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	Kinase Fusion Gene Summary
	Kinase Fusion Gene Sample Information
	Kinase Fusion ORF Analysis
	Kinase Fusion Amino Acid Sequences
	Multiple Sequence Alignment of All Fusion Protein Isoforms
	Kinase Fusion Protein Functional Features
	Kinase Fusion Protein Structures
	Comparison of Fusion Protein Isoforms
	Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB
	pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.
	Ramachandran Plot of Kinase Fusion Protein Structure
	Potential Active Site Information
	Virtual Screening Results
	Kinase-Substrate Information
	Related Drugs with This Kinase Fusion Protein
	Related Disease with This Kinase Fusion Protein
	Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:LONP1_MAP2K7

Kinase Fusion Protein Summary

Kinase Fusion gene summary

Kinase Fusion partner gene information	Kinase Fusion gene name: LONP1_MAP2K7
	KinaseFusionDB ID: KFG3196
	FusionGDB2.0 ID: KFG3196
		Hgene	Tgene
	Gene symbol	LONP1	MAP2K7
	Gene ID	9361	5609
	Gene name	lon peptidase 1, mitochondrial	mitogen-activated protein kinase kinase 7
	Synonyms	CODASS\|LON\|LONP\|LonHS\|PIM1\|PRSS15\|hLON	JNKK2\|MAPKK7\|MEK\|MEK 7\|MKK7\|PRKMK7\|SAPKK-4\|SAPKK4
	Cytomap	19p13.3	19p13.2
	Type of gene	protein-coding	protein-coding
	Description	lon protease homolog, mitochondrialhLON ATP-dependent proteasemitochondrial ATP-dependent protease Lonmitochondrial lon protease-like proteinserine protease 15	dual specificity mitogen-activated protein kinase kinase 7JNK-activating kinase 2MAP kinase kinase 7MAPK/ERK kinase 7SAPK kinase 4c-Jun N-terminal kinase kinase 2stress-activated protein kinase kinase 4
	Modification date	20240411	20240416
	UniProtAcc	P36776	O14733
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000590511, ENST00000360614, ENST00000590729, ENST00000593119, ENST00000585374, ENST00000540670,	ENST00000397979, ENST00000397981, ENST00000397983, ENST00000545011,
Context (manual curation of fusion genes in KinaseFusionDB)	PubMed: LONP1 [Title/Abstract] AND MAP2K7 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	LONP1(5719715)-MAP2K7(7974640), # samples:3

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	LONP1	GO:0030163	protein catabolic process	37327776
Hgene	LONP1	GO:0034599	cellular response to oxidative stress	17420247
Hgene	LONP1	GO:0051603	proteolysis involved in protein catabolic process	8248235\|17420247
Tgene	MAP2K7	GO:0006970	response to osmotic stress	9535930
Tgene	MAP2K7	GO:0009408	response to heat	9535930
Tgene	MAP2K7	GO:0009411	response to UV	9535930
Tgene	MAP2K7	GO:0034612	response to tumor necrosis factor	9535930
Tgene	MAP2K7	GO:0051403	stress-activated MAPK cascade	9535930

Kinase Fusion gene breakpoints across LONP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Kinase Fusion gene breakpoints across MAP2K7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Kinase Fusion Gene Sample Information

Kinase Fusion gene information.

Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Sample	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
ChimerDB4	TCGA-C8-A12L-01A	LONP1	chr19	5719715	MAP2K7	chr19	7974640
ChimerDB4	TCGA-C8-A12L	LONP1	chr19	5719714	MAP2K7	chr19	7974639

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Kinase Fusion ORF Analysis

Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (amino acids)
ENST00000585374	ENST00000397981	LONP1	chr19	5719715	MAP2K7	chr19	7974640	3438	458
ENST00000585374	ENST00000397981	LONP1	chr19	5719714	MAP2K7	chr19	7974639	3438	458

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Kinase Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

>ENST00000585374_ENST00000397981_LONP1_chr19_5719715_MAP2K7_chr19_7974640_length(amino acids)=458
MAASTGYVRLWGAARCWVLRRPMLAAAGGRRGRRGRPGHNGAHAHDDPRCVSAPAAHRHHPQPGVPALYQDYRALQLPLANDGGSRSPSS
ESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAV
KQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHG
VIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLPCPSPSQVELATGQFP
YKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLS

--------------------------------------------------------------

>ENST00000585374_ENST00000397981_LONP1_chr19_5719714_MAP2K7_chr19_7974639_length(amino acids)=458
MAASTGYVRLWGAARCWVLRRPMLAAAGGRRGRRGRPGHNGAHAHDDPRCVSAPAAHRHHPQPGVPALYQDYRALQLPLANDGGSRSPSS
ESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAV
KQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHG
VIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLPCPSPSQVELATGQFP
YKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLS

--------------------------------------------------------------

Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:5719715/chr19:7974640)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
LONP1 P36776	MAP2K7 O14733
FUNCTION: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix (PubMed:12198491, PubMed:15870080, PubMed:8248235, PubMed:17579211, PubMed:37327776). Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein, DELE1, helicase Twinkle (TWNK) and the large ribosomal subunit protein MRPL32/bL32m (PubMed:17579211, PubMed:28377575, PubMed:37327776). MRPL32/bL32m is protected from degradation by LONP1 when it is bound to a nucleic acid (RNA), but TWNK is not (PubMed:17579211, PubMed:28377575). May also have a chaperone function in the assembly of inner membrane protein complexes (By similarity). Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome (PubMed:17420247). Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner (PubMed:17420247). May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters (PubMed:14739292, PubMed:17420247). {ECO:0000255\|HAMAP-Rule:MF_03120, ECO:0000269\|PubMed:12198491, ECO:0000269\|PubMed:14739292, ECO:0000269\|PubMed:15870080, ECO:0000269\|PubMed:17420247, ECO:0000269\|PubMed:17579211, ECO:0000269\|PubMed:28377575, ECO:0000269\|PubMed:37327776, ECO:0000269\|PubMed:8248235}.	FUNCTION: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by pro-inflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE (PubMed:28111074). {ECO:0000269\|PubMed:28111074, ECO:0000269\|PubMed:9312068, ECO:0000269\|PubMed:9372971, ECO:0000269\|PubMed:9535930, ECO:0000269\|Ref.5}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).

Partner

Hgeneene

Hbp

Tgeneene

Tbp

ENST

BPexon

TotalExon

Protein feature loci

BPloci

TotalLen

Feature

Note

- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).

Partner

Hgeneene

Hbp

Tgeneene

Tbp

ENST

BPexon

TotalExon

Protein feature loci

BPloci

TotalLen

Feature

Note

Tgene

LONP1

5719714

MAP2K7

7974639

ENST00000585374

120_380

420

Domain

Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159

Tgene

LONP1

5719714

MAP2K7

7974639

ENST00000585374

120_380

427

Domain

Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159

Tgene

LONP1

5719714

MAP2K7

7974639

ENST00000585374

120_380

436

Domain

Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159

Tgene

LONP1

5719715

MAP2K7

7974640

ENST00000585374

120_380

420

Domain

Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159

Tgene

LONP1

5719715

MAP2K7

7974640

ENST00000585374

120_380

427

Domain

Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159

Tgene

LONP1

5719715

MAP2K7

7974640

ENST00000585374

120_380

436

Domain

Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159

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Kinase Fusion Protein Structures

CIF files of the predicted kinase fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Kinase Fusion protein CIF link (fusion AA seq ID in KinaseFusionDB)	Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	AA seq	Len(AA seq)
PDB file >>>287_LONP1_MAP2K7	ENST00000585374	ENST00000397981	LONP1	chr19	5719714	MAP2K7	chr19	7974639	MAASTGYVRLWGAARCWVLRRPMLAAAGGRRGRRGRPGHNGAHAHDDPRCVSAPAAHRHHPQPGVPALYQDYRALQLPLANDGGSRSPSS ESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAV KQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHG VIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLPCPSPSQVELATGQFP YKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLS	458
3D view using mol* of 287_LONP1_MAP2K7

PDB file >>>TKFP_501_LONP1_MAP2K7	ENST00000585374	ENST00000397981	LONP1	chr19	5719715	MAP2K7	chr19	7974640	MAASTGYVRLWGAARCWVLRRPMLAAAGGRRGRRGRPGHNGAHAHDDPRCVSAPAAHRHHPQPGVPALYQDYRALQLPLANDGGSRSPSS ESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAV KQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHG VIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLPCPSPSQVELATGQFP YKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLS	458_LONP1_MAP2K7
PDB file >>>TKFP_502_LONP1_MAP2K7	ENST00000585374	ENST00000397981	LONP1	chr19	5719714	MAP2K7	chr19	7974639	MAASTGYVRLWGAARCWVLRRPMLAAAGGRRGRRGRPGHNGAHAHDDPRCVSAPAAHRHHPQPGVPALYQDYRALQLPLANDGGSRSPSS ESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAV KQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHG VIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLPCPSPSQVELATGQFP YKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLS	458_LONP1_MAP2K7

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Comparison of Fusion Protein Isoforms

Superimpose the 3D Structures Among All Fusion Protein Isoforms
* Download the pdb file and open it from the molstar online viewer.

Comparison of the Secondary Structures of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

LONP1_MAP2K7 does not have any known PDB structures.

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pLDDT score distribution

all_data/KinaseFusionDB_T_Results/KinaseFusionDB_T_ViolinPlots/287_LONP1_MAP2K7.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
* The blue color at the bottom marks the best active site residues.

287_LONP1_MAP2K7.png

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Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Kinase Fusion AA seq ID in KinaseFusionDB

Site score

Size

Dscore

Volume

Exposure

Enclosure

Contact

Phobic

Philic

Balance

Don/Acc

Residues

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Ramachandran Plot of Kinase Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

287_LONP1_MAP2K7_ramachandran.png

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Virtual Screening Results

Distribution of the average docking score across all approved kinase inhibitors.
Distribution of the number of occurrence across all approved kinase inhibitors.

5'-kinase fusion protein case

3'-kinase fusion protein case

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Drug information from DrugBank of the top 20 interacting small molecules.
* The detailed information of individual kinase inhibitors are available in the download page.

Fusion gene name info

Drug

Docking score

Glide g score

Glide energy

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Kinase-Substrate Information of LONP1_MAP2K7

Phosphorylation target of the kinase
(phosphosite, 03-17-2024)

Kinase	Kinase UniProt Acc	Kinase species	Substrate	Substrate UniProt Acc	Substrate phosphorylated residues	Substrate phosphorylated sites (+/-7AA)	Domain
MAP2K7	O14733	human	MAPK10	P53779-2	T221	AGTSFMMtPyVVTRY	Pkinase
MAP2K7	O14733	human	MAPK9	P45984	T183	ACtNFMMtPyVVtRY	Pkinase
MAP2K7	O14733	human	MAPK8	P45983	Y185	tsFMMtPyVVtRYYR	Pkinase
MAP2K7	O14733	human	MAPK9	P45984	S407	STEQtLAsDTDSSLD
MAP2K7	O14733	human	MAPK8	P45983	T183	AGtsFMMtPyVVtRY	Pkinase
MAP2K7	O14733	human	FADD	Q13158	S194	QNRsGAMsPMsWNsD
MAP2K7	O14733	human	MAPK9	P45984	T404	SSMSTEQtLAsDTDS
MAP2K7	O14733	human	MAPK8	P45983-2	T183	AGTSFMMtPyVVTRY	Pkinase
MAP2K7	O14733	human	MAPK10	P53779	T221	AGtsFMMtPyVVtRY	Pkinase

Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

Enriched GO biological processes of the phosphorylation target genes of the kinase

Kinase	GOID	GO term	P.adjust
MAP2K7	ID	Description	0.00e+00
MAP2K7	GO:0038095	Fc-epsilon receptor signaling pathway	2.57e-06
MAP2K7	GO:0038093	Fc receptor signaling pathway	1.55e-05
MAP2K7	GO:0090398	cellular senescence	6.69e-05
MAP2K7	GO:0042752	regulation of circadian rhythm	6.69e-05
MAP2K7	GO:0007254	JNK cascade	1.57e-04
MAP2K7	GO:0007623	circadian rhythm	2.58e-04
MAP2K7	GO:0051403	stress-activated MAPK cascade	3.07e-04
MAP2K7	GO:0031098	stress-activated protein kinase signaling cascade	3.07e-04
MAP2K7	GO:0048511	rhythmic process	5.25e-04
MAP2K7	GO:0071276	cellular response to cadmium ion	6.86e-04
MAP2K7	GO:0002768	immune response-regulating cell surface receptor signaling pathway	6.86e-04
MAP2K7	GO:0046686	response to cadmium ion	1.50e-03
MAP2K7	GO:0002764	immune response-regulating signaling pathway	1.75e-03
MAP2K7	GO:0071260	cellular response to mechanical stimulus	1.92e-03
MAP2K7	GO:0031343	positive regulation of cell killing	1.99e-03
MAP2K7	GO:0031341	regulation of cell killing	3.99e-03
MAP2K7	GO:2001235	positive regulation of apoptotic signaling pathway	6.41e-03
MAP2K7	GO:0034614	cellular response to reactive oxygen species	6.83e-03
MAP2K7	GO:0031334	positive regulation of protein-containing complex assembly	1.03e-02
MAP2K7	GO:0071248	cellular response to metal ion	1.03e-02
MAP2K7	GO:0000302	response to reactive oxygen species	1.04e-02
MAP2K7	GO:0009612	response to mechanical stimulus	1.07e-02
MAP2K7	GO:0001906	cell killing	1.12e-02
MAP2K7	GO:0071241	cellular response to inorganic substance	1.13e-02
MAP2K7	GO:0034599	cellular response to oxidative stress	1.34e-02
MAP2K7	GO:0018105	peptidyl-serine phosphorylation	1.72e-02
MAP2K7	GO:0018209	peptidyl-serine modification	1.79e-02
MAP2K7	GO:0062197	cellular response to chemical stress	1.79e-02
MAP2K7	GO:0009416	response to light stimulus	1.79e-02
MAP2K7	GO:0071214	cellular response to abiotic stimulus	1.84e-02
MAP2K7	GO:0104004	cellular response to environmental stimulus	1.84e-02
MAP2K7	GO:0045089	positive regulation of innate immune response	1.84e-02
MAP2K7	GO:0071496	cellular response to external stimulus	1.84e-02
MAP2K7	GO:0045862	positive regulation of proteolysis	1.84e-02
MAP2K7	GO:0010038	response to metal ion	1.84e-02
MAP2K7	GO:0071803	positive regulation of podosome assembly	1.84e-02
MAP2K7	GO:0002833	positive regulation of response to biotic stimulus	1.89e-02
MAP2K7	GO:1901030	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	1.95e-02
MAP2K7	GO:2001233	regulation of apoptotic signaling pathway	1.95e-02
MAP2K7	GO:0006979	response to oxidative stress	1.95e-02
MAP2K7	GO:0036462	TRAIL-activated apoptotic signaling pathway	1.95e-02
MAP2K7	GO:0071801	regulation of podosome assembly	1.95e-02
MAP2K7	GO:0072683	T cell extravasation	1.95e-02
MAP2K7	GO:0043254	regulation of protein-containing complex assembly	1.95e-02
MAP2K7	GO:0045088	regulation of innate immune response	1.95e-02
MAP2K7	GO:0048148	behavioral response to cocaine	1.95e-02
MAP2K7	GO:0097202	activation of cysteine-type endopeptidase activity	1.95e-02
MAP2K7	GO:0009314	response to radiation	1.95e-02
MAP2K7	GO:0045651	positive regulation of macrophage differentiation	2.16e-02

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Related Drugs to LONP1_MAP2K7

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Distribution of the number of studies mentioning LONP1-MAP2K7 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1

Fusion gene - drug pair 2

PMID

Publication date

DOI

Study title

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Related Diseases to LONP1_MAP2K7

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)

MeSH ID

MeSH term

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Clinical Trials of the Found Drugs/Small Molecules

Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion Gene

Kinase Inhibitor

NCT ID

Study Status

Phases

Disease

# Enrolment

Date