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Kinase Fusion Gene:LIMK1_ABI2 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: LIMK1_ABI2 | KinaseFusionDB ID: KFG3147 | FusionGDB2.0 ID: KFG3147 | Hgene | Tgene | Gene symbol | LIMK1 | ABI2 | Gene ID | 3984 | 10152 | |
| Gene name | LIM domain kinase 1 | abl interactor 2 | ||||||||||
| Synonyms | LIMK|LIMK-1 | ABI-2|ABI2B|AIP-1|AIP1|AblBP3|SSH3BP2|argBP1|argBPIA|argBPIB | ||||||||||
| Cytomap | 7q11.23 | 2q33.2 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | LIM domain kinase 1LIM motif-containing protein kinase | abl interactor 2abelson interactor 2abl binding protein 3abl-interacting protein 1 (SH3-containing protein)abl-interactor protein 2barg protein tyrosine kinase-binding proteinarg-binding protein 1 | ||||||||||
| Modification date | 20240305 | 20240411 | ||||||||||
| UniProtAcc | P53667 | Q9NYB9 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000418310, ENST00000336180, ENST00000538333, ENST00000491052, | ENST00000295851, ENST00000261017, ENST00000430418, ENST00000424558, ENST00000261016, ENST00000422511, ENST00000430574, ENST00000261018, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: LIMK1 [Title/Abstract] AND ABI2 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | ||||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | LIMK1 | GO:0006468 | protein phosphorylation | 17512523|22328514 |
| Hgene | LIMK1 | GO:0032233 | positive regulation of actin filament bundle assembly | 17512523 |
| Hgene | LIMK1 | GO:0051444 | negative regulation of ubiquitin-protein transferase activity | 17512523 |
| Tgene | ABI2 | GO:0010592 | positive regulation of lamellipodium assembly | 21107423 |
| Tgene | ABI2 | GO:0016601 | Rac protein signal transduction | 21107423 |
| Tgene | ABI2 | GO:0018108 | peptidyl-tyrosine phosphorylation | 17101133 |
| Tgene | ABI2 | GO:2000601 | positive regulation of Arp2/3 complex-mediated actin nucleation | 21107423 |
| Kinase Fusion gene breakpoints across LIMK1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across ABI2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| CCLE | SW48 | LIMK1 | chr7 | 73520573 | ABI2 | chr2 | 204267299 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:/:) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LIMK1 | ABI2 |
| FUNCTION: Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:11832213, PubMed:12807904, PubMed:15660133, PubMed:16230460, PubMed:18028908, PubMed:22328514, PubMed:23633677). Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop (PubMed:10436159). LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton (PubMed:11832213, PubMed:15660133, PubMed:16230460, PubMed:23633677). In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation (PubMed:11832213, PubMed:15660133, PubMed:16230460, PubMed:23633677). Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly (PubMed:18028908). Stimulates axonal outgrowth and may be involved in brain development (PubMed:18028908). {ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:11832213, ECO:0000269|PubMed:12807904, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:16230460, ECO:0000269|PubMed:18028908, ECO:0000269|PubMed:22328514, ECO:0000269|PubMed:23633677}.; FUNCTION: [Isoform 3]: Has a dominant negative effect on actin cytoskeletal changes. Required for atypical chemokine receptor ACKR2-induced phosphorylation of cofilin (CFL1). {ECO:0000269|PubMed:10196227}. | FUNCTION: Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (PubMed:21107423). Acts as a regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (PubMed:7590236, PubMed:8649853, PubMed:10498863). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (By similarity). Also required for nascent adherens junction assembly in epithelial cells (PubMed:15572692). {ECO:0000250|UniProtKB:P62484, ECO:0000269|PubMed:10498863, ECO:0000269|PubMed:15572692, ECO:0000269|PubMed:21107423, ECO:0000269|PubMed:7590236, ECO:0000269|PubMed:8649853}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of LIMK1_ABI2 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| LIMK1 | P53667 | human | DSTN | P60981 | S3 | _____MAsGVQVADE | |
| LIMK1 | P53667 | human | CFL1 | P23528 | S3 | _____MAsGVAVsDG |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| LIMK1 | ID | Description | 0.00e+00 |
| LIMK1 | GO:0051014 | actin filament severing | 3.64e-05 |
| LIMK1 | GO:0030042 | actin filament depolymerization | 2.51e-04 |
| LIMK1 | GO:0051261 | protein depolymerization | 6.63e-04 |
| LIMK1 | GO:0008154 | actin polymerization or depolymerization | 1.45e-03 |
| LIMK1 | GO:0032984 | protein-containing complex disassembly | 1.81e-03 |
| LIMK1 | GO:0007015 | actin filament organization | 5.34e-03 |
| LIMK1 | GO:0022411 | cellular component disassembly | 5.34e-03 |
| LIMK1 | GO:0030836 | positive regulation of actin filament depolymerization | 9.30e-03 |
| LIMK1 | GO:1901881 | positive regulation of protein depolymerization | 1.20e-02 |
| LIMK1 | GO:0044794 | positive regulation by host of viral process | 1.20e-02 |
| LIMK1 | GO:0040019 | positive regulation of embryonic development | 1.20e-02 |
| LIMK1 | GO:0043243 | positive regulation of protein-containing complex disassembly | 1.76e-02 |
| LIMK1 | GO:0061001 | regulation of dendritic spine morphogenesis | 1.85e-02 |
| LIMK1 | GO:0044788 | modulation by host of viral process | 1.92e-02 |
| LIMK1 | GO:0030834 | regulation of actin filament depolymerization | 1.92e-02 |
| LIMK1 | GO:0060997 | dendritic spine morphogenesis | 1.92e-02 |
| LIMK1 | GO:0051293 | establishment of spindle localization | 1.92e-02 |
| LIMK1 | GO:0051653 | spindle localization | 1.97e-02 |
| LIMK1 | GO:0097061 | dendritic spine organization | 2.17e-02 |
| LIMK1 | GO:1901879 | regulation of protein depolymerization | 2.17e-02 |
| LIMK1 | GO:0051851 | modulation by host of symbiont process | 2.17e-02 |
| LIMK1 | GO:0000281 | mitotic cytokinesis | 2.17e-02 |
| LIMK1 | GO:0106027 | neuron projection organization | 2.17e-02 |
| LIMK1 | GO:0045995 | regulation of embryonic development | 2.17e-02 |
| LIMK1 | GO:0060996 | dendritic spine development | 2.17e-02 |
| LIMK1 | GO:0099175 | regulation of postsynapse organization | 2.26e-02 |
| LIMK1 | GO:0061640 | cytoskeleton-dependent cytokinesis | 2.42e-02 |
| LIMK1 | GO:0051702 | biological process involved in interaction with symbiont | 2.42e-02 |
| LIMK1 | GO:0043244 | regulation of protein-containing complex disassembly | 2.42e-02 |
| LIMK1 | GO:0007266 | Rho protein signal transduction | 2.56e-02 |
| LIMK1 | GO:0048813 | dendrite morphogenesis | 2.56e-02 |
| LIMK1 | GO:0008064 | regulation of actin polymerization or depolymerization | 2.71e-02 |
| LIMK1 | GO:0030832 | regulation of actin filament length | 2.71e-02 |
| LIMK1 | GO:1902905 | positive regulation of supramolecular fiber organization | 2.93e-02 |
| LIMK1 | GO:0051495 | positive regulation of cytoskeleton organization | 2.97e-02 |
| LIMK1 | GO:0000910 | cytokinesis | 2.97e-02 |
| LIMK1 | GO:0099173 | postsynapse organization | 3.02e-02 |
| LIMK1 | GO:0016358 | dendrite development | 3.47e-02 |
| LIMK1 | GO:0050807 | regulation of synapse organization | 3.47e-02 |
| LIMK1 | GO:0022604 | regulation of cell morphogenesis | 3.47e-02 |
| LIMK1 | GO:0050803 | regulation of synapse structure or activity | 3.47e-02 |
| LIMK1 | GO:0110053 | regulation of actin filament organization | 3.69e-02 |
| LIMK1 | GO:0044403 | biological process involved in symbiotic interaction | 4.25e-02 |
| LIMK1 | GO:0032956 | regulation of actin cytoskeleton organization | 4.30e-02 |
| LIMK1 | GO:0007265 | Ras protein signal transduction | 4.30e-02 |
| LIMK1 | GO:0032535 | regulation of cellular component size | 4.56e-02 |
| LIMK1 | GO:0032970 | regulation of actin filament-based process | 4.57e-02 |
| LIMK1 | GO:1902903 | regulation of supramolecular fiber organization | 4.59e-02 |
| LIMK1 | GO:0016032 | viral process | 4.93e-02 |
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Related Drugs to LIMK1_ABI2 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning LIMK1-ABI2 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to LIMK1_ABI2 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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