| UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY |
|
|||||||
|
Kinase Fusion Gene:MAP4K3_EML4 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: MAP4K3_EML4 | KinaseFusionDB ID: KFG3464 | FusionGDB2.0 ID: KFG3464 | Hgene | Tgene | Gene symbol | MAP4K3 | EML4 | Gene ID | 8491 | 27436 | |
| Gene name | mitogen-activated protein kinase kinase kinase kinase 3 | EMAP like 4 | ||||||||||
| Synonyms | GLK|MAPKKKK3|MEKKK 3|MEKKK3|RAB8IPL1 | C2orf2|ELP120|EMAP-4|EMAPL4|ROPP120 | ||||||||||
| Cytomap | 2p22.1 | 2p21 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | mitogen-activated protein kinase kinase kinase kinase 3MAPK/ERK kinase kinase kinase 3MEK kinase kinase 3germinal center kinase-like kinasegerminal center kinase-related protein kinase | echinoderm microtubule-associated protein-like 4echinoderm microtubule associated protein like 4restrictedly overexpressed proliferation-associated proteinropp 120 | ||||||||||
| Modification date | 20240408 | 20240411 | ||||||||||
| UniProtAcc | Q8IVH8 | Q9HC35 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000263881, ENST00000341681, ENST00000484274, ENST00000437545, ENST00000474502, ENST00000536018, | ENST00000401738, ENST00000453191, ENST00000482660, ENST00000318522, ENST00000402711, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: MAP4K3 [Title/Abstract] AND EML4 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | MAP4K3(39605207)-EML4(42507990), # samples:2 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MAP4K3 | GO:0006468 | protein phosphorylation | 9275185 |
| Hgene | MAP4K3 | GO:0009411 | response to UV | 9275185 |
| Hgene | MAP4K3 | GO:0034612 | response to tumor necrosis factor | 9275185 |
| Hgene | MAP4K3 | GO:0035556 | intracellular signal transduction | 9275185 |
| Kinase Fusion gene breakpoints across MAP4K3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Kinase Fusion gene breakpoints across EML4 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
Top |
Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChimerDB4 | TCGA-QK-A8ZB-01A | MAP4K3 | chr2 | 39605207 | EML4 | chr2 | 42507990 |
Top |
Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
Top |
Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
Top |
Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:39605207/chr2:42507990) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAP4K3 | EML4 |
| FUNCTION: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. {ECO:0000269|PubMed:9275185}. | FUNCTION: Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (PubMed:25789526). {ECO:0000269|PubMed:16890222, ECO:0000269|PubMed:25789526, ECO:0000269|PubMed:31409757}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
Top |
Kinase-Substrate Information of MAP4K3_EML4 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| MAP4K3 | Q8IVH8 | human | ACE2 | Q9BYF1 | S783 | sGENPyAsIDIsKGE | |
| MAP4K3 | Q8IVH8 | human | TFEB | P19484 | S3 | _____MAsRIGLrMQ | |
| MAP4K3 | Q8IVH8 | human | MAP4K3 | Q8IVH8 | S170 | AtIAkRKsFIGTPYW | Pkinase |
| MAP4K3 | Q8IVH8 | human | IQGAP1 | P46940 | S480 | NTVWKQLsSSVTGLT | |
| MAP4K3 | Q8IVH8 | human | PRKCQ | Q04759 | T538 | LGDAktNtFCGtPDy | Pkinase |
| MAP4K3 | Q8IVH8 | human | ACE2 | Q9BYF1 | S776 | KkkNkARsGENPyAs | |
| MAP4K3 | Q8IVH8 | human | IKBKB | O14920 | S733 | TVREQDQsFtALDWs | IKKbetaNEMObind |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| MAP4K3 | ID | Description | 0.00e+00 |
| MAP4K3 | GO:0038095 | Fc-epsilon receptor signaling pathway | 9.14e-03 |
| MAP4K3 | GO:0035305 | negative regulation of dephosphorylation | 9.14e-03 |
| MAP4K3 | GO:0030866 | cortical actin cytoskeleton organization | 9.14e-03 |
| MAP4K3 | GO:0030865 | cortical cytoskeleton organization | 9.74e-03 |
| MAP4K3 | GO:0038093 | Fc receptor signaling pathway | 9.79e-03 |
| MAP4K3 | GO:0035303 | regulation of dephosphorylation | 2.93e-02 |
| MAP4K3 | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 4.22e-02 |
| MAP4K3 | GO:0007043 | cell-cell junction assembly | 4.22e-02 |
| MAP4K3 | GO:1901888 | regulation of cell junction assembly | 4.22e-02 |
| MAP4K3 | GO:0002064 | epithelial cell development | 4.22e-02 |
| MAP4K3 | GO:0045216 | cell-cell junction organization | 4.22e-02 |
| MAP4K3 | GO:0051403 | stress-activated MAPK cascade | 4.22e-02 |
| MAP4K3 | GO:0031098 | stress-activated protein kinase signaling cascade | 4.22e-02 |
| MAP4K3 | GO:0051091 | positive regulation of DNA-binding transcription factor activity | 4.22e-02 |
| MAP4K3 | GO:0034612 | response to tumor necrosis factor | 4.22e-02 |
| MAP4K3 | GO:0002002 | regulation of angiotensin levels in blood | 4.22e-02 |
| MAP4K3 | GO:0042756 | drinking behavior | 4.22e-02 |
| MAP4K3 | GO:0044650 | adhesion of symbiont to host cell | 4.22e-02 |
| MAP4K3 | GO:0044837 | actomyosin contractile ring organization | 4.22e-02 |
| MAP4K3 | GO:1903596 | regulation of gap junction assembly | 4.22e-02 |
| MAP4K3 | GO:2000563 | positive regulation of CD4-positiv | 3.18e-03 |
| MAP4K3 | GO:0035666 | TRIF-dependent toll-like receptor signaling pathway | 4.22e-02 |
| MAP4K3 | GO:0072015 | podocyte development | 4.22e-02 |
| MAP4K3 | GO:0018105 | peptidyl-serine phosphorylation | 4.22e-02 |
| MAP4K3 | GO:0016311 | dephosphorylation | 4.22e-02 |
| MAP4K3 | GO:0015801 | aromatic amino acid transport | 4.22e-02 |
| MAP4K3 | GO:0035524 | proline transmembrane transport | 4.22e-02 |
| MAP4K3 | GO:0072310 | glomerular epithelial cell development | 4.22e-02 |
| MAP4K3 | GO:0018209 | peptidyl-serine modification | 4.22e-02 |
| MAP4K3 | GO:0015824 | proline transport | 4.22e-02 |
| MAP4K3 | GO:0044406 | adhesion of symbiont to host | 4.22e-02 |
| MAP4K3 | GO:0075509 | endocytosis involved in viral entry into host cell | 4.22e-02 |
| MAP4K3 | GO:0001976 | nervous system process involved in regulation of systemic arterial blood pressure | 4.22e-02 |
| MAP4K3 | GO:0045989 | positive regulation of striated muscle contraction | 4.22e-02 |
| MAP4K3 | GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 4.22e-02 |
| MAP4K3 | GO:0002756 | MyD88-independent toll-like receptor signaling pathway | 4.22e-02 |
| MAP4K3 | GO:0010958 | regulation of amino acid import across plasma membrane | 4.22e-02 |
| MAP4K3 | GO:1903789 | regulation of amino acid transmembrane transport | 4.22e-02 |
| MAP4K3 | GO:2000318 | positive regulation of T-helper 17 type immune response | 4.22e-02 |
| MAP4K3 | GO:0001991 | regulation of systemic arterial blood pressure by circulatory renin-angiotensin | 4.22e-02 |
| MAP4K3 | GO:1901550 | regulation of endothelial cell development | 4.22e-02 |
| MAP4K3 | GO:1903140 | regulation of establishment of endothelial barrier | 4.22e-02 |
| MAP4K3 | GO:1904355 | positive regulation of telomere capping | 4.22e-02 |
| MAP4K3 | GO:0045936 | negative regulation of phosphate metabolic process | 4.22e-02 |
| MAP4K3 | GO:0010563 | negative regulation of phosphorus metabolic process | 4.22e-02 |
| MAP4K3 | GO:0016264 | gap junction assembly | 4.22e-02 |
| MAP4K3 | GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | 4.22e-02 |
| MAP4K3 | GO:0032515 | negative regulation of phosphoprotein phosphatase activity | 4.22e-02 |
| MAP4K3 | GO:0051090 | regulation of DNA-binding transcription factor activity | 4.22e-02 |
Top |
Related Drugs to MAP4K3_EML4 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning MAP4K3-EML4 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
Top |
Related Diseases to MAP4K3_EML4 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | EML4 | C0007131 | Non-Small Cell Lung Carcinoma | 6 | CTD_human |
| Tgene | EML4 | C0027627 | Neoplasm Metastasis | 2 | CTD_human |
| Tgene | EML4 | C0152013 | Adenocarcinoma of lung (disorder) | 2 | CTD_human |
Top |
Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
Copyright 2024-Present -The University of Texas Health Science Center at Houston
Web File Viewing | Emergency Information |Campus Carry|Site Policies |