQYITVSPPGLPREALEPMLTPSLPMVSLQDEEVTSGWQNTTRQPAAYAESASHFH
TFRSAFRTSEGIVPTPGRNLVLYPTDAYSHLSSRTLPEIVASLTEGVETTLFLSSRSLMPQPLGDGITIPLPSLGEVSQPPEEVWATSAD
RYTDVTTVLSQSLEETISPRTYPTVTASHAALAFSRTHSPLLSTPLAFASSASPTDVSSNPFLPSDSSKTSELHSNSALPGPVDNTHILS
PVSSFRPYTWCAACTVPSPQQVLATSLMEKDVGSGDGAETLCMTVLEESSISLMSSVVADFSEFEEDPQVFNTLFPSRPIVPLSSRSMEI
SETSVGISAEVDMSSVTTTQVPPAHGRLSVPASLDPTAGSLSVAETQVTPSSVTTAFFSVITSILLDSSFSVIANKNTPSLAVRDPSVFT
PYSLVPSVESSLFSDQERSSFSEHKPRGALDFASSFFSTPPLELSGSISSPSEAPASLSLMPSDLSPFTSQSFSPLVETFTLFDSSDLQS
SQLSLPSSTNLEFSQLQPSSELPLNTIMLLPSRSEVSPWSSFPSDSLEFVEASTVSLTDSEAHFTSAFIETTSYLESSLISHESAVTALV
PPGSESFDILTAGIQATSPLTTVHTTPILTESSLFSTLTPPDDQISALDGHVSVLASFSKAIPTGTVLITDAYLPSGSSFVSEATPFPLP
TELTVVGPSLTPTEVPLNTSTEVSTTSTGAATGGPLDSTLMGDAASQSPPESSAAPPLPSLRPVTAFTLEATVDTPTLATAKPPYVCDIT
VPDAYLITTVLARRAVQEYIITAIKEVLRIHFNRAVELKVYELFTDFTFLVTSGPFVYTAISVINVLINSKLVRDQTPLILSVKPSFLVP
ESRFQVQTVLQFVPPSVDTGFCNFTQRIEKGLMTALFEVRKHHQGTYNLTVQILNITISSSRVTPRRGPVNIIFAVKSTQGFLNGSEVSE
LLRNLSVVEFSFYLGYPVLQIAEPFQYPQLNLSQLLKSSWVRTVLLGVMEKQLQNEVFQAEMERKLAQLLSEVSTRRRMWRRATVAAGNS
VVQVVNVSRLEGDDNPVQLIYFVEDQDGERLSAVKSSDLINKMDLQRAAIILGYRIQGVIAQPVDRVKRPSPESQSNNLWVIVGVVIPVL
VVMVIVVILYWKLCRTDKLDFQPDTVANIQQRQKLQIPSVKGFDFAKQHLGQHNKDDILIIHEPAPLPGPLKDHTTPSENGDVPSPKSKI
PSKNVRHRGRVSPSDADSTVSEESSERDAGDKTPGAVNDGRSHRAPQSGPPLPSSGNEQHSSASIFEHVDRISRPPEASRRVPSKIQLIA
MQPIPAPPVQRPSPADRVAESNKINKEIQTALRHKSEIEHHRNKIRLRAKRRGHYEFPVVDDLSSGDTKERHRVYRRAQMQIDKILDPTA
SVPSVFIEPRKSSRIKRSPKPRRKHQVNGCPADAEKDRLITTDSDGTYRRPPGVHNSAYIGCPSDPDLPADVQTPSSVELGRYPALPFPA
SQYIPPQPSIEEARQTMHSLLDDAFALVAPSSQPASTAGVGPGVPPGLPANSTPSQEERRATQWGSFYSPAQTANNPCSRYEDYGMTPPT
GPLPRPGFGPGLLQSTELVPPDPQQPQASAEAPFAARGIYSEEMPSVARPRPVGGTTGSQIQHLTQVGIASRIGAQPVEIPPSRGSQYGG
PGWPSYGEDEAGRREADLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPD
GQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHII
ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYS
FQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKI

--------------------------------------------------------------

>ENST00000242365_ENST00000288602_KIAA1549_chr7_138552721_BRAF_chr7_140481493_length(amino acids)=1921
MHCTNPALIFLIDELSPEQHNLSLYSMELVLKKSTGHSAAQVALTETAPGSQHSSPLHVTAPPSATTFDTAFFNQGKQTKSTADPSIFVA
TYVSVTSKEVAVNDDEMDNFLPDTHWTTPRMVSPIQYITVSPPGLPREALEPMLTPSLPMVSLQDEEVTSGWQNTTRQPAAYAESASHFH
TFRSAFRTSEGIVPTPGRNLVLYPTDAYSHLSSRTLPEIVASLTEGVETTLFLSSRSLMPQPLGDGITIPLPSLGEVSQPPEEVWATSAD
RYTDVTTVLSQSLEETISPRTYPTVTASHAALAFSRTHSPLLSTPLAFASSASPTDVSSNPFLPSDSSKTSELHSNSALPGPVDNTHILS
PVSSFRPYTWCAACTVPSPQQVLATSLMEKDVGSGDGAETLCMTVLEESSISLMSSVVADFSEFEEDPQVFNTLFPSRPIVPLSSRSMEI
SETSVGISAEVDMSSVTTTQVPPAHGRLSVPASLDPTAGSLSVAETQVTPSSVTTAFFSVITSILLDSSFSVIANKNTPSLAVRDPSVFT
PYSLVPSVESSLFSDQERSSFSEHKPRGALDFASSFFSTPPLELSGSISSPSEAPASLSLMPSDLSPFTSQSFSPLVETFTLFDSSDLQS
SQLSLPSSTNLEFSQLQPSSELPLNTIMLLPSRSEVSPWSSFPSDSLEFVEASTVSLTDSEAHFTSAFIETTSYLESSLISHESAVTALV
PPGSESFDILTAGIQATSPLTTVHTTPILTESSLFSTLTPPDDQISALDGHVSVLASFSKAIPTGTVLITDAYLPSGSSFVSEATPFPLP
TELTVVGPSLTPTEVPLNTSTEVSTTSTGAATGGPLDSTLMGDAASQSPPESSAAPPLPSLRPVTAFTLEATVDTPTLATAKPPYVCDIT
VPDAYLITTVLARRAVQEYIITAIKEVLRIHFNRAVELKVYELFTDFTFLVTSGPFVYTAISVINVLINSKLVRDQTPLILSVKPSFLVP
ESRFQVQTVLQFVPPSVDTGFCNFTQRIEKGLMTALFEVRKHHQGTYNLTVQILNITISSSRVTPRRGPVNIIFAVKSTQGFLNGSEVSE
LLRNLSVVEFSFYLGYPVLQIAEPFQYPQLNLSQLLKSSWVRTVLLGVMEKQLQNEVFQAEMERKLAQLLSEVSTRRRMWRRATVAAGNS
VVQVVNVSRLEGDDNPVQLIYFVEDQDGERLSAVKSSDLINKMDLQRAAIILGYRIQGVIAQPVDRVKRPSPESQSNNLWVIVGVVIPVL
VVMVIVVILYWKLCRTDKLDFQPDTVANIQQRQKLQIPSVKGFDFAKQHLGQHNKDDILIIHEPAPLPGPLKDHTTPSENGDVPSPKSKI
PSKNVRHRGRVSPSDADSTVSEESSERDAGDKTPGAVNDGRSHRAPQSGPPLPSSGNEQHSSASIFEHVDRISRPPEASRRVPSKIQLIA
MQPIPAPPVQRPSPADRVAESNKINKEIQTALRHKSEIEHHRNKIRLRAKRRGHYEFPVVDDLSSGDTKERHRVYRRAQMQIDKILDPTA
SVPSVFIEPRKSSRIKRSPKPRRKHQVNGCPADAEKDRLITTDSDGTYRRPPGVHNSAYIGCPKTLGRRDSSDDWEIPDGQITVGQRIGS
GSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLID
IARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIV
LYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNR

--------------------------------------------------------------

>ENST00000242365_ENST00000288602_KIAA1549_chr7_138555903_BRAF_chr7_140487384_length(amino acids)=1853
MHCTNPALIFLIDELSPEQHNLSLYSMELVLKKSTGHSAAQVALTETAPGSQHSSPLHVTAPPSATTFDTAFFNQGKQTKSTADPSIFVA
TYVSVTSKEVAVNDDEMDNFLPDTHWTTPRMVSPIQYITVSPPGLPREALEPMLTPSLPMVSLQDEEVTSGWQNTTRQPAAYAESASHFH
TFRSAFRTSEGIVPTPGRNLVLYPTDAYSHLSSRTLPEIVASLTEGVETTLFLSSRSLMPQPLGDGITIPLPSLGEVSQPPEEVWATSAD
RYTDVTTVLSQSLEETISPRTYPTVTASHAALAFSRTHSPLLSTPLAFASSASPTDVSSNPFLPSDSSKTSELHSNSALPGPVDNTHILS
PVSSFRPYTWCAACTVPSPQQVLATSLMEKDVGSGDGAETLCMTVLEESSISLMSSVVADFSEFEEDPQVFNTLFPSRPIVPLSSRSMEI
SETSVGISAEVDMSSVTTTQVPPAHGRLSVPASLDPTAGSLSVAETQVTPSSVTTAFFSVITSILLDSSFSVIANKNTPSLAVRDPSVFT
PYSLVPSVESSLFSDQERSSFSEHKPRGALDFASSFFSTPPLELSGSISSPSEAPASLSLMPSDLSPFTSQSFSPLVETFTLFDSSDLQS
SQLSLPSSTNLEFSQLQPSSELPLNTIMLLPSRSEVSPWSSFPSDSLEFVEASTVSLTDSEAHFTSAFIETTSYLESSLISHESAVTALV
PPGSESFDILTAGIQATSPLTTVHTTPILTESSLFSTLTPPDDQISALDGHVSVLASFSKAIPTGTVLITDAYLPSGSSFVSEATPFPLP
TELTVVGPSLTPTEVPLNTSTEVSTTSTGAATGGPLDSTLMGDAASQSPPESSAAPPLPSLRPVTAFTLEATVDTPTLATAKPPYVCDIT
VPDAYLITTVLARRAVQEYIITAIKEVLRIHFNRAVELKVYELFTDFTFLVTSGPFVYTAISVINVLINSKLVRDQTPLILSVKPSFLVP
ESRFQVQTVLQFVPPSVDTGFCNFTQRIEKGLMTALFEVRKHHQGTYNLTVQILNITISSSRVTPRRGPVNIIFAVKSTQGFLNGSEVSE
LLRNLSVVEFSFYLGYPVLQIAEPFQYPQLNLSQLLKSSWVRTVLLGVMEKQLQNEVFQAEMERKLAQLLSEVSTRRRMWRRATVAAGNS
VVQVVNVSRLEGDDNPVQLIYFVEDQDGERLSAVKSSDLINKMDLQRAAIILGYRIQGVIAQPVDRVKRPSPESQSNNLWVIVGVVIPVL
VVMVIVVILYWKLCRTDKLDFQPDTVANIQQRQKLQIPSVKGFDFAKQHLGQHNKDDILIIHEPAPLPGPLKDHTTPSENGDVPSPKSKI
PSKNVRHRGRVSPSDADSTVSEESSERDAGDKTPGAVNDGRSHRAPQSGPPLPSSGNEQHSSASIFEHVDRISRPPEASRRVPSKIQLIA
MQPIPAPPVQRPSPADRVAESNKINKEDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGR
RDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCE
GSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPE
VIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILAS

--------------------------------------------------------------

>ENST00000242365_ENST00000288602_KIAA1549_chr7_138545885_BRAF_chr7_140487384_length(amino acids)=2085
MHCTNPALIFLIDELSPEQHNLSLYSMELVLKKSTGHSAAQVALTETAPGSQHSSPLHVTAPPSATTFDTAFFNQGKQTKSTADPSIFVA
TYVSVTSKEVAVNDDEMDNFLPDTHWTTPRMVSPIQYITVSPPGLPREALEPMLTPSLPMVSLQDEEVTSGWQNTTRQPAAYAESASHFH
TFRSAFRTSEGIVPTPGRNLVLYPTDAYSHLSSRTLPEIVASLTEGVETTLFLSSRSLMPQPLGDGITIPLPSLGEVSQPPEEVWATSAD
RYTDVTTVLSQSLEETISPRTYPTVTASHAALAFSRTHSPLLSTPLAFASSASPTDVSSNPFLPSDSSKTSELHSNSALPGPVDNTHILS
PVSSFRPYTWCAACTVPSPQQVLATSLMEKDVGSGDGAETLCMTVLEESSISLMSSVVADFSEFEEDPQVFNTLFPSRPIVPLSSRSMEI
SETSVGISAEVDMSSVTTTQVPPAHGRLSVPASLDPTAGSLSVAETQVTPSSVTTAFFSVITSILLDSSFSVIANKNTPSLAVRDPSVFT
PYSLVPSVESSLFSDQERSSFSEHKPRGALDFASSFFSTPPLELSGSISSPSEAPASLSLMPSDLSPFTSQSFSPLVETFTLFDSSDLQS
SQLSLPSSTNLEFSQLQPSSELPLNTIMLLPSRSEVSPWSSFPSDSLEFVEASTVSLTDSEAHFTSAFIETTSYLESSLISHESAVTALV
PPGSESFDILTAGIQATSPLTTVHTTPILTESSLFSTLTPPDDQISALDGHVSVLASFSKAIPTGTVLITDAYLPSGSSFVSEATPFPLP
TELTVVGPSLTPTEVPLNTSTEVSTTSTGAATGGPLDSTLMGDAASQSPPESSAAPPLPSLRPVTAFTLEATVDTPTLATAKPPYVCDIT
VPDAYLITTVLARRAVQEYIITAIKEVLRIHFNRAVELKVYELFTDFTFLVTSGPFVYTAISVINVLINSKLVRDQTPLILSVKPSFLVP
ESRFQVQTVLQFVPPSVDTGFCNFTQRIEKGLMTALFEVRKHHQGTYNLTVQILNITISSSRVTPRRGPVNIIFAVKSTQGFLNGSEVSE
LLRNLSVVEFSFYLGYPVLQIAEPFQYPQLNLSQLLKSSWVRTVLLGVMEKQLQNEVFQAEMERKLAQLLSEVSTRRRMWRRATVAAGNS
VVQVVNVSRLEGDDNPVQLIYFVEDQDGERLSAVKSSDLINKMDLQRAAIILGYRIQGVIAQPVDRVKRPSPESQSNNLWVIVGVVIPVL
VVMVIVVILYWKLCRTDKLDFQPDTVANIQQRQKLQIPSVKGFDFAKQHLGQHNKDDILIIHEPAPLPGPLKDHTTPSENGDVPSPKSKI
PSKNVRHRGRVSPSDADSTVSEESSERDAGDKTPGAVNDGRSHRAPQSGPPLPSSGNEQHSSASIFEHVDRISRPPEASRRVPSKIQLIA
MQPIPAPPVQRPSPADRVAESNKINKEIQTALRHKSEIEHHRNKIRLRAKRRGHYEFPVVDDLSSGDTKERHRVYRRAQMQIDKILDPTA
SVPSVFIEPRKSSRIKRSPKPRRKHQVNGCPADAEKDRLITTDSDGTYRRPPGVHNSAYIGCPSDPDLPADVQTPSSVELGRYPALPFPA
SQYIPPQPSIEEARQTMHSLLDDAFALVAPSSQPASTAGVGPGVPPGLPANSTPSQEERRATQWGSFYSPAQTANNPCSDLIRDQGFRGD
GGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVA
VKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKS
IIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINN
RDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASP

--------------------------------------------------------------

>ENST00000242365_ENST00000288602_KIAA1549_chr7_138545884_BRAF_chr7_140487384_length(amino acids)=2085
MHCTNPALIFLIDELSPEQHNLSLYSMELVLKKSTGHSAAQVALTETAPGSQHSSPLHVTAPPSATTFDTAFFNQGKQTKSTADPSIFVA
TYVSVTSKEVAVNDDEMDNFLPDTHWTTPRMVSPIQYITVSPPGLPREALEPMLTPSLPMVSLQDEEVTSGWQNTTRQPAAYAESASHFH
TFRSAFRTSEGIVPTPGRNLVLYPTDAYSHLSSRTLPEIVASLTEGVETTLFLSSRSLMPQPLGDGITIPLPSLGEVSQPPEEVWATSAD
RYTDVTTVLSQSLEETISPRTYPTVTASHAALAFSRTHSPLLSTPLAFASSASPTDVSSNPFLPSDSSKTSELHSNSALPGPVDNTHILS
PVSSFRPYTWCAACTVPSPQQVLATSLMEKDVGSGDGAETLCMTVLEESSISLMSSVVADFSEFEEDPQVFNTLFPSRPIVPLSSRSMEI
SETSVGISAEVDMSSVTTTQVPPAHGRLSVPASLDPTAGSLSVAETQVTPSSVTTAFFSVITSILLDSSFSVIANKNTPSLAVRDPSVFT
PYSLVPSVESSLFSDQERSSFSEHKPRGALDFASSFFSTPPLELSGSISSPSEAPASLSLMPSDLSPFTSQSFSPLVETFTLFDSSDLQS
SQLSLPSSTNLEFSQLQPSSELPLNTIMLLPSRSEVSPWSSFPSDSLEFVEASTVSLTDSEAHFTSAFIETTSYLESSLISHESAVTALV
PPGSESFDILTAGIQATSPLTTVHTTPILTESSLFSTLTPPDDQISALDGHVSVLASFSKAIPTGTVLITDAYLPSGSSFVSEATPFPLP
TELTVVGPSLTPTEVPLNTSTEVSTTSTGAATGGPLDSTLMGDAASQSPPESSAAPPLPSLRPVTAFTLEATVDTPTLATAKPPYVCDIT
VPDAYLITTVLARRAVQEYIITAIKEVLRIHFNRAVELKVYELFTDFTFLVTSGPFVYTAISVINVLINSKLVRDQTPLILSVKPSFLVP
ESRFQVQTVLQFVPPSVDTGFCNFTQRIEKGLMTALFEVRKHHQGTYNLTVQILNITISSSRVTPRRGPVNIIFAVKSTQGFLNGSEVSE
LLRNLSVVEFSFYLGYPVLQIAEPFQYPQLNLSQLLKSSWVRTVLLGVMEKQLQNEVFQAEMERKLAQLLSEVSTRRRMWRRATVAAGNS
VVQVVNVSRLEGDDNPVQLIYFVEDQDGERLSAVKSSDLINKMDLQRAAIILGYRIQGVIAQPVDRVKRPSPESQSNNLWVIVGVVIPVL
VVMVIVVILYWKLCRTDKLDFQPDTVANIQQRQKLQIPSVKGFDFAKQHLGQHNKDDILIIHEPAPLPGPLKDHTTPSENGDVPSPKSKI
PSKNVRHRGRVSPSDADSTVSEESSERDAGDKTPGAVNDGRSHRAPQSGPPLPSSGNEQHSSASIFEHVDRISRPPEASRRVPSKIQLIA
MQPIPAPPVQRPSPADRVAESNKINKEIQTALRHKSEIEHHRNKIRLRAKRRGHYEFPVVDDLSSGDTKERHRVYRRAQMQIDKILDPTA
SVPSVFIEPRKSSRIKRSPKPRRKHQVNGCPADAEKDRLITTDSDGTYRRPPGVHNSAYIGCPSDPDLPADVQTPSSVELGRYPALPFPA
SQYIPPQPSIEEARQTMHSLLDDAFALVAPSSQPASTAGVGPGVPPGLPANSTPSQEERRATQWGSFYSPAQTANNPCSDLIRDQGFRGD
GGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVA
VKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKS
IIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINN
RDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASP

--------------------------------------------------------------

>ENST00000242365_ENST00000288602_KIAA1549_chr7_138545885_BRAF_chr7_140481493_length(amino acids)=2027
MHCTNPALIFLIDELSPEQHNLSLYSMELVLKKSTGHSAAQVALTETAPGSQHSSPLHVTAPPSATTFDTAFFNQGKQTKSTADPSIFVA
TYVSVTSKEVAVNDDEMDNFLPDTHWTTPRMVSPIQYITVSPPGLPREALEPMLTPSLPMVSLQDEEVTSGWQNTTRQPAAYAESASHFH
TFRSAFRTSEGIVPTPGRNLVLYPTDAYSHLSSRTLPEIVASLTEGVETTLFLSSRSLMPQPLGDGITIPLPSLGEVSQPPEEVWATSAD
RYTDVTTVLSQSLEETISPRTYPTVTASHAALAFSRTHSPLLSTPLAFASSASPTDVSSNPFLPSDSSKTSELHSNSALPGPVDNTHILS
PVSSFRPYTWCAACTVPSPQQVLATSLMEKDVGSGDGAETLCMTVLEESSISLMSSVVADFSEFEEDPQVFNTLFPSRPIVPLSSRSMEI
SETSVGISAEVDMSSVTTTQVPPAHGRLSVPASLDPTAGSLSVAETQVTPSSVTTAFFSVITSILLDSSFSVIANKNTPSLAVRDPSVFT
PYSLVPSVESSLFSDQERSSFSEHKPRGALDFASSFFSTPPLELSGSISSPSEAPASLSLMPSDLSPFTSQSFSPLVETFTLFDSSDLQS
SQLSLPSSTNLEFSQLQPSSELPLNTIMLLPSRSEVSPWSSFPSDSLEFVEASTVSLTDSEAHFTSAFIETTSYLESSLISHESAVTALV
PPGSESFDILTAGIQATSPLTTVHTTPILTESSLFSTLTPPDDQISALDGHVSVLASFSKAIPTGTVLITDAYLPSGSSFVSEATPFPLP
TELTVVGPSLTPTEVPLNTSTEVSTTSTGAATGGPLDSTLMGDAASQSPPESSAAPPLPSLRPVTAFTLEATVDTPTLATAKPPYVCDIT
VPDAYLITTVLARRAVQEYIITAIKEVLRIHFNRAVELKVYELFTDFTFLVTSGPFVYTAISVINVLINSKLVRDQTPLILSVKPSFLVP
ESRFQVQTVLQFVPPSVDTGFCNFTQRIEKGLMTALFEVRKHHQGTYNLTVQILNITISSSRVTPRRGPVNIIFAVKSTQGFLNGSEVSE
LLRNLSVVEFSFYLGYPVLQIAEPFQYPQLNLSQLLKSSWVRTVLLGVMEKQLQNEVFQAEMERKLAQLLSEVSTRRRMWRRATVAAGNS
VVQVVNVSRLEGDDNPVQLIYFVEDQDGERLSAVKSSDLINKMDLQRAAIILGYRIQGVIAQPVDRVKRPSPESQSNNLWVIVGVVIPVL
VVMVIVVILYWKLCRTDKLDFQPDTVANIQQRQKLQIPSVKGFDFAKQHLGQHNKDDILIIHEPAPLPGPLKDHTTPSENGDVPSPKSKI
PSKNVRHRGRVSPSDADSTVSEESSERDAGDKTPGAVNDGRSHRAPQSGPPLPSSGNEQHSSASIFEHVDRISRPPEASRRVPSKIQLIA
MQPIPAPPVQRPSPADRVAESNKINKEIQTALRHKSEIEHHRNKIRLRAKRRGHYEFPVVDDLSSGDTKERHRVYRRAQMQIDKILDPTA
SVPSVFIEPRKSSRIKRSPKPRRKHQVNGCPADAEKDRLITTDSDGTYRRPPGVHNSAYIGCPSDPDLPADVQTPSSVELGRYPALPFPA
SQYIPPQPSIEEARQTMHSLLDDAFALVAPSSQPASTAGVGPGVPPGLPANSTPSQEERRATQWGSFYSPAQTANNPCSKTLGRRDSSDD
WEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYH
HLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQD
KNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLAR

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>ENST00000242365_ENST00000288602_KIAA1549_chr7_138552720_BRAF_chr7_140487384_length(amino acids)=1979
MHCTNPALIFLIDELSPEQHNLSLYSMELVLKKSTGHSAAQVALTETAPGSQHSSPLHVTAPPSATTFDTAFFNQGKQTKSTADPSIFVA
TYVSVTSKEVAVNDDEMDNFLPDTHWTTPRMVSPIQYITVSPPGLPREALEPMLTPSLPMVSLQDEEVTSGWQNTTRQPAAYAESASHFH
TFRSAFRTSEGIVPTPGRNLVLYPTDAYSHLSSRTLPEIVASLTEGVETTLFLSSRSLMPQPLGDGITIPLPSLGEVSQPPEEVWATSAD
RYTDVTTVLSQSLEETISPRTYPTVTASHAALAFSRTHSPLLSTPLAFASSASPTDVSSNPFLPSDSSKTSELHSNSALPGPVDNTHILS
PVSSFRPYTWCAACTVPSPQQVLATSLMEKDVGSGDGAETLCMTVLEESSISLMSSVVADFSEFEEDPQVFNTLFPSRPIVPLSSRSMEI
SETSVGISAEVDMSSVTTTQVPPAHGRLSVPASLDPTAGSLSVAETQVTPSSVTTAFFSVITSILLDSSFSVIANKNTPSLAVRDPSVFT
PYSLVPSVESSLFSDQERSSFSEHKPRGALDFASSFFSTPPLELSGSISSPSEAPASLSLMPSDLSPFTSQSFSPLVETFTLFDSSDLQS
SQLSLPSSTNLEFSQLQPSSELPLNTIMLLPSRSEVSPWSSFPSDSLEFVEASTVSLTDSEAHFTSAFIETTSYLESSLISHESAVTALV
PPGSESFDILTAGIQATSPLTTVHTTPILTESSLFSTLTPPDDQISALDGHVSVLASFSKAIPTGTVLITDAYLPSGSSFVSEATPFPLP
TELTVVGPSLTPTEVPLNTSTEVSTTSTGAATGGPLDSTLMGDAASQSPPESSAAPPLPSLRPVTAFTLEATVDTPTLATAKPPYVCDIT
VPDAYLITTVLARRAVQEYIITAIKEVLRIHFNRAVELKVYELFTDFTFLVTSGPFVYTAISVINVLINSKLVRDQTPLILSVKPSFLVP
ESRFQVQTVLQFVPPSVDTGFCNFTQRIEKGLMTALFEVRKHHQGTYNLTVQILNITISSSRVTPRRGPVNIIFAVKSTQGFLNGSEVSE
LLRNLSVVEFSFYLGYPVLQIAEPFQYPQLNLSQLLKSSWVRTVLLGVMEKQLQNEVFQAEMERKLAQLLSEVSTRRRMWRRATVAAGNS
VVQVVNVSRLEGDDNPVQLIYFVEDQDGERLSAVKSSDLINKMDLQRAAIILGYRIQGVIAQPVDRVKRPSPESQSNNLWVIVGVVIPVL
VVMVIVVILYWKLCRTDKLDFQPDTVANIQQRQKLQIPSVKGFDFAKQHLGQHNKDDILIIHEPAPLPGPLKDHTTPSENGDVPSPKSKI
PSKNVRHRGRVSPSDADSTVSEESSERDAGDKTPGAVNDGRSHRAPQSGPPLPSSGNEQHSSASIFEHVDRISRPPEASRRVPSKIQLIA
MQPIPAPPVQRPSPADRVAESNKINKEIQTALRHKSEIEHHRNKIRLRAKRRGHYEFPVVDDLSSGDTKERHRVYRRAQMQIDKILDPTA
SVPSVFIEPRKSSRIKRSPKPRRKHQVNGCPADAEKDRLITTDSDGTYRRPPGVHNSAYIGCPDLIRDQGFRGDGGSTTGLSATPPASLP
GSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQA
FKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHED
LTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPD

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:138545884/chr7:140487384)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
KIAA1549 Q6ZVL6	BRAF P15056
	FUNCTION: Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126). Phosphorylates PFKFB2 (PubMed:36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179). {ECO:0000269\|PubMed:1508179, ECO:0000269\|PubMed:21441910, ECO:0000269\|PubMed:29433126, ECO:0000269\|PubMed:36402789, ECO:0000305}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).

Partner

Hgeneene

Hbp

Tgeneene

Tbp

ENST

BPexon

TotalExon

Protein feature loci

BPloci

TotalLen

Feature

Note

- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).

Partner	Hgeneene	Hbp	Tgeneene	Tbp	ENST	BPexon	TotalExon	Protein feature loci	BPloci	TotalLen	Feature	Note
Tgene	KIAA1549	138524878	BRAF	140487384	ENST00000242365	7	18	457_717	380	767	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	KIAA1549	138529062	BRAF	140482957	ENST00000242365	8	18	457_717	392	767	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	KIAA1549	138545884	BRAF	140487384	ENST00000242365	7	18	457_717	380	767	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	KIAA1549	138545885	BRAF	140481493	ENST00000242365	9	18	457_717	438	767	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	KIAA1549	138545885	BRAF	140487384	ENST00000242365	7	18	457_717	380	767	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	KIAA1549	138552720	BRAF	140487384	ENST00000242365	7	18	457_717	380	767	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	KIAA1549	138552721	BRAF	140481493	ENST00000242365	9	18	457_717	438	767	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	KIAA1549	138552721	BRAF	140487384	ENST00000242365	7	18	457_717	380	767	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	KIAA1549	138555903	BRAF	140487384	ENST00000242365	7	18	457_717	380	767	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159

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Kinase Fusion Protein Structures

CIF files of the predicted kinase fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Kinase Fusion protein CIF link (fusion AA seq ID in KinaseFusionDB)	Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	AA seq	Len(AA seq)
PDB file >>>267_KIAA1549_BRAF	ENST00000242365	ENST00000288602	KIAA1549	chr7	138552720	BRAF	chr7	140487384	MHCTNPALIFLIDELSPEQHNLSLYSMELVLKKSTGHSAAQVALTETAPGSQHSSPLHVTAPPSATTFDTAFFNQGKQTKSTADPSIFVA TYVSVTSKEVAVNDDEMDNFLPDTHWTTPRMVSPIQYITVSPPGLPREALEPMLTPSLPMVSLQDEEVTSGWQNTTRQPAAYAESASHFH TFRSAFRTSEGIVPTPGRNLVLYPTDAYSHLSSRTLPEIVASLTEGVETTLFLSSRSLMPQPLGDGITIPLPSLGEVSQPPEEVWATSAD RYTDVTTVLSQSLEETISPRTYPTVTASHAALAFSRTHSPLLSTPLAFASSASPTDVSSNPFLPSDSSKTSELHSNSALPGPVDNTHILS PVSSFRPYTWCAACTVPSPQQVLATSLMEKDVGSGDGAETLCMTVLEESSISLMSSVVADFSEFEEDPQVFNTLFPSRPIVPLSSRSMEI SETSVGISAEVDMSSVTTTQVPPAHGRLSVPASLDPTAGSLSVAETQVTPSSVTTAFFSVITSILLDSSFSVIANKNTPSLAVRDPSVFT PYSLVPSVESSLFSDQERSSFSEHKPRGALDFASSFFSTPPLELSGSISSPSEAPASLSLMPSDLSPFTSQSFSPLVETFTLFDSSDLQS SQLSLPSSTNLEFSQLQPSSELPLNTIMLLPSRSEVSPWSSFPSDSLEFVEASTVSLTDSEAHFTSAFIETTSYLESSLISHESAVTALV PPGSESFDILTAGIQATSPLTTVHTTPILTESSLFSTLTPPDDQISALDGHVSVLASFSKAIPTGTVLITDAYLPSGSSFVSEATPFPLP TELTVVGPSLTPTEVPLNTSTEVSTTSTGAATGGPLDSTLMGDAASQSPPESSAAPPLPSLRPVTAFTLEATVDTPTLATAKPPYVCDIT VPDAYLITTVLARRAVQEYIITAIKEVLRIHFNRAVELKVYELFTDFTFLVTSGPFVYTAISVINVLINSKLVRDQTPLILSVKPSFLVP ESRFQVQTVLQFVPPSVDTGFCNFTQRIEKGLMTALFEVRKHHQGTYNLTVQILNITISSSRVTPRRGPVNIIFAVKSTQGFLNGSEVSE LLRNLSVVEFSFYLGYPVLQIAEPFQYPQLNLSQLLKSSWVRTVLLGVMEKQLQNEVFQAEMERKLAQLLSEVSTRRRMWRRATVAAGNS VVQVVNVSRLEGDDNPVQLIYFVEDQDGERLSAVKSSDLINKMDLQRAAIILGYRIQGVIAQPVDRVKRPSPESQSNNLWVIVGVVIPVL VVMVIVVILYWKLCRTDKLDFQPDTVANIQQRQKLQIPSVKGFDFAKQHLGQHNKDDILIIHEPAPLPGPLKDHTTPSENGDVPSPKSKI PSKNVRHRGRVSPSDADSTVSEESSERDAGDKTPGAVNDGRSHRAPQSGPPLPSSGNEQHSSASIFEHVDRISRPPEASRRVPSKIQLIA MQPIPAPPVQRPSPADRVAESNKINKEIQTALRHKSEIEHHRNKIRLRAKRRGHYEFPVVDDLSSGDTKERHRVYRRAQMQIDKILDPTA SVPSVFIEPRKSSRIKRSPKPRRKHQVNGCPADAEKDRLITTDSDGTYRRPPGVHNSAYIGCPDLIRDQGFRGDGGSTTGLSATPPASLP GSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQA FKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHED LTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPD	1979
3D view using mol* of 267_KIAA1549_BRAF

PDB file >>>TKFP_456_KIAA1549_BRAF	ENST00000242365	ENST00000288602	KIAA1549	chr7	138552721	BRAF	chr7	140487384	MHCTNPALIFLIDELSPEQHNLSLYSMELVLKKSTGHSAAQVALTETAPGSQHSSPLHVTAPPSATTFDTAFFNQGKQTKSTADPSIFVA TYVSVTSKEVAVNDDEMDNFLPDTHWTTPRMVSPIQYITVSPPGLPREALEPMLTPSLPMVSLQDEEVTSGWQNTTRQPAAYAESASHFH TFRSAFRTSEGIVPTPGRNLVLYPTDAYSHLSSRTLPEIVASLTEGVETTLFLSSRSLMPQPLGDGITIPLPSLGEVSQPPEEVWATSAD RYTDVTTVLSQSLEETISPRTYPTVTASHAALAFSRTHSPLLSTPLAFASSASPTDVSSNPFLPSDSSKTSELHSNSALPGPVDNTHILS PVSSFRPYTWCAACTVPSPQQVLATSLMEKDVGSGDGAETLCMTVLEESSISLMSSVVADFSEFEEDPQVFNTLFPSRPIVPLSSRSMEI SETSVGISAEVDMSSVTTTQVPPAHGRLSVPASLDPTAGSLSVAETQVTPSSVTTAFFSVITSILLDSSFSVIANKNTPSLAVRDPSVFT PYSLVPSVESSLFSDQERSSFSEHKPRGALDFASSFFSTPPLELSGSISSPSEAPASLSLMPSDLSPFTSQSFSPLVETFTLFDSSDLQS SQLSLPSSTNLEFSQLQPSSELPLNTIMLLPSRSEVSPWSSFPSDSLEFVEASTVSLTDSEAHFTSAFIETTSYLESSLISHESAVTALV PPGSESFDILTAGIQATSPLTTVHTTPILTESSLFSTLTPPDDQISALDGHVSVLASFSKAIPTGTVLITDAYLPSGSSFVSEATPFPLP TELTVVGPSLTPTEVPLNTSTEVSTTSTGAATGGPLDSTLMGDAASQSPPESSAAPPLPSLRPVTAFTLEATVDTPTLATAKPPYVCDIT VPDAYLITTVLARRAVQEYIITAIKEVLRIHFNRAVELKVYELFTDFTFLVTSGPFVYTAISVINVLINSKLVRDQTPLILSVKPSFLVP ESRFQVQTVLQFVPPSVDTGFCNFTQRIEKGLMTALFEVRKHHQGTYNLTVQILNITISSSRVTPRRGPVNIIFAVKSTQGFLNGSEVSE LLRNLSVVEFSFYLGYPVLQIAEPFQYPQLNLSQLLKSSWVRTVLLGVMEKQLQNEVFQAEMERKLAQLLSEVSTRRRMWRRATVAAGNS VVQVVNVSRLEGDDNPVQLIYFVEDQDGERLSAVKSSDLINKMDLQRAAIILGYRIQGVIAQPVDRVKRPSPESQSNNLWVIVGVVIPVL VVMVIVVILYWKLCRTDKLDFQPDTVANIQQRQKLQIPSVKGFDFAKQHLGQHNKDDILIIHEPAPLPGPLKDHTTPSENGDVPSPKSKI PSKNVRHRGRVSPSDADSTVSEESSERDAGDKTPGAVNDGRSHRAPQSGPPLPSSGNEQHSSASIFEHVDRISRPPEASRRVPSKIQLIA MQPIPAPPVQRPSPADRVAESNKINKEIQTALRHKSEIEHHRNKIRLRAKRRGHYEFPVVDDLSSGDTKERHRVYRRAQMQIDKILDPTA SVPSVFIEPRKSSRIKRSPKPRRKHQVNGCPADAEKDRLITTDSDGTYRRPPGVHNSAYIGCPDLIRDQGFRGDGGSTTGLSATPPASLP GSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQA FKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHED LTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPD	1979_KIAA1549_BRAF
PDB file >>>TKFP_457_KIAA1549_BRAF	ENST00000242365	ENST00000288602	KIAA1549	chr7	138529062	BRAF	chr7	140482957	MHCTNPALIFLIDELSPEQHNLSLYSMELVLKKSTGHSAAQVALTETAPGSQHSSPLHVTAPPSATTFDTAFFNQGKQTKSTADPSIFVA TYVSVTSKEVAVNDDEMDNFLPDTHWTTPRMVSPIQYITVSPPGLPREALEPMLTPSLPMVSLQDEEVTSGWQNTTRQPAAYAESASHFH TFRSAFRTSEGIVPTPGRNLVLYPTDAYSHLSSRTLPEIVASLTEGVETTLFLSSRSLMPQPLGDGITIPLPSLGEVSQPPEEVWATSAD RYTDVTTVLSQSLEETISPRTYPTVTASHAALAFSRTHSPLLSTPLAFASSASPTDVSSNPFLPSDSSKTSELHSNSALPGPVDNTHILS PVSSFRPYTWCAACTVPSPQQVLATSLMEKDVGSGDGAETLCMTVLEESSISLMSSVVADFSEFEEDPQVFNTLFPSRPIVPLSSRSMEI SETSVGISAEVDMSSVTTTQVPPAHGRLSVPASLDPTAGSLSVAETQVTPSSVTTAFFSVITSILLDSSFSVIANKNTPSLAVRDPSVFT PYSLVPSVESSLFSDQERSSFSEHKPRGALDFASSFFSTPPLELSGSISSPSEAPASLSLMPSDLSPFTSQSFSPLVETFTLFDSSDLQS SQLSLPSSTNLEFSQLQPSSELPLNTIMLLPSRSEVSPWSSFPSDSLEFVEASTVSLTDSEAHFTSAFIETTSYLESSLISHESAVTALV PPGSESFDILTAGIQATSPLTTVHTTPILTESSLFSTLTPPDDQISALDGHVSVLASFSKAIPTGTVLITDAYLPSGSSFVSEATPFPLP TELTVVGPSLTPTEVPLNTSTEVSTTSTGAATGGPLDSTLMGDAASQSPPESSAAPPLPSLRPVTAFTLEATVDTPTLATAKPPYVCDIT VPDAYLITTVLARRAVQEYIITAIKEVLRIHFNRAVELKVYELFTDFTFLVTSGPFVYTAISVINVLINSKLVRDQTPLILSVKPSFLVP ESRFQVQTVLQFVPPSVDTGFCNFTQRIEKGLMTALFEVRKHHQGTYNLTVQILNITISSSRVTPRRGPVNIIFAVKSTQGFLNGSEVSE LLRNLSVVEFSFYLGYPVLQIAEPFQYPQLNLSQLLKSSWVRTVLLGVMEKQLQNEVFQAEMERKLAQLLSEVSTRRRMWRRATVAAGNS VVQVVNVSRLEGDDNPVQLIYFVEDQDGERLSAVKSSDLINKMDLQRAAIILGYRIQGVIAQPVDRVKRPSPESQSNNLWVIVGVVIPVL VVMVIVVILYWKLCRTDKLDFQPDTVANIQQRQKLQIPSVKGFDFAKQHLGQHNKDDILIIHEPAPLPGPLKDHTTPSENGDVPSPKSKI PSKNVRHRGRVSPSDADSTVSEESSERDAGDKTPGAVNDGRSHRAPQSGPPLPSSGNEQHSSASIFEHVDRISRPPEASRRVPSKIQLIA MQPIPAPPVQRPSPADRVAESNKINKEIQTALRHKSEIEHHRNKIRLRAKRRGHYEFPVVDDLSSGDTKERHRVYRRAQMQIDKILDPTA SVPSVFIEPRKSSRIKRSPKPRRKHQVNGCPADAEKDRLITTDSDGTYRRPPGVHNSAYIGCPSDPDLPADVQTPSSVELGRYPALPFPA SQYIPPQPSIEEARQTMHSLLDDAFALVAPSSQPASTAGVGPGVPPGLPANSTPSQEERRATQWGSFYSPAQTANNPCSRYEDYGMTPPT GPLPRPGFGPGLLQSTELVPPDPQQPQASAEAPFAARGIYSEEMPSVARPRPVGGTTGSTTGLSATPPASLPGSLTNVKALQKSPGPQRE RKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILL FMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWS GSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAE	2141_KIAA1549_BRAF
3D view using mol* of TKFP_457_KIAA1549_BRAF

PDB file >>>TKFP_458_KIAA1549_BRAF	ENST00000242365	ENST00000288602	KIAA1549	chr7	138524878	BRAF	chr7	140487384	MHCTNPALIFLIDELSPEQHNLSLYSMELVLKKSTGHSAAQVALTETAPGSQHSSPLHVTAPPSATTFDTAFFNQGKQTKSTADPSIFVA TYVSVTSKEVAVNDDEMDNFLPDTHWTTPRMVSPIQYITVSPPGLPREALEPMLTPSLPMVSLQDEEVTSGWQNTTRQPAAYAESASHFH TFRSAFRTSEGIVPTPGRNLVLYPTDAYSHLSSRTLPEIVASLTEGVETTLFLSSRSLMPQPLGDGITIPLPSLGEVSQPPEEVWATSAD RYTDVTTVLSQSLEETISPRTYPTVTASHAALAFSRTHSPLLSTPLAFASSASPTDVSSNPFLPSDSSKTSELHSNSALPGPVDNTHILS PVSSFRPYTWCAACTVPSPQQVLATSLMEKDVGSGDGAETLCMTVLEESSISLMSSVVADFSEFEEDPQVFNTLFPSRPIVPLSSRSMEI SETSVGISAEVDMSSVTTTQVPPAHGRLSVPASLDPTAGSLSVAETQVTPSSVTTAFFSVITSILLDSSFSVIANKNTPSLAVRDPSVFT PYSLVPSVESSLFSDQERSSFSEHKPRGALDFASSFFSTPPLELSGSISSPSEAPASLSLMPSDLSPFTSQSFSPLVETFTLFDSSDLQS SQLSLPSSTNLEFSQLQPSSELPLNTIMLLPSRSEVSPWSSFPSDSLEFVEASTVSLTDSEAHFTSAFIETTSYLESSLISHESAVTALV PPGSESFDILTAGIQATSPLTTVHTTPILTESSLFSTLTPPDDQISALDGHVSVLASFSKAIPTGTVLITDAYLPSGSSFVSEATPFPLP TELTVVGPSLTPTEVPLNTSTEVSTTSTGAATGGPLDSTLMGDAASQSPPESSAAPPLPSLRPVTAFTLEATVDTPTLATAKPPYVCDIT VPDAYLITTVLARRAVQEYIITAIKEVLRIHFNRAVELKVYELFTDFTFLVTSGPFVYTAISVINVLINSKLVRDQTPLILSVKPSFLVP ESRFQVQTVLQFVPPSVDTGFCNFTQRIEKGLMTALFEVRKHHQGTYNLTVQILNITISSSRVTPRRGPVNIIFAVKSTQGFLNGSEVSE LLRNLSVVEFSFYLGYPVLQIAEPFQYPQLNLSQLLKSSWVRTVLLGVMEKQLQNEVFQAEMERKLAQLLSEVSTRRRMWRRATVAAGNS VVQVVNVSRLEGDDNPVQLIYFVEDQDGERLSAVKSSDLINKMDLQRAAIILGYRIQGVIAQPVDRVKRPSPESQSNNLWVIVGVVIPVL VVMVIVVILYWKLCRTDKLDFQPDTVANIQQRQKLQIPSVKGFDFAKQHLGQHNKDDILIIHEPAPLPGPLKDHTTPSENGDVPSPKSKI PSKNVRHRGRVSPSDADSTVSEESSERDAGDKTPGAVNDGRSHRAPQSGPPLPSSGNEQHSSASIFEHVDRISRPPEASRRVPSKIQLIA MQPIPAPPVQRPSPADRVAESNKINKEIQTALRHKSEIEHHRNKIRLRAKRRGHYEFPVVDDLSSGDTKERHRVYRRAQMQIDKILDPTA SVPSVFIEPRKSSRIKRSPKPRRKHQVNGCPADAEKDRLITTDSDGTYRRPPGVHNSAYIGCPSDPDLPADVQTPSSVELGRYPALPFPA SQYIPPQPSIEEARQTMHSLLDDAFALVAPSSQPASTAGVGPGVPPGLPANSTPSQEERRATQWGSFYSPAQTANNPCSRYEDYGMTPPT GPLPRPGFGPGLLQSTELVPPDPQQPQASAEAPFAARGIYSEEMPSVARPRPVGGTTGSQIQHLTQVGIASRIGAQPVEIPPSRGSQYGG PGWPSYGEDEAGRREADLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPD GQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHII ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYS FQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKI	2202_KIAA1549_BRAF
3D view using mol* of TKFP_458_KIAA1549_BRAF

PDB file >>>TKFP_459_KIAA1549_BRAF	ENST00000242365	ENST00000288602	KIAA1549	chr7	138552721	BRAF	chr7	140481493	MHCTNPALIFLIDELSPEQHNLSLYSMELVLKKSTGHSAAQVALTETAPGSQHSSPLHVTAPPSATTFDTAFFNQGKQTKSTADPSIFVA TYVSVTSKEVAVNDDEMDNFLPDTHWTTPRMVSPIQYITVSPPGLPREALEPMLTPSLPMVSLQDEEVTSGWQNTTRQPAAYAESASHFH TFRSAFRTSEGIVPTPGRNLVLYPTDAYSHLSSRTLPEIVASLTEGVETTLFLSSRSLMPQPLGDGITIPLPSLGEVSQPPEEVWATSAD RYTDVTTVLSQSLEETISPRTYPTVTASHAALAFSRTHSPLLSTPLAFASSASPTDVSSNPFLPSDSSKTSELHSNSALPGPVDNTHILS PVSSFRPYTWCAACTVPSPQQVLATSLMEKDVGSGDGAETLCMTVLEESSISLMSSVVADFSEFEEDPQVFNTLFPSRPIVPLSSRSMEI SETSVGISAEVDMSSVTTTQVPPAHGRLSVPASLDPTAGSLSVAETQVTPSSVTTAFFSVITSILLDSSFSVIANKNTPSLAVRDPSVFT PYSLVPSVESSLFSDQERSSFSEHKPRGALDFASSFFSTPPLELSGSISSPSEAPASLSLMPSDLSPFTSQSFSPLVETFTLFDSSDLQS SQLSLPSSTNLEFSQLQPSSELPLNTIMLLPSRSEVSPWSSFPSDSLEFVEASTVSLTDSEAHFTSAFIETTSYLESSLISHESAVTALV PPGSESFDILTAGIQATSPLTTVHTTPILTESSLFSTLTPPDDQISALDGHVSVLASFSKAIPTGTVLITDAYLPSGSSFVSEATPFPLP TELTVVGPSLTPTEVPLNTSTEVSTTSTGAATGGPLDSTLMGDAASQSPPESSAAPPLPSLRPVTAFTLEATVDTPTLATAKPPYVCDIT VPDAYLITTVLARRAVQEYIITAIKEVLRIHFNRAVELKVYELFTDFTFLVTSGPFVYTAISVINVLINSKLVRDQTPLILSVKPSFLVP ESRFQVQTVLQFVPPSVDTGFCNFTQRIEKGLMTALFEVRKHHQGTYNLTVQILNITISSSRVTPRRGPVNIIFAVKSTQGFLNGSEVSE LLRNLSVVEFSFYLGYPVLQIAEPFQYPQLNLSQLLKSSWVRTVLLGVMEKQLQNEVFQAEMERKLAQLLSEVSTRRRMWRRATVAAGNS VVQVVNVSRLEGDDNPVQLIYFVEDQDGERLSAVKSSDLINKMDLQRAAIILGYRIQGVIAQPVDRVKRPSPESQSNNLWVIVGVVIPVL VVMVIVVILYWKLCRTDKLDFQPDTVANIQQRQKLQIPSVKGFDFAKQHLGQHNKDDILIIHEPAPLPGPLKDHTTPSENGDVPSPKSKI PSKNVRHRGRVSPSDADSTVSEESSERDAGDKTPGAVNDGRSHRAPQSGPPLPSSGNEQHSSASIFEHVDRISRPPEASRRVPSKIQLIA MQPIPAPPVQRPSPADRVAESNKINKEIQTALRHKSEIEHHRNKIRLRAKRRGHYEFPVVDDLSSGDTKERHRVYRRAQMQIDKILDPTA SVPSVFIEPRKSSRIKRSPKPRRKHQVNGCPADAEKDRLITTDSDGTYRRPPGVHNSAYIGCPKTLGRRDSSDDWEIPDGQITVGQRIGS GSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLID IARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIV LYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNR	1921_KIAA1549_BRAF
3D view using mol* of TKFP_459_KIAA1549_BRAF

PDB file >>>TKFP_460_KIAA1549_BRAF	ENST00000242365	ENST00000288602	KIAA1549	chr7	138555903	BRAF	chr7	140487384	MHCTNPALIFLIDELSPEQHNLSLYSMELVLKKSTGHSAAQVALTETAPGSQHSSPLHVTAPPSATTFDTAFFNQGKQTKSTADPSIFVA TYVSVTSKEVAVNDDEMDNFLPDTHWTTPRMVSPIQYITVSPPGLPREALEPMLTPSLPMVSLQDEEVTSGWQNTTRQPAAYAESASHFH TFRSAFRTSEGIVPTPGRNLVLYPTDAYSHLSSRTLPEIVASLTEGVETTLFLSSRSLMPQPLGDGITIPLPSLGEVSQPPEEVWATSAD RYTDVTTVLSQSLEETISPRTYPTVTASHAALAFSRTHSPLLSTPLAFASSASPTDVSSNPFLPSDSSKTSELHSNSALPGPVDNTHILS PVSSFRPYTWCAACTVPSPQQVLATSLMEKDVGSGDGAETLCMTVLEESSISLMSSVVADFSEFEEDPQVFNTLFPSRPIVPLSSRSMEI SETSVGISAEVDMSSVTTTQVPPAHGRLSVPASLDPTAGSLSVAETQVTPSSVTTAFFSVITSILLDSSFSVIANKNTPSLAVRDPSVFT PYSLVPSVESSLFSDQERSSFSEHKPRGALDFASSFFSTPPLELSGSISSPSEAPASLSLMPSDLSPFTSQSFSPLVETFTLFDSSDLQS SQLSLPSSTNLEFSQLQPSSELPLNTIMLLPSRSEVSPWSSFPSDSLEFVEASTVSLTDSEAHFTSAFIETTSYLESSLISHESAVTALV PPGSESFDILTAGIQATSPLTTVHTTPILTESSLFSTLTPPDDQISALDGHVSVLASFSKAIPTGTVLITDAYLPSGSSFVSEATPFPLP TELTVVGPSLTPTEVPLNTSTEVSTTSTGAATGGPLDSTLMGDAASQSPPESSAAPPLPSLRPVTAFTLEATVDTPTLATAKPPYVCDIT VPDAYLITTVLARRAVQEYIITAIKEVLRIHFNRAVELKVYELFTDFTFLVTSGPFVYTAISVINVLINSKLVRDQTPLILSVKPSFLVP ESRFQVQTVLQFVPPSVDTGFCNFTQRIEKGLMTALFEVRKHHQGTYNLTVQILNITISSSRVTPRRGPVNIIFAVKSTQGFLNGSEVSE LLRNLSVVEFSFYLGYPVLQIAEPFQYPQLNLSQLLKSSWVRTVLLGVMEKQLQNEVFQAEMERKLAQLLSEVSTRRRMWRRATVAAGNS VVQVVNVSRLEGDDNPVQLIYFVEDQDGERLSAVKSSDLINKMDLQRAAIILGYRIQGVIAQPVDRVKRPSPESQSNNLWVIVGVVIPVL VVMVIVVILYWKLCRTDKLDFQPDTVANIQQRQKLQIPSVKGFDFAKQHLGQHNKDDILIIHEPAPLPGPLKDHTTPSENGDVPSPKSKI PSKNVRHRGRVSPSDADSTVSEESSERDAGDKTPGAVNDGRSHRAPQSGPPLPSSGNEQHSSASIFEHVDRISRPPEASRRVPSKIQLIA MQPIPAPPVQRPSPADRVAESNKINKEDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGR RDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCE GSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPE VIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILAS	1853_KIAA1549_BRAF
3D view using mol* of TKFP_460_KIAA1549_BRAF

PDB file >>>TKFP_461_KIAA1549_BRAF	ENST00000242365	ENST00000288602	KIAA1549	chr7	138545885	BRAF	chr7	140487384	MHCTNPALIFLIDELSPEQHNLSLYSMELVLKKSTGHSAAQVALTETAPGSQHSSPLHVTAPPSATTFDTAFFNQGKQTKSTADPSIFVA TYVSVTSKEVAVNDDEMDNFLPDTHWTTPRMVSPIQYITVSPPGLPREALEPMLTPSLPMVSLQDEEVTSGWQNTTRQPAAYAESASHFH TFRSAFRTSEGIVPTPGRNLVLYPTDAYSHLSSRTLPEIVASLTEGVETTLFLSSRSLMPQPLGDGITIPLPSLGEVSQPPEEVWATSAD RYTDVTTVLSQSLEETISPRTYPTVTASHAALAFSRTHSPLLSTPLAFASSASPTDVSSNPFLPSDSSKTSELHSNSALPGPVDNTHILS PVSSFRPYTWCAACTVPSPQQVLATSLMEKDVGSGDGAETLCMTVLEESSISLMSSVVADFSEFEEDPQVFNTLFPSRPIVPLSSRSMEI SETSVGISAEVDMSSVTTTQVPPAHGRLSVPASLDPTAGSLSVAETQVTPSSVTTAFFSVITSILLDSSFSVIANKNTPSLAVRDPSVFT PYSLVPSVESSLFSDQERSSFSEHKPRGALDFASSFFSTPPLELSGSISSPSEAPASLSLMPSDLSPFTSQSFSPLVETFTLFDSSDLQS SQLSLPSSTNLEFSQLQPSSELPLNTIMLLPSRSEVSPWSSFPSDSLEFVEASTVSLTDSEAHFTSAFIETTSYLESSLISHESAVTALV PPGSESFDILTAGIQATSPLTTVHTTPILTESSLFSTLTPPDDQISALDGHVSVLASFSKAIPTGTVLITDAYLPSGSSFVSEATPFPLP TELTVVGPSLTPTEVPLNTSTEVSTTSTGAATGGPLDSTLMGDAASQSPPESSAAPPLPSLRPVTAFTLEATVDTPTLATAKPPYVCDIT VPDAYLITTVLARRAVQEYIITAIKEVLRIHFNRAVELKVYELFTDFTFLVTSGPFVYTAISVINVLINSKLVRDQTPLILSVKPSFLVP ESRFQVQTVLQFVPPSVDTGFCNFTQRIEKGLMTALFEVRKHHQGTYNLTVQILNITISSSRVTPRRGPVNIIFAVKSTQGFLNGSEVSE LLRNLSVVEFSFYLGYPVLQIAEPFQYPQLNLSQLLKSSWVRTVLLGVMEKQLQNEVFQAEMERKLAQLLSEVSTRRRMWRRATVAAGNS VVQVVNVSRLEGDDNPVQLIYFVEDQDGERLSAVKSSDLINKMDLQRAAIILGYRIQGVIAQPVDRVKRPSPESQSNNLWVIVGVVIPVL VVMVIVVILYWKLCRTDKLDFQPDTVANIQQRQKLQIPSVKGFDFAKQHLGQHNKDDILIIHEPAPLPGPLKDHTTPSENGDVPSPKSKI PSKNVRHRGRVSPSDADSTVSEESSERDAGDKTPGAVNDGRSHRAPQSGPPLPSSGNEQHSSASIFEHVDRISRPPEASRRVPSKIQLIA MQPIPAPPVQRPSPADRVAESNKINKEIQTALRHKSEIEHHRNKIRLRAKRRGHYEFPVVDDLSSGDTKERHRVYRRAQMQIDKILDPTA SVPSVFIEPRKSSRIKRSPKPRRKHQVNGCPADAEKDRLITTDSDGTYRRPPGVHNSAYIGCPSDPDLPADVQTPSSVELGRYPALPFPA SQYIPPQPSIEEARQTMHSLLDDAFALVAPSSQPASTAGVGPGVPPGLPANSTPSQEERRATQWGSFYSPAQTANNPCSDLIRDQGFRGD GGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVA VKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKS IIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINN RDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASP	2085_KIAA1549_BRAF
3D view using mol* of TKFP_461_KIAA1549_BRAF

PDB file >>>TKFP_462_KIAA1549_BRAF	ENST00000242365	ENST00000288602	KIAA1549	chr7	138545884	BRAF	chr7	140487384	MHCTNPALIFLIDELSPEQHNLSLYSMELVLKKSTGHSAAQVALTETAPGSQHSSPLHVTAPPSATTFDTAFFNQGKQTKSTADPSIFVA TYVSVTSKEVAVNDDEMDNFLPDTHWTTPRMVSPIQYITVSPPGLPREALEPMLTPSLPMVSLQDEEVTSGWQNTTRQPAAYAESASHFH TFRSAFRTSEGIVPTPGRNLVLYPTDAYSHLSSRTLPEIVASLTEGVETTLFLSSRSLMPQPLGDGITIPLPSLGEVSQPPEEVWATSAD RYTDVTTVLSQSLEETISPRTYPTVTASHAALAFSRTHSPLLSTPLAFASSASPTDVSSNPFLPSDSSKTSELHSNSALPGPVDNTHILS PVSSFRPYTWCAACTVPSPQQVLATSLMEKDVGSGDGAETLCMTVLEESSISLMSSVVADFSEFEEDPQVFNTLFPSRPIVPLSSRSMEI SETSVGISAEVDMSSVTTTQVPPAHGRLSVPASLDPTAGSLSVAETQVTPSSVTTAFFSVITSILLDSSFSVIANKNTPSLAVRDPSVFT PYSLVPSVESSLFSDQERSSFSEHKPRGALDFASSFFSTPPLELSGSISSPSEAPASLSLMPSDLSPFTSQSFSPLVETFTLFDSSDLQS SQLSLPSSTNLEFSQLQPSSELPLNTIMLLPSRSEVSPWSSFPSDSLEFVEASTVSLTDSEAHFTSAFIETTSYLESSLISHESAVTALV PPGSESFDILTAGIQATSPLTTVHTTPILTESSLFSTLTPPDDQISALDGHVSVLASFSKAIPTGTVLITDAYLPSGSSFVSEATPFPLP TELTVVGPSLTPTEVPLNTSTEVSTTSTGAATGGPLDSTLMGDAASQSPPESSAAPPLPSLRPVTAFTLEATVDTPTLATAKPPYVCDIT VPDAYLITTVLARRAVQEYIITAIKEVLRIHFNRAVELKVYELFTDFTFLVTSGPFVYTAISVINVLINSKLVRDQTPLILSVKPSFLVP ESRFQVQTVLQFVPPSVDTGFCNFTQRIEKGLMTALFEVRKHHQGTYNLTVQILNITISSSRVTPRRGPVNIIFAVKSTQGFLNGSEVSE LLRNLSVVEFSFYLGYPVLQIAEPFQYPQLNLSQLLKSSWVRTVLLGVMEKQLQNEVFQAEMERKLAQLLSEVSTRRRMWRRATVAAGNS VVQVVNVSRLEGDDNPVQLIYFVEDQDGERLSAVKSSDLINKMDLQRAAIILGYRIQGVIAQPVDRVKRPSPESQSNNLWVIVGVVIPVL VVMVIVVILYWKLCRTDKLDFQPDTVANIQQRQKLQIPSVKGFDFAKQHLGQHNKDDILIIHEPAPLPGPLKDHTTPSENGDVPSPKSKI PSKNVRHRGRVSPSDADSTVSEESSERDAGDKTPGAVNDGRSHRAPQSGPPLPSSGNEQHSSASIFEHVDRISRPPEASRRVPSKIQLIA MQPIPAPPVQRPSPADRVAESNKINKEIQTALRHKSEIEHHRNKIRLRAKRRGHYEFPVVDDLSSGDTKERHRVYRRAQMQIDKILDPTA SVPSVFIEPRKSSRIKRSPKPRRKHQVNGCPADAEKDRLITTDSDGTYRRPPGVHNSAYIGCPSDPDLPADVQTPSSVELGRYPALPFPA SQYIPPQPSIEEARQTMHSLLDDAFALVAPSSQPASTAGVGPGVPPGLPANSTPSQEERRATQWGSFYSPAQTANNPCSDLIRDQGFRGD GGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVA VKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKS IIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINN RDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASP	2085_KIAA1549_BRAF
PDB file >>>TKFP_463_KIAA1549_BRAF	ENST00000242365	ENST00000288602	KIAA1549	chr7	138545885	BRAF	chr7	140481493	MHCTNPALIFLIDELSPEQHNLSLYSMELVLKKSTGHSAAQVALTETAPGSQHSSPLHVTAPPSATTFDTAFFNQGKQTKSTADPSIFVA TYVSVTSKEVAVNDDEMDNFLPDTHWTTPRMVSPIQYITVSPPGLPREALEPMLTPSLPMVSLQDEEVTSGWQNTTRQPAAYAESASHFH TFRSAFRTSEGIVPTPGRNLVLYPTDAYSHLSSRTLPEIVASLTEGVETTLFLSSRSLMPQPLGDGITIPLPSLGEVSQPPEEVWATSAD RYTDVTTVLSQSLEETISPRTYPTVTASHAALAFSRTHSPLLSTPLAFASSASPTDVSSNPFLPSDSSKTSELHSNSALPGPVDNTHILS PVSSFRPYTWCAACTVPSPQQVLATSLMEKDVGSGDGAETLCMTVLEESSISLMSSVVADFSEFEEDPQVFNTLFPSRPIVPLSSRSMEI SETSVGISAEVDMSSVTTTQVPPAHGRLSVPASLDPTAGSLSVAETQVTPSSVTTAFFSVITSILLDSSFSVIANKNTPSLAVRDPSVFT PYSLVPSVESSLFSDQERSSFSEHKPRGALDFASSFFSTPPLELSGSISSPSEAPASLSLMPSDLSPFTSQSFSPLVETFTLFDSSDLQS SQLSLPSSTNLEFSQLQPSSELPLNTIMLLPSRSEVSPWSSFPSDSLEFVEASTVSLTDSEAHFTSAFIETTSYLESSLISHESAVTALV PPGSESFDILTAGIQATSPLTTVHTTPILTESSLFSTLTPPDDQISALDGHVSVLASFSKAIPTGTVLITDAYLPSGSSFVSEATPFPLP TELTVVGPSLTPTEVPLNTSTEVSTTSTGAATGGPLDSTLMGDAASQSPPESSAAPPLPSLRPVTAFTLEATVDTPTLATAKPPYVCDIT VPDAYLITTVLARRAVQEYIITAIKEVLRIHFNRAVELKVYELFTDFTFLVTSGPFVYTAISVINVLINSKLVRDQTPLILSVKPSFLVP ESRFQVQTVLQFVPPSVDTGFCNFTQRIEKGLMTALFEVRKHHQGTYNLTVQILNITISSSRVTPRRGPVNIIFAVKSTQGFLNGSEVSE LLRNLSVVEFSFYLGYPVLQIAEPFQYPQLNLSQLLKSSWVRTVLLGVMEKQLQNEVFQAEMERKLAQLLSEVSTRRRMWRRATVAAGNS VVQVVNVSRLEGDDNPVQLIYFVEDQDGERLSAVKSSDLINKMDLQRAAIILGYRIQGVIAQPVDRVKRPSPESQSNNLWVIVGVVIPVL VVMVIVVILYWKLCRTDKLDFQPDTVANIQQRQKLQIPSVKGFDFAKQHLGQHNKDDILIIHEPAPLPGPLKDHTTPSENGDVPSPKSKI PSKNVRHRGRVSPSDADSTVSEESSERDAGDKTPGAVNDGRSHRAPQSGPPLPSSGNEQHSSASIFEHVDRISRPPEASRRVPSKIQLIA MQPIPAPPVQRPSPADRVAESNKINKEIQTALRHKSEIEHHRNKIRLRAKRRGHYEFPVVDDLSSGDTKERHRVYRRAQMQIDKILDPTA SVPSVFIEPRKSSRIKRSPKPRRKHQVNGCPADAEKDRLITTDSDGTYRRPPGVHNSAYIGCPSDPDLPADVQTPSSVELGRYPALPFPA SQYIPPQPSIEEARQTMHSLLDDAFALVAPSSQPASTAGVGPGVPPGLPANSTPSQEERRATQWGSFYSPAQTANNPCSKTLGRRDSSDD WEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYH HLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQD KNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLAR	2027_KIAA1549_BRAF
3D view using mol* of TKFP_463_KIAA1549_BRAF

PDB file >>>TKFP_464_KIAA1549_BRAF	ENST00000242365	ENST00000288602	KIAA1549	chr7	138552720	BRAF	chr7	140487384	MHCTNPALIFLIDELSPEQHNLSLYSMELVLKKSTGHSAAQVALTETAPGSQHSSPLHVTAPPSATTFDTAFFNQGKQTKSTADPSIFVA TYVSVTSKEVAVNDDEMDNFLPDTHWTTPRMVSPIQYITVSPPGLPREALEPMLTPSLPMVSLQDEEVTSGWQNTTRQPAAYAESASHFH TFRSAFRTSEGIVPTPGRNLVLYPTDAYSHLSSRTLPEIVASLTEGVETTLFLSSRSLMPQPLGDGITIPLPSLGEVSQPPEEVWATSAD RYTDVTTVLSQSLEETISPRTYPTVTASHAALAFSRTHSPLLSTPLAFASSASPTDVSSNPFLPSDSSKTSELHSNSALPGPVDNTHILS PVSSFRPYTWCAACTVPSPQQVLATSLMEKDVGSGDGAETLCMTVLEESSISLMSSVVADFSEFEEDPQVFNTLFPSRPIVPLSSRSMEI SETSVGISAEVDMSSVTTTQVPPAHGRLSVPASLDPTAGSLSVAETQVTPSSVTTAFFSVITSILLDSSFSVIANKNTPSLAVRDPSVFT PYSLVPSVESSLFSDQERSSFSEHKPRGALDFASSFFSTPPLELSGSISSPSEAPASLSLMPSDLSPFTSQSFSPLVETFTLFDSSDLQS SQLSLPSSTNLEFSQLQPSSELPLNTIMLLPSRSEVSPWSSFPSDSLEFVEASTVSLTDSEAHFTSAFIETTSYLESSLISHESAVTALV PPGSESFDILTAGIQATSPLTTVHTTPILTESSLFSTLTPPDDQISALDGHVSVLASFSKAIPTGTVLITDAYLPSGSSFVSEATPFPLP TELTVVGPSLTPTEVPLNTSTEVSTTSTGAATGGPLDSTLMGDAASQSPPESSAAPPLPSLRPVTAFTLEATVDTPTLATAKPPYVCDIT VPDAYLITTVLARRAVQEYIITAIKEVLRIHFNRAVELKVYELFTDFTFLVTSGPFVYTAISVINVLINSKLVRDQTPLILSVKPSFLVP ESRFQVQTVLQFVPPSVDTGFCNFTQRIEKGLMTALFEVRKHHQGTYNLTVQILNITISSSRVTPRRGPVNIIFAVKSTQGFLNGSEVSE LLRNLSVVEFSFYLGYPVLQIAEPFQYPQLNLSQLLKSSWVRTVLLGVMEKQLQNEVFQAEMERKLAQLLSEVSTRRRMWRRATVAAGNS VVQVVNVSRLEGDDNPVQLIYFVEDQDGERLSAVKSSDLINKMDLQRAAIILGYRIQGVIAQPVDRVKRPSPESQSNNLWVIVGVVIPVL VVMVIVVILYWKLCRTDKLDFQPDTVANIQQRQKLQIPSVKGFDFAKQHLGQHNKDDILIIHEPAPLPGPLKDHTTPSENGDVPSPKSKI PSKNVRHRGRVSPSDADSTVSEESSERDAGDKTPGAVNDGRSHRAPQSGPPLPSSGNEQHSSASIFEHVDRISRPPEASRRVPSKIQLIA MQPIPAPPVQRPSPADRVAESNKINKEIQTALRHKSEIEHHRNKIRLRAKRRGHYEFPVVDDLSSGDTKERHRVYRRAQMQIDKILDPTA SVPSVFIEPRKSSRIKRSPKPRRKHQVNGCPADAEKDRLITTDSDGTYRRPPGVHNSAYIGCPDLIRDQGFRGDGGSTTGLSATPPASLP GSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQA FKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHED LTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPD	1979_KIAA1549_BRAF

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Comparison of Fusion Protein Isoforms

Superimpose the 3D Structures Among All Fusion Protein Isoforms
* Download the pdb file and open it from the molstar online viewer.

3D view using mol* of viewer/superimpose_isoforms/TKFP_456_KIAA1549_BRAF_vs_TKFP_457_KIAA1549_BRAF_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_456_KIAA1549_BRAF_vs_TKFP_458_KIAA1549_BRAF_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_456_KIAA1549_BRAF_vs_TKFP_459_KIAA1549_BRAF_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_456_KIAA1549_BRAF_vs_TKFP_460_KIAA1549_BRAF_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_456_KIAA1549_BRAF_vs_TKFP_461_KIAA1549_BRAF_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_456_KIAA1549_BRAF_vs_TKFP_463_KIAA1549_BRAF_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_457_KIAA1549_BRAF_vs_TKFP_458_KIAA1549_BRAF_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_457_KIAA1549_BRAF_vs_TKFP_459_KIAA1549_BRAF_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_457_KIAA1549_BRAF_vs_TKFP_460_KIAA1549_BRAF_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_457_KIAA1549_BRAF_vs_TKFP_461_KIAA1549_BRAF_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_457_KIAA1549_BRAF_vs_TKFP_463_KIAA1549_BRAF_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_458_KIAA1549_BRAF_vs_TKFP_459_KIAA1549_BRAF_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_458_KIAA1549_BRAF_vs_TKFP_460_KIAA1549_BRAF_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_458_KIAA1549_BRAF_vs_TKFP_461_KIAA1549_BRAF_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_458_KIAA1549_BRAF_vs_TKFP_463_KIAA1549_BRAF_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_459_KIAA1549_BRAF_vs_TKFP_460_KIAA1549_BRAF_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_459_KIAA1549_BRAF_vs_TKFP_461_KIAA1549_BRAF_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_459_KIAA1549_BRAF_vs_TKFP_463_KIAA1549_BRAF_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_460_KIAA1549_BRAF_vs_TKFP_461_KIAA1549_BRAF_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_460_KIAA1549_BRAF_vs_TKFP_463_KIAA1549_BRAF_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_461_KIAA1549_BRAF_vs_TKFP_463_KIAA1549_BRAF_superimposed.pdb.html

Comparison of the Secondary Structures of Fusion Protein Isoforms

./secondary_str/TKFP_456_KIAA1549_BRAF_vs_TKFP_457_KIAA1549_BRAF.png

./secondary_str/TKFP_456_KIAA1549_BRAF_vs_TKFP_460_KIAA1549_BRAF.png

./secondary_str/TKFP_457_KIAA1549_BRAF_vs_TKFP_460_KIAA1549_BRAF.png

./secondary_str/TKFP_458_KIAA1549_BRAF_vs_TKFP_456_KIAA1549_BRAF.png

./secondary_str/TKFP_458_KIAA1549_BRAF_vs_TKFP_457_KIAA1549_BRAF.png

./secondary_str/TKFP_458_KIAA1549_BRAF_vs_TKFP_459_KIAA1549_BRAF.png

./secondary_str/TKFP_458_KIAA1549_BRAF_vs_TKFP_460_KIAA1549_BRAF.png

./secondary_str/TKFP_458_KIAA1549_BRAF_vs_TKFP_461_KIAA1549_BRAF.png

./secondary_str/TKFP_458_KIAA1549_BRAF_vs_TKFP_463_KIAA1549_BRAF.png

./secondary_str/TKFP_459_KIAA1549_BRAF_vs_TKFP_456_KIAA1549_BRAF.png

./secondary_str/TKFP_459_KIAA1549_BRAF_vs_TKFP_457_KIAA1549_BRAF.png

./secondary_str/TKFP_459_KIAA1549_BRAF_vs_TKFP_460_KIAA1549_BRAF.png

./secondary_str/TKFP_461_KIAA1549_BRAF_vs_TKFP_456_KIAA1549_BRAF.png

./secondary_str/TKFP_461_KIAA1549_BRAF_vs_TKFP_457_KIAA1549_BRAF.png

./secondary_str/TKFP_461_KIAA1549_BRAF_vs_TKFP_459_KIAA1549_BRAF.png

./secondary_str/TKFP_461_KIAA1549_BRAF_vs_TKFP_460_KIAA1549_BRAF.png

./secondary_str/TKFP_461_KIAA1549_BRAF_vs_TKFP_463_KIAA1549_BRAF.png

./secondary_str/TKFP_463_KIAA1549_BRAF_vs_TKFP_456_KIAA1549_BRAF.png

./secondary_str/TKFP_463_KIAA1549_BRAF_vs_TKFP_457_KIAA1549_BRAF.png

./secondary_str/TKFP_463_KIAA1549_BRAF_vs_TKFP_459_KIAA1549_BRAF.png

./secondary_str/TKFP_463_KIAA1549_BRAF_vs_TKFP_460_KIAA1549_BRAF.png

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

KIAA1549_BRAF does not have any known PDB structures.

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pLDDT score distribution

all_data/KinaseFusionDB_T_Results/KinaseFusionDB_T_ViolinPlots/TKFP_457_KIAA1549_BRAF_updated_violin_plot.pngall_data/KinaseFusionDB_T_Results/KinaseFusionDB_T_ViolinPlots/TKFP_458_KIAA1549_BRAF_updated_violin_plot.pngall_data/KinaseFusionDB_T_Results/KinaseFusionDB_T_ViolinPlots/TKFP_459_KIAA1549_BRAF_updated_violin_plot.pngall_data/KinaseFusionDB_T_Results/KinaseFusionDB_T_ViolinPlots/TKFP_460_KIAA1549_BRAF_updated_violin_plot.pngall_data/KinaseFusionDB_T_Results/KinaseFusionDB_T_ViolinPlots/TKFP_461_KIAA1549_BRAF_updated_violin_plot.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
* The blue color at the bottom marks the best active site residues.

TKFP_457_KIAA1549_BRAF.png

TKFP_458_KIAA1549_BRAF.png

TKFP_459_KIAA1549_BRAF.png

TKFP_460_KIAA1549_BRAF.png

TKFP_461_KIAA1549_BRAF.png

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Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Kinase Fusion AA seq ID in KinaseFusionDB	Site score	Size	Dscore	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
TKFP_457_KIAA1549_BRAF	1.045	350	1.063	1073.247	0.55	0.761	1.017	0.707	1.024	0.69	0.833	Chain A: 1162,1822,1838,1839,1840,1841,1842,1843,1 844,1846,1856,1858,1860,1862,1865,1869,1872,1873,1 874,1875,1876,1877,1878,1879,1880,1881,1882,1889,1 894,1900,1902,1904,1905,1906,1907,1908,1909,1910,1 950,1951,1952,1953,1956,1958,1968,1969,1970,1971,1 972,1973,1974,1975,1978,1979,1982,1984,1986,1987,1 988,1989,1990,1991,1994,1995,1996,1999,2002,2008,2 012,2013,2016
TKFP_458_KIAA1549_BRAF	1.108	153	1.15	416.745	0.522	0.795	1.014	1.34	0.819	1.637	0.781	Chain A: 1899,1900,1902,1903,1904,1907,1917,1919,1 941,1950,1952,1963,1965,1966,1967,1968,1970,1971,2 010,2011,2012,2014,2016,2017,2019,2029,2030,2031,2 032,2033,2034,2037,2051,2052,2069
TKFP_459_KIAA1549_BRAF	1.056	365	1.093	979.265	0.569	0.739	0.961	0.907	0.891	1.018	1.1	Chain A: 1053,1618,1619,1620,1621,1622,1623,1624,1 626,1636,1638,1641,1642,1648,1649,1652,1660,1663,1 668,1669,1670,1671,1682,1684,1685,1686,1687,1688,1 689,1690,1691,1729,1730,1731,1732,1733,1735,1736,1 738,1748,1749,1750,1752,1753,1754,1755,1756,1757,1 758,1759,1760,1761,1763,1764,1765,1766,1767,1768,1 769,1770,1771,1774,1775,1776,1779,1782,1784,1785,1 786,1787,1788,1792,1793,1795,1796
TKFP_460_KIAA1549_BRAF	1.053	382	1.081	1032.087	0.534	0.751	0.99	0.751	0.95	0.791	1.144	Chain A: 1052,1053,1054,1055,1550,1551,1552,1553,1 554,1555,1556,1558,1568,1570,1573,1574,1580,1581,1 584,1592,1601,1603,1614,1616,1617,1618,1619,1620,1 621,1622,1623,1662,1663,1664,1665,1668,1670,1671,1 672,1680,1681,1682,1684,1685,1686,1688,1689,1690,1 691,1692,1693,1694,1695,1696,1697,1698,1699,1700,1 701,1703,1706,1707,1708,1711,1714,1717,1718,1719,1 720,1724,1725,1728
TKFP_461_KIAA1549_BRAF	1.016	281	1.054	765.919	0.57	0.683	0.907	0.536	0.907	0.59	1.134	Chain A: 373,374,375,376,457,458,459,460,776,777,7 78,779,780,781,782,783,784,786,787,788,992,993,995 ,1030,1033,1035,1037,1073,1074,1075,1076,1077,1079 ,1080,1081,1083,1084,1104,1105,1106,1107,1108,1109 ,1110,1112,1130,1133,1134,1135,1136,1138,1139,1140 ,1143,1173,1174,1175,1176,1177,1187,1188,1189,1190

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Ramachandran Plot of Kinase Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

TKFP_457_KIAA1549_BRAF_ramachandran.png

TKFP_458_KIAA1549_BRAF_ramachandran.png

TKFP_459_KIAA1549_BRAF_ramachandran.png

TKFP_460_KIAA1549_BRAF_ramachandran.png

TKFP_461_KIAA1549_BRAF_ramachandran.png

TKFP_463_KIAA1549_BRAF_ramachandran.png

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Virtual Screening Results

Distribution of the average docking score across all approved kinase inhibitors.
Distribution of the number of occurrence across all approved kinase inhibitors.

5'-kinase fusion protein case

3'-kinase fusion protein case

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Drug information from DrugBank of the top 20 interacting small molecules.
* The detailed information of individual kinase inhibitors are available in the download page.

Fusion gene name info

Drug

Docking score

Glide g score

Glide energy

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Kinase-Substrate Information of KIAA1549_BRAF

Phosphorylation target of the kinase
(phosphosite, 03-17-2024)

Kinase	Kinase UniProt Acc	Kinase species	Substrate	Substrate UniProt Acc	Substrate phosphorylated residues	Substrate phosphorylated sites (+/-7AA)	Domain
BRAF	P15056	human	SLC9A1	P19634	T653	LRsYNRHtLVADPyE	NEXCaM_BD
BRAF	P15056	human	EEF1A1	P68104	T88	EtSkyyVtIIDAPGH	GTP_EFTU
BRAF	P15056	human	BRAF	P15056	S465	tVGQRIGsGsFGtVY	PK_Tyr_Ser-Thr
BRAF	P15056	human	MAP2K1	Q02750	S222	LIDsMANsFVGtRSY	Pkinase
BRAF	P15056	human	EEF1A2	Q05639	S21	GHVDSGkstttGHLI	GTP_EFTU
BRAF	P15056	human	MAP2K1	Q02750	S218	VsGQLIDsMANsFVG	Pkinase
BRAF	P15056	human	TTK	P33981	S281	VPVNLLNsPDCDVkt
BRAF	P15056	human	BAD	Q92934	S99	PFrGrsRsAPPNLWA	Bcl-2_BAD
BRAF	P15056	human	MAP2K2	P36507	S222	VsGQLIDsMANsFVG	Pkinase
BRAF	P15056	human	BAD	Q92934	S75	EIRsRHssyPAGtED	Bcl-2_BAD
BRAF	P15056	human	NANOG	Q9H9S0	S68	LIQDsPDsStsPKGK
BRAF	P15056	human	EEF1A1	P68104	S21	GHVDSGkstttGHLI	GTP_EFTU
BRAF	P15056	human	BRAF	P15056	S614	SHQFEQLsGSILWMA	PK_Tyr_Ser-Thr
BRAF	P15056	human	BAD	Q92934	S118	GRELRRMsDEFVDsF	Bcl-2_BAD
BRAF	P15056	human	BRAF	P15056	S467	GQRIGsGsFGtVYkG	PK_Tyr_Ser-Thr
BRAF	P15056	human	BRAF	P15056	T373	APNVHINtIEPVNID
BRAF	P15056	human	MAP2K2	P36507	S226	LIDsMANsFVGtRSY	Pkinase
BRAF	P15056	human	TTK	P33981	S436	VFSVskQsPPIsTSk
BRAF	P15056	human	BAD	Q92934	S134	KGLPRPKsAGtAtQM	Bcl-2_BAD

Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

Enriched GO biological processes of the phosphorylation target genes of the kinase

Kinase	GOID	GO term	P.adjust
BRAF	ID	Description	0.00e+00
BRAF	GO:0048679	regulation of axon regeneration	5.62e-05
BRAF	GO:0030878	thyroid gland development	5.62e-05
BRAF	GO:0035270	endocrine system development	5.62e-05
BRAF	GO:0070570	regulation of neuron projection regeneration	5.62e-05
BRAF	GO:0048538	thymus development	1.42e-04
BRAF	GO:0031103	axon regeneration	1.42e-04
BRAF	GO:0060324	face development	1.42e-04
BRAF	GO:0031102	neuron projection regeneration	1.74e-04
BRAF	GO:0050772	positive regulation of axonogenesis	3.79e-04
BRAF	GO:0048678	response to axon injury	4.26e-04
BRAF	GO:0060502	epithelial cell proliferation involved in lung morphogenesis	5.02e-04
BRAF	GO:0060439	trachea morphogenesis	5.09e-04
BRAF	GO:0048534	hematopoietic or lymphoid organ development	5.09e-04
BRAF	GO:0033674	positive regulation of kinase activity	5.09e-04
BRAF	GO:0048308	organelle inheritance	7.57e-04
BRAF	GO:0048313	Golgi inheritance	7.57e-04
BRAF	GO:0061684	chaperone-mediated autophagy	7.57e-04
BRAF	GO:1903358	regulation of Golgi organization	8.17e-04
BRAF	GO:0051347	positive regulation of transferase activity	8.44e-04
BRAF	GO:0060438	trachea development	9.59e-04
BRAF	GO:2000641	regulation of early endosome to late endosome transport	9.59e-04
BRAF	GO:0010720	positive regulation of cell development	9.59e-04
BRAF	GO:0050770	regulation of axonogenesis	1.21e-03
BRAF	GO:1903034	regulation of response to wounding	1.55e-03
BRAF	GO:0044342	type B pancreatic cell proliferation	1.85e-03
BRAF	GO:0031099	regeneration	1.92e-03
BRAF	GO:0002520	immune system development	2.09e-03
BRAF	GO:1903649	regulation of cytoplasmic transport	2.16e-03
BRAF	GO:0043550	regulation of lipid kinase activity	3.11e-03
BRAF	GO:0050769	positive regulation of neurogenesis	3.35e-03
BRAF	GO:0045022	early endosome to late endosome transport	3.60e-03
BRAF	GO:0060428	lung epithelium development	3.60e-03
BRAF	GO:0035987	endodermal cell differentiation	4.20e-03
BRAF	GO:0098927	vesicle-mediated transport between endosomal compartments	4.20e-03
BRAF	GO:0048009	insulin-like growth factor receptor signaling pathway	4.60e-03
BRAF	GO:0051962	positive regulation of nervous system development	4.69e-03
BRAF	GO:0060425	lung morphogenesis	4.69e-03
BRAF	GO:0018105	peptidyl-serine phosphorylation	4.74e-03
BRAF	GO:0001706	endoderm formation	5.11e-03
BRAF	GO:0018209	peptidyl-serine modification	5.11e-03
BRAF	GO:0046902	regulation of mitochondrial membrane permeability	5.41e-03
BRAF	GO:0070371	ERK1 and ERK2 cascade	6.22e-03
BRAF	GO:0048645	animal organ formation	6.22e-03
BRAF	GO:0035019	somatic stem cell population maintenance	6.45e-03
BRAF	GO:0006414	translational elongation	6.46e-03
BRAF	GO:0071260	cellular response to mechanical stimulus	6.46e-03
BRAF	GO:0010506	regulation of autophagy	6.46e-03
BRAF	GO:0031346	positive regulation of cell projection organization	6.46e-03
BRAF	GO:0090559	regulation of membrane permeability	6.84e-03

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Related Drugs to KIAA1549_BRAF

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene	Tgene	Drug	Source	PMID
KIAA1549	BRAF	Sorafenib-Based Combination Therapy	PubMed	24422672

Distribution of the number of studies mentioning KIAA1549-BRAF and kinase inhibitors the PubMed Abstract (04-01-2024)

all structure sitemap plddt KIAA1549-BRAF

Fusion gene - drug pair 1	Fusion gene - drug pair 2	PMID	Publication date	DOI	Study title
KIAA1549-BRAF AND Vemurafenib		25524464	2014-12	10.1186/s12967-014-0356-1	Response of recurrent BRAFV600E mutated ganglioglioma to Vemurafenib as single agent.
KIAA1549-BRAF AND Dabrafenib	KIAA1549-BRAF AND Capmatinib	35372088	2022-03-18	10.3389/fonc.2022.838798	"Durable Response of Dabrafenib, Trametinib, and Capmatinib in an NSCLC Patient With Co-Existing BRAF-KIAA1549 Fusion and MET Amplification: A Case Report."
KIAA1549-BRAF AND Trametinib		32780261	2020-08-11	10.1007/s11060-020-03592-8	Trametinib for the treatment of recurrent/progressive pediatric low-grade glioma.
KIAA1549-BRAF AND Trametinib		31881853	2019-12	10.1186/s12885-019-6442-2	A phase 2 study of trametinib for patients with pediatric glioma or plexiform neurofibroma with refractory tumor and activation of the MAPK/ERK pathway: TRAM-01.
KIAA1549-BRAF AND Trametinib		30097824	2018-08-10	10.1007/s11060-018-2971-9	Trametinib for progressive pediatric low-grade gliomas.
KIAA1549-BRAF AND Selumetinib		35210278	2022-02-24	10.3174/ajnr.a7433	ADC Histogram Analysis of Pediatric Low-Grade Glioma Treated with Selumetinib: A Report from the Pediatric Brain Tumor Consortium.
KIAA1549-BRAF AND Selumetinib		31151904	2019-7	10.1016/s1470-2045(19)30277-3	"Selumetinib in paediatric patients with BRAF-aberrant or neurofibromatosis type 1-associated recurrent, refractory, or progressive low-grade glioma: a multicentre, phase 2 trial."

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Related Diseases to KIAA1549_BRAF

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene	Tgene	Disease	Source	PMID
KIAA1549	BRAF	Spindle Cell Neoplasm	PubMed	24422672
KIAA1549	BRAF	Pilocytic Astrocytoma	MyCancerGenome
KIAA1549	BRAF	Low-Grade Glioma	MyCancerGenome
KIAA1549	BRAF	Nos	MyCancerGenome
KIAA1549	BRAF	Astrocytoma	MyCancerGenome
KIAA1549	BRAF	Pilomyxoid Astrocytoma	MyCancerGenome
KIAA1549	BRAF	Ganglioglioma	MyCancerGenome

Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)

MeSH ID	MeSH term
D018450	Disease Progression

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	KIAA1549	C1519086	Pilomyxoid astrocytoma	2	ORPHANET
Tgene	BRAF	C0025202	melanoma	24	CGI;CTD_human;UNIPROT
Tgene	BRAF	C1275081	Cardio-facio-cutaneous syndrome	14	CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene	BRAF	C0009402	Colorectal Carcinoma	8	CTD_human;UNIPROT
Tgene	BRAF	C0028326	Noonan Syndrome	8	CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET
Tgene	BRAF	C0238463	Papillary thyroid carcinoma	8	CTD_human;ORPHANET
Tgene	BRAF	C0040136	Thyroid Neoplasm	6	CGI;CTD_human
Tgene	BRAF	C0151468	Thyroid Gland Follicular Adenoma	6	CTD_human
Tgene	BRAF	C0175704	LEOPARD Syndrome	6	CLINGEN;GENOMICS_ENGLAND
Tgene	BRAF	C0549473	Thyroid carcinoma	6	CGI;CTD_human
Tgene	BRAF	C3150970	NOONAN SYNDROME 7	5	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene	BRAF	C0009404	Colorectal Neoplasms	4	CTD_human
Tgene	BRAF	C3150971	LEOPARD SYNDROME 3	4	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene	BRAF	C1519086	Pilomyxoid astrocytoma	3	ORPHANET
Tgene	BRAF	C0004565	Melanoma, B16	2	CTD_human
Tgene	BRAF	C0009075	Melanoma, Cloudman S91	2	CTD_human
Tgene	BRAF	C0018598	Melanoma, Harding-Passey	2	CTD_human
Tgene	BRAF	C0023443	Hairy Cell Leukemia	2	CGI;ORPHANET
Tgene	BRAF	C0025205	Melanoma, Experimental	2	CTD_human
Tgene	BRAF	C0033578	Prostatic Neoplasms	2	CTD_human
Tgene	BRAF	C0152013	Adenocarcinoma of lung (disorder)	2	CGI;CTD_human
Tgene	BRAF	C0376358	Malignant neoplasm of prostate	2	CTD_human
Tgene	BRAF	C0587248	Costello syndrome (disorder)	2	CLINGEN;CTD_human
Tgene	BRAF	C3501843	Nonmedullary Thyroid Carcinoma	2	CTD_human
Tgene	BRAF	C3501844	Familial Nonmedullary Thyroid Cancer	2	CTD_human

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Clinical Trials of the Found Drugs/Small Molecules

Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion Gene	Kinase Inhibitor	NCT ID	Study Status	Phases	Disease	# Enrolment	Date
KIAA1549-BRAF	Trametinib	NCT03363217	Active, not recruiting	Phase 2	Low-grade Glioma	114	March 1, 2027