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Kinase Fusion Gene:MAP3K3_PTPN21 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: MAP3K3_PTPN21 | KinaseFusionDB ID: KFG3407 | FusionGDB2.0 ID: KFG3407 | Hgene | Tgene | Gene symbol | MAP3K3 | PTPN21 | Gene ID | 4215 | 11099 | |
| Gene name | mitogen-activated protein kinase kinase kinase 3 | protein tyrosine phosphatase non-receptor type 21 | ||||||||||
| Synonyms | MAPKKK3|MEKK3 | PTPD1|PTPRL10 | ||||||||||
| Cytomap | 17q23.3 | 14q31.3 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | mitogen-activated protein kinase kinase kinase 3MAP/ERK kinase kinase 3MAPK/ERK kinase kinase 3MEK kinase 3MEKK 3 | tyrosine-protein phosphatase non-receptor type 21dJ1175B15.2 (protein tyrosine phosphatase, non-receptor type 21)protein-tyrosine phosphatase D1 | ||||||||||
| Modification date | 20240305 | 20240407 | ||||||||||
| UniProtAcc | Q99759 | Q16825 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000361357, ENST00000361733, ENST00000577395, ENST00000577784, ENST00000579585, ENST00000584573, | ENST00000328736, ENST00000554628, ENST00000556564, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: MAP3K3 [Title/Abstract] AND PTPN21 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | MAP3K3(61720009)-PTPN21(89016193), # samples:1 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MAP3K3 | GO:0035556 | intracellular signal transduction | 15001576 |
| Hgene | MAP3K3 | GO:0046777 | protein autophosphorylation | 15001576 |
| Kinase Fusion gene breakpoints across MAP3K3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across PTPN21 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChiTaRS5.0 | EC515140 | MAP3K3 | chr17 | 61720009 | PTPN21 | chr14 | 89016193 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:61720009/:89016193) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAP3K3 | PTPN21 |
| FUNCTION: Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. {ECO:0000269|PubMed:12912994, ECO:0000269|PubMed:14661019, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:9006902}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of MAP3K3_PTPN21 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| MAP3K3 | Q99759 | human | GLI1 | P08151 | S201 | PLEGDMSsPNstGIQ | |
| MAP3K3 | Q99759 | human | GLI1 | P08151 | S243 | DCRWDGCsQEFDSQE | |
| MAP3K3 | Q99759 | human | RCAN1 | P53805 | S163 | PDKQFLIsPPAsPPV | Calcipressin |
| MAP3K3 | Q99759 | human | RCAN1 | P53805 | S167 | FLIsPPAsPPVGWKQ | Calcipressin |
| MAP3K3 | Q99759 | human | GLI1 | P08151 | T1074 | QRGSsGHtPPPsGPP | |
| MAP3K3 | Q99759 | human | GLI1 | P08151 | S1078 | sGHtPPPsGPPNMAV | |
| MAP3K3 | Q99759 | human | GLI1 | P08151 | S968 | SGSYPTPsPCHENFV | |
| MAP3K3 | Q99759 | human | GLI1 | P08151 | S204 | GDMSsPNstGIQDPL |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| MAP3K3 | ID | Description | 0.00e+00 |
| MAP3K3 | GO:0060537 | muscle tissue development | 1.79e-02 |
| MAP3K3 | GO:0007614 | short-term memory | 1.79e-02 |
| MAP3K3 | GO:0021936 | regulation of cerebellar granule cell precursor proliferation | 1.79e-02 |
| MAP3K3 | GO:0031987 | locomotion involved in locomotory behavior | 1.79e-02 |
| MAP3K3 | GO:0070885 | negative regulation of calcineurin-NFAT signaling cascade | 1.79e-02 |
| MAP3K3 | GO:0106057 | negative regulation of calcineurin-mediated signaling | 1.79e-02 |
| MAP3K3 | GO:0021534 | cell proliferation in hindbrain | 1.79e-02 |
| MAP3K3 | GO:0021924 | cell proliferation in external granule layer | 1.79e-02 |
| MAP3K3 | GO:0021930 | cerebellar granule cell precursor proliferation | 1.79e-02 |
| MAP3K3 | GO:0060033 | anatomical structure regression | 1.79e-02 |
| MAP3K3 | GO:2000345 | regulation of hepatocyte proliferation | 1.79e-02 |
| MAP3K3 | GO:0030903 | notochord development | 1.79e-02 |
| MAP3K3 | GO:0050849 | negative regulation of calcium-mediated signaling | 1.79e-02 |
| MAP3K3 | GO:0072574 | hepatocyte proliferation | 1.79e-02 |
| MAP3K3 | GO:0072575 | epithelial cell proliferation involved in liver morphogenesis | 1.79e-02 |
| MAP3K3 | GO:0072576 | liver morphogenesis | 1.79e-02 |
| MAP3K3 | GO:0097421 | liver regeneration | 1.79e-02 |
| MAP3K3 | GO:0060045 | positive regulation of cardiac muscle cell proliferation | 1.79e-02 |
| MAP3K3 | GO:0009954 | proximal/distal pattern formation | 1.79e-02 |
| MAP3K3 | GO:0021696 | cerebellar cortex morphogenesis | 1.79e-02 |
| MAP3K3 | GO:0055023 | positive regulation of cardiac muscle tissue growth | 1.79e-02 |
| MAP3K3 | GO:0045880 | positive regulation of smoothened signaling pathway | 1.79e-02 |
| MAP3K3 | GO:0045740 | positive regulation of DNA replication | 1.79e-02 |
| MAP3K3 | GO:0048741 | skeletal muscle fiber development | 1.79e-02 |
| MAP3K3 | GO:0060421 | positive regulation of heart growth | 1.79e-02 |
| MAP3K3 | GO:0070884 | regulation of calcineurin-NFAT signaling cascade | 1.79e-02 |
| MAP3K3 | GO:0106056 | regulation of calcineurin-mediated signaling | 1.79e-02 |
| MAP3K3 | GO:0014904 | myotube cell development | 1.79e-02 |
| MAP3K3 | GO:0021983 | pituitary gland development | 1.79e-02 |
| MAP3K3 | GO:0021587 | cerebellum morphogenesis | 1.79e-02 |
| MAP3K3 | GO:0033173 | calcineurin-NFAT signaling cascade | 1.79e-02 |
| MAP3K3 | GO:0021575 | hindbrain morphogenesis | 1.79e-02 |
| MAP3K3 | GO:0060043 | regulation of cardiac muscle cell proliferation | 1.79e-02 |
| MAP3K3 | GO:0097720 | calcineurin-mediated signaling | 1.79e-02 |
| MAP3K3 | GO:0048546 | digestive tract morphogenesis | 1.79e-02 |
| MAP3K3 | GO:0030850 | prostate gland development | 1.79e-02 |
| MAP3K3 | GO:0021695 | cerebellar cortex development | 1.79e-02 |
| MAP3K3 | GO:0046622 | positive regulation of organ growth | 1.79e-02 |
| MAP3K3 | GO:0060038 | cardiac muscle cell proliferation | 1.97e-02 |
| MAP3K3 | GO:0002931 | response to ischemia | 1.97e-02 |
| MAP3K3 | GO:2000179 | positive regulation of neural precursor cell proliferation | 1.97e-02 |
| MAP3K3 | GO:0031100 | animal organ regeneration | 1.97e-02 |
| MAP3K3 | GO:0055021 | regulation of cardiac muscle tissue growth | 1.97e-02 |
| MAP3K3 | GO:1902808 | positive regulation of cell cycle G1/S phase transition | 1.97e-02 |
| MAP3K3 | GO:0001655 | urogenital system development | 1.98e-02 |
| MAP3K3 | GO:0060420 | regulation of heart growth | 2.06e-02 |
| MAP3K3 | GO:0021536 | diencephalon development | 2.24e-02 |
| MAP3K3 | GO:0014855 | striated muscle cell proliferation | 2.26e-02 |
| MAP3K3 | GO:0050848 | regulation of calcium-mediated signaling | 2.26e-02 |
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Related Drugs to MAP3K3_PTPN21 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning MAP3K3-PTPN21 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to MAP3K3_PTPN21 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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