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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:LEMD3_MAPK14

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: LEMD3_MAPK14
KinaseFusionDB ID: KFG3139
FusionGDB2.0 ID: KFG3139
HgeneTgene
Gene symbol

LEMD3

MAPK14

Gene ID

23592

1432

Gene nameLEM domain containing 3mitogen-activated protein kinase 14
SynonymsMAN1CSBP|CSBP1|CSBP2|CSPB1|EXIP|Mxi2|PRKM14|PRKM15|RK|SAPK2A|p38|p38ALPHA
Cytomap

12q14.3

6p21.31

Type of geneprotein-codingprotein-coding
Descriptioninner nuclear membrane protein Man1LEM domain-containing protein 3LEMD3/MKX fusionMAN antigen 1integral inner nuclear membrane proteinmitogen-activated protein kinase 14CSAID-binding proteinMAP kinase 14MAP kinase Mxi2MAP kinase p38 alphaMAX-interacting protein 2cytokine suppressive anti-inflammatory drug binding proteinmitogen-activated protein kinase p38 alphap38 MAP kinasep3
Modification date2024041120240411
UniProtAcc

Q9Y2U8

Q16539

Ensembl transtripts involved in fusion geneENST idsENST00000541171, ENST00000308330, 
ENST00000229794, ENST00000229795, 
ENST00000310795, ENST00000468133, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: LEMD3 [Title/Abstract] AND MAPK14 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)LEMD3(65563588)-MAPK14(35995917), # samples:2
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLEMD3

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

15647271

HgeneLEMD3

GO:0030514

negative regulation of BMP signaling pathway

15647271

HgeneLEMD3

GO:0032926

negative regulation of activin receptor signaling pathway

15647271

TgeneMAPK14

GO:0031098

stress-activated protein kinase signaling cascade

35857590

TgeneMAPK14

GO:0035556

intracellular signal transduction

10838079

TgeneMAPK14

GO:0038066

p38MAPK cascade

10330143

TgeneMAPK14

GO:0051403

stress-activated MAPK cascade

35857590

TgeneMAPK14

GO:0071222

cellular response to lipopolysaccharide

23776175

TgeneMAPK14

GO:0071493

cellular response to UV-B

35857590

TgeneMAPK14

GO:1900015

regulation of cytokine production involved in inflammatory response

15251176


check buttonKinase Fusion gene breakpoints across LEMD3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonKinase Fusion gene breakpoints across MAPK14 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChiTaRS5.0GM682306LEMD3chr12

65563588

MAPK14chr6

35995917



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:65563588/:35995917)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LEMD3

