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Kinase Fusion Gene:MAP2K2_CAMKK1 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: MAP2K2_CAMKK1 | KinaseFusionDB ID: KFG3289 | FusionGDB2.0 ID: KFG3289 | Hgene | Tgene | Gene symbol | MAP2K2 | CAMKK1 | Gene ID | 5605 | 84254 | |
| Gene name | mitogen-activated protein kinase kinase 2 | calcium/calmodulin dependent protein kinase kinase 1 | ||||||||||
| Synonyms | CFC4|MAPKK2|MEK2|MKK2|PRKMK2 | CAMKKA | ||||||||||
| Cytomap | 19p13.3 | 17p13.2 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | dual specificity mitogen-activated protein kinase kinase 2ERK activator kinase 2MAP kinase kinase 2MAPK/ERK kinase 2mitogen-activated protein kinase kinase 2, p45 | calcium/calmodulin-dependent protein kinase kinase 1CAMKK alpha proteincaM-KK 1caM-KK alphacaM-kinase IV kinasecaM-kinase kinase 1caM-kinase kinase alphacaMKK 1calcium/calmodulin-dependent protein kinase kinase 1, alphacalcium/calmodulin-dependen | ||||||||||
| Modification date | 20240411 | 20240305 | ||||||||||
| UniProtAcc | P36507 | Q8N5S9 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000262948, ENST00000394867, ENST00000599345, | ENST00000158166, ENST00000348335, ENST00000381771, ENST00000381769, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: MAP2K2 [Title/Abstract] AND CAMKK1 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | MAP2K2(4110507)-CAMKK1(3789024), # samples:3 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MAP2K2 | GO:0036289 | peptidyl-serine autophosphorylation | 8388392 |
| Hgene | MAP2K2 | GO:0071902 | positive regulation of protein serine/threonine kinase activity | 8388392 |
| Kinase Fusion gene breakpoints across MAP2K2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across CAMKK1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChimerDB4 | TCGA-AQ-A0Y5-01A | MAP2K2 | chr19 | 4110507 | CAMKK1 | chr17 | 3789024 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:4110507/:3789024) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAP2K2 | CAMKK1 |
| FUNCTION: Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126). {ECO:0000250|UniProtKB:Q63932, ECO:0000269|PubMed:29433126}. | FUNCTION: Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. {ECO:0000269|PubMed:12935886}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of MAP2K2_CAMKK1 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| CAMKK1 | Q8N5S9 | human | PRKAA1 | Q13131 | T183 | sDGEFLRtsCGsPNy | Pkinase |
| CAMKK1 | Q8N5S9 | human | CAMK1D | Q8IU85 | T180 | GkGDVMstACGTPGY | Pkinase |
| CAMKK1 | Q8N5S9 | human | CAMK4 | Q16566 | S12 | TVPSCSAssCSSVTA | |
| CAMKK1 | Q8N5S9 | human | CAMK4 | Q16566 | T200 | EHQVLMktVCGtPGY | Pkinase |
| CAMKK1 | Q8N5S9 | human | BRSK1 | Q8TDC3-2 | T205 | VGDSLLEtSCGsPHY | Pkinase |
| CAMKK1 | Q8N5S9 | human | CAMK4 | Q16566 | S13 | VPSCSAssCSSVTAS | |
| CAMKK1 | Q8N5S9 | human | CAMK1 | Q14012 | T177 | DPGsVLstACGTPGY | Pkinase |
| MAP2K2 | P36507 | human | KRT8 | P05787 | S74 | tVNQsLLsPLVLEVD | Keratin_2_head |
| MAP2K2 | P36507 | human | MAPK3 | P27361 | T202 | HDHtGFLtEyVAtRW | Pkinase |
| MAP2K2 | P36507 | human | MAPK3 | P27361 | Y204 | HtGFLtEyVAtRWyr | Pkinase |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| CAMKK1 | ID | Description | 0.00e+00 |
| CAMKK1 | GO:0018105 | peptidyl-serine phosphorylation | 2.14e-07 |
| CAMKK1 | GO:0018209 | peptidyl-serine modification | 2.14e-07 |
| CAMKK1 | GO:0010975 | regulation of neuron projection development | 1.69e-02 |
| CAMKK1 | GO:0009411 | response to UV | 4.36e-02 |
| CAMKK1 | GO:0010976 | positive regulation of neuron projection development | 4.36e-02 |
| CAMKK1 | GO:0090316 | positive regulation of intracellular protein transport | 4.36e-02 |
| CAMKK1 | GO:0032388 | positive regulation of intracellular transport | 4.40e-02 |
| CAMKK1 | GO:0033157 | regulation of intracellular protein transport | 4.40e-02 |
| CAMKK1 | GO:0016358 | dendrite development | 4.40e-02 |
| CAMKK1 | GO:0007611 | learning or memory | 4.40e-02 |
| CAMKK1 | GO:0051222 | positive regulation of protein transport | 4.40e-02 |
| CAMKK1 | GO:0045542 | positive regulation of cholesterol biosynthetic process | 4.40e-02 |
| CAMKK1 | GO:0106120 | positive regulation of sterol biosynthetic process | 4.40e-02 |
| CAMKK1 | GO:1903943 | regulation of hepatocyte apoptotic process | 4.40e-02 |
| CAMKK1 | GO:1904179 | positive regulation of adipose tissue development | 4.40e-02 |
| CAMKK1 | GO:0050890 | cognition | 4.40e-02 |
| CAMKK1 | GO:0009416 | response to light stimulus | 4.40e-02 |
| CAMKK1 | GO:1904951 | positive regulation of establishment of protein localization | 4.40e-02 |
| CAMKK1 | GO:0038183 | bile acid signaling pathway | 4.40e-02 |
| CAMKK1 | GO:0099004 | calmodulin dependent kinase signaling pathway | 4.40e-02 |
| CAMKK1 | GO:0032386 | regulation of intracellular transport | 4.40e-02 |
| CAMKK1 | GO:0032782 | bile acid secretion | 4.40e-02 |
| CAMKK1 | GO:2000303 | regulation of ceramide biosynthetic process | 4.40e-02 |
| CAMKK1 | GO:0031346 | positive regulation of cell projection organization | 4.40e-02 |
| CAMKK1 | GO:0071361 | cellular response to ethanol | 4.40e-02 |
| CAMKK1 | GO:0090153 | regulation of sphingolipid biosynthetic process | 4.40e-02 |
| CAMKK1 | GO:1905038 | regulation of membrane lipid metabolic process | 4.40e-02 |
| CAMKK1 | GO:0031000 | response to caffeine | 4.40e-02 |
| CAMKK1 | GO:0090205 | positive regulation of cholesterol metabolic process | 4.40e-02 |
| CAMKK1 | GO:0032793 | positive regulation of CREB transcription factor activity | 4.40e-02 |
| CAMKK1 | GO:0071380 | cellular response to prostaglandin E stimulus | 4.40e-02 |
| CAMKK1 | GO:0097091 | synaptic vesicle clustering | 4.40e-02 |
| CAMKK1 | GO:1904177 | regulation of adipose tissue development | 4.40e-02 |
| CAMKK1 | GO:2000758 | positive regulation of peptidyl-lysine acetylation | 4.40e-02 |
| CAMKK1 | GO:0006677 | glycosylceramide metabolic process | 4.40e-02 |
| CAMKK1 | GO:0055089 | fatty acid homeostasis | 4.40e-02 |
| CAMKK1 | GO:0060263 | regulation of respiratory burst | 4.40e-02 |
| CAMKK1 | GO:0009314 | response to radiation | 4.40e-02 |
| CAMKK1 | GO:0006390 | mitochondrial transcription | 4.40e-02 |
| CAMKK1 | GO:0046827 | positive regulation of protein export from nucleus | 4.40e-02 |
| CAMKK1 | GO:0043011 | myeloid dendritic cell differentiation | 4.40e-02 |
| CAMKK1 | GO:0048643 | positive regulation of skeletal muscle tissue development | 4.40e-02 |
| CAMKK1 | GO:0071379 | cellular response to prostaglandin stimulus | 4.40e-02 |
| CAMKK1 | GO:0090043 | regulation of tubulin deacetylation | 4.40e-02 |
| CAMKK1 | GO:0097284 | hepatocyte apoptotic process | 4.40e-02 |
| CAMKK1 | GO:0045821 | positive regulation of glycolytic process | 4.40e-02 |
| CAMKK1 | GO:1903829 | positive regulation of protein localization | 4.40e-02 |
| CAMKK1 | GO:0010893 | positive regulation of steroid biosynthetic process | 4.40e-02 |
| CAMKK1 | GO:0061744 | motor behavior | 4.40e-02 |
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Related Drugs to MAP2K2_CAMKK1 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning MAP2K2-CAMKK1 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to MAP2K2_CAMKK1 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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