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Kinase Fusion Gene:MAP4K5_PKN3 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: MAP4K5_PKN3 | KinaseFusionDB ID: KFG3503 | FusionGDB2.0 ID: KFG3503 | Hgene | Tgene | Gene symbol | MAP4K5 | PKN3 | Gene ID | 11183 | 29941 | |
| Gene name | mitogen-activated protein kinase kinase kinase kinase 5 | protein kinase N3 | ||||||||||
| Synonyms | GCKR|KHS|KHS1|MAPKKKK5 | UTDP4-1 | ||||||||||
| Cytomap | 14q22.1 | 9q34.11 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | mitogen-activated protein kinase kinase kinase kinase 5MAPK/ERK kinase kinase kinase 5MEK kinase kinase 5MEKKK 5germinal center kinase-relatedkinase homologous to SPS1/STE20 | serine/threonine-protein kinase N3protein kinase PKN-betaprotein-kinase C-related kinase 3 | ||||||||||
| Modification date | 20240403 | 20240305 | ||||||||||
| UniProtAcc | Q9Y4K4 | Q6P5Z2 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000013125, ENST00000557578, | ENST00000291906, ENST00000485301, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: MAP4K5 [Title/Abstract] AND PKN3 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | MAP4K5(51022256)-PKN3(131470388), # samples:1 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MAP4K5 | GO:0035556 | intracellular signal transduction | 9038372 |
| Tgene | PKN3 | GO:0010631 | epithelial cell migration | 21754995 |
| Kinase Fusion gene breakpoints across MAP4K5 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across PKN3 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChiTaRS5.0 | FN134290 | MAP4K5 | chr14 | 51022256 | PKN3 | chr9 | 131470388 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:51022256/:131470388) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAP4K5 | PKN3 |
| FUNCTION: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. {ECO:0000269|PubMed:9038372}. | FUNCTION: Contributes to invasiveness in malignant prostate cancer. {ECO:0000269|PubMed:15282551}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of MAP4K5_PKN3 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| MAP4K5 | Q9Y4K4 | human | GSK3B | P49841 | S9 | SGRPRttsFAEsCkP | |
| PKN3 | Q6P5Z2 | human | EGFR | P00533 | T678 | RHIVRKRtLRRLLQE | |
| PKN3 | Q6P5Z2 | human | CLIP1 | P30622 | S312 | AsLKRsPsAssLsSM |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| MAP4K5 | ID | Description | 0.00e+00 |
| MAP4K5 | GO:0070874 | negative regulation of glycogen metabolic process | 1.15e-02 |
| MAP4K5 | GO:0006983 | ER overload response | 1.15e-02 |
| MAP4K5 | GO:1901984 | negative regulation of protein acetylation | 1.15e-02 |
| MAP4K5 | GO:1903564 | regulation of protein localization to cilium | 1.15e-02 |
| MAP4K5 | GO:0034454 | microtubule anchoring at centrosome | 1.15e-02 |
| MAP4K5 | GO:0072497 | mesenchymal stem cell differentiation | 1.15e-02 |
| MAP4K5 | GO:1901030 | positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | 1.15e-02 |
| MAP4K5 | GO:1904338 | regulation of dopaminergic neuron differentiation | 1.15e-02 |
| MAP4K5 | GO:1904779 | regulation of protein localization to centrosome | 1.15e-02 |
| MAP4K5 | GO:0072393 | microtubule anchoring at microtubule organizing center | 1.15e-02 |
| MAP4K5 | GO:0070885 | negative regulation of calcineurin-NFAT signaling cascade | 1.15e-02 |
| MAP4K5 | GO:0106057 | negative regulation of calcineurin-mediated signaling | 1.15e-02 |
| MAP4K5 | GO:1900034 | regulation of cellular response to heat | 1.15e-02 |
| MAP4K5 | GO:0030011 | maintenance of cell polarity | 1.15e-02 |
| MAP4K5 | GO:0046827 | positive regulation of protein export from nucleus | 1.15e-02 |
| MAP4K5 | GO:0032515 | negative regulation of phosphoprotein phosphatase activity | 1.15e-02 |
| MAP4K5 | GO:0050849 | negative regulation of calcium-mediated signaling | 1.15e-02 |
| MAP4K5 | GO:0003323 | type B pancreatic cell development | 1.15e-02 |
| MAP4K5 | GO:0010923 | negative regulation of phosphatase activity | 1.15e-02 |
| MAP4K5 | GO:0034453 | microtubule anchoring | 1.15e-02 |
| MAP4K5 | GO:1901028 | regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | 1.15e-02 |
| MAP4K5 | GO:2000737 | negative regulation of stem cell differentiation | 1.15e-02 |
| MAP4K5 | GO:0035308 | negative regulation of protein dephosphorylation | 1.15e-02 |
| MAP4K5 | GO:0045724 | positive regulation of cilium assembly | 1.15e-02 |
| MAP4K5 | GO:0003309 | type B pancreatic cell differentiation | 1.15e-02 |
| MAP4K5 | GO:0005979 | regulation of glycogen biosynthetic process | 1.15e-02 |
| MAP4K5 | GO:0010962 | regulation of glucan biosynthetic process | 1.15e-02 |
| MAP4K5 | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | 1.15e-02 |
| MAP4K5 | GO:0019082 | viral protein processing | 1.15e-02 |
| MAP4K5 | GO:0099171 | presynaptic modulation of chemical synaptic transmission | 1.15e-02 |
| MAP4K5 | GO:0046825 | regulation of protein export from nucleus | 1.15e-02 |
| MAP4K5 | GO:0071539 | protein localization to centrosome | 1.15e-02 |
| MAP4K5 | GO:0035305 | negative regulation of dephosphorylation | 1.15e-02 |
| MAP4K5 | GO:1905508 | protein localization to microtubule organizing center | 1.15e-02 |
| MAP4K5 | GO:0002068 | glandular epithelial cell development | 1.15e-02 |
| MAP4K5 | GO:0035883 | enteroendocrine cell differentiation | 1.15e-02 |
| MAP4K5 | GO:0097345 | mitochondrial outer membrane permeabilization | 1.15e-02 |
| MAP4K5 | GO:0007212 | dopamine receptor signaling pathway | 1.15e-02 |
| MAP4K5 | GO:0070873 | regulation of glycogen metabolic process | 1.15e-02 |
| MAP4K5 | GO:1900181 | negative regulation of protein localization to nucleus | 1.15e-02 |
| MAP4K5 | GO:0032885 | regulation of polysaccharide biosynthetic process | 1.15e-02 |
| MAP4K5 | GO:0070884 | regulation of calcineurin-NFAT signaling cascade | 1.15e-02 |
| MAP4K5 | GO:0106056 | regulation of calcineurin-mediated signaling | 1.15e-02 |
| MAP4K5 | GO:0071542 | dopaminergic neuron differentiation | 1.15e-02 |
| MAP4K5 | GO:1901983 | regulation of protein acetylation | 1.15e-02 |
| MAP4K5 | GO:1902110 | positive regulation of mitochondrial membrane permeability involved in apoptotic process | 1.15e-02 |
| MAP4K5 | GO:1904646 | cellular response to amyloid-beta | 1.15e-02 |
| MAP4K5 | GO:0033173 | calcineurin-NFAT signaling cascade | 1.15e-02 |
| MAP4K5 | GO:1902686 | mitochondrial outer membrane permeabilization involved in programmed cell death | 1.15e-02 |
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Related Drugs to MAP4K5_PKN3 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning MAP4K5-PKN3 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to MAP4K5_PKN3 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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