Q9Y2U8

MAPK14

Q16539

FUNCTION: Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}.FUNCTION: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1 (PubMed:9687510, PubMed:9792677). RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery (PubMed:9687510, PubMed:9792677). On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2 (PubMed:11154262). MAPK14 interacts also with casein kinase II, leading to its activation through autophosphorylation and further phosphorylation of TP53/p53 (PubMed:10747897). In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. In a similar way, MAPK14 phosphorylates the ubiquitin ligase SIAH2, regulating its activity towards EGLN3 (PubMed:17003045). MAPK14 may also inhibit the lysosomal degradation pathway of autophagy by interfering with the intracellular trafficking of the transmembrane protein ATG9 (PubMed:19893488). Another function of MAPK14 is to regulate the endocytosis of membrane receptors by different mechanisms that impinge on the small GTPase RAB5A. In addition, clathrin-mediated EGFR internalization induced by inflammatory cytokines and UV irradiation depends on MAPK14-mediated phosphorylation of EGFR itself as well as of RAB5A effectors (PubMed:16932740). Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17 (PubMed:20188673). Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Another p38 MAPK substrate is FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A (PubMed:9430721, PubMed:9858528, PubMed:10330143). The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment. Phosphorylates CDC25B and CDC25C which is required for binding to 14-3-3 proteins and leads to initiation of a G2 delay after ultraviolet radiation (PubMed:11333986). Phosphorylates TIAR following DNA damage, releasing TIAR from GADD45A mRNA and preventing mRNA degradation (PubMed:20932473). The p38 MAPKs may also have kinase-independent roles, which are thought to be due to the binding to targets in the absence of phosphorylation. Protein O-Glc-N-acylation catalyzed by the OGT is regulated by MAPK14, and, although OGT does not seem to be phosphorylated by MAPK14, their interaction increases upon MAPK14 activation induced by glucose deprivation. This interaction may regulate OGT activity by recruiting it to specific targets such as neurofilament H, stimulating its O-Glc-N-acylation. Required in mid-fetal development for the growth of embryo-derived blood vessels in the labyrinth layer of the placenta. Also plays an essential role in developmental and stress-induced erythropoiesis, through regulation of EPO gene expression (PubMed:10943842). Isoform MXI2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform EXIP may play a role in the early onset of apoptosis. Phosphorylates S100A9 at 'Thr-113' (PubMed:15905572). Phosphorylates NLRP1 downstream of MAP3K20/ZAK in response to UV-B irradiation and ribosome collisions, promoting activation of the NLRP1 inflammasome and pyroptosis (PubMed:35857590). {ECO:0000269|PubMed:10330143, ECO:0000269|PubMed:10747897, ECO:0000269|PubMed:10943842, ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:11333986, ECO:0000269|PubMed:15905572, ECO:0000269|PubMed:16932740, ECO:0000269|PubMed:17003045, ECO:0000269|PubMed:17724032, ECO:0000269|PubMed:19893488, ECO:0000269|PubMed:20188673, ECO:0000269|PubMed:20932473, ECO:0000269|PubMed:35857590, ECO:0000269|PubMed:9430721, ECO:0000269|PubMed:9687510, ECO:0000269|PubMed:9792677, ECO:0000269|PubMed:9858528}.; FUNCTION: (Microbial infection) Activated by phosphorylation by M.tuberculosis EsxA in T-cells leading to inhibition of IFN-gamma production; phosphorylation is apparent within 15 minutes and is inhibited by kinase-specific inhibitors SB203580 and siRNA (PubMed:21586573). {ECO:0000269|PubMed:21586573}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


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Kinase-Substrate Information of LEMD3_MAPK14


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
MAPK14Q16539humanMAPTP10636-8T231KKVAVVRtPPKsPss
MAPK14Q16539humanAIMP2Q13155S156LSTVHtHssVkSVPEThioredoxin_16
MAPK14Q16539humanSLC9A1P19634S726IDPAsPQsPEsVDLV
MAPK14Q16539humanMEF2DQ14814S180LTDPRLLsPQQPALQ
MAPK14Q16539humanATF2P15336T69sVIVADQtPtPtRFL
MAPK14Q16539humanSTAT1P42224S727TDNLLPMsPEEFDEVSTAT1_TAZ2bind
MAPK14Q16539humanMAPTP10636-8S199GDRsGyssPGsPGtP
MAPK14Q16539humanDDIT3P35638S79EVTSTSQsPHsPDSS
MAPK14Q16539humanNCF1P14598S348PGPQsPGsPLEEERQ
MAPK14Q16539humanSLC6A2P23975T30QPLRARKtAELLVVK
MAPK14Q16539humanATF2P15336T71IVADQtPtPtRFLkN
MAPK14Q16539humanJDP2Q8WYK2T148VRtDsVKtPEsEGNP
MAPK14Q16539humanADAM17P78536T735kPFPAPQtPGRLQPA
MAPK14Q16539humanELK4P28324S387LsPVAPLsPARLQGA
MAPK14Q16539humanTP63Q9H3D4-2S361QKQtsIQsPSSYGNs
MAPK14Q16539humanSHC1P29353S54PPLPGDDsPTTLCSF
MAPK14Q16539humanNOXA1Q86UR1S239ARsLIMDsPRAGTHQ
MAPK14Q16539humanETV6P41212S257ESHPKPSsPRQESTR
MAPK14Q16539humanRBM17Q96I25S222EEQDRPRsPtGPsNs
MAPK14Q16539humanELK1P19419S389LsPIAPRsPAKLSFQ
MAPK14Q16539humanFPR1P21462S342AtNstLPsAEVELQA
MAPK14Q16539humanPPARGC1AQ9UBK2T263TTLSLPLtPEsPNDP
MAPK14Q16539humanMYLKQ15746T978VPPPKPAtPDFRSVL
MAPK14Q16539humanKCNQ2O43526-4S436QAQTVRRsPsADQSLKCNQ_channel
MAPK14Q16539humanSHC1P29353T386PTAPNAQtPSHLGAT
MAPK14Q16539humanFOXC1Q12948S241PsPPQPLsPAAALGS
MAPK14Q16539humanMEF2DQ14814S98KGFNGCDsPEPDGEDHJURP_C
MAPK14Q16539humanPPARGC1AQ9UBK2T299AGLtPPTtPPHKANQ
MAPK14Q16539humanPDX1P52945S66QGsPPDIsPYEVPPL
MAPK14Q16539humanEIF2AK2P19525T451kRtRSKGtLRyMsPEPkinase
MAPK14Q16539humanTP63Q9H3D4S160SSTFDALsPsPAIPS
MAPK14Q16539humanNOS3P29474S600MSGPYNSsPRPEQHKFlavodoxin_1
MAPK14Q16539humanMAP4P27816S696PNKELPPsPEKKTkP
MAPK14Q16539humanCASP8Q14790S347FTGLkCPsLAGkPkVPeptidase_C14
MAPK14Q16539humanCDT1Q9H211S391LRSAAPssPGsPrPA
MAPK14Q16539humanDDX5P17844T446GtAyTFFtPNNIkQV
MAPK14Q16539humanUSP21Q9UK80S538VYNDSRVsPVSENQVUCH
MAPK14Q16539humanMKNK1Q9BUB5-2T214ITtPELTtPCGSAEYPkinase
MAPK14Q16539humanTP53P04637S46AMDDLMLsPDDIEQWTAD2
MAPK14Q16539humanKCNB1Q14721S805ESsPLPtsPKFLRQN
MAPK14Q16539humanBAZ1BQ9UIG0S158ksDGACDsPssDKEN
MAPK14Q16539humanMKNK1Q9BUB5T250NSCTPITtPELTtPCPkinase
MAPK14Q16539humanMEF2AQ02078T319tPVVSVTtPSLPPQG
MAPK14Q16539humanELAVL1Q15717T118sGLPRTMtQkDVEDMRRM_1
MAPK14Q16539humanMAPTP10636-8S396GAEIVyKsPVVsGDt
MAPK14Q16539humanSLC6A4P31645T616IKsItPEtPTEIPCG
MAPK14Q16539humanMAPTP10636-8S404PVVsGDtsPRHLsNV
MAPK14Q16539humanTAB1Q15750T431ASTLDEAtPTLTNQs
MAPK14Q16539humanMAPKAPK2P49137S272SNHGLAIsPGMKTRIPkinase
MAPK14Q16539humanPOU3F2P20265S96DGsPWSTsPLGQPDI
MAPK14Q16539humanS100A9P06702T113KPGLGEGtP______
MAPK14Q16539humanMAFAQ8NHW3T57LSStPLStPCSsVPS
MAPK14Q16539humanCDT1Q9H211T402PrPALPAtPPAtPPA
MAPK14Q16539humanNFATC4Q14934S168QGGGAFFsPsPGsSS
MAPK14Q16539humanPTPN7P35236S93ALQRQPPsPKQLEEE
MAPK14Q16539humanFOXO3O43524S7_MAEAPAsPAPLsPL
MAPK14Q16539humanEPS15P42566S796RsINkLDsPDPFkLN
MAPK14Q16539humanNCOA3Q9Y6Q9S860NRAVsLDsPVsVGss
MAPK14Q16539humanHBP1O60381S402GFSkNCGsPGSSQLS
MAPK14Q16539humanRB1P06400T841sIGEsFGtsEkFQkIRb_C
MAPK14Q16539humanRPS27P42677S27KKkRLVQsPNsyFMD
MAPK14Q16539humanTAB1Q15750S452STNTHTQssSSssDG
MAPK14Q16539humanFOXO3O43524S294QLskWPGsPtsRsSD
MAPK14Q16539humanKARS1Q15046S49ELsEKQLsQAtAAAT
MAPK14Q16539humanMEF2DQ14814S251NkVIPAksPPPPtHS
MAPK14Q16539humanHTRA2O43464S142VPSPPPAsPRSQYNFPeptidase_M50
MAPK14Q16539humanKRT8P05787S74tVNQsLLsPLVLEVDKeratin_2_head
MAPK14Q16539humanISL1P61371S269GTPMVAAsPERHDGG
MAPK14Q16539humanFGFR1P11362S777SMPLDQysPsFPDTR
MAPK14Q16539humanTP63Q9H3D4-2S68TFDALsPsPAIPSNT
MAPK14Q16539humanGSK3BP49841T43kVTTVVAtPGQGPDR
MAPK14Q16539humanFHP07954T90GVtERMPtPVIkAFGLyase_1
MAPK14Q16539humanEGFRP00533T1041LLSsLsAtsNNstVA
MAPK14Q16539humanCDX2Q99626S283RsVPEPLsPVSSLQA
MAPK14Q16539humanMYLKQ15746S947EEERKVHsPQQVDFR
MAPK14Q16539humanPOU3F2P20265T440PPHHGVQtPVQ____
MAPK14Q16539humanTAB1Q15750S456HTQssSSssDGGLFR
MAPK14Q16539humanNFATC4Q14934S170GGAFFsPsPGsSSLS
MAPK14Q16539humanCBX4O00257T497SLQVkPEtPASAAVA
MAPK14Q16539humanUSF1P22415T153EALLGQAtPPGTGQF
MAPK14Q16539humanMEF2CQ06413-3T300tPVVSVAtPTLPGQG
MAPK14Q16539humanRAB7AP51149S72AGQERFQsLGVAFYRRas
MAPK14Q16539humanTP53P04637S33LPENNVLsPLPsQAM
MAPK14Q16539humanNCOA3Q9Y6Q9S543SLLSTLSsPGPKLDNNCOA_u2
MAPK14Q16539humanARP10275S651GEASSTTsPTEETTQ
MAPK14Q16539humanTP63Q9H3D4S162TFDALsPsPAIPSNT
MAPK14Q16539humanRB1P06400T252PINGsPRtPRRGQNR
MAPK14Q16539humanMEF2AQ02078S223VPNGAGSsPVGNGFV
MAPK14Q16539humanSTAT3P40763S727NtIDLPMsPrTLDSL
MAPK14Q16539humanBUB3O43684S211AVEyLDPsPEVQkkk
MAPK14Q16539humanFOXO3O43524S425TKGsGLGsPtSSFNS
MAPK14Q16539humanCDT1Q9H211S411PAtPPAAsPsALkGV
MAPK14Q16539humanMEF2AQ02078S408SIkSEPIsPPRDRMT
MAPK14Q16539humanCDKN2DP55273S66ELLKQGAsPNVQDTSAnk_2
MAPK14Q16539humanETV6P41212S22IsytPPEsPVPsyAs
MAPK14Q16539humanSOX9P48436S211FKALQADsPHsSSGM
MAPK14Q16539humanGRHL3Q8TE85T454RPETDLEtPPVLFIP
MAPK14Q16539humanDROSHAQ9NRR4T274sDyDrGRtPsRHRSY
MAPK14Q16539humanRBPJQ06330T339STDKAEYtFYEGMGP
MAPK14Q16539humanTP63Q9H3D4-2S66SSTFDALsPsPAIPS
MAPK14Q16539humanSLC9A1P19634T718KEDLPVItIDPAsPQ
MAPK14Q16539humanBCL2L1Q07817S62PSWHLADsPAVNGAT
MAPK14Q16539humanGATA2P23769S192PsTTGAAsPASSSAG
MAPK14Q16539humanSREBF1P36956S63AGGtDPAsPDTSSPG
MAPK14Q16539humanCRYABP02511S59PsFLRAPsWFDTGLS
MAPK14Q16539humanNOS3P29474S114RKLQGRPsPGPPAPE
MAPK14Q16539humanDDX5P17844T564SFRTGNPtGTYQNGYP68HR
MAPK14Q16539humanRB1P06400S567SLAWLSDsPLFDLIkRB_A
MAPK14Q16539humanCDKN1AP38936S98GGRRPGTsPALLQGT
MAPK14Q16539humanLAMP2P13473T213PSPtttPtPKEKPEA
MAPK14Q16539humanRB1P06400S249AVIPINGsPRtPRRG
MAPK14Q16539humanMEF2DQ14814S192ALQRNSVsPGLPQRP
MAPK14Q16539humanTRIM9Q9C026-5S80EADsGYGsYGGFASA
MAPK14Q16539humanSREBF1P36956T426TEVEDTLtPPPsDAG
MAPK14Q16539humanSMAD9O15198T136YHYRRVEtPVLPPVL
MAPK14Q16539humanSNAI1O95863S107sQPPsPPsPAPssFS
MAPK14Q16539humanDDIT3P35638S82STSQsPHsPDSSQSS
MAPK14Q16539humanKHSRPQ92945T692QAAyYGQtPGPGGPQ
MAPK14Q16539humanDROSHAQ9NRR4S300RHRDNRRsPsLERSY
MAPK14Q16539humanZNHIT1O43257T103AEGPNYLtACAGPPS
MAPK14Q16539humanFOXO3O43524S12PAsPAPLsPLEVELD
MAPK14Q16539humanTP63Q9H3D4-2S301TSIKKRRsPDDELLYP53_tetramer
MAPK14Q16539humanNR3C1P04150S226IDENCLLsPLAGEDDGCR
MAPK14Q16539humanSKP2Q13309S64sNLGHPEsPPRkRLk
MAPK14Q16539humanBCL2P10415S87AAAGPALsPVPPVVH
MAPK14Q16539humanRBM17Q96I25T71DDrQIVDtPPHVAAG
MAPK14Q16539humanATF6P18850T166NKTENGLtPKKKIQV
MAPK14Q16539humanPXNP49023S85HQQPQsssPVyGsSAPaxillin
MAPK14Q16539humanMEF2AQ02078S192TTLHRNVsPGAPQRP
MAPK14Q16539humanNR3C1P04150S203DLEFSSGsPGkEtNEGCR
MAPK14Q16539humanMEF2AQ02078S98KEHRGCDsPDPDtsyHJURP_C
MAPK14Q16539humanMAPTP10636-8S202sGyssPGsPGtPGsR
MAPK14Q16539humanDROSHAQ9NRR4S255DRRERGRsPDRRRQD
MAPK14Q16539humanFOXC2Q99958S367DHPSGPTsPLSALNL
MAPK14Q16539humanSREBF1P36956-3S39AGGTDPAsPDTSSPG
MAPK14Q16539humanCDKN1AP38936S130sGEQAEGsPGGPGDs
MAPK14Q16539humanTAB1Q15750S423QMVNGAHsASTLDEA
MAPK14Q16539humanKARS1Q15046T52EKQLsQAtAAATNHT
MAPK14Q16539humanPIP4K2BP78356S326SYGtPPDsPGNLLsFPIP5K
MAPK14Q16539humanSUCLA2Q9P2R7S79PKGyVAksPDEAyAIATP-grasp_2
MAPK14Q16539humanFOXN3O00409S83FGESVLRsVsPVQDL
MAPK14Q16539humanKCNB1Q14721S800EKNHFESsPLPtsPK
MAPK14Q16539humanTP63Q9H3D4S395TSIKKRRsPDDELLYP53_tetramer
MAPK14Q16539humanSLC9A1P19634S723VItIDPAsPQsPEsV
MAPK14Q16539humanHSPB1P04792S176MPkLAtQsNEItIPVHSP20
MAPK14Q16539humanESR1P03372S118LHPPPQLsPFLQPHGOest_recep
MAPK14Q16539humanSNX27Q96L92S51VRIVksEsGYGFNVRPDZ
MAPK14Q16539humanMRTFAQ969V6S333CGLARQNstsLtGKP
MAPK14Q16539humanAGO2Q9UKV8S387SkLMRsAsFNtDPyVArgoL2
MAPK14Q16539humanNCF1P14598S345QARPGPQsPGsPLEE
MAPK14Q16539humanGSK3BP49841T390RIQAAAstPtNAtAA
MAPK14Q16539humanFOXN3O00409S85ESVLRsVsPVQDLDD
MAPK14Q16539humanMKNK1Q9BUB5T255ITtPELTtPCGSAEYPkinase
MAPK14Q16539humanESR1P03372S294RAANLWPsPLMIkRS
MAPK14Q16539humanSLC9A1P19634S729AsPQsPEsVDLVNEE
MAPK14Q16539humanDROSHAQ9NRR4S221KAPSERRsPERLKHy
MAPK14Q16539humanNCOA3Q9Y6Q9S867sPVsVGssPPVKNIS
MAPK14Q16539humanLIMK1P53667S310PGAGsLGsPAsQRKD
MAPK14Q16539humanTWIST1Q15672S68GGGDEPGsPAQGkRG
MAPK14Q16539humanMEF2AQ02078T312QATQPLAtPVVSVTt
MAPK14Q16539humanMAPKAPK2P49137T222tSHNsLttPCytPYYPkinase
MAPK14Q16539humanRPS6KA5O75582S360TEMDPTYsPAALPQSPkinase_C
MAPK14Q16539humanMAOAP21397S209GGTTRIFsVTNGGQEAmino_oxidase
MAPK14Q16539humanZAP70P43403T293tLNsDGytPEPARIt
MAPK14Q16539humanPTPN7P35236T66EPICsVNtPREVTLH
MAPK14Q16539humanHSF1Q00613S307EPPsPPQsPRVEEAsVert_HS_TF
MAPK14Q16539humanDROSHAQ9NRR4S355LEIVNHRsPsREKKR
MAPK14Q16539humanTAB1Q15750S457TQssSSssDGGLFRS
MAPK14Q16539humanMEF2AQ02078S479DPRGDFHsPIVLGRP
MAPK14Q16539humanPAK6Q9NQU5S165MPWPEPQsPRVLPNG
MAPK14Q16539humanEGFRP00533S1039tPLLSsLsAtsNNst
MAPK14Q16539humanMEF2CQ06413-3S387TRHEAGRsPVDSLSS
MAPK14Q16539humanCASP3P42574S150FRGDRCRsLtGKPKLPeptidase_C14
MAPK14Q16539humanESR1P03372T311NsLALSLtADQMVSA
MAPK14Q16539humanMAPTP10636-8T181ktPPAPktPPssGEP
MAPK14Q16539humanCORO1BQ9BR76S2______MsFRKVVRQ
MAPK14Q16539humanEGFRP00533T693RELVEPLtPsGEAPN
MAPK14Q16539humanMKNK1Q9BUB5-2T209NSCTPITtPELTtPCPkinase
MAPK14Q16539humanRB1P06400S838ILVsIGEsFGtsEkFRb_C
MAPK14Q16539humanMAPKAPK5Q8IW41T182IDQGDLMtPQFtPyYPkinase
MAPK14Q16539humanGSK3BP49841S389ARIQAAAstPtNAtA
MAPK14Q16539humanFOXO3O43524S344QDDDAPLsPMLYSSS
MAPK14Q16539humanELK4P28324S381IHFWSTLsPVAPLsP
MAPK14Q16539humanNLRP1Q9C000S107PSEPHLGsPSQPTST
MAPK14Q16539humanGJA1P17302S279sSPtAPLsPMsPPGy
MAPK14Q16539humanHSF1Q00613S303RVkEEPPsPPQsPRVVert_HS_TF
MAPK14Q16539humanCDT1Q9H211S491GSCCTIMsPGEMEKHCDT1_C
MAPK14Q16539humanKAT5Q92993-2T106VEVVsPAtPVPSETA
MAPK14Q16539humanMAFAQ8NHW3T134NPEALNLtPEDAVEAMaf_N
MAPK14Q16539humanMEF2AQ02078T108PDtsyVLtPHtEEKyHJURP_C
MAPK14Q16539humanHNF4AP41235S167VLSRQItsPVsGING
MAPK14Q16539humanPRKNO60260S131HTDsRkDsPPAGsPA
MAPK14Q16539humanMDM4O15151S314TECKKFNsPSKRYCFzf-RanBP
MAPK14Q16539humanNFATC1O95644S172YRDPsCLsPASSLSS
MAPK14Q16539humanPDX1P52945S61LGALEQGsPPDIsPY
MAPK14Q16539humanEEA1Q15075T1392CSAKNALtPSSKKPVFYVE
MAPK14Q16539humanTRIM28Q13263S473sGVkRsRsGEGEVsG
MAPK14Q16539humanF3P13726S290GQsWkENsPLNVs__
MAPK14Q16539humanRPS6KA4O75676S196EEkERtFsFCGTIEYPkinase
MAPK14Q16539humanGJA1P17302S282tAPLsPMsPPGykLV
MAPK14Q16539humanTAB1Q15750S453TNTHTQssSSssDGG
MAPK14Q16539humanMAPKAPK2P49137T25APPPQPPtPALPHPP
MAPK14Q16539humanMEF2DQ14814S231GYVsARAsPGLLPVA
MAPK14Q16539humanHSF1Q00613S326ssVDtLLsPTALIDsVert_HS_TF
MAPK14Q16539humanTAB1Q15750S438tPTLTNQsPTLtLQS
MAPK14Q16539humanMAPKAPK2P49137T334QstKVPQtPLHtsRV
MAPK14Q16539humanRPS6KA5O75582T581PDNQPLKtPCFTLHYPkinase
MAPK14Q16539humanIFNAR1P17181S532KKySSQTsQDsGNys
MAPK14Q16539humanMRTFAQ969V6S312tPPVRsLstTNSsSS
MAPK14Q16539humanNOXA1Q86UR1S282VGKQAPLsPGLPAMG
MAPK14Q16539humanBCL2P10415T56FSSQPGHtPHPAASR
MAPK14Q16539humanCCND2P30279T280DELDQAstPtDVRDICyclin_C
MAPK14Q16539humanLAMP2P13473T211tVPSPtttPtPKEKP
MAPK14Q16539humanMEF2DQ14814S450VsPsRERsPAPPPPA
MAPK14Q16539humanELK1P19419S383IHFWSTLsPIAPRsP
MAPK14Q16539humanTP53P04637S15PsVEPPLsQEtFsDLP53_TAD
MAPK14Q16539humanTRIM9Q9C026-5S76SLYSEADsGYGsYGG
MAPK14Q16539humanRBSNQ9H1K0S215EsLSTHtsPsQsPNsFYVE
MAPK14Q16539humanPRKCEQ02156S350RsKsAPtsPCDQEIK
MAPK14Q16539humanF3P13726S285RKAGVGQsWkENsPL
MAPK14Q16539humanPOU3F2P20265S91GGGGGDGsPWSTSPL
MAPK14Q16539humanFOXC1Q12948S272SSLSSGSsPPGSLPS
MAPK14Q16539humanMFFQ9GZY8S155GRLkRERsMsENAVRMiff
MAPK14Q16539humanEZH2Q15910T367NNssRPstPtINVLE
MAPK14Q16539humanMAPTP10636-8T205ssPGsPGtPGsRsRt
MAPK14Q16539humanSREBF1P36956-3T402TEVEDTLtPPPSDAG
MAPK14Q16539humanKCNQ2O43526-4S427VAAKGKGsPQAQTVR
MAPK14Q16539humanEWSR1Q01844T79QPPTGYTtPTAPQAY
MAPK14Q16539humanPPARGC1AQ9UBK2S266SLPLtPEsPNDPKGs
MAPK14Q16539humanBACE1P56817S83YVEMTVGsPPQTLNIAsp
MAPK14Q16539humanCDT1Q9H211T406LPAtPPAtPPAAsPs
MAPK14Q16539humanMAPTP10636-8S422GsIDMVDsPQLAtLA
MAPK14Q16539humanCDKN1AP38936T57NFDFVtEtPLEGDFACDI
MAPK14Q16539humanELAVL1Q15717S88LNGLRLQskTIkVSYRRM_1
MAPK14Q16539humanEIF2S1P05198S52MILLsELsRRRIRsIS1
MAPK14Q16539humanKAT5Q92993T158VEVVsPAtPVPSETA
MAPK14Q16539humanNCOA3Q9Y6Q9S505SPVAGVHsPMAsSGNNCOA_u2
MAPK14Q16539humanNR3C1P04150S211PGkEtNEsPWRSDLLGCR
MAPK14Q16539humanMAP4P27816S787KAPEkRAsPsKPAsA
MAPK14Q16539humanTXNIPQ9H3M7S361DMDGsQDsPIFMYAP
MAPK14Q16539humanMEF2AQ02078S494PNTEDREsPsVKRMR
MAPK14Q16539humanMEF2CQ06413-3T293QSAQSLAtPVVSVAt
MAPK14Q16539humanTP63Q9H3D4S455QKQtSIQsPSSYGNs


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
MAPK14IDDescription0.00e+00
MAPK14GO:0010586miRNA metabolic process1.55e-15
MAPK14GO:0061614miRNA transcription6.25e-14
MAPK14GO:0051402neuron apoptotic process2.74e-13
MAPK14GO:2000628regulation of miRNA metabolic process5.41e-13
MAPK14GO:1902893regulation of miRNA transcription8.07e-13
MAPK14GO:0048863stem cell differentiation2.72e-12
MAPK14GO:0140747regulation of ncRNA transcription2.39e-11
MAPK14GO:0098781ncRNA transcription1.91e-10
MAPK14GO:0043523regulation of neuron apoptotic process1.70e-09
MAPK14GO:0032355response to estradiol5.31e-09
MAPK14GO:0006979response to oxidative stress8.53e-09
MAPK14GO:0062197cellular response to chemical stress1.43e-08
MAPK14GO:0097193intrinsic apoptotic signaling pathway1.46e-08
MAPK14GO:1902895positive regulation of miRNA transcription1.61e-08
MAPK14GO:0060485mesenchyme development1.86e-08
MAPK14GO:0072132mesenchyme morphogenesis3.34e-08
MAPK14GO:2001233regulation of apoptotic signaling pathway4.26e-08
MAPK14GO:0048762mesenchymal cell differentiation5.70e-08
MAPK14GO:2000630positive regulation of miRNA metabolic process8.27e-08
MAPK14GO:0031667response to nutrient levels1.72e-07
MAPK14GO:0003170heart valve development2.51e-07
MAPK14GO:0009408response to heat3.11e-07
MAPK14GO:0034599cellular response to oxidative stress3.11e-07
MAPK14GO:0010212response to ionizing radiation3.53e-07
MAPK14GO:0072331signal transduction by p53 class mediator3.53e-07
MAPK14GO:0010038response to metal ion3.75e-07
MAPK14GO:0043525positive regulation of neuron apoptotic process4.92e-07
MAPK14GO:0050673epithelial cell proliferation5.08e-07
MAPK14GO:0009314response to radiation5.86e-07
MAPK14GO:0048638regulation of developmental growth7.43e-07
MAPK14GO:0016049cell growth7.89e-07
MAPK14GO:0003179heart valve morphogenesis8.36e-07
MAPK14GO:0071214cellular response to abiotic stimulus8.37e-07
MAPK14GO:0104004cellular response to environmental stimulus8.37e-07
MAPK14GO:0001701in utero embryonic development9.71e-07
MAPK14GO:0003203endocardial cushion morphogenesis9.86e-07
MAPK14GO:0070482response to oxygen levels1.10e-06
MAPK14GO:0071496cellular response to external stimulus1.20e-06
MAPK14GO:0003176aortic valve development1.28e-06
MAPK14GO:0001666response to hypoxia1.28e-06
MAPK14GO:0000302response to reactive oxygen species1.28e-06
MAPK14GO:0010506regulation of autophagy1.53e-06
MAPK14GO:0071480cellular response to gamma radiation1.81e-06
MAPK14GO:0001558regulation of cell growth1.81e-06
MAPK14GO:0009266response to temperature stimulus1.81e-06
MAPK14GO:1905314semi-lunar valve development2.02e-06
MAPK14GO:0042060wound healing2.02e-06
MAPK14GO:0003007heart morphogenesis2.02e-06
MAPK14GO:0042594response to starvation2.02e-06

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Related Drugs to LEMD3_MAPK14


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning LEMD3-MAPK14 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

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Related Diseases to LEMD3_MAPK14


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate