Ensembl transtripts involved in fusion gene | ENST ids | ENST00000013125, ENST00000557578,
| ENST00000482876, ENST00000416149, ENST00000282574, ENST00000415783, ENST00000433529, ENST00000445587,
|
Hgene | Tgene |
MAP4K5
Q9Y4K4 | TIA1
P31483 |
FUNCTION: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. {ECO:0000269|PubMed:9038372}. | FUNCTION: RNA-binding protein involved in the regulation of alternative pre-RNA splicing and mRNA translation by binding to uridine-rich (U-rich) RNA sequences (PubMed:8576255, PubMed:11106748, PubMed:12486009, PubMed:17488725). Binds to U-rich sequences immediately downstream from a 5' splice sites in a uridine-rich small nuclear ribonucleoprotein (U snRNP)-dependent fashion, thereby modulating alternative pre-RNA splicing (PubMed:11106748, PubMed:8576255). Preferably binds to the U-rich IAS1 sequence in a U1 snRNP-dependent manner; this binding is optimal if a 5' splice site is adjacent to IAS1 (By similarity). Activates the use of heterologous 5' splice sites; the activation depends on the intron sequence downstream from the 5' splice site, with a preference for a downstream U-rich sequence (PubMed:11106748). By interacting with SNRPC/U1-C, promotes recruitment and binding of spliceosomal U1 snRNP to 5' splice sites followed by U-rich sequences, thereby facilitating atypical 5' splice site recognition by U1 snRNP (PubMed:11106748, PubMed:12486009, PubMed:17488725). Activates splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on its own pre-mRNA and on TIAR mRNA (By similarity). Acts as a modulator of alternative splicing for the apoptotic FAS receptor, thereby promoting apoptosis (PubMed:11106748, PubMed:1934064, PubMed:17488725). Binds to the 5' splice site region of FAS intron 5 to promote accumulation of transcripts that include exon 6 at the expense of transcripts in which exon 6 is skipped, thereby leading to the transcription of a membrane-bound apoptotic FAS receptor, which promotes apoptosis (PubMed:11106748, PubMed:1934064, PubMed:17488725). Binds to a conserved AU-rich cis element in COL2A1 intron 2 and modulates alternative splicing of COL2A1 exon 2 (PubMed:17580305). Also binds to the equivalent AT-rich element in COL2A1 genomic DNA, and may thereby be involved in the regulation of transcription (PubMed:17580305). Binds specifically to a polypyrimidine-rich controlling element (PCE) located between the weak 5' splice site and the intronic splicing silencer of CFTR mRNA to promote exon 9 inclusion, thereby antagonizing PTB1 and its role in exon skipping of CFTR exon 9 (PubMed:14966131). Involved in the repression of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs), including target ARE-bearing mRNAs encoding TNF and PTGS2 (By similarity). Also participates in the cellular response to environmental stress, by acting downstream of the stress-induced phosphorylation of EIF2S1/EIF2A to promote the recruitment of untranslated mRNAs to cytoplasmic stress granules (SGs), leading to stress-induced translational arrest (PubMed:10613902). Formation and recruitment to SGs is regulated by Zn(2+) (By similarity). Possesses nucleolytic activity against cytotoxic lymphocyte target cells (PubMed:1934064). {ECO:0000250|UniProtKB:P52912, ECO:0000269|PubMed:10613902, ECO:0000269|PubMed:11106748, ECO:0000269|PubMed:12486009, ECO:0000269|PubMed:14966131, ECO:0000269|PubMed:17488725, ECO:0000269|PubMed:17580305, ECO:0000269|PubMed:1934064, ECO:0000269|PubMed:8576255}.; FUNCTION: [Isoform Short]: Displays enhanced splicing regulatory activity compared with TIA isoform Long. {ECO:0000269|PubMed:17488725}. |
Kinase | GOID | GO term | P.adjust |
MAP4K5 | ID | Description | 0.00e+00 |
MAP4K5 | GO:0070874 | negative regulation of glycogen metabolic process | 1.15e-02 |
MAP4K5 | GO:0006983 | ER overload response | 1.15e-02 |
MAP4K5 | GO:1901984 | negative regulation of protein acetylation | 1.15e-02 |
MAP4K5 | GO:1903564 | regulation of protein localization to cilium | 1.15e-02 |
MAP4K5 | GO:0034454 | microtubule anchoring at centrosome | 1.15e-02 |
MAP4K5 | GO:0072497 | mesenchymal stem cell differentiation | 1.15e-02 |
MAP4K5 | GO:1901030 | positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | 1.15e-02 |
MAP4K5 | GO:1904338 | regulation of dopaminergic neuron differentiation | 1.15e-02 |
MAP4K5 | GO:1904779 | regulation of protein localization to centrosome | 1.15e-02 |
MAP4K5 | GO:0072393 | microtubule anchoring at microtubule organizing center | 1.15e-02 |
MAP4K5 | GO:0070885 | negative regulation of calcineurin-NFAT signaling cascade | 1.15e-02 |
MAP4K5 | GO:0106057 | negative regulation of calcineurin-mediated signaling | 1.15e-02 |
MAP4K5 | GO:1900034 | regulation of cellular response to heat | 1.15e-02 |
MAP4K5 | GO:0030011 | maintenance of cell polarity | 1.15e-02 |
MAP4K5 | GO:0046827 | positive regulation of protein export from nucleus | 1.15e-02 |
MAP4K5 | GO:0032515 | negative regulation of phosphoprotein phosphatase activity | 1.15e-02 |
MAP4K5 | GO:0050849 | negative regulation of calcium-mediated signaling | 1.15e-02 |
MAP4K5 | GO:0003323 | type B pancreatic cell development | 1.15e-02 |
MAP4K5 | GO:0010923 | negative regulation of phosphatase activity | 1.15e-02 |
MAP4K5 | GO:0034453 | microtubule anchoring | 1.15e-02 |
MAP4K5 | GO:1901028 | regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | 1.15e-02 |
MAP4K5 | GO:2000737 | negative regulation of stem cell differentiation | 1.15e-02 |
MAP4K5 | GO:0035308 | negative regulation of protein dephosphorylation | 1.15e-02 |
MAP4K5 | GO:0045724 | positive regulation of cilium assembly | 1.15e-02 |
MAP4K5 | GO:0003309 | type B pancreatic cell differentiation | 1.15e-02 |
MAP4K5 | GO:0005979 | regulation of glycogen biosynthetic process | 1.15e-02 |
MAP4K5 | GO:0010962 | regulation of glucan biosynthetic process | 1.15e-02 |
MAP4K5 | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | 1.15e-02 |
MAP4K5 | GO:0019082 | viral protein processing | 1.15e-02 |
MAP4K5 | GO:0099171 | presynaptic modulation of chemical synaptic transmission | 1.15e-02 |
MAP4K5 | GO:0046825 | regulation of protein export from nucleus | 1.15e-02 |
MAP4K5 | GO:0071539 | protein localization to centrosome | 1.15e-02 |
MAP4K5 | GO:0035305 | negative regulation of dephosphorylation | 1.15e-02 |
MAP4K5 | GO:1905508 | protein localization to microtubule organizing center | 1.15e-02 |
MAP4K5 | GO:0002068 | glandular epithelial cell development | 1.15e-02 |
MAP4K5 | GO:0035883 | enteroendocrine cell differentiation | 1.15e-02 |
MAP4K5 | GO:0097345 | mitochondrial outer membrane permeabilization | 1.15e-02 |
MAP4K5 | GO:0007212 | dopamine receptor signaling pathway | 1.15e-02 |
MAP4K5 | GO:0070873 | regulation of glycogen metabolic process | 1.15e-02 |
MAP4K5 | GO:1900181 | negative regulation of protein localization to nucleus | 1.15e-02 |
MAP4K5 | GO:0032885 | regulation of polysaccharide biosynthetic process | 1.15e-02 |
MAP4K5 | GO:0070884 | regulation of calcineurin-NFAT signaling cascade | 1.15e-02 |
MAP4K5 | GO:0106056 | regulation of calcineurin-mediated signaling | 1.15e-02 |
MAP4K5 | GO:0071542 | dopaminergic neuron differentiation | 1.15e-02 |
MAP4K5 | GO:1901983 | regulation of protein acetylation | 1.15e-02 |
MAP4K5 | GO:1902110 | positive regulation of mitochondrial membrane permeability involved in apoptotic process | 1.15e-02 |
MAP4K5 | GO:1904646 | cellular response to amyloid-beta | 1.15e-02 |
MAP4K5 | GO:0033173 | calcineurin-NFAT signaling cascade | 1.15e-02 |
MAP4K5 | GO:1902686 | mitochondrial outer membrane permeabilization involved in programmed cell death | 1.15e-02 |