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Kinase Fusion Gene:KSR1_PIPOX |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: KSR1_PIPOX | KinaseFusionDB ID: KFG3091 | FusionGDB2.0 ID: KFG3091 | Hgene | Tgene | Gene symbol | KSR1 | PIPOX | Gene ID | 8844 | 51268 | |
| Gene name | kinase suppressor of ras 1 | pipecolic acid and sarcosine oxidase | ||||||||||
| Synonyms | KSR|RSU2 | LPIPOX | ||||||||||
| Cytomap | 17q11.2 | 17q11.2 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | kinase suppressor of Ras 1 | peroxisomal sarcosine oxidaseL-pipecolate oxidaseL-pipecolic acid oxidasePSOpipecolic acid oxidase | ||||||||||
| Modification date | 20240411 | 20240305 | ||||||||||
| UniProtAcc | Q8IVT5 | Q9P0Z9 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000319524, ENST00000509603, ENST00000268763, ENST00000398988, ENST00000578981, ENST00000581975, ENST00000582410, | ENST00000323372, ENST00000583215, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: KSR1 [Title/Abstract] AND PIPOX [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | KSR1(25783900)-PIPOX(27371877), # samples:1 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | KSR1 | GO:0043410 | positive regulation of MAPK cascade | 29433126 |
| Tgene | PIPOX | GO:0033514 | L-lysine catabolic process to acetyl-CoA via L-pipecolate | 10642506 |
| Kinase Fusion gene breakpoints across KSR1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across PIPOX (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChimerDB4 | TCGA-OL-A5RZ-01A | KSR1 | chr17 | 25783900 | PIPOX | chr17 | 27371877 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:25783900/:27371877) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KSR1 | PIPOX |
| FUNCTION: Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases (By similarity). Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP (By similarity). Its kinase activity is unsure (By similarity). Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown (By similarity). {ECO:0000250|UniProtKB:Q61097, ECO:0000269|PubMed:29433126}. | FUNCTION: Metabolizes sarcosine and L-pipecolic acid. {ECO:0000269|PubMed:10642506}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of KSR1_PIPOX |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| KSR1 | Q8IVT5 | human | RAF1 | P04049 | T269 | NVHMVsttLPVDSRM |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| KSR1 | ID | Description | 0.00e+00 |
| KSR1 | GO:0007190 | activation of adenylate cyclase activity | 1.46e-02 |
| KSR1 | GO:0035994 | response to muscle stretch | 1.46e-02 |
| KSR1 | GO:0048011 | neurotrophin TRK receptor signaling pathway | 1.46e-02 |
| KSR1 | GO:0060333 | type II interferon-mediated signaling pathway | 1.46e-02 |
| KSR1 | GO:0044342 | type B pancreatic cell proliferation | 1.46e-02 |
| KSR1 | GO:0030878 | thyroid gland development | 1.46e-02 |
| KSR1 | GO:0045762 | positive regulation of adenylate cyclase activity | 1.46e-02 |
| KSR1 | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | 1.46e-02 |
| KSR1 | GO:0031281 | positive regulation of cyclase activity | 1.46e-02 |
| KSR1 | GO:0038179 | neurotrophin signaling pathway | 1.46e-02 |
| KSR1 | GO:0051349 | positive regulation of lyase activity | 1.46e-02 |
| KSR1 | GO:0045761 | regulation of adenylate cyclase activity | 1.46e-02 |
| KSR1 | GO:0048538 | thymus development | 1.46e-02 |
| KSR1 | GO:1902041 | regulation of extrinsic apoptotic signaling pathway via death domain receptors | 1.46e-02 |
| KSR1 | GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | 1.46e-02 |
| KSR1 | GO:0048009 | insulin-like growth factor receptor signaling pathway | 1.46e-02 |
| KSR1 | GO:0060324 | face development | 1.46e-02 |
| KSR1 | GO:0031279 | regulation of cyclase activity | 1.46e-02 |
| KSR1 | GO:0051339 | regulation of lyase activity | 1.49e-02 |
| KSR1 | GO:0035773 | insulin secretion involved in cellular response to glucose stimulus | 1.51e-02 |
| KSR1 | GO:2000117 | negative regulation of cysteine-type endopeptidase activity | 1.51e-02 |
| KSR1 | GO:0035019 | somatic stem cell population maintenance | 1.53e-02 |
| KSR1 | GO:0035023 | regulation of Rho protein signal transduction | 1.70e-02 |
| KSR1 | GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors | 1.70e-02 |
| KSR1 | GO:0045104 | intermediate filament cytoskeleton organization | 1.70e-02 |
| KSR1 | GO:0045103 | intermediate filament-based process | 1.70e-02 |
| KSR1 | GO:0048534 | hematopoietic or lymphoid organ development | 1.70e-02 |
| KSR1 | GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway | 1.70e-02 |
| KSR1 | GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 1.70e-02 |
| KSR1 | GO:0140888 | interferon-mediated signaling pathway | 1.70e-02 |
| KSR1 | GO:0071346 | cellular response to type II interferon | 1.70e-02 |
| KSR1 | GO:0008286 | insulin receptor signaling pathway | 1.70e-02 |
| KSR1 | GO:0010951 | negative regulation of endopeptidase activity | 1.70e-02 |
| KSR1 | GO:0071333 | cellular response to glucose stimulus | 1.70e-02 |
| KSR1 | GO:0007266 | Rho protein signal transduction | 1.70e-02 |
| KSR1 | GO:0010466 | negative regulation of peptidase activity | 1.70e-02 |
| KSR1 | GO:0033135 | regulation of peptidyl-serine phosphorylation | 1.70e-02 |
| KSR1 | GO:0071331 | cellular response to hexose stimulus | 1.70e-02 |
| KSR1 | GO:0035270 | endocrine system development | 1.70e-02 |
| KSR1 | GO:0071326 | cellular response to monosaccharide stimulus | 1.70e-02 |
| KSR1 | GO:0034341 | response to type II interferon | 1.70e-02 |
| KSR1 | GO:0031333 | negative regulation of protein-containing complex assembly | 1.71e-02 |
| KSR1 | GO:0071322 | cellular response to carbohydrate stimulus | 1.71e-02 |
| KSR1 | GO:0001678 | intracellular glucose homeostasis | 1.71e-02 |
| KSR1 | GO:2001236 | regulation of extrinsic apoptotic signaling pathway | 1.71e-02 |
| KSR1 | GO:0043281 | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 1.73e-02 |
| KSR1 | GO:0019827 | stem cell population maintenance | 1.79e-02 |
| KSR1 | GO:0046578 | regulation of Ras protein signal transduction | 1.79e-02 |
| KSR1 | GO:0098727 | maintenance of cell number | 1.79e-02 |
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Related Drugs to KSR1_PIPOX |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning KSR1-PIPOX and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to KSR1_PIPOX |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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