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Kinase Fusion Gene:MAP3K4_FNDC1 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: MAP3K4_FNDC1 | KinaseFusionDB ID: KFG3414 | FusionGDB2.0 ID: KFG3414 | Hgene | Tgene | Gene symbol | MAP3K4 | FNDC1 | Gene ID | 4216 | 84624 | |
| Gene name | mitogen-activated protein kinase kinase kinase 4 | fibronectin type III domain containing 1 | ||||||||||
| Synonyms | MAPKKK4|MEKK 4|MEKK4|MTK1|PRO0412 | AGS8|FNDC2|MEL4B3|bA243O10.1|dJ322A24.1 | ||||||||||
| Cytomap | 6q26 | 6q25.3 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | mitogen-activated protein kinase kinase kinase 4MAP three kinase 1MAP/ERK kinase kinase 4MAPK/ERK kinase kinase 4MEK kinase 4SSK2/SSK22 MAP kinase kinase kinase, yeast, homolog ofdJ473J16.1 (mitogen-activated protein kinase kinase kinase 4)predicte | fibronectin type III domain-containing protein 1activation-associated cDNA proteinexpressed in synovial lining proteinfibronectin type III domain containing 2 | ||||||||||
| Modification date | 20240407 | 20240403 | ||||||||||
| UniProtAcc | Q9Y6R4 | Q4ZHG4 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000348824, ENST00000366919, ENST00000366920, ENST00000392142, ENST00000446500, | ENST00000480856, ENST00000297267, ENST00000340366, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: MAP3K4 [Title/Abstract] AND FNDC1 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | MAP3K4(161471011)-FNDC1(159618463), # samples:3 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MAP3K4 | GO:0000165 | MAPK cascade | 9305639|9827804 |
| Hgene | MAP3K4 | GO:0043507 | positive regulation of JUN kinase activity | 9305639 |
| Hgene | MAP3K4 | GO:1900745 | positive regulation of p38MAPK cascade | 9305639 |
| Kinase Fusion gene breakpoints across MAP3K4 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across FNDC1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChimerDB4 | TCGA-AR-A251-01A | MAP3K4 | chr6 | 161471011 | FNDC1 | chr6 | 159618463 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:161471011/:159618463) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAP3K4 | FNDC1 |
| FUNCTION: Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6. {ECO:0000269|PubMed:12052864, ECO:0000269|PubMed:9305639}. | FUNCTION: May be an activator of G protein signaling. {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of MAP3K4_FNDC1 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| MAP3K4 | Q9Y6R4 | human | HOXA10 | P31260 | T362 | FLFNMyLtRERRLEI | |
| MAP3K4 | Q9Y6R4 | human | MAP3K4 | Q9Y6R4 | T1494 | KLKNNAQtMPGEVNS | Pkinase |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| MAP3K4 | ID | Description | 0.00e+00 |
| MAP3K4 | GO:0060717 | chorion development | 1.97e-02 |
| MAP3K4 | GO:1903867 | extraembryonic membrane development | 1.97e-02 |
| MAP3K4 | GO:0010225 | response to UV-C | 1.97e-02 |
| MAP3K4 | GO:0030238 | male sex determination | 1.97e-02 |
| MAP3K4 | GO:1904355 | positive regulation of telomere capping | 1.97e-02 |
| MAP3K4 | GO:0007530 | sex determination | 1.97e-02 |
| MAP3K4 | GO:0060065 | uterus development | 1.97e-02 |
| MAP3K4 | GO:1904353 | regulation of telomere capping | 1.97e-02 |
| MAP3K4 | GO:0043507 | positive regulation of JUN kinase activity | 1.97e-02 |
| MAP3K4 | GO:1900745 | positive regulation of p38MAPK cascade | 1.97e-02 |
| MAP3K4 | GO:0009954 | proximal/distal pattern formation | 1.97e-02 |
| MAP3K4 | GO:0032212 | positive regulation of telomere maintenance via telomerase | 1.97e-02 |
| MAP3K4 | GO:0051973 | positive regulation of telomerase activity | 1.97e-02 |
| MAP3K4 | GO:1904358 | positive regulation of telomere maintenance via telomere lengthening | 1.97e-02 |
| MAP3K4 | GO:0016233 | telomere capping | 1.97e-02 |
| MAP3K4 | GO:0043506 | regulation of JUN kinase activity | 1.97e-02 |
| MAP3K4 | GO:0033574 | response to testosterone | 1.97e-02 |
| MAP3K4 | GO:1900744 | regulation of p38MAPK cascade | 1.97e-02 |
| MAP3K4 | GO:0051972 | regulation of telomerase activity | 1.97e-02 |
| MAP3K4 | GO:0030850 | prostate gland development | 2.04e-02 |
| MAP3K4 | GO:0032210 | regulation of telomere maintenance via telomerase | 2.04e-02 |
| MAP3K4 | GO:0038066 | p38MAPK cascade | 2.04e-02 |
| MAP3K4 | GO:1904356 | regulation of telomere maintenance via telomere lengthening | 2.04e-02 |
| MAP3K4 | GO:0001655 | urogenital system development | 2.04e-02 |
| MAP3K4 | GO:0007004 | telomere maintenance via telomerase | 2.04e-02 |
| MAP3K4 | GO:0043627 | response to estrogen | 2.04e-02 |
| MAP3K4 | GO:2000573 | positive regulation of DNA biosynthetic process | 2.04e-02 |
| MAP3K4 | GO:0032206 | positive regulation of telomere maintenance | 2.04e-02 |
| MAP3K4 | GO:0006278 | RNA-templated DNA biosynthetic process | 2.11e-02 |
| MAP3K4 | GO:0010833 | telomere maintenance via telomere lengthening | 2.20e-02 |
| MAP3K4 | GO:0043406 | positive regulation of MAP kinase activity | 2.31e-02 |
| MAP3K4 | GO:0032204 | regulation of telomere maintenance | 2.65e-02 |
| MAP3K4 | GO:2001252 | positive regulation of chromosome organization | 2.65e-02 |
| MAP3K4 | GO:2000278 | regulation of DNA biosynthetic process | 2.65e-02 |
| MAP3K4 | GO:0030326 | embryonic limb morphogenesis | 2.65e-02 |
| MAP3K4 | GO:0035113 | embryonic appendage morphogenesis | 2.65e-02 |
| MAP3K4 | GO:0032874 | positive regulation of stress-activated MAPK cascade | 2.65e-02 |
| MAP3K4 | GO:0070304 | positive regulation of stress-activated protein kinase signaling cascade | 2.65e-02 |
| MAP3K4 | GO:0071902 | positive regulation of protein serine/threonine kinase activity | 2.69e-02 |
| MAP3K4 | GO:0043405 | regulation of MAP kinase activity | 2.69e-02 |
| MAP3K4 | GO:0035107 | appendage morphogenesis | 2.69e-02 |
| MAP3K4 | GO:0035108 | limb morphogenesis | 2.69e-02 |
| MAP3K4 | GO:0008584 | male gonad development | 2.69e-02 |
| MAP3K4 | GO:0001890 | placenta development | 2.69e-02 |
| MAP3K4 | GO:0046546 | development of primary male sexual characteristics | 2.69e-02 |
| MAP3K4 | GO:0009411 | response to UV | 2.69e-02 |
| MAP3K4 | GO:0000723 | telomere maintenance | 2.70e-02 |
| MAP3K4 | GO:0007338 | single fertilization | 2.81e-02 |
| MAP3K4 | GO:0046661 | male sex differentiation | 2.84e-02 |
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Related Drugs to MAP3K4_FNDC1 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning MAP3K4-FNDC1 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to MAP3K4_FNDC1 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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