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Kinase Fusion Gene:LIMK1_GNAT3 |
Kinase Fusion Protein Summary |
Kinase Fusion gene summary |
Kinase Fusion partner gene information | Kinase Fusion gene name: LIMK1_GNAT3 | KinaseFusionDB ID: KFG3149 | FusionGDB2.0 ID: KFG3149 | Hgene | Tgene | Gene symbol | LIMK1 | GNAT3 | Gene ID | 3984 | 346562 | |
Gene name | LIM domain kinase 1 | G protein subunit alpha transducin 3 | ||||||||||
Synonyms | LIMK|LIMK-1 | GDCA|HG1E | ||||||||||
Cytomap | 7q11.23 | 7q21.11 | ||||||||||
Type of gene | protein-coding | protein-coding | ||||||||||
Description | LIM domain kinase 1LIM motif-containing protein kinase | guanine nucleotide-binding protein G(t) subunit alpha-3guanine nucleotide binding protein, alpha transducing 3gustatory G proteingustducin alpha-3 chaingustducin, alpha polypeptideheterotrimeric guanine nucleotide-binding protein 1E | ||||||||||
Modification date | 20240305 | 20240305 | ||||||||||
UniProtAcc | P53667 | A8MTJ3 | ||||||||||
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000336180, ENST00000418310, ENST00000538333, ENST00000491052, | ENST00000398291, | |||||||||
Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: LIMK1 [Title/Abstract] AND GNAT3 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | LIMK1(73530288)-GNAT3(80123963), # samples:3 |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | LIMK1 | GO:0006468 | protein phosphorylation | 17512523|22328514 |
Hgene | LIMK1 | GO:0032233 | positive regulation of actin filament bundle assembly | 17512523 |
Hgene | LIMK1 | GO:0051444 | negative regulation of ubiquitin-protein transferase activity | 17512523 |
Kinase Fusion gene breakpoints across LIMK1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Kinase Fusion gene breakpoints across GNAT3 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
Kinase Fusion gene information. |
Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
ChimerDB4 | TCGA-X6-A8C6-01A | LIMK1 | chr7 | 73530288 | GNAT3 | chr7 | 80123963 |
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Kinase Fusion ORF Analysis |
Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
ENST00000418310 | ENST00000398291 | LIMK1 | chr7 | 73530288 | GNAT3 | chr7 | 80123963 | 2706 | 869 |
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Kinase Fusion Amino Acid Sequences |
For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq >ENST00000418310_ENST00000398291_LIMK1_chr7_73530288_GNAT3_chr7_80123963_length(amino acids)=869 MPMSSILELSTSRQGVPPSVLDWTTQFLWTLDSAQTRAPSRTLGRAAPAPGSELPVCASCGQRIYDGQYLQALNADWHADCFRCCDCSAS LSHQYYEKDGQLFCKKDYWARYGESCHGCSEQITKGLVMVAGELKYHPECFICLTCGTFIGDGDTYTLVEHSKLYCGHCYYQTVVTPVIE QILPDSPGSHLPHTVTLVSIPASSHGKRGLSVSIDPPHGPPGCGTEHSHTVRVQGVDPGCMSPDVKNSIHVGDRILEINGTPIRNVPLDE IDLLIQETSRLLQLTLEHDPHDTLGHGLGPETSPLSSPAYTPSGEAGSSARQKPVLRSCSIDRSPGAGSLGSPASQRKDLGRSESLRVVC RPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKG GTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYT VVGNPYWMAPEMINGAGESGKSTIVKQMKIIHKNGYSEQECMEFKAVIYSNTLQSILAIVKAMTTLGIDYVNPRSAEDQRQLYAMANTLE DGGMTPQLAEVIKRLWRDPGIQACFERASEYQLNDSAAYYLNDLDRITASGYVPNEQDVLHSRVKTTGIIETQFSFKDLHFRMFDVGGQR SERKKWIHCFEGVTCIIFCAALSAYDMVLVEDEEVNRMHESLHLFNSICNHKYFSTTSIVLFLNKKDIFQEKVTKVHLSICFPEYTGPNT -------------------------------------------------------------- |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:73530288/chr7:80123963) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
LIMK1 | GNAT3 |
FUNCTION: Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:11832213, PubMed:12807904, PubMed:15660133, PubMed:16230460, PubMed:18028908, PubMed:22328514, PubMed:23633677). Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop (PubMed:10436159). LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton (PubMed:11832213, PubMed:15660133, PubMed:16230460, PubMed:23633677). In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation (PubMed:11832213, PubMed:15660133, PubMed:16230460, PubMed:23633677). Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly (PubMed:18028908). Stimulates axonal outgrowth and may be involved in brain development (PubMed:18028908). {ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:11832213, ECO:0000269|PubMed:12807904, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:16230460, ECO:0000269|PubMed:18028908, ECO:0000269|PubMed:22328514, ECO:0000269|PubMed:23633677}.; FUNCTION: [Isoform 3]: Has a dominant negative effect on actin cytoskeletal changes. Required for atypical chemokine receptor ACKR2-induced phosphorylation of cofilin (CFL1). {ECO:0000269|PubMed:10196227}. | FUNCTION: Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter. Indeed, denatonium and strychnine induce transient reduction in cAMP and cGMP in taste tissue, whereas this decrease is inhibited by GNAT3 antibody. Gustducin heterotrimer transduces response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit, as well as via activation of phospholipase C for beta and gamma subunits, with ultimate increase inositol trisphosphate and increase of intracellular Calcium. GNAT3 can functionally couple to taste receptors to transmit intracellular signal: receptor heterodimer TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs act as bitter sensors. Functions also as lumenal sugar sensors in the gut to control the expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of Glucagon-like peptide-1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP. Thus, may modulate the gut capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including diabetes and obesity. {ECO:0000269|PubMed:11917125, ECO:0000269|PubMed:17724330}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
Hgene | LIMK1 | 73530288 | GNAT3 | 80123963 | ENST00000418310 | 12 | 15 | 25_75 | 4881 | 614 | Domain | Note=LIM zinc-binding 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125 |
Hgene | LIMK1 | 73530288 | GNAT3 | 80123963 | ENST00000418310 | 13 | 16 | 25_75 | 5221 | 648 | Domain | Note=LIM zinc-binding 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125 |
Hgene | LIMK1 | 73530288 | GNAT3 | 80123963 | ENST00000418310 | 12 | 15 | 84_137 | 4881 | 614 | Domain | Note=LIM zinc-binding 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125 |
Hgene | LIMK1 | 73530288 | GNAT3 | 80123963 | ENST00000418310 | 13 | 16 | 84_137 | 5221 | 648 | Domain | Note=LIM zinc-binding 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00125 |
Hgene | LIMK1 | 73530288 | GNAT3 | 80123963 | ENST00000418310 | 12 | 15 | 165_258 | 4881 | 614 | Domain | Note=PDZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143 |
Hgene | LIMK1 | 73530288 | GNAT3 | 80123963 | ENST00000418310 | 13 | 16 | 165_258 | 5221 | 648 | Domain | Note=PDZ;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00143 |
- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase Fusion Protein Structures |
CIF files of the predicted kinase fusion proteins * Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
Kinase Fusion protein CIF link (fusion AA seq ID in KinaseFusionDB) | Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | AA seq | Len(AA seq) |
PDB file >>>142_LIMK1_GNAT3 | ENST00000418310 | ENST00000398291 | LIMK1 | chr7 | 73530288 | GNAT3 | chr7 | 80123963 | MPMSSILELSTSRQGVPPSVLDWTTQFLWTLDSAQTRAPSRTLGRAAPAPGSELPVCASCGQRIYDGQYLQALNADWHADCFRCCDCSAS LSHQYYEKDGQLFCKKDYWARYGESCHGCSEQITKGLVMVAGELKYHPECFICLTCGTFIGDGDTYTLVEHSKLYCGHCYYQTVVTPVIE QILPDSPGSHLPHTVTLVSIPASSHGKRGLSVSIDPPHGPPGCGTEHSHTVRVQGVDPGCMSPDVKNSIHVGDRILEINGTPIRNVPLDE IDLLIQETSRLLQLTLEHDPHDTLGHGLGPETSPLSSPAYTPSGEAGSSARQKPVLRSCSIDRSPGAGSLGSPASQRKDLGRSESLRVVC RPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKG GTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYT VVGNPYWMAPEMINGAGESGKSTIVKQMKIIHKNGYSEQECMEFKAVIYSNTLQSILAIVKAMTTLGIDYVNPRSAEDQRQLYAMANTLE DGGMTPQLAEVIKRLWRDPGIQACFERASEYQLNDSAAYYLNDLDRITASGYVPNEQDVLHSRVKTTGIIETQFSFKDLHFRMFDVGGQR SERKKWIHCFEGVTCIIFCAALSAYDMVLVEDEEVNRMHESLHLFNSICNHKYFSTTSIVLFLNKKDIFQEKVTKVHLSICFPEYTGPNT | 869 |
3D view using mol* of 142_LIMK1_GNAT3 | ||||||||||
PDB file >>>HKFP_212_LIMK1_GNAT3 | ENST00000418310 | ENST00000398291 | LIMK1 | chr7 | 73530288 | GNAT3 | chr7 | 80123963 | MPMSSILELSTSRQGVPPSVLDWTTQFLWTLDSAQTRAPSRTLGRAAPAPGSELPVCASCGQRIYDGQYLQALNADWHADCFRCCDCSAS LSHQYYEKDGQLFCKKDYWARYGESCHGCSEQITKGLVMVAGELKYHPECFICLTCGTFIGDGDTYTLVEHSKLYCGHCYYQTVVTPVIE QILPDSPGSHLPHTVTLVSIPASSHGKRGLSVSIDPPHGPPGCGTEHSHTVRVQGVDPGCMSPDVKNSIHVGDRILEINGTPIRNVPLDE IDLLIQETSRLLQLTLEHDPHDTLGHGLGPETSPLSSPAYTPSGEAGSSARQKPVLRSCSIDRSPGAGSLGSPASQRKDLGRSESLRVVC RPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKG GTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYT VVGNPYWMAPEMINGAGESGKSTIVKQMKIIHKNGYSEQECMEFKAVIYSNTLQSILAIVKAMTTLGIDYVNPRSAEDQRQLYAMANTLE DGGMTPQLAEVIKRLWRDPGIQACFERASEYQLNDSAAYYLNDLDRITASGYVPNEQDVLHSRVKTTGIIETQFSFKDLHFRMFDVGGQR SERKKWIHCFEGVTCIIFCAALSAYDMVLVEDEEVNRMHESLHLFNSICNHKYFSTTSIVLFLNKKDIFQEKVTKVHLSICFPEYTGPNT | 869_LIMK1_GNAT3 |
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Comparison of Fusion Protein Isoforms |
Superimpose the 3D Structures Among All Fusion Protein Isoforms * Download the pdb file and open it from the molstar online viewer. |
Comparison of the Secondary Structures of Fusion Protein Isoforms |
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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB |
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pLDDT score distribution |
pLDDT score distribution of the predicted fusion protein structures from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. * The blue color at the bottom marks the best active site residues. |
142_LIMK1_GNAT3.png |
142_LIMK1_GNAT3.png |
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Potential Active Site Information |
The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite. |
Kinase Fusion AA seq ID in KinaseFusionDB | Site score | Size | Dscore | Volume | Exposure | Enclosure | Contact | Phobic | Philic | Balance | Don/Acc | Residues |
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Ramachandran Plot of Kinase Fusion Protein Structure |
Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide. |
142_LIMK1_GNAT3_ramachandran.png |
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Virtual Screening Results |
Distribution of the average docking score across all approved kinase inhibitors. Distribution of the number of occurrence across all approved kinase inhibitors. |
5'-kinase fusion protein case |
3'-kinase fusion protein case |
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Drug information from DrugBank of the top 20 interacting small molecules. * The detailed information of individual kinase inhibitors are available in the download page. |
Fusion gene name info | Drug | Docking score | Glide g score | Glide energy |
142_LIMK1_GNAT3-DOCK_HTVS_1-001 | Pazopanib | -8.07964 | -8.08654 | -57.4404 |
142_LIMK1_GNAT3-DOCK_HTVS_1-001 | Pazopanib | -8.07964 | -8.08654 | -57.4404 |
142_LIMK1_GNAT3-DOCK_HTVS_1-001 | Nilotinib | -6.75515 | -7.67995 | -56.2459 |
142_LIMK1_GNAT3-DOCK_HTVS_1-001 | Nilotinib | -6.75515 | -7.67995 | -56.2459 |
142_LIMK1_GNAT3-DOCK_HTVS_1-001 | Neratinib | -6.50329 | -6.689189999999999 | -59.8167 |
142_LIMK1_GNAT3-DOCK_HTVS_1-001 | Neratinib | -6.34334 | -6.52564 | -60.0888 |
142_LIMK1_GNAT3-DOCK_HTVS_1-001 | Neratinib | -6.34334 | -6.52564 | -60.0888 |
142_LIMK1_GNAT3-DOCK_HTVS_1-001 | Netarsudil | -6.23468 | -6.24578 | -57.2987 |
142_LIMK1_GNAT3-DOCK_HTVS_1-001 | Netarsudil | -6.23468 | -6.24578 | -57.2987 |
142_LIMK1_GNAT3-DOCK_HTVS_1-001 | Dacomitinib | -6.20442 | -6.31272 | -50.3376 |
142_LIMK1_GNAT3-DOCK_HTVS_1-001 | Dacomitinib | -6.20442 | -6.31272 | -50.3376 |
142_LIMK1_GNAT3-DOCK_HTVS_1-001 | Gefitinib | -6.14424 | -6.559239999999999 | -47.0029 |
142_LIMK1_GNAT3-DOCK_HTVS_1-001 | Gefitinib | -6.14424 | -6.559239999999999 | -47.0029 |
142_LIMK1_GNAT3-DOCK_HTVS_1-001 | Upadacitinib | -5.61587 | -5.61687 | -40.1482 |
142_LIMK1_GNAT3-DOCK_HTVS_1-001 | Dasatinib | -5.58014 | -6.0784400000000005 | -48.3844 |
142_LIMK1_GNAT3-DOCK_HTVS_1-001 | Dasatinib | -5.58014 | -6.0784400000000005 | -48.3844 |
142_LIMK1_GNAT3-DOCK_HTVS_1-001 | Dasatinib | -5.58014 | -6.0784400000000005 | -48.3844 |
142_LIMK1_GNAT3-DOCK_HTVS_1-001 | Fedratinib | -5.55547 | -5.60687 | -57.0329 |
142_LIMK1_GNAT3-DOCK_HTVS_1-001 | Fedratinib | -5.55547 | -5.60687 | -57.0329 |
142_LIMK1_GNAT3-DOCK_HTVS_1-001 | Tivozanib | -5.50789 | -5.50789 | -50.9417 |
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Kinase-Substrate Information of LIMK1_GNAT3 |
Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
LIMK1 | P53667 | human | DSTN | P60981 | S3 | _____MAsGVQVADE | |
LIMK1 | P53667 | human | CFL1 | P23528 | S3 | _____MAsGVAVsDG |
Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
Enriched GO biological processes of the phosphorylation target genes of the kinase |
Kinase | GOID | GO term | P.adjust |
LIMK1 | ID | Description | 0.00e+00 |
LIMK1 | GO:0051014 | actin filament severing | 3.64e-05 |
LIMK1 | GO:0030042 | actin filament depolymerization | 2.51e-04 |
LIMK1 | GO:0051261 | protein depolymerization | 6.63e-04 |
LIMK1 | GO:0008154 | actin polymerization or depolymerization | 1.45e-03 |
LIMK1 | GO:0032984 | protein-containing complex disassembly | 1.81e-03 |
LIMK1 | GO:0007015 | actin filament organization | 5.34e-03 |
LIMK1 | GO:0022411 | cellular component disassembly | 5.34e-03 |
LIMK1 | GO:0030836 | positive regulation of actin filament depolymerization | 9.30e-03 |
LIMK1 | GO:1901881 | positive regulation of protein depolymerization | 1.20e-02 |
LIMK1 | GO:0044794 | positive regulation by host of viral process | 1.20e-02 |
LIMK1 | GO:0040019 | positive regulation of embryonic development | 1.20e-02 |
LIMK1 | GO:0043243 | positive regulation of protein-containing complex disassembly | 1.76e-02 |
LIMK1 | GO:0061001 | regulation of dendritic spine morphogenesis | 1.85e-02 |
LIMK1 | GO:0044788 | modulation by host of viral process | 1.92e-02 |
LIMK1 | GO:0030834 | regulation of actin filament depolymerization | 1.92e-02 |
LIMK1 | GO:0060997 | dendritic spine morphogenesis | 1.92e-02 |
LIMK1 | GO:0051293 | establishment of spindle localization | 1.92e-02 |
LIMK1 | GO:0051653 | spindle localization | 1.97e-02 |
LIMK1 | GO:0097061 | dendritic spine organization | 2.17e-02 |
LIMK1 | GO:1901879 | regulation of protein depolymerization | 2.17e-02 |
LIMK1 | GO:0051851 | modulation by host of symbiont process | 2.17e-02 |
LIMK1 | GO:0000281 | mitotic cytokinesis | 2.17e-02 |
LIMK1 | GO:0106027 | neuron projection organization | 2.17e-02 |
LIMK1 | GO:0045995 | regulation of embryonic development | 2.17e-02 |
LIMK1 | GO:0060996 | dendritic spine development | 2.17e-02 |
LIMK1 | GO:0099175 | regulation of postsynapse organization | 2.26e-02 |
LIMK1 | GO:0061640 | cytoskeleton-dependent cytokinesis | 2.42e-02 |
LIMK1 | GO:0051702 | biological process involved in interaction with symbiont | 2.42e-02 |
LIMK1 | GO:0043244 | regulation of protein-containing complex disassembly | 2.42e-02 |
LIMK1 | GO:0007266 | Rho protein signal transduction | 2.56e-02 |
LIMK1 | GO:0048813 | dendrite morphogenesis | 2.56e-02 |
LIMK1 | GO:0008064 | regulation of actin polymerization or depolymerization | 2.71e-02 |
LIMK1 | GO:0030832 | regulation of actin filament length | 2.71e-02 |
LIMK1 | GO:1902905 | positive regulation of supramolecular fiber organization | 2.93e-02 |
LIMK1 | GO:0051495 | positive regulation of cytoskeleton organization | 2.97e-02 |
LIMK1 | GO:0000910 | cytokinesis | 2.97e-02 |
LIMK1 | GO:0099173 | postsynapse organization | 3.02e-02 |
LIMK1 | GO:0016358 | dendrite development | 3.47e-02 |
LIMK1 | GO:0050807 | regulation of synapse organization | 3.47e-02 |
LIMK1 | GO:0022604 | regulation of cell morphogenesis | 3.47e-02 |
LIMK1 | GO:0050803 | regulation of synapse structure or activity | 3.47e-02 |
LIMK1 | GO:0110053 | regulation of actin filament organization | 3.69e-02 |
LIMK1 | GO:0044403 | biological process involved in symbiotic interaction | 4.25e-02 |
LIMK1 | GO:0032956 | regulation of actin cytoskeleton organization | 4.30e-02 |
LIMK1 | GO:0007265 | Ras protein signal transduction | 4.30e-02 |
LIMK1 | GO:0032535 | regulation of cellular component size | 4.56e-02 |
LIMK1 | GO:0032970 | regulation of actin filament-based process | 4.57e-02 |
LIMK1 | GO:1902903 | regulation of supramolecular fiber organization | 4.59e-02 |
LIMK1 | GO:0016032 | viral process | 4.93e-02 |
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Related Drugs to LIMK1_GNAT3 |
Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
Distribution of the number of studies mentioning LIMK1-GNAT3 and kinase inhibitors the PubMed Abstract (04-01-2024) |
Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to LIMK1_GNAT3 |
Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
MeSH ID | MeSH term |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
Clinical Trials from clinicaltrials.gov (06-17-2024) |
Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |