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	Kinase Fusion Gene Summary
	Kinase Fusion Gene Sample Information
	Kinase Fusion ORF Analysis
	Kinase Fusion Amino Acid Sequences
	Multiple Sequence Alignment of All Fusion Protein Isoforms
	Kinase Fusion Protein Functional Features
	Kinase Fusion Protein Structures
	Comparison of Fusion Protein Isoforms
	Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB
	pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.
	Ramachandran Plot of Kinase Fusion Protein Structure
	Potential Active Site Information
	Virtual Screening Results
	Kinase-Substrate Information
	Related Drugs with This Kinase Fusion Protein
	Related Disease with This Kinase Fusion Protein
	Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:MAP3K2_WBP2NL

Kinase Fusion Protein Summary

Kinase Fusion gene summary

Kinase Fusion partner gene information	Kinase Fusion gene name: MAP3K2_WBP2NL
	KinaseFusionDB ID: KFG3397
	FusionGDB2.0 ID: KFG3397
		Hgene	Tgene
	Gene symbol	MAP3K2	WBP2NL
	Gene ID	10746	164684
	Gene name	mitogen-activated protein kinase kinase kinase 2	WBP2 N-terminal like
	Synonyms	MEKK2\|MEKK2B	GRAMD7\|PAWP
	Cytomap	2q14.3	22q13.2
	Type of gene	protein-coding	protein-coding
	Description	mitogen-activated protein kinase kinase kinase 2MAP/ERK kinase kinase 2MAPK/ERK kinase kinase 2MEK kinase 2MEKK 2	postacrosomal sheath WW domain-binding proteinWW domain-binding protein 2-like
	Modification date	20240305	20240305
	UniProtAcc	Q9Y2U5	Q6ICG8
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000344908, ENST00000409947,	ENST00000328823, ENST00000461730, ENST00000543212,
Context (manual curation of fusion genes in KinaseFusionDB)	PubMed: MAP3K2 [Title/Abstract] AND WBP2NL [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	MAP3K2(128056517)-WBP2NL(42420503), # samples:1

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MAP3K2	GO:0035556	intracellular signal transduction	14515274
Tgene	WBP2NL	GO:0051480	regulation of cytosolic calcium ion concentration	26116451

Kinase Fusion gene breakpoints across MAP3K2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Kinase Fusion gene breakpoints across WBP2NL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Kinase Fusion Gene Sample Information

Kinase Fusion gene information.

Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Sample	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
ChiTaRS5.0	BF215608	MAP3K2	chr2	128056517	WBP2NL	chr22	42420503

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Kinase Fusion ORF Analysis

Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.

Henst

Tenst

Hgene

Hchr

Hbp

Tgene

Tchr

Tbp

Seq length
(transcript)

Seq length
(amino acids)

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Kinase Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:128056517/:42420503)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MAP3K2 Q9Y2U5	WBP2NL Q6ICG8
FUNCTION: Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics. {ECO:0000250, ECO:0000269\|PubMed:10713157, ECO:0000269\|PubMed:16001074}.	FUNCTION: May play a role in meiotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization. {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).

Partner

Hgeneene

Hbp

Tgeneene

Tbp

ENST

BPexon

TotalExon

Protein feature loci

BPloci

TotalLen

Feature

Note

- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).

Partner

Hgeneene

Hbp

Tgeneene

Tbp

ENST

BPexon

TotalExon

Protein feature loci

BPloci

TotalLen

Feature

Note

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Kinase-Substrate Information of MAP3K2_WBP2NL

Phosphorylation target of the kinase
(phosphosite, 03-17-2024)

Kinase	Kinase UniProt Acc	Kinase species	Substrate	Substrate UniProt Acc	Substrate phosphorylated residues	Substrate phosphorylated sites (+/-7AA)	Domain
MAP3K2	Q9Y2U5	human	CTNNB1	P35222	S675	QDykKRLsVELtsSL
MAP3K2	Q9Y2U5	human	STK38	Q15208	S91	LGLEDFEsLkVIGRG	Pkinase
MAP3K2	Q9Y2U5	human	IRF3	Q14653	S173	PCPQPLRsPsLDNPt

Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

Enriched GO biological processes of the phosphorylation target genes of the kinase

Kinase	GOID	GO term	P.adjust
MAP3K2	ID	Description	0.00e+00
MAP3K2	GO:0043123	positive regulation of canonical NF-kappaB signal transduction	2.38e-02
MAP3K2	GO:0043122	regulation of canonical NF-kappaB signal transduction	2.38e-02
MAP3K2	GO:0007249	canonical NF-kappaB signal transduction	2.38e-02
MAP3K2	GO:0031400	negative regulation of protein modification process	2.38e-02
MAP3K2	GO:0007440	foregut morphogenesis	2.38e-02
MAP3K2	GO:0043587	tongue morphogenesis	2.38e-02
MAP3K2	GO:0048263	determination of dorsal identity	2.38e-02
MAP3K2	GO:0048664	neuron fate determination	2.38e-02
MAP3K2	GO:0060768	regulation of epithelial cell proliferation involved in prostate gland development	2.38e-02
MAP3K2	GO:0003263	cardioblast proliferation	2.38e-02
MAP3K2	GO:0003264	regulation of cardioblast proliferation	2.38e-02
MAP3K2	GO:0003337	mesenchymal to epithelial transition involved in metanephros morphogenesis	2.38e-02
MAP3K2	GO:0033234	negative regulation of protein sumoylation	2.38e-02
MAP3K2	GO:0035666	TRIF-dependent toll-like receptor signaling pathway	2.38e-02
MAP3K2	GO:0039530	MDA-5 signaling pathway	2.38e-02
MAP3K2	GO:0044848	biological phase	2.38e-02
MAP3K2	GO:0048262	determination of dorsal/ventral asymmetry	2.38e-02
MAP3K2	GO:0060272	embryonic skeletal joint morphogenesis	2.38e-02
MAP3K2	GO:0060439	trachea morphogenesis	2.38e-02
MAP3K2	GO:0060742	epithelial cell differentiation involved in prostate gland development	2.38e-02
MAP3K2	GO:0060767	epithelial cell proliferation involved in prostate gland development	2.38e-02
MAP3K2	GO:0070601	centromeric sister chromatid cohesion	2.38e-02
MAP3K2	GO:0003306	Wnt signaling pathway involved in heart development	2.38e-02
MAP3K2	GO:0009950	dorsal/ventral axis specification	2.38e-02
MAP3K2	GO:0035112	genitalia morphogenesis	2.38e-02
MAP3K2	GO:0060788	ectodermal placode formation	2.38e-02
MAP3K2	GO:0071697	ectodermal placode morphogenesis	2.38e-02
MAP3K2	GO:0072182	regulation of nephron tubule epithelial cell differentiation	2.38e-02
MAP3K2	GO:0072497	mesenchymal stem cell differentiation	2.38e-02
MAP3K2	GO:1904953	Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation	2.38e-02
MAP3K2	GO:0050808	synapse organization	2.38e-02
MAP3K2	GO:0021781	glial cell fate commitment	2.38e-02
MAP3K2	GO:0034333	adherens junction assembly	2.38e-02
MAP3K2	GO:1903377	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	2.38e-02
MAP3K2	GO:0021819	layer formation in cerebral cortex	2.38e-02
MAP3K2	GO:0042762	regulation of sulfur metabolic process	2.38e-02
MAP3K2	GO:0048715	negative regulation of oligodendrocyte differentiation	2.38e-02
MAP3K2	GO:0071696	ectodermal placode development	2.38e-02
MAP3K2	GO:0071888	macrophage apoptotic process	2.38e-02
MAP3K2	GO:0072160	nephron tubule epithelial cell differentiation	2.38e-02
MAP3K2	GO:0072283	metanephric renal vesicle morphogenesis	2.38e-02
MAP3K2	GO:2000288	positive regulation of myoblast proliferation	2.38e-02
MAP3K2	GO:0001711	endodermal cell fate commitment	2.38e-02
MAP3K2	GO:0010457	centriole-centriole cohesion	2.38e-02
MAP3K2	GO:0048820	hair follicle maturation	2.38e-02
MAP3K2	GO:0060572	morphogenesis of an epithelial bud	2.38e-02
MAP3K2	GO:0072498	embryonic skeletal joint development	2.38e-02
MAP3K2	GO:0002756	MyD88-independent toll-like receptor signaling pathway	2.38e-02
MAP3K2	GO:0060856	establishment of blood-brain barrier	2.38e-02

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Related Drugs to MAP3K2_WBP2NL

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Distribution of the number of studies mentioning MAP3K2-WBP2NL and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1

Fusion gene - drug pair 2

PMID

Publication date

DOI

Study title

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Related Diseases to MAP3K2_WBP2NL

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)

MeSH ID

MeSH term

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Clinical Trials of the Found Drugs/Small Molecules

Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion Gene

Kinase Inhibitor

NCT ID

Study Status

Phases

Disease

# Enrolment

Date