| UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY |
|
|||||||
|
Kinase Fusion Gene:MAP3K1_ABLIM3 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: MAP3K1_ABLIM3 | KinaseFusionDB ID: KFG3382 | FusionGDB2.0 ID: KFG3382 | Hgene | Tgene | Gene symbol | MAP3K1 | ABLIM3 | Gene ID | 4214 | 22885 | |
| Gene name | mitogen-activated protein kinase kinase kinase 1 | actin binding LIM protein family member 3 | ||||||||||
| Synonyms | MAPKKK1|MEKK|MEKK 1|MEKK1|SRXY6 | HMFN1661 | ||||||||||
| Cytomap | 5q11.2 | 5q32 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | mitogen-activated protein kinase kinase kinase 1MAP/ERK kinase kinase 1MAPK/ERK kinase kinase 1MEK kinase 1mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase | actin-binding LIM protein 3abLIM-3 | ||||||||||
| Modification date | 20240305 | 20240305 | ||||||||||
| UniProtAcc | Q56UN5 | O94929 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000399503, | ENST00000326685, ENST00000356541, ENST00000309868, ENST00000506113, ENST00000504238, ENST00000508983, ENST00000517451, ENST00000519549, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: MAP3K1 [Title/Abstract] AND ABLIM3 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | ||||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Kinase Fusion gene breakpoints across MAP3K1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across ABLIM3 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Top |
Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| CCLE | NCI-H2444 | MAP3K1 | chr5 | 56171137 | ABLIM3 | chr5 | 148563015 |
Top |
Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
Top |
Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
Top |
Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:/:) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAP3K1 | ABLIM3 |
| FUNCTION: May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity. {ECO:0000269|PubMed:17194709}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
Top |
Kinase-Substrate Information of MAP3K1_ABLIM3 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| MAP3K1 | Q13233 | human | MAFA | Q8NHW3 | S14 | MGAELPSsPLAIEYV | |
| MAP3K1 | Q13233 | human | MAP2K7 | O14733 | T275 | LVDsKAKtRsAGCAA | Pkinase |
| MAP3K1 | Q13233 | human | MAP2K7 | O14733 | S271 | IsGRLVDsKAKtRsA | Pkinase |
| MAP3K1 | Q13233 | human | NOTCH1 | P46531 | T2511 | VPEHPFLtPsPEsPD | |
| MAP3K1 | Q13233 | human | FADD | Q13158 | S194 | QNRsGAMsPMsWNsD | |
| MAP3K1 | Q13233 | human | MAFA | Q8NHW3 | S65 | PCSsVPSsPSFCAPS | |
| MAP3K1 | Q13233 | human | IKBKB | O14920 | S181 | DQGsLCtsFVGTLQy | Pkinase |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| MAP3K1 | ID | Description | 0.00e+00 |
| MAP3K1 | GO:0097049 | motor neuron apoptotic process | 6.79e-03 |
| MAP3K1 | GO:0038095 | Fc-epsilon receptor signaling pathway | 6.79e-03 |
| MAP3K1 | GO:0045601 | regulation of endothelial cell differentiation | 1.63e-02 |
| MAP3K1 | GO:0038093 | Fc receptor signaling pathway | 1.74e-02 |
| MAP3K1 | GO:0071347 | cellular response to interleukin-1 | 3.56e-02 |
| MAP3K1 | GO:0045446 | endothelial cell differentiation | 3.56e-02 |
| MAP3K1 | GO:0070555 | response to interleukin-1 | 3.56e-02 |
| MAP3K1 | GO:0003158 | endothelium development | 3.56e-02 |
| MAP3K1 | GO:0001959 | regulation of cytokine-mediated signaling pathway | 3.56e-02 |
| MAP3K1 | GO:0030856 | regulation of epithelial cell differentiation | 3.56e-02 |
| MAP3K1 | GO:0060759 | regulation of response to cytokine stimulus | 3.56e-02 |
| MAP3K1 | GO:0043123 | positive regulation of canonical NF-kappaB signal transduction | 3.56e-02 |
| MAP3K1 | GO:0002064 | epithelial cell development | 3.56e-02 |
| MAP3K1 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 3.56e-02 |
| MAP3K1 | GO:0051403 | stress-activated MAPK cascade | 3.56e-02 |
| MAP3K1 | GO:0031098 | stress-activated protein kinase signaling cascade | 3.56e-02 |
| MAP3K1 | GO:0034612 | response to tumor necrosis factor | 3.56e-02 |
| MAP3K1 | GO:0043122 | regulation of canonical NF-kappaB signal transduction | 3.56e-02 |
| MAP3K1 | GO:0071216 | cellular response to biotic stimulus | 3.56e-02 |
| MAP3K1 | GO:0051402 | neuron apoptotic process | 3.56e-02 |
| MAP3K1 | GO:0007249 | canonical NF-kappaB signal transduction | 3.56e-02 |
| MAP3K1 | GO:0007440 | foregut morphogenesis | 3.56e-02 |
| MAP3K1 | GO:0060525 | prostate glandular acinus development | 3.56e-02 |
| MAP3K1 | GO:0060768 | regulation of epithelial cell proliferation involved in prostate gland development | 3.56e-02 |
| MAP3K1 | GO:0060947 | cardiac vascular smooth muscle cell differentiation | 3.56e-02 |
| MAP3K1 | GO:0062042 | regulation of cardiac epithelial to mesenchymal transition | 3.56e-02 |
| MAP3K1 | GO:0071372 | cellular response to follicle-stimulating hormone stimulus | 3.56e-02 |
| MAP3K1 | GO:2000048 | negative regulation of cell-cell adhesion mediated by cadherin | 3.56e-02 |
| MAP3K1 | GO:0070372 | regulation of ERK1 and ERK2 cascade | 3.56e-02 |
| MAP3K1 | GO:0001822 | kidney development | 3.56e-02 |
| MAP3K1 | GO:0048872 | homeostasis of number of cells | 3.56e-02 |
| MAP3K1 | GO:0072001 | renal system development | 3.56e-02 |
| MAP3K1 | GO:0003263 | cardioblast proliferation | 3.56e-02 |
| MAP3K1 | GO:0003264 | regulation of cardioblast proliferation | 3.56e-02 |
| MAP3K1 | GO:0032966 | negative regulation of collagen biosynthetic process | 3.56e-02 |
| MAP3K1 | GO:0035666 | TRIF-dependent toll-like receptor signaling pathway | 3.56e-02 |
| MAP3K1 | GO:0048103 | somatic stem cell division | 3.56e-02 |
| MAP3K1 | GO:0048505 | regulation of timing of cell differentiation | 3.56e-02 |
| MAP3K1 | GO:0060742 | epithelial cell differentiation involved in prostate gland development | 3.56e-02 |
| MAP3K1 | GO:0060767 | epithelial cell proliferation involved in prostate gland development | 3.56e-02 |
| MAP3K1 | GO:0061314 | Notch signaling involved in heart development | 3.56e-02 |
| MAP3K1 | GO:0097400 | interleukin-17-mediated signaling pathway | 3.56e-02 |
| MAP3K1 | GO:1904238 | pericyte cell differentiation | 3.56e-02 |
| MAP3K1 | GO:1905651 | regulation of artery morphogenesis | 3.56e-02 |
| MAP3K1 | GO:0070371 | ERK1 and ERK2 cascade | 3.56e-02 |
| MAP3K1 | GO:0002328 | pro-B cell differentiation | 3.56e-02 |
| MAP3K1 | GO:0003157 | endocardium development | 3.56e-02 |
| MAP3K1 | GO:0003183 | mitral valve morphogenesis | 3.56e-02 |
| MAP3K1 | GO:0003207 | cardiac chamber formation | 3.56e-02 |
Top |
Related Drugs to MAP3K1_ABLIM3 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning MAP3K1-ABLIM3 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
Top |
Related Diseases to MAP3K1_ABLIM3 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Top |
Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
Copyright 2024-Present -The University of Texas Health Science Center at Houston
Web File Viewing | Emergency Information |Campus Carry|Site Policies |