| UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY |
|
|||||||
|
Kinase Fusion Gene:LIMK2_TTC17 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: LIMK2_TTC17 | KinaseFusionDB ID: KFG3167 | FusionGDB2.0 ID: KFG3167 | Hgene | Tgene | Gene symbol | LIMK2 | TTC17 | Gene ID | 3985 | 55761 | |
| Gene name | LIM domain kinase 2 | tetratricopeptide repeat domain 17 | ||||||||||
| Synonyms | - | - | ||||||||||
| Cytomap | 22q12.2 | 11p12-p11.2 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | LIM domain kinase 2 | tetratricopeptide repeat protein 17TPR repeat protein 17 | ||||||||||
| Modification date | 20240305 | 20240403 | ||||||||||
| UniProtAcc | P53671 | Q96AE7 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000331728, ENST00000333611, ENST00000340552, ENST00000406516, ENST00000444929, ENST00000467301, | ENST00000039989, ENST00000299240, ENST00000526774, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: LIMK2 [Title/Abstract] AND TTC17 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | LIMK2(31653126)-TTC17(43468762), # samples:1 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | LIMK2 | GO:0006468 | protein phosphorylation | 22328514 |
| Hgene | LIMK2 | GO:0030953 | astral microtubule organization | 22328514 |
| Kinase Fusion gene breakpoints across LIMK2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across TTC17 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Top |
Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChiTaRS5.0 | CB047836 | LIMK2 | chr22 | 31653126 | TTC17 | chr11 | 43468762 |
Top |
Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
Top |
Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
Top |
Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:31653126/:43468762) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LIMK2 | TTC17 |
| FUNCTION: Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics (PubMed:10436159, PubMed:11018042). Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:11018042). Involved in astral microtubule organization and mitotic spindle orientation during early stages of mitosis by mediating phosphorylation of TPPP (PubMed:22328514). Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro (PubMed:8537403). Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of directional trafficking of ciliary vesicles to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865). {ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:22328514, ECO:0000269|PubMed:25849865, ECO:0000269|PubMed:8537403}. | FUNCTION: Plays a role in primary ciliogenesis by modulating actin polymerization. {ECO:0000269|PubMed:24475127}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
Top |
Kinase-Substrate Information of LIMK2_TTC17 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| LIMK2 | P53671 | human | DSTN | P60981 | S3 | _____MAsGVQVADE | |
| LIMK2 | P53671 | human | CFL1 | P23528 | S3 | _____MAsGVAVsDG | |
| LIMK2 | P53671 | human | G3BP1 | Q13283 | S149 | VtEPQEEsEEEVEEP |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| LIMK2 | ID | Description | 0.00e+00 |
| LIMK2 | GO:0051014 | actin filament severing | 1.50e-04 |
| LIMK2 | GO:0030042 | actin filament depolymerization | 1.03e-03 |
| LIMK2 | GO:0051261 | protein depolymerization | 2.71e-03 |
| LIMK2 | GO:0008154 | actin polymerization or depolymerization | 5.92e-03 |
| LIMK2 | GO:0032984 | protein-containing complex disassembly | 7.39e-03 |
| LIMK2 | GO:0007265 | Ras protein signal transduction | 1.19e-02 |
| LIMK2 | GO:0009615 | response to virus | 1.39e-02 |
| LIMK2 | GO:0007015 | actin filament organization | 1.39e-02 |
| LIMK2 | GO:0007264 | small GTPase mediated signal transduction | 1.39e-02 |
| LIMK2 | GO:0022411 | cellular component disassembly | 1.39e-02 |
| LIMK2 | GO:0030836 | positive regulation of actin filament depolymerization | 1.39e-02 |
| LIMK2 | GO:1901881 | positive regulation of protein depolymerization | 1.86e-02 |
| LIMK2 | GO:0044794 | positive regulation by host of viral process | 1.90e-02 |
| LIMK2 | GO:0040019 | positive regulation of embryonic development | 1.93e-02 |
| LIMK2 | GO:0034063 | stress granule assembly | 2.43e-02 |
| LIMK2 | GO:0043243 | positive regulation of protein-containing complex disassembly | 2.72e-02 |
| LIMK2 | GO:0061001 | regulation of dendritic spine morphogenesis | 2.90e-02 |
| LIMK2 | GO:0044788 | modulation by host of viral process | 3.18e-02 |
| LIMK2 | GO:0030834 | regulation of actin filament depolymerization | 3.18e-02 |
| LIMK2 | GO:0060997 | dendritic spine morphogenesis | 3.18e-02 |
| LIMK2 | GO:0051293 | establishment of spindle localization | 3.18e-02 |
| LIMK2 | GO:0051653 | spindle localization | 3.27e-02 |
| LIMK2 | GO:0032481 | positive regulation of type I interferon production | 3.27e-02 |
| LIMK2 | GO:0032508 | DNA duplex unwinding | 3.27e-02 |
| LIMK2 | GO:0097061 | dendritic spine organization | 3.27e-02 |
| LIMK2 | GO:1902117 | positive regulation of organelle assembly | 3.27e-02 |
| LIMK2 | GO:0032392 | DNA geometric change | 3.27e-02 |
| LIMK2 | GO:1901879 | regulation of protein depolymerization | 3.27e-02 |
| LIMK2 | GO:0051851 | modulation by host of symbiont process | 3.27e-02 |
| LIMK2 | GO:0000281 | mitotic cytokinesis | 3.27e-02 |
| LIMK2 | GO:0106027 | neuron projection organization | 3.27e-02 |
| LIMK2 | GO:0071103 | DNA conformation change | 3.27e-02 |
| LIMK2 | GO:0045995 | regulation of embryonic development | 3.27e-02 |
| LIMK2 | GO:0060996 | dendritic spine development | 3.27e-02 |
| LIMK2 | GO:0099175 | regulation of postsynapse organization | 3.44e-02 |
| LIMK2 | GO:0061640 | cytoskeleton-dependent cytokinesis | 3.59e-02 |
| LIMK2 | GO:0051702 | biological process involved in interaction with symbiont | 3.59e-02 |
| LIMK2 | GO:0032479 | regulation of type I interferon production | 3.59e-02 |
| LIMK2 | GO:0032606 | type I interferon production | 3.59e-02 |
| LIMK2 | GO:0043244 | regulation of protein-containing complex disassembly | 3.59e-02 |
| LIMK2 | GO:0007266 | Rho protein signal transduction | 3.80e-02 |
| LIMK2 | GO:0048813 | dendrite morphogenesis | 3.80e-02 |
| LIMK2 | GO:0090090 | negative regulation of canonical Wnt signaling pathway | 3.80e-02 |
| LIMK2 | GO:0008064 | regulation of actin polymerization or depolymerization | 4.07e-02 |
| LIMK2 | GO:0030832 | regulation of actin filament length | 4.07e-02 |
| LIMK2 | GO:0030178 | negative regulation of Wnt signaling pathway | 4.34e-02 |
| LIMK2 | GO:1902905 | positive regulation of supramolecular fiber organization | 4.34e-02 |
| LIMK2 | GO:0051495 | positive regulation of cytoskeleton organization | 4.47e-02 |
| LIMK2 | GO:0000910 | cytokinesis | 4.47e-02 |
Top |
Related Drugs to LIMK2_TTC17 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning LIMK2-TTC17 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
Top |
Related Diseases to LIMK2_TTC17 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Top |
Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
Copyright 2024-Present -The University of Texas Health Science Center at Houston
Web File Viewing | Emergency Information |Campus Carry|Site Policies |