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Kinase Fusion Gene:KPNA6_MET |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: KPNA6_MET | KinaseFusionDB ID: KFG3066 | FusionGDB2.0 ID: KFG3066 | Hgene | Tgene | Gene symbol | KPNA6 | MET | Gene ID | 23633 | 8731 | |
| Gene name | karyopherin subunit alpha 6 | RNA guanine-7 methyltransferase | ||||||||||
| Synonyms | IPOA7 | CMT1|CMT1c|MET|Met|N7-MTase|RG7MT1|cm1p|hCMT1|hMet | ||||||||||
| Cytomap | 1p35.2 | 18p11.21 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | importin subunit alpha-7importin alpha 7 subunitimportin-alpha-S2karyopherin alpha 6 (importin alpha 7) | mRNA cap guanine-N7 methyltransferaseRNA (guanine-7-) methyltransferasehcm1pmRNA (guanine-7-)methyltransferasemRNA (guanine-N(7)-)-methyltransferasemRNA cap methyltransferase | ||||||||||
| Modification date | 20240407 | 20240403 | ||||||||||
| UniProtAcc | O60684 | Q9H1A3 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000373625, ENST00000537234, ENST00000469790, ENST00000545542, | ENST00000397752, ENST00000318493, ENST00000436117, ENST00000495962, ENST00000539704, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: KPNA6 [Title/Abstract] AND MET [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | ||||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MET | GO:0006370 | 7-methylguanosine mRNA capping | 27422871 |
| Kinase Fusion gene breakpoints across KPNA6 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across MET (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| CCLE | SNU-81 | KPNA6 | chr1 | 32637364 | MET | chr7 | 116395426 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:/:) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KPNA6 | MET |
| FUNCTION: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. {ECO:0000269|PubMed:10523667}. | FUNCTION: Protein-histidine N-methyltransferase that specifically catalyzes 1-methylhistidine (pros-methylhistidine) methylation of target proteins (PubMed:33563959, PubMed:34562450). Mediates methylation of proteins with a His-x-His (HxH) motif (where 'x' is preferably a small amino acid) (PubMed:33563959). Catalyzes methylation of target proteins such as S100A9, NDUFB3, SLC39A5, SLC39A7, ARMC6 and DNAJB12; 1-methylhistidine modification may affect the binding of zinc and other metals to its target proteins (PubMed:33563959, PubMed:34562450). Constitutes the main methyltransferase for the 1-methylhistidine modification in cell (PubMed:33563959). {ECO:0000269|PubMed:33563959, ECO:0000269|PubMed:34562450}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of KPNA6_MET |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| MET | P08581 | human | MST1R | Q04912 | Y1353 | SALLGDHyVQLPATy | |
| MET | P08581 | human | FIS1 | Q9Y3D6 | Y38 | sKSTQFEyAWCLVRS | Fis1_TPR_N |
| MET | P08581 | human | IRS1 | P35568 | Y612 | tLHtDDGyMPMsPGV | |
| MET | P08581 | human | PTK2 | Q05397 | Y925 | DRsNDkVyENVtGLV | Focal_AT |
| MET | P08581 | human | MET | P08581 | Y1349 | stFIGEHyVHVNAty | |
| MET | P08581 | human | MET | P08581 | Y1365 | NVKCVAPyPsLLssE | |
| MET | P08581 | human | IRS1 | P35568 | Y896 | EPKsPGEyVNIEFGS | |
| MET | P08581 | human | PTK2 | Q05397 | Y577 | yMEDstyyKAsKGKL | PK_Tyr_Ser-Thr |
| MET | P08581 | human | RHOA | P61586 | Y42 | VPTVFENyVADIEVD | Ras |
| MET | P08581 | human | MST1R | Q04912 | Y1360 | yVQLPATyMNLGPST | |
| MET | P08581 | human | MST1R | Q04912 | Y1238 | RDILDREyysVQQHR | PK_Tyr_Ser-Thr |
| MET | P08581 | human | IQGAP1 | P46940 | Y1510 | LVkLQQtyAALNskA | RasGAP_C |
| MET | P08581 | human | PTK2 | Q05397 | Y407 | IIDEEDtytMPSTRD | |
| MET | P08581 | human | MET | P08581 | Y1230 | FGLARDMyDkEyysV | PK_Tyr_Ser-Thr |
| MET | P08581 | human | PARP1 | P09874 | Y907 | MVSKSANyCHTSQGD | PARP |
| MET | P08581 | human | SHC1 | P29353 | Y427 | ELFDDPsyVNVQNLD | |
| MET | P08581 | human | MET | P08581 | Y1356 | yVHVNAtyVNVKCVA | |
| MET | P08581 | human | PTK2 | Q05397 | Y5 | ___MAAAyLDPNLNH | |
| MET | P08581 | human | PTK2 | Q05397 | Y397 | sVsEtDDyAEIIDEE | |
| MET | P08581 | human | PTK2 | Q05397 | Y861 | PIGNQHIyQPVGKPD | |
| MET | P08581 | human | PBK | Q96KB5 | Y74 | NPICNDHyRsVyQkR | Pkinase |
| MET | P08581 | human | PTK2 | Q05397 | Y194 | ALEKKSNyEVLEkDV | FERM_M |
| MET | P08581 | human | MET | P08581 | Y1234 | RDMyDkEyysVHNkt | PK_Tyr_Ser-Thr |
| MET | P08581 | human | PTK2 | Q05397 | Y576 | RyMEDstyyKAsKGK | PK_Tyr_Ser-Thr |
| MET | P08581 | human | INSR | P06213 | Y1185 | FGMTRDIyEtDyyRk | PK_Tyr_Ser-Thr |
| MET | P08581 | human | MET | P08581 | Y1235 | DMyDkEyysVHNktG | PK_Tyr_Ser-Thr |
| MET | P08581 | human | GSK3B | P49841 | Y56 | DRPQEVSyTDTKVIG | Pkinase |
| MET | P08581 | human | MST1R | Q04912 | Y1239 | DILDREyysVQQHRH | PK_Tyr_Ser-Thr |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| MET | ID | Description | 0.00e+00 |
| MET | GO:0033674 | positive regulation of kinase activity | 4.44e-07 |
| MET | GO:0051347 | positive regulation of transferase activity | 9.31e-07 |
| MET | GO:0071375 | cellular response to peptide hormone stimulus | 5.90e-06 |
| MET | GO:1901653 | cellular response to peptide | 1.35e-05 |
| MET | GO:0032869 | cellular response to insulin stimulus | 2.06e-05 |
| MET | GO:0043434 | response to peptide hormone | 2.06e-05 |
| MET | GO:0032868 | response to insulin | 6.57e-05 |
| MET | GO:0045860 | positive regulation of protein kinase activity | 7.26e-05 |
| MET | GO:0008286 | insulin receptor signaling pathway | 8.83e-05 |
| MET | GO:0005979 | regulation of glycogen biosynthetic process | 8.83e-05 |
| MET | GO:0010962 | regulation of glucan biosynthetic process | 8.83e-05 |
| MET | GO:0043467 | regulation of generation of precursor metabolites and energy | 1.23e-04 |
| MET | GO:0070873 | regulation of glycogen metabolic process | 1.40e-04 |
| MET | GO:0032885 | regulation of polysaccharide biosynthetic process | 1.41e-04 |
| MET | GO:0045936 | negative regulation of phosphate metabolic process | 1.52e-04 |
| MET | GO:0010563 | negative regulation of phosphorus metabolic process | 1.52e-04 |
| MET | GO:0005978 | glycogen biosynthetic process | 1.72e-04 |
| MET | GO:0009250 | glucan biosynthetic process | 1.72e-04 |
| MET | GO:0032881 | regulation of polysaccharide metabolic process | 1.72e-04 |
| MET | GO:0016051 | carbohydrate biosynthetic process | 4.12e-04 |
| MET | GO:0000271 | polysaccharide biosynthetic process | 4.65e-04 |
| MET | GO:0005977 | glycogen metabolic process | 6.80e-04 |
| MET | GO:0044042 | glucan metabolic process | 7.00e-04 |
| MET | GO:0031016 | pancreas development | 7.00e-04 |
| MET | GO:1900543 | negative regulation of purine nucleotide metabolic process | 7.39e-04 |
| MET | GO:0045980 | negative regulation of nucleotide metabolic process | 8.69e-04 |
| MET | GO:0006112 | energy reserve metabolic process | 8.90e-04 |
| MET | GO:0043491 | phosphatidylinositol 3-kinase/protein kinase B signal transduction | 9.74e-04 |
| MET | GO:0005976 | polysaccharide metabolic process | 1.25e-03 |
| MET | GO:0043255 | regulation of carbohydrate biosynthetic process | 1.32e-03 |
| MET | GO:0007173 | epidermal growth factor receptor signaling pathway | 1.35e-03 |
| MET | GO:0045725 | positive regulation of glycogen biosynthetic process | 1.35e-03 |
| MET | GO:0015980 | energy derivation by oxidation of organic compounds | 1.44e-03 |
| MET | GO:0062012 | regulation of small molecule metabolic process | 1.44e-03 |
| MET | GO:0070875 | positive regulation of glycogen metabolic process | 1.59e-03 |
| MET | GO:0038127 | ERBB signaling pathway | 1.79e-03 |
| MET | GO:0001952 | regulation of cell-matrix adhesion | 1.79e-03 |
| MET | GO:0071902 | positive regulation of protein serine/threonine kinase activity | 2.45e-03 |
| MET | GO:1903578 | regulation of ATP metabolic process | 2.89e-03 |
| MET | GO:0030010 | establishment of cell polarity | 3.21e-03 |
| MET | GO:0070507 | regulation of microtubule cytoskeleton organization | 3.41e-03 |
| MET | GO:1902410 | mitotic cytokinetic process | 3.41e-03 |
| MET | GO:0051897 | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | 3.91e-03 |
| MET | GO:0043410 | positive regulation of MAPK cascade | 4.19e-03 |
| MET | GO:2000058 | regulation of ubiquitin-dependent protein catabolic process | 4.21e-03 |
| MET | GO:0001667 | ameboidal-type cell migration | 4.74e-03 |
| MET | GO:0006109 | regulation of carbohydrate metabolic process | 4.74e-03 |
| MET | GO:0035305 | negative regulation of dephosphorylation | 5.05e-03 |
| MET | GO:0031334 | positive regulation of protein-containing complex assembly | 5.26e-03 |
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Related Drugs to KPNA6_MET |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning KPNA6-MET and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to KPNA6_MET |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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