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Kinase Fusion Gene:LYN_TMEM68 |
Kinase Fusion Protein Summary |
Kinase Fusion gene summary |
Kinase Fusion partner gene information | Kinase Fusion gene name: LYN_TMEM68 | KinaseFusionDB ID: KFG3248 | FusionGDB2.0 ID: KFG3248 | Hgene | Tgene | Gene symbol | LYN | TMEM68 | Gene ID | 4067 | 137695 | |
Gene name | LYN proto-oncogene, Src family tyrosine kinase | transmembrane protein 68 | ||||||||||
Synonyms | JTK8|SAIDV|p53Lyn|p56Lyn | DIESL|MGAT/DGAT | ||||||||||
Cytomap | 8q12.1 | 8q12.1 | ||||||||||
Type of gene | protein-coding | protein-coding | ||||||||||
Description | tyrosine-protein kinase Lynlck/Yes-related novel protein tyrosine kinasev-yes-1 Yamaguchi sarcoma viral related oncogene homolog | DGAT1/2-independent enzyme synthesizing storage lipidsmonoacylglycerol/Diacylglycerol O-acyltransferase2-acylglycerol/1,2-diacylglycerol O-acyltransferase | ||||||||||
Modification date | 20240411 | 20240411 | ||||||||||
UniProtAcc | P07948 | Q96MH6 | ||||||||||
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000519728, ENST00000520220, ENST00000420292, | ENST00000434581, ENST00000334667, ENST00000519784, ENST00000523073, ENST00000521229, ENST00000522576, | |||||||||
Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: LYN [Title/Abstract] AND TMEM68 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | LYN | GO:0000077 | DNA damage checkpoint signaling | 10891478 |
Hgene | LYN | GO:0006468 | protein phosphorylation | 11517336 |
Hgene | LYN | GO:0006974 | DNA damage response | 11517336 |
Hgene | LYN | GO:0018108 | peptidyl-tyrosine phosphorylation | 7682714|11782428 |
Hgene | LYN | GO:0030222 | eosinophil differentiation | 11823534 |
Hgene | LYN | GO:0038043 | interleukin-5-mediated signaling pathway | 11823534 |
Hgene | LYN | GO:0043410 | positive regulation of MAPK cascade | 10891478 |
Hgene | LYN | GO:0046777 | protein autophosphorylation | 7682714 |
Tgene | TMEM68 | GO:0019432 | triglyceride biosynthetic process | 37648867 |
Kinase Fusion gene breakpoints across LYN (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Kinase Fusion gene breakpoints across TMEM68 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
Kinase Fusion gene information. |
Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
CCLE | SLVL | LYN | chr8 | 56882352 | TMEM68 | chr8 | 56637818 |
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Kinase Fusion ORF Analysis |
Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:/:) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
LYN | TMEM68 |
FUNCTION: Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation. Phosphorylates SCIMP on 'Tyr-107'; this enhances binding of SCIMP to TLR4, promoting the phosphorylation of TLR4, and a selective cytokine response to lipopolysaccharide in macrophages (By similarity). Phosphorylates CLNK (By similarity). Phosphorylates BCAR1/CAS and NEDD9/HEF1 (PubMed:9020138). {ECO:0000250|UniProtKB:P25911, ECO:0000269|PubMed:10574931, ECO:0000269|PubMed:10748115, ECO:0000269|PubMed:10891478, ECO:0000269|PubMed:11435302, ECO:0000269|PubMed:11517336, ECO:0000269|PubMed:11825908, ECO:0000269|PubMed:14726379, ECO:0000269|PubMed:15795233, ECO:0000269|PubMed:16467205, ECO:0000269|PubMed:17640867, ECO:0000269|PubMed:17977829, ECO:0000269|PubMed:18056483, ECO:0000269|PubMed:18070987, ECO:0000269|PubMed:18235045, ECO:0000269|PubMed:18577747, ECO:0000269|PubMed:18802065, ECO:0000269|PubMed:19290919, ECO:0000269|PubMed:20037584, ECO:0000269|PubMed:7687428, ECO:0000269|PubMed:9020138}. | FUNCTION: Catalytic subunit of the alternative triglyceride biosynthesis pathway, which mediates formation of triacylglycerol from diacylglycerol and membrane phospholipids (PubMed:37648867). Synthesizes triacylglycerol at the expense of membrane phospholipids, such as phosphatidylcholine (PC) and its ether-linked form (ePC), thereby altering the composition of membranes (PubMed:37648867). The alternative triglyceride biosynthesis pathway is probably required to provide the energy required for rapid growth when fuel sources are limiting (PubMed:37648867). It maintains mitochondrial function during periods of extracellular lipid starvation (PubMed:37648867). Can also use acyl-CoA as donor: acts as a acyl-CoA:monoacylglycerol acyltransferase (MGAT), but also shows acyl-CoA:diacylglycerol acyltransferase (DGAT) activity (By similarity). {ECO:0000250|UniProtKB:Q9D850, ECO:0000269|PubMed:37648867}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of LYN_TMEM68 |
Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
LYN | P07948 | human | NMT1 | P30419 | Y180 | YTLLNENyVEDDDNM | NMT |
LYN | P07948 | human | ABL1 | P00519 | Y393 | RLMtGDtytAHAGAk | PK_Tyr_Ser-Thr |
LYN | P07948 | human | YY1 | P25490 | Y8 | MASGDTLyIATDGSE | |
LYN | P07948 | human | AKAP8 | O43823 | Y53 | TTGATySyGPASWEA | |
LYN | P07948 | human | GCSAM | Q8N6F7 | Y106 | sGNsAEEyyENVPCk | HGAL |
LYN | P07948 | human | ACLY | P53396 | Y682 | sRtTDGVyEGVAIGG | Ligase_CoA |
LYN | P07948 | human | RGS16 | O15492 | Y177 | RFLkSPAyRDLAAQA | RGS |
LYN | P07948 | human | SLC4A1 | P02730 | Y21 | ENLEQEEyEDPDIPE | |
LYN | P07948 | human | SLC4A1 | P02730 | Y8 | MEELQDDyEDMMEEN | |
LYN | P07948 | human | PTPN6 | P29350 | Y564 | sKHkEDVyENLHTkN | |
LYN | P07948 | human | FCGR2A | P12318 | Y304 | tDDDKNIyLTLPPND | |
LYN | P07948 | human | ACLY | P53396 | Y131 | YATREGDyVLFHHEG | |
LYN | P07948 | human | CSF2RB | P32927 | Y882 | KALKQQDyLSLPPWE | |
LYN | P07948 | human | RMDN3 | Q96TC7 | Y176 | DAESEGGytTANAEs | |
LYN | P07948 | human | CSF2RB | P32927 | Y822 | VLQQVGDyCFLPGLG | |
LYN | P07948 | human | TRIM28 | Q13263 | Y517 | PGsTtEDyNLIVIER | |
LYN | P07948 | human | CASP8 | Q14790 | Y380 | tDsEEQPyLEMDLSs | Peptidase_C14 |
LYN | P07948 | human | SYK | P43405 | Y323 | sTVsFNPyEPELAPW | |
LYN | P07948 | human | CSF2RB | P32927 | Y466 | ALRFCGIyGyRLRRk | |
LYN | P07948 | human | CASP8 | Q14790 | Y448 | TILTEVNyEVSNKDD | Peptidase_C14 |
LYN | P07948 | human | CD19 | P15391 | Y500 | TSLGsQsyEDMRGIL | |
LYN | P07948 | human | IRF5 | Q13568 | Y335 | QLQGQDLyAIRLCQC | IRF-3 |
LYN | P07948 | human | LY96 | Q9Y6Y9 | Y131 | IKFSKGKyKCVVEAI | E1_DerP2_DerF2 |
LYN | P07948 | human | YY1 | P25490 | Y383 | IHtGDrPyVCPFDGC | zf-C2H2 |
LYN | P07948 | human | SLC4A1 | P02730 | Y359 | AKPDssFyKGLDLNG | |
LYN | P07948 | human | ABL1 | P00519 | Y128 | SLEKHSWyHGPVSRN | SH2 |
LYN | P07948 | human | AKAP8 | O43823 | Y154 | RPsySyDyEFDLGSD | |
LYN | P07948 | human | CDKN1B | P46527 | Y88 | kGsLPEFyyRPPRPP | |
LYN | P07948 | human | FCGR2B | P31994 | Y292 | GAENTITysLLMHPD | |
LYN | P07948 | human | TRIM28 | Q13263 | Y449 | PMEVQEGyGFGsGDD | |
LYN | P07948 | human | AKAP8 | O43823 | Y539 | IVkMLEkyLKGEDPF | AKAP95 |
LYN | P07948 | human | PTEN | P60484 | Y240 | RREDKFMyFEFPQPL | PTEN_C2 |
LYN | P07948 | human | LAT2 | Q9GZY6 | Y95 | EDPASSRyQNFSkGs | LAT2 |
LYN | P07948 | human | CBL | P22681 | Y371 | TQEQyELyCEMGSTF | |
LYN | P07948 | human | ABL1 | P00519 | Y226 | KRNKPtVyGVsPNyD | |
LYN | P07948 | human | LY96 | Q9Y6Y9 | Y22 | FTEAQKQyWVCNSSD | |
LYN | P07948 | human | ABL1 | P00519 | Y115 | QGWVPsNyItPVNSL | |
LYN | P07948 | human | GCSAM | Q8N6F7 | Y128 | LGGTEtEySLLHMPS | HGAL |
LYN | P07948 | human | SYK | P43405 | Y348 | LPMDtEVyEsPyADP | |
LYN | P07948 | human | GCSAM | Q8N6F7 | Y107 | GNsAEEyyENVPCkA | HGAL |
LYN | P07948 | human | IKBKB | O14920 | Y188 | sFVGTLQyLAPELLE | Pkinase |
LYN | P07948 | human | ACLY | P53396 | Y252 | EAyPEEAyIADLDAk | Citrate_bind |
LYN | P07948 | human | ABL1 | P00519 | Y215 | GLITTLHyPAPKRNK | |
LYN | P07948 | human | ABL1 | P00519 | Y70 | PNLFVALyDFVAsGD | SH3_1 |
LYN | P07948 | human | PEAK1 | Q9H792 | Y635 | IVINPNAyDNLAIyK | |
LYN | P07948 | human | CDK4 | P11802 | Y17 | AEIGVGAyGTVYkAR | Pkinase |
LYN | P07948 | human | AKAP8 | O43823 | Y146 | CLPEHNPyRPsySyD | |
LYN | P07948 | human | AKAP8 | O43823 | Y170 | NGsFGGQySECRDPA | |
LYN | P07948 | human | SYK | P43405 | Y526 | LRADENyykAQtHGK | PK_Tyr_Ser-Thr |
LYN | P07948 | human | SOCS1 | O15524 | Y80 | LLDACGFyWGPLSVH | SH2 |
LYN | P07948 | human | LYN | P07948 | Y508 | ytAtEGQyQQQP___ | |
LYN | P07948 | human | PTGS2 | P35354 | Y120 | PPTYNADyGYKSWEA | |
LYN | P07948 | human | GLO1 | Q04760 | Y136 | GIAVPDVysACkRFE | Glyoxalase |
LYN | P07948 | human | LAT2 | Q9GZY6 | Y119 | DPIAMEyyNWGRFSk | LAT2 |
LYN | P07948 | human | SLC4A1 | P02730 | Y904 | EEEGRDEyDEVAMPV | |
LYN | P07948 | human | FCGR2C | P31995 | Y310 | tDDDKNIyLTLPPND | |
LYN | P07948 | human | BCR | P11274 | Y177 | ADAEKPFyVNVEFHH | |
LYN | P07948 | human | ACLY | P53396 | Y659 | yRPGsVAyVSRsGGM | |
LYN | P07948 | human | BTK | Q06187 | Y223 | LKKVVALyDyMPMNA | SH3_1 |
LYN | P07948 | human | AKAP8 | O43823 | Y51 | SVTTGATySyGPASW | |
LYN | P07948 | human | CD19 | P15391 | Y531 | HEEDADsyENMDNPD | |
LYN | P07948 | human | ABL1 | P00519 | Y139 | VSRNAAEyLLsSGIN | SH2 |
LYN | P07948 | human | LAT2 | Q9GZY6 | Y110 | RHGsEEAyIDPIAME | LAT2 |
LYN | P07948 | human | IRF5 | Q13568 | Y313 | PSDkQRFyTNQLLDV | IRF-3 |
LYN | P07948 | human | LYN | P07948 | Y397 | RVIEDNEytAREGAk | PK_Tyr_Ser-Thr |
LYN | P07948 | human | AKAP8 | O43823 | Y152 | PyRPsySyDyEFDLG | |
LYN | P07948 | human | AKAP8 | O43823 | Y150 | HNPyRPsySyDyEFD | |
LYN | P07948 | human | PTPN6 | P29350 | Y536 | QkGQEsEyGNItyPP | |
LYN | P07948 | human | SLAMF1 | Q13291 | Y327 | ETNSITVyASVTLPE | |
LYN | P07948 | human | GCSAM | Q8N6F7 | Y86 | tysEELCytLINHRV | HGAL |
LYN | P07948 | human | RGS16 | O15492 | Y168 | TLMEKDSyPRFLkSP | RGS |
LYN | P07948 | human | ABL1 | P00519 | Y172 | LRyEGRVyHyRINTA | SH2 |
LYN | P07948 | human | AKAP8 | O43823 | Y80 | PAMHMASyGPEPCTD | |
LYN | P07948 | human | LAT2 | Q9GZY6 | Y136 | EDDDANsyENVLICK | LAT2 |
LYN | P07948 | human | LAT2 | Q9GZY6 | Y118 | IDPIAMEyyNWGRFS | LAT2 |
LYN | P07948 | human | SYK | P43405 | Y352 | tEVyEsPyADPEEIR | |
LYN | P07948 | human | ACLY | P53396 | Y384 | VRrGGPNyQEGLrVM | Citrate_bind |
LYN | P07948 | human | ACLY | P53396 | Y227 | KVDATADyICkVkWG | |
LYN | P07948 | human | HCLS1 | P14317 | Y222 | MEAPttAykkTTPIE | |
LYN | P07948 | human | BTK | Q06187 | Y551 | RYVLDDEytsSVGSk | PK_Tyr_Ser-Thr |
LYN | P07948 | human | ABL1 | P00519 | Y185 | TAsDGKLyVsSESRF | SH2 |
LYN | P07948 | human | GCSAM | Q8N6F7 | Y80 | QDNVDQtysEELCyt | HGAL |
LYN | P07948 | human | SYK | P43405 | Y525 | ALRADENyykAQtHG | PK_Tyr_Ser-Thr |
LYN | P07948 | human | IKBKB | O14920 | Y199 | ELLEQQKyTVTVDYW | Pkinase |
LYN | P07948 | human | CSF2RB | P32927 | Y468 | RFCGIyGyRLRRkWE | |
LYN | P07948 | human | LASP1 | Q14847 | Y171 | IPtsAPVyQQPQQQP | |
LYN | P07948 | human | YY1 | P25490 | Y254 | sPPDySEyMTGkKLP | |
LYN | P07948 | human | WAS | P42768 | Y291 | AEtsKLIyDFIEDQG | PBD |
LYN | P07948 | human | SLCO1B1 | Q9Y6L6 | Y645 | VLyIILIyAMKKKYQ | TM |
LYN | P07948 | human | MCM7 | P33993 | Y600 | WASkDAtyTSARtLL | MCM_lid |
LYN | P07948 | human | DAPP1 | Q9UN19 | Y139 | kVEEPsIyEsVRVHT | |
LYN | P07948 | human | TRIM28 | Q13263 | Y458 | FGsGDDPyssAEPHV | |
LYN | P07948 | human | AKAP8 | O43823 | Y311 | KRkQFQLyEEPDTkL | |
LYN | P07948 | human | AKAP8 | O43823 | Y436 | TVEFLQEyIVNRNKK | AKAP95 |
LYN | P07948 | human | PPP1R8 | Q12972 | Y335 | NEPKKKKyAKEAWPG | |
LYN | P07948 | human | IKBKG | Q9Y6K9 | Y374 | PLPPAPAyLssPLAL |
Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
Enriched GO biological processes of the phosphorylation target genes of the kinase |
Kinase | GOID | GO term | P.adjust |
LYN | ID | Description | 0.00e+00 |
LYN | GO:0050853 | B cell receptor signaling pathway | 1.46e-10 |
LYN | GO:0050851 | antigen receptor-mediated signaling pathway | 5.71e-10 |
LYN | GO:0002429 | immune response-activating cell surface receptor signaling pathway | 1.89e-09 |
LYN | GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 3.80e-09 |
LYN | GO:0002237 | response to molecule of bacterial origin | 6.44e-09 |
LYN | GO:0002366 | leukocyte activation involved in immune response | 1.06e-08 |
LYN | GO:0002275 | myeloid cell activation involved in immune response | 1.06e-08 |
LYN | GO:0002263 | cell activation involved in immune response | 1.06e-08 |
LYN | GO:0002443 | leukocyte mediated immunity | 5.29e-08 |
LYN | GO:0002757 | immune response-activating signaling pathway | 5.65e-08 |
LYN | GO:0042113 | B cell activation | 6.82e-08 |
LYN | GO:0043299 | leukocyte degranulation | 7.74e-08 |
LYN | GO:0002764 | immune response-regulating signaling pathway | 8.18e-08 |
LYN | GO:0002274 | myeloid leukocyte activation | 2.95e-07 |
LYN | GO:0002279 | mast cell activation involved in immune response | 2.95e-07 |
LYN | GO:0038093 | Fc receptor signaling pathway | 2.95e-07 |
LYN | GO:0032496 | response to lipopolysaccharide | 3.87e-07 |
LYN | GO:0002444 | myeloid leukocyte mediated immunity | 4.51e-07 |
LYN | GO:0071216 | cellular response to biotic stimulus | 5.48e-07 |
LYN | GO:0050854 | regulation of antigen receptor-mediated signaling pathway | 6.50e-07 |
LYN | GO:0045576 | mast cell activation | 8.13e-07 |
LYN | GO:1902105 | regulation of leukocyte differentiation | 2.49e-06 |
LYN | GO:0030183 | B cell differentiation | 3.50e-06 |
LYN | GO:0070661 | leukocyte proliferation | 4.79e-06 |
LYN | GO:0002703 | regulation of leukocyte mediated immunity | 4.97e-06 |
LYN | GO:1903131 | mononuclear cell differentiation | 5.42e-06 |
LYN | GO:0045936 | negative regulation of phosphate metabolic process | 7.73e-06 |
LYN | GO:0010563 | negative regulation of phosphorus metabolic process | 7.73e-06 |
LYN | GO:0043303 | mast cell degranulation | 8.10e-06 |
LYN | GO:0018108 | peptidyl-tyrosine phosphorylation | 9.04e-06 |
LYN | GO:0002697 | regulation of immune effector process | 9.04e-06 |
LYN | GO:0018212 | peptidyl-tyrosine modification | 9.04e-06 |
LYN | GO:0002448 | mast cell mediated immunity | 9.38e-06 |
LYN | GO:0050855 | regulation of B cell receptor signaling pathway | 1.01e-05 |
LYN | GO:0002886 | regulation of myeloid leukocyte mediated immunity | 1.05e-05 |
LYN | GO:0038095 | Fc-epsilon receptor signaling pathway | 1.36e-05 |
LYN | GO:1903706 | regulation of hemopoiesis | 1.37e-05 |
LYN | GO:0002433 | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis | 1.48e-05 |
LYN | GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | 1.48e-05 |
LYN | GO:0046651 | lymphocyte proliferation | 1.54e-05 |
LYN | GO:0030098 | lymphocyte differentiation | 1.57e-05 |
LYN | GO:0032943 | mononuclear cell proliferation | 1.74e-05 |
LYN | GO:0031400 | negative regulation of protein modification process | 1.75e-05 |
LYN | GO:0050864 | regulation of B cell activation | 1.75e-05 |
LYN | GO:0045055 | regulated exocytosis | 2.63e-05 |
LYN | GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | 2.89e-05 |
LYN | GO:0002431 | Fc receptor mediated stimulatory signaling pathway | 2.92e-05 |
LYN | GO:0038094 | Fc-gamma receptor signaling pathway | 3.22e-05 |
LYN | GO:0006909 | phagocytosis | 3.22e-05 |
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Related Drugs to LYN_TMEM68 |
Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
Distribution of the number of studies mentioning LYN-TMEM68 and kinase inhibitors the PubMed Abstract (04-01-2024) |
Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to LYN_TMEM68 |
Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
MeSH ID | MeSH term |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
Clinical Trials from clinicaltrials.gov (06-17-2024) |
Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |