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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:MAF1_CSNK1D

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: MAF1_CSNK1D
KinaseFusionDB ID: KFG3260
FusionGDB2.0 ID: KFG3260
HgeneTgene
Gene symbol

MAF1

CSNK1D

Gene ID

84232

1453

Gene nameMAF1 homolog, negative regulator of RNA polymerase IIIcasein kinase 1 delta
Synonyms-ASPS|CKI-delta|CKId|CKIdelta|FASPS2|HCKID
Cytomap

8q24.3

17q25.3

Type of geneprotein-codingprotein-coding
Descriptionrepressor of RNA polymerase III transcription MAF1 homologMAF1 negative regulator of RNA polymerase IIIhomolog of yeast MAF1casein kinase I isoform deltacasein kinase Itau-protein kinase CSNK1D
Modification date2024030520240407
UniProtAcc

Q9H063

P48730

Ensembl transtripts involved in fusion geneENST idsENST00000322428, ENST00000534585, 
ENST00000532522, 		ENST00000314028, 
ENST00000392334, ENST00000398519, 
ENST00000578904, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: MAF1 [Title/Abstract] AND CSNK1D [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MAF1(145162420)-CSNK1D(80203774), # samples:1
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAF1

GO:0016479

negative regulation of transcription by RNA polymerase I

17499043

HgeneMAF1

GO:0016480

negative regulation of transcription by RNA polymerase III

17499043|18377933|20233713

TgeneCSNK1D

GO:0006468

protein phosphorylation

16618118

TgeneCSNK1D

GO:0051225

spindle assembly

10826492


check buttonKinase Fusion gene breakpoints across MAF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonKinase Fusion gene breakpoints across CSNK1D (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChiTaRS5.0CA449192MAF1chr8

145162420

CSNK1Dchr17

80203774



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:145162420/:80203774)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAF1

Q9H063

CSNK1D

P48730

FUNCTION: Plays a role in the repression of RNA polymerase III-mediated transcription in response to changing nutritional, environmental and cellular stress conditions to balance the production of highly abundant tRNAs, 5S rRNA, and other small non-coding RNAs with cell growth and maintenance (PubMed:18377933, PubMed:20233713, PubMed:20516213, PubMed:20543138). Also plays a key role in cell fate determination by promoting mesorderm induction and adipocyte differentiation (By similarity). Mechanistically, associates with the RNA polymerase III clamp and thereby impairs its recruitment to the complex made of the promoter DNA, TBP and the initiation factor TFIIIB (PubMed:20887893, PubMed:17505538). When nutrients are available and mTOR kinase is active, MAF1 is hyperphosphorylated and RNA polymerase III is engaged in transcription. Stress-induced MAF1 dephosphorylation results in nuclear localization, increased targeting of gene-bound RNA polymerase III and a decrease in the transcriptional readout (PubMed:26941251). Additionally, may also regulate RNA polymerase I and RNA polymerase II-dependent transcription through its ability to regulate expression of the central initiation factor TBP (PubMed:17499043). {ECO:0000250|UniProtKB:Q9D0U6, ECO:0000269|PubMed:17499043, ECO:0000269|PubMed:17505538, ECO:0000269|PubMed:18377933, ECO:0000269|PubMed:20233713, ECO:0000269|PubMed:20516213, ECO:0000269|PubMed:20543138, ECO:0000269|PubMed:20887893, ECO:0000269|PubMed:26941251}.FUNCTION: Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. Phosphorylates NEDD9/HEF1 (By similarity). EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate. {ECO:0000250|UniProtKB:Q9DC28, ECO:0000269|PubMed:10606744, ECO:0000269|PubMed:12270943, ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:16027726, ECO:0000269|PubMed:17562708, ECO:0000269|PubMed:17962809, ECO:0000269|PubMed:19043076, ECO:0000269|PubMed:20041275, ECO:0000269|PubMed:20048001, ECO:0000269|PubMed:20407760, ECO:0000269|PubMed:20637175, ECO:0000269|PubMed:20696890, ECO:0000269|PubMed:20699359, ECO:0000269|PubMed:21084295, ECO:0000269|PubMed:21422228, ECO:0000269|PubMed:23636092}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


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Kinase-Substrate Information of MAF1_CSNK1D


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
CSNK1DP48730humanEPAS1Q99814T528FNELDLEtLAPYIPMHIF-1
CSNK1DP48730humanTARDBPQ13148S393GsAsNAGsGsGFNGG
CSNK1DP48730humanLZTS2Q9BRK4S224LSDsGRNsLSSLPTY
CSNK1DP48730humanFUSP35637S163GQQNQYNssSGGGGG
CSNK1DP48730humanSNCAP37840T64EktkEQVtNVGGAVVSynuclein
CSNK1DP48730humanYAP1P46937S400SRDEstDsGLsMsSy
CSNK1DP48730humanMDM2Q00987T351kAkLENstQAEEGFD
CSNK1DP48730humanMDM2Q00987S386DDKITQAsQsQESED
CSNK1DP48730humanBACE1P56817S498DDFADDIsLLk____
CSNK1DP48730humanSMARCA4P51532S35LGPsPGPsPGSAHSM
CSNK1DP48730humanAPCP25054S1507FsCsssLsALsLDEPAPC_r
CSNK1DP48730humanMDM2Q00987S260sLDsEDYsLsEEGQE
CSNK1DP48730humanMDM2Q00987S350EkAkLENstQAEEGF
CSNK1DP48730humanTP53P04637S9EEPQsDPsVEPPLsQP53_TAD
CSNK1DP48730humanLZTS2Q9BRK4S273TGPsHsDsGRsssSK
CSNK1DP48730humanTP53P04637T18EPPLsQEtFsDLWkLP53_TAD
CSNK1DP48730humanMAPTP10636-8S396GAEIVyKsPVVsGDt
CSNK1DP48730humanMAPTP10636-8S404PVVsGDtsPRHLsNV
CSNK1DP48730humanFUSP35637S183NYGQDQssMSSGGGS
CSNK1DP48730humanEPAS1Q99814S383SSGKGAVsEkSNFLF
CSNK1DP48730humanCTNNB1P35222S45GATtTAPsLsGkGNP
CSNK1DP48730humanMDM2Q00987S172IsEtEENsDELsGER
CSNK1DP48730humanLRP6O75581S1490AILNPPPsPAtERsH
CSNK1DP48730humanDCKP27707S11PPKRsCPsFsAssEG
CSNK1DP48730humanTARDBPQ13148S317GMNFGAFsINPAMMA
CSNK1DP48730humanTARDBPQ13148S409GssMDskssGWGM__
CSNK1DP48730humanFUSP35637S182GNYGQDQssMSSGGG
CSNK1DP48730humanUHRF1Q96T88S95sELsDtDsGCCLGQS
CSNK1DP48730humanSMARCA4P51532S31PGAMLGPsPGPsPGS
CSNK1DP48730humanLZTS2Q9BRK4S220PSGTLSDsGRNsLSS
CSNK1DP48730humanFUSP35637S221GGrGrGGsGGGGGGG
CSNK1DP48730humanMDM2Q00987T365DVPDCkktIVNDSRE
CSNK1DP48730humanYAP1P46937S403EstDsGLsMsSySVP
CSNK1DP48730humanNEDD9Q14511T804AALHYPStTALQEMVCAS_C
CSNK1DP48730humanAPCP25054S1510sssLsALsLDEPFIQ
CSNK1DP48730humanPRKD2Q9BZL6S244sssSssAssyTGRPI
CSNK1DP48730humanMDM2Q00987S176EENsDELsGERQRkR
CSNK1DP48730humanNCOA3Q9Y6Q9S601SDKESKEsSVEGAEN
CSNK1DP48730humanMDM2Q00987S229PDLDAGVsEHSGDWL
CSNK1DP48730humanAPCP25054S1504PDGFsCsssLsALsLAPC_r
CSNK1DP48730humanMDM2Q00987S269sEEGQELsDEDDEVy
CSNK1DP48730humanTOP2BQ02880-2S1130HDDSSSDsGTPsGPDDNA_topoisoIV
CSNK1DP48730humanTARDBPQ13148S305GLGNNQGsNMGGGMN
CSNK1DP48730humanWEE1P30291S212SVkLRGssLFMDtEK
CSNK1DP48730humanFUSP35637S273GGPrDQGsRHDsEQD
CSNK1DP48730humanHIF1AQ16665S247KTFLSRHsLDMkFSY
CSNK1DP48730humanZNF322Q6U7Q0S396ELsPPHAsEAsQMS_
CSNK1DP48730humanPER2O15055S662ALPGKAEsVAsLTsQ
CSNK1DP48730humanDCKP27707T72QDEFEELtMsQkNGGdNK
CSNK1DP48730humanMAPTP10636-8S202sGyssPGsPGtPGsR
CSNK1DP48730humanFUSP35637S346VsFDDPPsAkAAIDWRRM_1
CSNK1DP48730humanDVL2O14641S143FHPNVSssHENLEPEDishevelled
CSNK1DP48730humanTARDBPQ13148S410ssMDskssGWGM___
CSNK1DP48730humanPPP5CP53041T362LFSEDGVtLDDIRKIMetallophos
CSNK1DP48730humanMDM2Q00987S220SESTGtPsNPDLDAG
CSNK1DP48730humanMDM2Q00987S262DsEDYsLsEEGQELs
CSNK1DP48730humanCDH1P12830S844GsGsEAAsLSsLNsSCADH_Y-type_LIR
CSNK1DP48730humanDCKP27707S15sCPsFsAssEGtRIK
CSNK1DP48730humanTARDBPQ13148S333AQAALQSsWGMMGML
CSNK1DP48730humanTARDBPQ13148S395AsNAGsGsGFNGGFG
CSNK1DP48730humanMDM2Q00987S342GkDkGEIsEkAkLEN
CSNK1DP48730humanFUSP35637S462PGGGPGGsHMGGNyG
CSNK1DP48730humanMDM2Q00987S166SsRRRAIsEtEENsD
CSNK1DP48730humanDVL2O14641T224MSRFssStEQSsASRDishevelled
CSNK1DP48730humanTARDBPQ13148S403GFNGGFGssMDskss
CSNK1DP48730humanFUSP35637S277DQGsRHDsEQDNSDN
CSNK1DP48730humanMDM2Q00987T419KEFEREEtQDKEEsV
CSNK1DP48730humanPER2O15055S668EsVAsLTsQCsYSST
CSNK1DP48730humanDCKP27707S74EFEELtMsQkNGGNVdNK
CSNK1DP48730humanTARDBPQ13148S404FNGGFGssMDskssG
CSNK1DP48730humanFUSP35637T338GkLkGEAtVsFDDPP
CSNK1DP48730humanPSEN2P49810S330MEEDsYDsFGEPsYPPresenilin; Presenilin
CSNK1DP48730humanTP53P04637S20PLsQEtFsDLWkLLPP53_TAD
CSNK1DP48730humanMDM2Q00987S373IVNDSREsCVEENDD
CSNK1DP48730humanTARDBPQ13148S389AIGWGsAsNAGsGsG
CSNK1DP48730humanNEDD9Q14511S780RNkVMNSsNQLCEQLCAS_C
CSNK1DP48730humanMDM2Q00987S290AGEsDtDsFEEDPEI
CSNK1DP48730humanYAP1P46937-2S384SRDEsTDsGLsMSSY
CSNK1DP48730humanMDM2Q00987S118NQQESSDsGTsVSEN
CSNK1DP48730humanTARDBPQ13148S292NQGGFGNsrGGGAGL
CSNK1DP48730humanPER2O15055S665GKAEsVAsLTsQCsY
CSNK1DP48730humanLZTS2Q9BRK4S277HsDsGRsssSKsTGS
CSNK1DP48730humanTARDBPQ13148S92MDEtDAssAVkVKRA
CSNK1DP48730humanAPCP25054S1505DGFsCsssLsALsLDAPC_r
CSNK1DP48730humanMTSS1O43312S322SSVsSHDsGFISQDA
CSNK1DP48730humanMDM2Q00987S253sVEFEVEsLDsEDYs
CSNK1DP48730humanKIR3DL1P43629S388RTANsEDsDEQDPEE
CSNK1DP48730humanPSEN2P49810S327DPEMEEDsYDsFGEPPresenilin; Presenilin
CSNK1DP48730humanFUSP35637S164QQNQYNssSGGGGGG
CSNK1DP48730humanMDM2Q00987S121ESSDsGTsVSENRCH
CSNK1DP48730humanMAPTP10636-8T205ssPGsPGtPGsRsRt
CSNK1DP48730humanKIR3DL1P43629S385AGNRTANsEDsDEQD
CSNK1DP48730humanMDM2Q00987S240GDWLDQDsVsDQFsV
CSNK1DP48730humanMDM2Q00987T279DDEVyQVtVyQAGEs


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
CSNK1DIDDescription0.00e+00
CSNK1DGO:1990000amyloid fibril formation9.50e-08
CSNK1DGO:1903829positive regulation of protein localization3.40e-05
CSNK1DGO:0034599cellular response to oxidative stress7.44e-05
CSNK1DGO:0003007heart morphogenesis7.44e-05
CSNK1DGO:0062197cellular response to chemical stress2.05e-04
CSNK1DGO:0060562epithelial tube morphogenesis2.43e-04
CSNK1DGO:1902459positive regulation of stem cell population maintenance2.88e-04
CSNK1DGO:0010038response to metal ion2.88e-04
CSNK1DGO:0072160nephron tubule epithelial cell differentiation2.88e-04
CSNK1DGO:0050767regulation of neurogenesis4.10e-04
CSNK1DGO:0006979response to oxidative stress4.40e-04
CSNK1DGO:0006089lactate metabolic process4.82e-04
CSNK1DGO:0031400negative regulation of protein modification process6.68e-04
CSNK1DGO:0010288response to lead ion6.71e-04
CSNK1DGO:2000036regulation of stem cell population maintenance7.26e-04
CSNK1DGO:0016055Wnt signaling pathway7.26e-04
CSNK1DGO:0198738cell-cell signaling by wnt7.26e-04
CSNK1DGO:0051960regulation of nervous system development7.35e-04
CSNK1DGO:0006302double-strand break repair7.41e-04
CSNK1DGO:0034504protein localization to nucleus7.41e-04
CSNK1DGO:0060070canonical Wnt signaling pathway7.41e-04
CSNK1DGO:0019827stem cell population maintenance7.41e-04
CSNK1DGO:2000045regulation of G1/S transition of mitotic cell cycle7.41e-04
CSNK1DGO:0035050embryonic heart tube development7.41e-04
CSNK1DGO:0048771tissue remodeling7.41e-04
CSNK1DGO:2000134negative regulation of G1/S transition of mitotic cell cycle7.41e-04
CSNK1DGO:0071480cellular response to gamma radiation7.41e-04
CSNK1DGO:0098727maintenance of cell number7.41e-04
CSNK1DGO:0060485mesenchyme development7.41e-04
CSNK1DGO:0010039response to iron ion9.47e-04
CSNK1DGO:1902807negative regulation of cell cycle G1/S phase transition9.58e-04
CSNK1DGO:1902806regulation of cell cycle G1/S phase transition1.09e-03
CSNK1DGO:0072080nephron tubule development1.09e-03
CSNK1DGO:0120162positive regulation of cold-induced thermogenesis1.09e-03
CSNK1DGO:0043618regulation of transcription from RNA polymerase II promoter in response to stress1.09e-03
CSNK1DGO:0097306cellular response to alcohol1.14e-03
CSNK1DGO:0061326renal tubule development1.15e-03
CSNK1DGO:0045936negative regulation of phosphate metabolic process1.23e-03
CSNK1DGO:0010563negative regulation of phosphorus metabolic process1.23e-03
CSNK1DGO:0051348negative regulation of transferase activity1.28e-03
CSNK1DGO:0043523regulation of neuron apoptotic process1.45e-03
CSNK1DGO:0043620regulation of DNA-templated transcription in response to stress1.51e-03
CSNK1DGO:0070232regulation of T cell apoptotic process1.59e-03
CSNK1DGO:0050678regulation of epithelial cell proliferation1.61e-03
CSNK1DGO:0072009nephron epithelium development1.61e-03
CSNK1DGO:0051091positive regulation of DNA-binding transcription factor activity1.61e-03
CSNK1DGO:0060560developmental growth involved in morphogenesis1.61e-03
CSNK1DGO:0048863stem cell differentiation1.62e-03
CSNK1DGO:0071542dopaminergic neuron differentiation1.62e-03

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Related Drugs to MAF1_CSNK1D


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning MAF1-CSNK1D and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

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Related Diseases to MAF1_CSNK1D


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate