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Kinase Fusion Gene:LRRK2_MON2 |
Kinase Fusion Protein Summary |
Kinase Fusion gene summary |
Kinase Fusion partner gene information | Kinase Fusion gene name: LRRK2_MON2 | KinaseFusionDB ID: KFG3222 | FusionGDB2.0 ID: KFG3222 | Hgene | Tgene | Gene symbol | LRRK2 | MON2 | Gene ID | 120892 | 23041 | |
Gene name | leucine rich repeat kinase 2 | MON2 homolog, regulator of endosome-to-Golgi trafficking | ||||||||||
Synonyms | AURA17|DARDARIN|PARK8|RIPK7|ROCO2 | - | ||||||||||
Cytomap | 12q12 | 12q14.1 | ||||||||||
Type of gene | protein-coding | protein-coding | ||||||||||
Description | leucine-rich repeat serine/threonine-protein kinase 2augmented in rheumatoid arthritis 17 | protein MON2 homologMON2 regulator of endosome-to-Golgi trafficking | ||||||||||
Modification date | 20240416 | 20240403 | ||||||||||
UniProtAcc | Q5S007 | Q7Z3U7 | ||||||||||
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000298910, ENST00000343742, ENST00000481256, | ENST00000549378, ENST00000551397, ENST00000552115, ENST00000280379, ENST00000393629, ENST00000393630, ENST00000393632, ENST00000546600, ENST00000552738, | |||||||||
Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: LRRK2 [Title/Abstract] AND MON2 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | LRRK2(40637483)-MON2(62972225), # samples:1 |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | LRRK2 | GO:0000165 | MAPK cascade | 17200152 |
Hgene | LRRK2 | GO:0001934 | positive regulation of protein phosphorylation | 22012985 |
Hgene | LRRK2 | GO:0007254 | JNK cascade | 19302196 |
Hgene | LRRK2 | GO:0007266 | Rho protein signal transduction | 25500533 |
Hgene | LRRK2 | GO:0010955 | negative regulation of protein processing | 21370995 |
Hgene | LRRK2 | GO:0018105 | peptidyl-serine phosphorylation | 19576176 |
Hgene | LRRK2 | GO:0018107 | peptidyl-threonine phosphorylation | 21048939 |
Hgene | LRRK2 | GO:0031398 | positive regulation of protein ubiquitination | 16352719|20173330 |
Hgene | LRRK2 | GO:0032092 | positive regulation of protein binding | 21370995 |
Hgene | LRRK2 | GO:0034260 | negative regulation of GTPase activity | 22423108 |
Hgene | LRRK2 | GO:0043068 | positive regulation of programmed cell death | 17200152 |
Hgene | LRRK2 | GO:0045860 | positive regulation of protein kinase activity | 19302196 |
Hgene | LRRK2 | GO:0046039 | GTP metabolic process | 21048939 |
Hgene | LRRK2 | GO:0046777 | protein autophosphorylation | 16269541|16321986|17200152|17442267 |
Hgene | LRRK2 | GO:1902499 | positive regulation of protein autoubiquitination | 16352719 |
Hgene | LRRK2 | GO:1903125 | negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation | 21850687 |
Hgene | LRRK2 | GO:1903215 | negative regulation of protein targeting to mitochondrion | 21370995 |
Kinase Fusion gene breakpoints across LRRK2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Kinase Fusion gene breakpoints across MON2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
Kinase Fusion gene information. |
Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
ChimerDB4 | TCGA-BT-A20X-01A | LRRK2 | chr12 | 40637483 | MON2 | chr12 | 62972225 |
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Kinase Fusion ORF Analysis |
Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:40637483/:62972225) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
LRRK2 | MON2 |
FUNCTION: Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking (PubMed:20949042, PubMed:22012985, PubMed:26824392, PubMed:27830463, PubMed:29125462, PubMed:28720718, PubMed:29127255, PubMed:30398148, PubMed:29212815, PubMed:30635421, PubMed:21850687, PubMed:23395371, PubMed:17114044, PubMed:24687852, PubMed:26014385, PubMed:25201882). Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation (PubMed:26824392, PubMed:28720718, PubMed:29127255, PubMed:30398148, PubMed:29212815, PubMed:29125462, PubMed:30635421). Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB35, and RAB43 (PubMed:26824392, PubMed:28720718, PubMed:29127255, PubMed:30398148, PubMed:29212815, PubMed:29125462, PubMed:30635421, PubMed:23395371). Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (PubMed:26824392). Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A (PubMed:26824392). Regulates primary ciliogenesis through phosphorylation of RAB8A and RAB10, which promotes SHH signaling in the brain (PubMed:29125462, PubMed:30398148). Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose-6-phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:17114044). Plays a role in synaptic vesicle trafficking (PubMed:24687852). Plays an important role in recruiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway (PubMed:22012985). The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes (PubMed:22012985). Phosphorylates PRDX3 (PubMed:21850687). By phosphorylating APP on 'Thr-743', which promotes the production and the nuclear translocation of the APP intracellular domain (AICD), regulates dopaminergic neuron apoptosis (PubMed:28720718). Acts as a positive regulator of innate immunity by mediating phosphorylation of RIPK2 downstream of NOD1 and NOD2, thereby enhancing RIPK2 activation (PubMed:27830463). Independent of its kinase activity, inhibits the proteasomal degradation of MAPT, thus promoting MAPT oligomerization and secretion (PubMed:26014385). In addition, has GTPase activity via its Roc domain which regulates LRRK2 kinase activity (PubMed:18230735, PubMed:26824392, PubMed:29125462, PubMed:28720718, PubMed:29212815). {ECO:0000269|PubMed:17114044, ECO:0000269|PubMed:18230735, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:21850687, ECO:0000269|PubMed:22012985, ECO:0000269|PubMed:23395371, ECO:0000269|PubMed:24687852, ECO:0000269|PubMed:25201882, ECO:0000269|PubMed:26014385, ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28720718, ECO:0000269|PubMed:29125462, ECO:0000269|PubMed:29127255, ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:30398148, ECO:0000269|PubMed:30635421}. | FUNCTION: Plays a role in regulating membrane trafficking of cargo proteins. Together with ATP9A and DOP1B, regulates SNX3 retromer-mediated endosomal sorting of WLS away from lysosomal degradation. {ECO:0000269|PubMed:30213940}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of LRRK2_MON2 |
Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
LRRK2 | Q5S007 | human | MAPT | P10636-8 | T231 | KKVAVVRtPPKsPss | |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | T2031 | CCRMGIKtsEGtPGF | Pkinase |
LRRK2 | Q5S007 | human | RAB10 | P61026 | T73 | AGQERFHtITtsYYR | Ras |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | T424 | ASANALStLLEQNVN | |
LRRK2 | Q5S007 | human | RDX | P35241 | T564 | AGRDKyKtLRQIRQG | ERM_C |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | T1967 | QQDKASLtRtLQHRI | Pkinase |
LRRK2 | Q5S007 | human | DNAJC6 | O75061 | S570 | sATstSAsPtLRVGE | |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | Y1485 | GFPAIRDyHFVNAtE | |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | Y1402 | FAGREEFystHPHFM | Roc |
LRRK2 | Q5S007 | human | EZR | P15311 | T567 | QGRDkyKtLRQIRQG | ERM_C |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | S1853 | PRLtIPIsQIAPDLI | |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | T1503 | ALAKLRKtIINEsLN | |
LRRK2 | Q5S007 | human | RAB5B | P61020 | T6 | __MTSRStARPNGQP | |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | S955 | RKRKILssDDsLRSs | |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | S1292 | PNEMGKLsKIWDLPL | LRR_4 |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | T1404 | GREEFystHPHFMtQ | Roc |
LRRK2 | Q5S007 | human | MAP3K5 | Q99683 | T838 | GINPCTEtFTGtLQY | Pkinase |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | S973 | SHMRHsDsIssLAsE | |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | T838 | KQtNIAstLARMVIR | |
LRRK2 | Q5S007 | human | AKT1 | P31749 | S473 | RPHFPQFsysAsGtA | Pkinase_C |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | S1457 | VGtHLDVsDEKQRKA | |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | T1491 | DyHFVNAtEESDALA | |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | S1443 | FNIKARAsssPVILV | Roc |
LRRK2 | Q5S007 | human | MAPT | P10636-8 | T263 | VKskIGstENLkHQP | Tubulin-binding |
LRRK2 | Q5S007 | human | NSF | P46459 | T645 | RKLLIIGtTSRKDVL | AAA |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | T1470 | KACMsKItKELLNKR | |
LRRK2 | Q5S007 | human | DNM1L | O00429 | T595 | NWRGMLktSkAEELL | |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | T1343 | KLMIVGNtGsGKttL | Roc |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | T1969 | DKASLtRtLQHRIAL | Pkinase |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | S1253 | RVEKLHLsHNKLKEI | LRR_4 |
LRRK2 | Q5S007 | human | HDAC3 | O15379 | S424 | DHDNDKEsDVEI___ | |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | S1345 | MIVGNtGsGKttLLQ | Roc |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | S935 | NLQRHsNsLGPIFDH | |
LRRK2 | Q5S007 | human | MAPT | P10636-8 | T153 | DGKtKIAtPRGAAPP | |
LRRK2 | Q5S007 | human | APP | P05067 | T743 | VEVDAAVtPEERHLS | APP_amyloid |
LRRK2 | Q5S007 | human | MAPT | P10636-8 | T149 | AKGADGKtKIAtPRG | |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | S2032 | CRMGIKtsEGtPGFR | Pkinase |
LRRK2 | Q5S007 | human | AP2M1 | Q96CW1 | T156 | SQItsQVtGQIGWRR | |
LRRK2 | Q5S007 | human | MAP3K5 | Q99683 | T825 | LKIsDFGtSkRLAGI | Pkinase |
LRRK2 | Q5S007 | human | SQSTM1 | Q13501 | T138 | CNGPVVGtRYkCsVC | ZZ |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | S1913 | KIFNKHtsLRLLRQE | Pkinase |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | S1444 | NIKARAsssPVILVG | Roc |
LRRK2 | Q5S007 | human | RPS11 | P62280 | T28 | kRVLLGEtGkEkLPR | Ribosomal_S17_N |
LRRK2 | Q5S007 | human | RAB8A | P61006 | T72 | AGQERFRtITTAyyR | Ras |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | T2524 | LAEKMRRtSVE____ | |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | T776 | QDVRKALtISIGKGD | |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | T1452 | sPVILVGtHLDVsDE | Roc |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | S1283 | SYNLELRsFPNEMGK | LRR_4 |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | T1368 | DLGMQSAtVGIDVKD | Roc |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | T1410 | stHPHFMtQRALYLA | Roc |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | T1612 | KIMAQILtVKVEGCP | COR |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | S1403 | AGREEFystHPHFMt | Roc |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | S910 | LVKKKsNsIsVGEFY | |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | S1467 | KQRKACMsKItKELL | |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | T1849 | NPDQPRLtIPIsQIA | |
LRRK2 | Q5S007 | human | TP53 | P04637 | T377 | kskkGQstsRHkkLM | |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | T1357 | LLQQLMKtKKSDLGM | Roc |
LRRK2 | Q5S007 | human | LARS1 | Q9P2J5 | T293 | NIFLVAAtLRPETMF | tRNA-synt_1 |
LRRK2 | Q5S007 | human | RPS11 | P62280 | T46 | NIGLGFktPkEAIEG | Ribosomal_S17_N |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | S2257 | CNSFSKQsKQKNFLL | |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | T524 | PEESREDtEFHHKLN | |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | T2483 | NRKNTEGtQKQKEIQ | |
LRRK2 | Q5S007 | human | TP53 | P04637 | T304 | HELPPGStkRALPNN | |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | T1912 | VKIFNKHtsLRLLRQ | Pkinase |
LRRK2 | Q5S007 | human | MAPT | P10636-8 | T169 | QkGQANAtRIPAktP | |
LRRK2 | Q5S007 | human | FZD3 | Q9NPG1 | T598 | RSRDGRYtPCSYRGM | |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | T1348 | GNtGsGKttLLQQLM | Roc |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | S1124 | NkISGICsPLRLkEL | |
LRRK2 | Q5S007 | human | MAPT | P10636-8 | T181 | ktPPAPktPPssGEP | |
LRRK2 | Q5S007 | human | RPS15 | P62841 | T136 | GRPGIGAtHssRFIP | |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | T833 | tSNLRKQtNIAstLA | |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | S5 | ___MAsGsCQGCEED | |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | Y1332 | RLKKAVPyNRMKLMI | |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | T2035 | GIKtsEGtPGFRAPE | Pkinase |
LRRK2 | Q5S007 | human | MSN | P26038 | T558 | LGRDKyKtLRQIRQG | ERM_C |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | S1445 | IKARAsssPVILVGt | Roc |
LRRK2 | Q5S007 | human | MAPT | P10636-8 | T212 | tPGsRsRtPsLPtPP | |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | S1647 | KFPKNYMsQYFKLLE | COR |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | S1508 | RKtIINEsLNFKIRD | |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | T826 | GPLFPDKtSNLRKQt | |
LRRK2 | Q5S007 | human | SNAPIN | O95295 | T117 | NHsVAKEtARRRAML | |
LRRK2 | Q5S007 | human | MAPT | P10636-8 | T205 | ssPGsPGtPGsRsRt | |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | S1536 | ELEKIILsERKNVPI | COR |
LRRK2 | Q5S007 | human | RPS11 | P62280 | T54 | PkEAIEGtyIDkkCP | Ribosomal_S17_N |
LRRK2 | Q5S007 | human | LRRK2 | Q5S007 | S3 | _____MAsGsCQGCE |
Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
Enriched GO biological processes of the phosphorylation target genes of the kinase |
Kinase | GOID | GO term | P.adjust |
LRRK2 | ID | Description | 0.00e+00 |
LRRK2 | GO:0072659 | protein localization to plasma membrane | 1.78e-06 |
LRRK2 | GO:1990778 | protein localization to cell periphery | 4.16e-06 |
LRRK2 | GO:0010821 | regulation of mitochondrion organization | 1.16e-05 |
LRRK2 | GO:1903829 | positive regulation of protein localization | 1.85e-05 |
LRRK2 | GO:1903649 | regulation of cytoplasmic transport | 1.85e-05 |
LRRK2 | GO:0010506 | regulation of autophagy | 3.41e-05 |
LRRK2 | GO:0045732 | positive regulation of protein catabolic process | 3.41e-05 |
LRRK2 | GO:0032535 | regulation of cellular component size | 3.86e-05 |
LRRK2 | GO:0006979 | response to oxidative stress | 4.92e-05 |
LRRK2 | GO:1902946 | protein localization to early endosome | 4.92e-05 |
LRRK2 | GO:1905668 | positive regulation of protein localization to endosome | 4.92e-05 |
LRRK2 | GO:1905666 | regulation of protein localization to endosome | 5.76e-05 |
LRRK2 | GO:0034599 | cellular response to oxidative stress | 5.76e-05 |
LRRK2 | GO:1903651 | positive regulation of cytoplasmic transport | 7.97e-05 |
LRRK2 | GO:0072594 | establishment of protein localization to organelle | 8.74e-05 |
LRRK2 | GO:0061951 | establishment of protein localization to plasma membrane | 8.74e-05 |
LRRK2 | GO:0051656 | establishment of organelle localization | 8.77e-05 |
LRRK2 | GO:0034614 | cellular response to reactive oxygen species | 8.77e-05 |
LRRK2 | GO:0048311 | mitochondrion distribution | 8.77e-05 |
LRRK2 | GO:0006606 | protein import into nucleus | 9.89e-05 |
LRRK2 | GO:0022411 | cellular component disassembly | 1.03e-04 |
LRRK2 | GO:0051170 | import into nucleus | 1.03e-04 |
LRRK2 | GO:2000641 | regulation of early endosome to late endosome transport | 1.03e-04 |
LRRK2 | GO:0062197 | cellular response to chemical stress | 1.11e-04 |
LRRK2 | GO:0006913 | nucleocytoplasmic transport | 1.29e-04 |
LRRK2 | GO:0051169 | nuclear transport | 1.29e-04 |
LRRK2 | GO:0032386 | regulation of intracellular transport | 1.38e-04 |
LRRK2 | GO:0007405 | neuroblast proliferation | 1.46e-04 |
LRRK2 | GO:0031503 | protein-containing complex localization | 1.46e-04 |
LRRK2 | GO:0032388 | positive regulation of intracellular transport | 1.91e-04 |
LRRK2 | GO:0042176 | regulation of protein catabolic process | 1.91e-04 |
LRRK2 | GO:0000302 | response to reactive oxygen species | 2.02e-04 |
LRRK2 | GO:0036010 | protein localization to endosome | 2.15e-04 |
LRRK2 | GO:1902115 | regulation of organelle assembly | 2.57e-04 |
LRRK2 | GO:0099003 | vesicle-mediated transport in synapse | 2.61e-04 |
LRRK2 | GO:0090140 | regulation of mitochondrial fission | 2.73e-04 |
LRRK2 | GO:0051403 | stress-activated MAPK cascade | 3.07e-04 |
LRRK2 | GO:0016242 | negative regulation of macroautophagy | 3.16e-04 |
LRRK2 | GO:1903076 | regulation of protein localization to plasma membrane | 3.32e-04 |
LRRK2 | GO:0031098 | stress-activated protein kinase signaling cascade | 3.35e-04 |
LRRK2 | GO:0010737 | protein kinase A signaling | 4.96e-04 |
LRRK2 | GO:0000266 | mitochondrial fission | 5.66e-04 |
LRRK2 | GO:0070585 | protein localization to mitochondrion | 6.46e-04 |
LRRK2 | GO:0050808 | synapse organization | 6.76e-04 |
LRRK2 | GO:0045022 | early endosome to late endosome transport | 6.87e-04 |
LRRK2 | GO:0050804 | modulation of chemical synaptic transmission | 6.87e-04 |
LRRK2 | GO:0099177 | regulation of trans-synaptic signaling | 6.87e-04 |
LRRK2 | GO:1904375 | regulation of protein localization to cell periphery | 6.90e-04 |
LRRK2 | GO:0090199 | regulation of release of cytochrome c from mitochondria | 6.94e-04 |
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Related Drugs to LRRK2_MON2 |
Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
Distribution of the number of studies mentioning LRRK2-MON2 and kinase inhibitors the PubMed Abstract (04-01-2024) |
Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to LRRK2_MON2 |
Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
MeSH ID | MeSH term |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
Clinical Trials from clinicaltrials.gov (06-17-2024) |
Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |