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Kinase Fusion Gene:LTBP2_NEK9 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: LTBP2_NEK9 | KinaseFusionDB ID: KFG3231 | FusionGDB2.0 ID: KFG3231 | Hgene | Tgene | Gene symbol | LTBP2 | NEK9 | Gene ID | 4054 | 91754 | |
| Gene name | latent transforming growth factor beta binding protein 3 | NIMA related kinase 9 | ||||||||||
| Synonyms | DASS|GPHYSD3|LTBP-3|LTBP2|STHAG6|pp6425 | APUG|LCCS10|NC|NERCC|NERCC1 | ||||||||||
| Cytomap | 11q13.1 | 14q24.3 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | latent-transforming growth factor beta-binding protein 3latent TGF beta binding protein 3 | serine/threonine-protein kinase Nek9NIMA (never in mitosis gene a)- related kinase 9nercc1 kinasenimA-related protein kinase 9 | ||||||||||
| Modification date | 20240411 | 20240407 | ||||||||||
| UniProtAcc | Q14767 | Q8TD19 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000261978, ENST00000556690, ENST00000557425, | ENST00000555763, ENST00000238616, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: LTBP2 [Title/Abstract] AND NEK9 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | LTBP2(74999129)-NEK9(75558181), # samples:2 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | NEK9 | GO:0000278 | mitotic cell cycle | 12840024|19941817 |
| Tgene | NEK9 | GO:0007346 | regulation of mitotic cell cycle | 19941817 |
| Kinase Fusion gene breakpoints across LTBP2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Kinase Fusion gene breakpoints across NEK9 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChimerDB4 | TCGA-25-1315-01A | LTBP2 | chr14 | 74999129 | NEK9 | chr14 | 75558181 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:74999129/chr14:75558181) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LTBP2 | NEK9 |
| FUNCTION: May play an integral structural role in elastic-fiber architectural organization and/or assembly. {ECO:0000303|PubMed:10743502, ECO:0000303|PubMed:11104663}. | FUNCTION: Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation (PubMed:12101123, PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2 (PubMed:11864968). Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues (PubMed:11864968). Important for G1/S transition and S phase progression (PubMed:12840024, PubMed:14660563, PubMed:19941817). Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively (PubMed:12840024, PubMed:14660563, PubMed:19941817, PubMed:26522158). {ECO:0000269|PubMed:11864968, ECO:0000269|PubMed:12101123, ECO:0000269|PubMed:12840024, ECO:0000269|PubMed:14660563, ECO:0000269|PubMed:19941817, ECO:0000269|PubMed:26522158}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of LTBP2_NEK9 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| NEK9 | Q8TD19 | human | NEK9 | Q8TD19 | S944 | GQQVGMHskGTQTAK | |
| NEK9 | Q8TD19 | human | NEDD1 | Q8NHV4 | S377 | EkAGLPRsINTDtLS | |
| NEK9 | Q8TD19 | human | MAP1LC3B | Q9GZQ8 | T50 | QLPVLDktkFLVPDH | ATG8 |
| NEK9 | Q8TD19 | human | NEK7 | Q8TDX7 | S195 | skttAAHsLVGtPyy | Pkinase |
| NEK9 | Q8TD19 | human | NEK6 | Q9HC98 | S206 | sEttAAHsLVGtPyy | Pkinase |
| NEK9 | Q8TD19 | human | NEK9 | Q8TD19 | T210 | SEYsMAEtLVGtPYY | Pkinase |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| NEK9 | ID | Description | 0.00e+00 |
| NEK9 | GO:0051225 | spindle assembly | 3.68e-02 |
| NEK9 | GO:0007051 | spindle organization | 3.68e-02 |
| NEK9 | GO:0033044 | regulation of chromosome organization | 3.68e-02 |
| NEK9 | GO:0018105 | peptidyl-serine phosphorylation | 3.68e-02 |
| NEK9 | GO:0018209 | peptidyl-serine modification | 3.68e-02 |
| NEK9 | GO:0051081 | nuclear membrane disassembly | 3.68e-02 |
| NEK9 | GO:0030397 | membrane disassembly | 3.68e-02 |
| NEK9 | GO:0006995 | cellular response to nitrogen starvation | 3.68e-02 |
| NEK9 | GO:0043562 | cellular response to nitrogen levels | 3.68e-02 |
| NEK9 | GO:0035865 | cellular response to potassium ion | 3.68e-02 |
| NEK9 | GO:0140694 | non-membrane-bounded organelle assembly | 3.68e-02 |
| NEK9 | GO:1904355 | positive regulation of telomere capping | 3.68e-02 |
| NEK9 | GO:0035864 | response to potassium ion | 3.68e-02 |
| NEK9 | GO:0007059 | chromosome segregation | 3.68e-02 |
| NEK9 | GO:1900227 | positive regulation of NLRP3 inflammasome complex assembly | 3.71e-02 |
| NEK9 | GO:0141087 | positive regulation of inflammasome-mediated signaling pathway | 3.71e-02 |
| NEK9 | GO:0022411 | cellular component disassembly | 4.08e-02 |
| NEK9 | GO:1904353 | regulation of telomere capping | 4.08e-02 |
| NEK9 | GO:0032212 | positive regulation of telomere maintenance via telomerase | 4.08e-02 |
| NEK9 | GO:0051973 | positive regulation of telomerase activity | 4.08e-02 |
| NEK9 | GO:1900225 | regulation of NLRP3 inflammasome complex assembly | 4.08e-02 |
| NEK9 | GO:0044546 | NLRP3 inflammasome complex assembly | 4.08e-02 |
| NEK9 | GO:0141085 | regulation of inflammasome-mediated signaling pathway | 4.08e-02 |
| NEK9 | GO:1904358 | positive regulation of telomere maintenance via telomere lengthening | 4.08e-02 |
| NEK9 | GO:0000423 | mitophagy | 4.08e-02 |
| NEK9 | GO:0016233 | telomere capping | 4.08e-02 |
| NEK9 | GO:0140632 | canonical inflammasome complex assembly | 4.08e-02 |
| NEK9 | GO:0141084 | inflammasome-mediated signaling pathway | 4.19e-02 |
| NEK9 | GO:0071763 | nuclear membrane organization | 4.19e-02 |
| NEK9 | GO:0007020 | microtubule nucleation | 4.19e-02 |
| NEK9 | GO:0051972 | regulation of telomerase activity | 4.19e-02 |
| NEK9 | GO:0032210 | regulation of telomere maintenance via telomerase | 4.48e-02 |
| NEK9 | GO:0006998 | nuclear envelope organization | 4.48e-02 |
| NEK9 | GO:2000772 | regulation of cellular senescence | 4.48e-02 |
| NEK9 | GO:0097352 | autophagosome maturation | 4.75e-02 |
| NEK9 | GO:1904356 | regulation of telomere maintenance via telomere lengthening | 4.77e-02 |
| NEK9 | GO:0062208 | positive regulation of pattern recognition receptor signaling pathway | 4.87e-02 |
| NEK9 | GO:0007004 | telomere maintenance via telomerase | 4.93e-02 |
| NEK9 | GO:2000573 | positive regulation of DNA biosynthetic process | 4.93e-02 |
| NEK9 | GO:0032206 | positive regulation of telomere maintenance | 4.93e-02 |
| NEK9 | GO:0006278 | RNA-templated DNA biosynthetic process | 5.15e-02 |
| NEK9 | GO:0010833 | telomere maintenance via telomere lengthening | 5.39e-02 |
| NEK9 | GO:0030071 | regulation of mitotic metaphase/anaphase transition | 5.39e-02 |
| NEK9 | GO:0039531 | regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway | 5.39e-02 |
| NEK9 | GO:1902099 | regulation of metaphase/anaphase transition of cell cycle | 5.39e-02 |
| NEK9 | GO:0007091 | metaphase/anaphase transition of mitotic cell cycle | 5.39e-02 |
| NEK9 | GO:0046785 | microtubule polymerization | 5.39e-02 |
| NEK9 | GO:0061912 | selective autophagy | 5.39e-02 |
| NEK9 | GO:0044784 | metaphase/anaphase transition of cell cycle | 5.39e-02 |
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Related Drugs to LTBP2_NEK9 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning LTBP2-NEK9 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to LTBP2_NEK9 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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