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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:LYZ_IRAK1

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: LYZ_IRAK1
KinaseFusionDB ID: KFG3254
FusionGDB2.0 ID: KFG3254
HgeneTgene
Gene symbol

LYZ

IRAK1

Gene ID

4069

3654

Gene namelysozymeinterleukin 1 receptor associated kinase 1
SynonymsLYZF1|LZMIRAK|pelle
Cytomap

12q15

Xq28

Type of geneprotein-codingprotein-coding
Descriptionlysozyme C1,4-beta-N-acetylmuramidase Cc-type lysozymelysozyme F1interleukin-1 receptor-associated kinase 1Pelle homolog
Modification date2024040720240305
UniProtAcc

Q7Z4W2

Q5VVH5

Ensembl transtripts involved in fusion geneENST idsENST00000261267, ENST00000548839, 
ENST00000549690, 		ENST00000369974, 
ENST00000369980, ENST00000393682, 
ENST00000477274, ENST00000393687, 
ENST00000429936, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: LYZ [Title/Abstract] AND IRAK1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)LYZ(69742294)-IRAK1(153276193), # samples:1
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLYZ

GO:0031640

killing of cells of another organism

9727055

HgeneLYZ

GO:0042742

defense response to bacterium

21093056

HgeneLYZ

GO:0050830

defense response to Gram-positive bacterium

21093056

TgeneIRAK1

GO:0046777

protein autophosphorylation

12054681

TgeneIRAK1

GO:0046777

protein autophosphorylation

10383454

TgeneIRAK1

GO:0051092

positive regulation of NF-kappaB transcription factor activity

10383454

TgeneIRAK1

GO:0070498

interleukin-1-mediated signaling pathway

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check buttonKinase Fusion gene breakpoints across LYZ (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonKinase Fusion gene breakpoints across IRAK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChimerDB4TCGA-AB-2844-03ALYZchr12

69742294

IRAK1chrX

153276193



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:69742294/:153276193)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LYZ

Q7Z4W2

IRAK1

Q5VVH5

FUNCTION: Component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival. Acts by enhancing RELA transcriptional activity (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


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Kinase-Substrate Information of LYZ_IRAK1


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
IRAK1P51617humanPELI1Q96FA3T80DQHsIsYtLsRAQtVPellino
IRAK1P51617humanIRAK1P51617T387RtQTVRGtLAYLPEEPkinase
IRAK1P51617humanPELI1Q96FA3S78NKDQHsIsYtLsRAQPellino
IRAK1P51617humanPELI1Q96FA3T86YtLsRAQtVVVEYTHPellino
IRAK1P51617humanPELI1Q96FA3T288QCPVGFNtLAFPsMkPellino
IRAK1P51617humanPELI1Q96FA3T127GSQSNsDtQSVQSTIPellino
IRAK1P51617humanPELI2Q9HAT8T290QCPVGLNtLAFPsINPellino
IRAK1P51617humanIRAK1P51617T209LCEISRGtHNFSEEL
IRAK1P51617humanPELI1Q96FA3S293FNtLAFPsMkRkDVVPellino
IRAK1P51617humanPELI1Q96FA3S125VPGSQSNsDtQSVQSPellino
IRAK1P51617humanSTAT3P40763S727NtIDLPMsPrTLDSL
IRAK1P51617humanPELI1Q96FA3S76IsNKDQHsIsYtLsRPellino
IRAK1P51617humanPELI1Q96FA3S82HsIsYtLsRAQtVVVPellino
IRAK1P51617humanPELI1Q96FA3S70PQAAKAIsNKDQHsIPellino


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
IRAK1IDDescription0.00e+00
IRAK1GO:0008063Toll signaling pathway2.09e-07
IRAK1GO:0043123positive regulation of canonical NF-kappaB signal transduction7.75e-04
IRAK1GO:0043122regulation of canonical NF-kappaB signal transduction1.28e-03
IRAK1GO:0007249canonical NF-kappaB signal transduction1.39e-03
IRAK1GO:0030522intracellular receptor signaling pathway1.81e-03
IRAK1GO:0140894endolysosomal toll-like receptor signaling pathway1.96e-03
IRAK1GO:0034142toll-like receptor 4 signaling pathway2.52e-03
IRAK1GO:0140895cell surface toll-like receptor signaling pathway2.84e-03
IRAK1GO:0001819positive regulation of cytokine production2.84e-03
IRAK1GO:0002752cell surface pattern recognition receptor signaling pathway2.87e-03
IRAK1GO:0002220innate immune response activating cell surface receptor signaling pathway4.41e-03
IRAK1GO:0002753cytosolic pattern recognition receptor signaling pathway1.01e-02
IRAK1GO:0051092positive regulation of NF-kappaB transcription factor activity1.01e-02
IRAK1GO:0000209protein polyubiquitination2.13e-02
IRAK1GO:0002221pattern recognition receptor signaling pathway2.17e-02
IRAK1GO:0051091positive regulation of DNA-binding transcription factor activity2.17e-02
IRAK1GO:0002758innate immune response-activating signaling pathway2.23e-02
IRAK1GO:0002218activation of innate immune response2.27e-02
IRAK1GO:0002429immune response-activating cell surface receptor signaling pathway2.27e-02
IRAK1GO:0045089positive regulation of innate immune response2.27e-02
IRAK1GO:0002768immune response-regulating cell surface receptor signaling pathway2.27e-02
IRAK1GO:0032496response to lipopolysaccharide2.27e-02
IRAK1GO:0033210leptin-mediated signaling pathway2.27e-02
IRAK1GO:0060397growth hormone receptor signaling pathway via JAK-STAT2.27e-02
IRAK1GO:1903799negative regulation of miRNA processing2.27e-02
IRAK1GO:1905050positive regulation of metallopeptidase activity2.27e-02
IRAK1GO:0002237response to molecule of bacterial origin2.27e-02
IRAK1GO:0002833positive regulation of response to biotic stimulus2.27e-02
IRAK1GO:0034139regulation of toll-like receptor 3 signaling pathway2.27e-02
IRAK1GO:0035723interleukin-15-mediated signaling pathway2.27e-02
IRAK1GO:0070669response to interleukin-22.27e-02
IRAK1GO:0071350cellular response to interleukin-152.27e-02
IRAK1GO:2001223negative regulation of neuron migration2.27e-02
IRAK1GO:1903037regulation of leukocyte cell-cell adhesion2.27e-02
IRAK1GO:0060965negative regulation of miRNA-mediated gene silencing2.27e-02
IRAK1GO:0070672response to interleukin-152.27e-02
IRAK1GO:0106014regulation of inflammatory response to wounding2.27e-02
IRAK1GO:0051090regulation of DNA-binding transcription factor activity2.27e-02
IRAK1GO:0034145positive regulation of toll-like receptor 4 signaling pathway2.27e-02
IRAK1GO:0060149negative regulation of post-transcriptional gene silencing2.27e-02
IRAK1GO:0060967negative regulation of gene silencing by regulatory ncRNA2.27e-02
IRAK1GO:1900369negative regulation of post-transcriptional gene silencing by regulatory ncRNA2.27e-02
IRAK1GO:0007159leukocyte cell-cell adhesion2.27e-02
IRAK1GO:0045088regulation of innate immune response2.27e-02
IRAK1GO:0060019radial glial cell differentiation2.27e-02
IRAK1GO:0060221retinal rod cell differentiation2.27e-02
IRAK1GO:0007250activation of NF-kappaB-inducing kinase activity2.27e-02
IRAK1GO:0072540T-helper 17 cell lineage commitment2.27e-02
IRAK1GO:1903798regulation of miRNA processing2.27e-02

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Related Drugs to LYZ_IRAK1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning LYZ-IRAK1 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

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Related Diseases to LYZ_IRAK1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate