Description | dual specificity mitogen-activated protein kinase kinase 6MAPK/ERK kinase 6MAPKK 6MEK 6SAPK kinase 3protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6)stress-activated protein kinase kinase 3 | dual specificity mitogen-activated protein kinase kinase 6MAPK/ERK kinase 6MAPKK 6MEK 6SAPK kinase 3protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6)stress-activated protein kinase kinase 3 |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000589647, ENST00000590474,
| ENST00000589647, ENST00000590474,
|
Hgene | Tgene |
MAP2K6
P52564 | MAP2K6
P52564 |
FUNCTION: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation. The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction; and for IFNG-dependent gene transcription. Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediates apoptotic cell death in thymocytes. Acts also as a regulator for melanocytes dendricity, through the modulation of Rho family GTPases. {ECO:0000269|PubMed:10961885, ECO:0000269|PubMed:11727828, ECO:0000269|PubMed:15550393, ECO:0000269|PubMed:20869211, ECO:0000269|PubMed:8622669, ECO:0000269|PubMed:8626699, ECO:0000269|PubMed:8663074, ECO:0000269|PubMed:9218798}. | FUNCTION: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation. The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction; and for IFNG-dependent gene transcription. Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediates apoptotic cell death in thymocytes. Acts also as a regulator for melanocytes dendricity, through the modulation of Rho family GTPases. {ECO:0000269|PubMed:10961885, ECO:0000269|PubMed:11727828, ECO:0000269|PubMed:15550393, ECO:0000269|PubMed:20869211, ECO:0000269|PubMed:8622669, ECO:0000269|PubMed:8626699, ECO:0000269|PubMed:8663074, ECO:0000269|PubMed:9218798}. |
Kinase | GOID | GO term | P.adjust |
MAP2K6 | ID | Description | 0.00e+00 |
MAP2K6 | GO:0042770 | signal transduction in response to DNA damage | 4.08e-03 |
MAP2K6 | GO:0051403 | stress-activated MAPK cascade | 4.08e-03 |
MAP2K6 | GO:0031098 | stress-activated protein kinase signaling cascade | 4.08e-03 |
MAP2K6 | GO:0018105 | peptidyl-serine phosphorylation | 5.28e-03 |
MAP2K6 | GO:0018209 | peptidyl-serine modification | 5.28e-03 |
MAP2K6 | GO:0038066 | p38MAPK cascade | 7.07e-03 |
MAP2K6 | GO:0051149 | positive regulation of muscle cell differentiation | 1.29e-02 |
MAP2K6 | GO:0034644 | cellular response to UV | 1.32e-02 |
MAP2K6 | GO:0045445 | myoblast differentiation | 1.58e-02 |
MAP2K6 | GO:0090398 | cellular senescence | 1.58e-02 |
MAP2K6 | GO:0071482 | cellular response to light stimulus | 1.80e-02 |
MAP2K6 | GO:0071322 | cellular response to carbohydrate stimulus | 2.32e-02 |
MAP2K6 | GO:0009411 | response to UV | 2.32e-02 |
MAP2K6 | GO:0051147 | regulation of muscle cell differentiation | 2.44e-02 |
MAP2K6 | GO:0071478 | cellular response to radiation | 2.84e-02 |
MAP2K6 | GO:0060348 | bone development | 3.74e-02 |
MAP2K6 | GO:0009743 | response to carbohydrate | 4.02e-02 |
MAP2K6 | GO:0001649 | osteoblast differentiation | 4.72e-02 |
MAP2K6 | GO:0070391 | response to lipoteichoic acid | 4.75e-02 |
MAP2K6 | GO:0071223 | cellular response to lipoteichoic acid | 4.75e-02 |
MAP2K6 | GO:0071493 | cellular response to UV-B | 4.75e-02 |
MAP2K6 | GO:0009416 | response to light stimulus | 4.75e-02 |
MAP2K6 | GO:0032306 | regulation of prostaglandin secretion | 4.75e-02 |
MAP2K6 | GO:0032308 | positive regulation of prostaglandin secretion | 4.75e-02 |
MAP2K6 | GO:0035331 | negative regulation of hippo signaling | 4.75e-02 |
MAP2K6 | GO:0071214 | cellular response to abiotic stimulus | 4.75e-02 |
MAP2K6 | GO:0104004 | cellular response to environmental stimulus | 4.75e-02 |
MAP2K6 | GO:0007517 | muscle organ development | 4.75e-02 |
MAP2K6 | GO:0051770 | positive regulation of nitric-oxide synthase biosynthetic process | 4.75e-02 |
MAP2K6 | GO:0090336 | positive regulation of brown fat cell differentiation | 4.75e-02 |
MAP2K6 | GO:1901741 | positive regulation of myoblast fusion | 4.75e-02 |
MAP2K6 | GO:0010831 | positive regulation of myotube differentiation | 4.75e-02 |
MAP2K6 | GO:0032310 | prostaglandin secretion | 4.75e-02 |
MAP2K6 | GO:0071243 | cellular response to arsenic-containing substance | 4.75e-02 |
MAP2K6 | GO:0001502 | cartilage condensation | 4.75e-02 |
MAP2K6 | GO:0032305 | positive regulation of icosanoid secretion | 4.75e-02 |
MAP2K6 | GO:0032303 | regulation of icosanoid secretion | 4.75e-02 |
MAP2K6 | GO:0051767 | nitric-oxide synthase biosynthetic process | 4.75e-02 |
MAP2K6 | GO:0051769 | regulation of nitric-oxide synthase biosynthetic process | 4.75e-02 |
MAP2K6 | GO:0045786 | negative regulation of cell cycle | 4.75e-02 |
MAP2K6 | GO:0010224 | response to UV-B | 4.75e-02 |
MAP2K6 | GO:0032495 | response to muramyl dipeptide | 4.75e-02 |
MAP2K6 | GO:1901739 | regulation of myoblast fusion | 4.75e-02 |
MAP2K6 | GO:0042692 | muscle cell differentiation | 4.75e-02 |
MAP2K6 | GO:0050727 | regulation of inflammatory response | 4.75e-02 |
MAP2K6 | GO:0009314 | response to radiation | 4.75e-02 |
MAP2K6 | GO:0098743 | cell aggregation | 4.75e-02 |
MAP2K6 | GO:2000193 | positive regulation of fatty acid transport | 4.75e-02 |
MAP2K6 | GO:0060143 | positive regulation of syncytium formation by plasma membrane fusion | 4.75e-02 |