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Kinase Fusion Gene:MAP7_MAP3K5 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: MAP7_MAP3K5 | KinaseFusionDB ID: KFG3518 | FusionGDB2.0 ID: KFG3518 | Hgene | Tgene | Gene symbol | MAP7 | MAP3K5 | Gene ID | 9053 | 4217 | |
| Gene name | microtubule associated protein 7 | mitogen-activated protein kinase kinase kinase 5 | ||||||||||
| Synonyms | E-MAP-115|EMAP115 | ASK1|MAPKKK5|MEKK5 | ||||||||||
| Cytomap | 6q23.3 | 6q23.3 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | ensconsindJ325F22.2 (microtubule-associated protein 7 (EMAP115, E-MAP-115))epithelial microtubule-associated protein of 115 kDa | mitogen-activated protein kinase kinase kinase 5ASK-1MAP/ERK kinase kinase 5MAPK/ERK kinase kinase 5MEK kinase 5MEKK 5apoptosis signal-regulating kinase 1 | ||||||||||
| Modification date | 20240403 | 20240403 | ||||||||||
| UniProtAcc | Q96T17 | Q99683 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000354570, ENST00000432797, ENST00000438100, ENST00000454590, ENST00000544465, | ENST00000355845, ENST00000463140, ENST00000359015, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: MAP7 [Title/Abstract] AND MAP3K5 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | MAP7(136871480)-MAP3K5(136904878), # samples:2 MAP7(136677830)-MAP3K5(136960776), # samples:2 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MAP3K5 | GO:0000165 | MAPK cascade | 17210579|21771788 |
| Tgene | MAP3K5 | GO:0006468 | protein phosphorylation | 11096076|15983381 |
| Tgene | MAP3K5 | GO:0007254 | JNK cascade | 11959862|21771788 |
| Tgene | MAP3K5 | GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress | 21771788|26095851 |
| Tgene | MAP3K5 | GO:0034198 | cellular response to amino acid starvation | 11096076 |
| Tgene | MAP3K5 | GO:0043065 | positive regulation of apoptotic process | 21771788 |
| Tgene | MAP3K5 | GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 20674765 |
| Tgene | MAP3K5 | GO:0045860 | positive regulation of protein kinase activity | 11959862 |
| Tgene | MAP3K5 | GO:0045893 | positive regulation of DNA-templated transcription | 11096076 |
| Tgene | MAP3K5 | GO:0051403 | stress-activated MAPK cascade | 11096076 |
| Tgene | MAP3K5 | GO:0070301 | cellular response to hydrogen peroxide | 20674765 |
| Kinase Fusion gene breakpoints across MAP7 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Kinase Fusion gene breakpoints across MAP3K5 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChimerDB4 | TCGA-HC-A632-01A | MAP7 | chr6 | 136677830 | MAP3K5 | chr6 | 136960776 |
| ChimerDB4 | TCGA-RW-A688-01A | MAP7 | chr6 | 136871480 | MAP3K5 | chr6 | 136904878 |
| CCLE | HT-55 | MAP7 | chr6 | 136871480 | MAP3K5 | chr6 | 137041727 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
| ENST00000354570 | ENST00000359015 | MAP7 | chr6 | 136677830 | MAP3K5 | chr6 | 136960776 | 5424 | 1558 |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq >ENST00000354570_ENST00000359015_MAP7_chr6_136677830_MAP3K5_chr6_136960776_length(amino acids)=1558 MLLGPPLVPDSRRRHQASLTPLHISGSPQLVGRGDRKLRTEVLVPPAALPAETRQRRSERLPRRTCPRGGAPGPGRSRLPRSLSPPSAIP GLRSPVWAAGLGGGGRREPSRGKGGAALRARHRSTMAELGAGGDGHRGGDGAVRSETAPDSYKVQDKKNASSRPASAISGQNNNHSGNKP DPPPVLRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRR TMERSQKPKQKHNRWSWGGSLHGSPSIHSADPDRRSVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESSVVNRLLTPTHS FLARSKSTAALSGEAASCSPIIMPYKAAHSRNSMDRPKLFVTPPEGSSRRRIIHGTASYKKERERENVLFLTSGTRRAVSPSNPKARQPA RSRLWLPSKSLPHLPGTPRPTSSLPPGSVKAAPAQVRPPSPGNIRPVKREVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEATVEER TPAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQE ELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQE RLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVSALPCTTNAPGNGKPVGSPHVVTSHQSKVTVESISKFEERCCFLYV LHNSDDFQIYFCTELHCKKFFEMVNTITEEKGRSTEEGDCESDLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDS RYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKG DNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGM FKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKKKKTQPKLSALSAGSNEYLRSISLPVPVLVEDTSSSSEYGSVS PDTELKVDPFSFKTRAKSCGERDVKGIRTLFLGIPDENFEDHSAPPSPEEKDSGFFMLRKDSERRATLHRILTEDQDKIVRNLMESLAQG AEEPKLKWEHITTLIASLREFVRSTDRKIIATTLSKLKLELDFDSHGISQVQVVLFGFQDAVNKVLRNHNIKPHWMFALDSIIRKAVQTA ITILVPELRPHFSLASESDTADQEDLDVEDDHEEQPSNQTVRRPQAVIEDAVATSGVSTLSSTVSHDSQSAHRSLNVQLGRMKIETNRLL EELVRKEKELQALLHRAIEEKDQEIKHLKLKSQPIEIPELPVFHLNSSGTNTEDSELTDWLRVNGADEDTISRFLAEDYTLLDVLYYVTR -------------------------------------------------------------- |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:136871480/chr6:136904878) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAP7 | MAP3K5 |
| FUNCTION: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1). {ECO:0000269|PubMed:10411906, ECO:0000269|PubMed:10688666, ECO:0000269|PubMed:10849426, ECO:0000269|PubMed:11029458, ECO:0000269|PubMed:11154276, ECO:0000269|PubMed:11689443, ECO:0000269|PubMed:11920685, ECO:0000269|PubMed:14688258, ECO:0000269|PubMed:14749717, ECO:0000269|PubMed:15023544, ECO:0000269|PubMed:16129676, ECO:0000269|PubMed:17220297, ECO:0000269|PubMed:23102700, ECO:0000269|PubMed:26095851, ECO:0000269|PubMed:8940179, ECO:0000269|PubMed:8974401, ECO:0000269|PubMed:9564042, ECO:0000269|PubMed:9774977}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| Tgene | MAP7 | 136677830 | MAP3K5 | 136960776 | ENST00000354570 | 11 | 30 | 680_938 | 612 | 1375 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
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Kinase Fusion Protein Structures |
| CIF files of the predicted kinase fusion proteins * Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
| Kinase Fusion protein CIF link (fusion AA seq ID in KinaseFusionDB) | Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | AA seq | Len(AA seq) |
| PDB file >>>298_MAP7_MAP3K5 | ENST00000354570 | ENST00000359015 | MAP7 | chr6 | 136677830 | MAP3K5 | chr6 | 136960776 | MLLGPPLVPDSRRRHQASLTPLHISGSPQLVGRGDRKLRTEVLVPPAALPAETRQRRSERLPRRTCPRGGAPGPGRSRLPRSLSPPSAIP GLRSPVWAAGLGGGGRREPSRGKGGAALRARHRSTMAELGAGGDGHRGGDGAVRSETAPDSYKVQDKKNASSRPASAISGQNNNHSGNKP DPPPVLRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRR TMERSQKPKQKHNRWSWGGSLHGSPSIHSADPDRRSVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESSVVNRLLTPTHS FLARSKSTAALSGEAASCSPIIMPYKAAHSRNSMDRPKLFVTPPEGSSRRRIIHGTASYKKERERENVLFLTSGTRRAVSPSNPKARQPA RSRLWLPSKSLPHLPGTPRPTSSLPPGSVKAAPAQVRPPSPGNIRPVKREVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEATVEER TPAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQE ELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQE RLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVSALPCTTNAPGNGKPVGSPHVVTSHQSKVTVESISKFEERCCFLYV LHNSDDFQIYFCTELHCKKFFEMVNTITEEKGRSTEEGDCESDLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDS RYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKG DNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGM FKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKKKKTQPKLSALSAGSNEYLRSISLPVPVLVEDTSSSSEYGSVS PDTELKVDPFSFKTRAKSCGERDVKGIRTLFLGIPDENFEDHSAPPSPEEKDSGFFMLRKDSERRATLHRILTEDQDKIVRNLMESLAQG AEEPKLKWEHITTLIASLREFVRSTDRKIIATTLSKLKLELDFDSHGISQVQVVLFGFQDAVNKVLRNHNIKPHWMFALDSIIRKAVQTA ITILVPELRPHFSLASESDTADQEDLDVEDDHEEQPSNQTVRRPQAVIEDAVATSGVSTLSSTVSHDSQSAHRSLNVQLGRMKIETNRLL EELVRKEKELQALLHRAIEEKDQEIKHLKLKSQPIEIPELPVFHLNSSGTNTEDSELTDWLRVNGADEDTISRFLAEDYTLLDVLYYVTR | 1558 |
| 3D view using mol* of 298_MAP7_MAP3K5 | ||||||||||
| PDB file >>>TKFP_518_MAP7_MAP3K5 | ENST00000354570 | ENST00000359015 | MAP7 | chr6 | 136677830 | MAP3K5 | chr6 | 136960776 | MLLGPPLVPDSRRRHQASLTPLHISGSPQLVGRGDRKLRTEVLVPPAALPAETRQRRSERLPRRTCPRGGAPGPGRSRLPRSLSPPSAIP GLRSPVWAAGLGGGGRREPSRGKGGAALRARHRSTMAELGAGGDGHRGGDGAVRSETAPDSYKVQDKKNASSRPASAISGQNNNHSGNKP DPPPVLRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRR TMERSQKPKQKHNRWSWGGSLHGSPSIHSADPDRRSVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESSVVNRLLTPTHS FLARSKSTAALSGEAASCSPIIMPYKAAHSRNSMDRPKLFVTPPEGSSRRRIIHGTASYKKERERENVLFLTSGTRRAVSPSNPKARQPA RSRLWLPSKSLPHLPGTPRPTSSLPPGSVKAAPAQVRPPSPGNIRPVKREVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEATVEER TPAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQE ELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQE RLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVSALPCTTNAPGNGKPVGSPHVVTSHQSKVTVESISKFEERCCFLYV LHNSDDFQIYFCTELHCKKFFEMVNTITEEKGRSTEEGDCESDLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDS RYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKG DNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGM FKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKKKKTQPKLSALSAGSNEYLRSISLPVPVLVEDTSSSSEYGSVS PDTELKVDPFSFKTRAKSCGERDVKGIRTLFLGIPDENFEDHSAPPSPEEKDSGFFMLRKDSERRATLHRILTEDQDKIVRNLMESLAQG AEEPKLKWEHITTLIASLREFVRSTDRKIIATTLSKLKLELDFDSHGISQVQVVLFGFQDAVNKVLRNHNIKPHWMFALDSIIRKAVQTA ITILVPELRPHFSLASESDTADQEDLDVEDDHEEQPSNQTVRRPQAVIEDAVATSGVSTLSSTVSHDSQSAHRSLNVQLGRMKIETNRLL EELVRKEKELQALLHRAIEEKDQEIKHLKLKSQPIEIPELPVFHLNSSGTNTEDSELTDWLRVNGADEDTISRFLAEDYTLLDVLYYVTR | 1558_MAP7_MAP3K5 |
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Comparison of Fusion Protein Isoforms |
| Superimpose the 3D Structures Among All Fusion Protein Isoforms * Download the pdb file and open it from the molstar online viewer. |
| Comparison of the Secondary Structures of Fusion Protein Isoforms |
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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB |
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pLDDT score distribution |
| pLDDT score distribution of the predicted fusion protein structures from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. * The blue color at the bottom marks the best active site residues. |
| 298_MAP7_MAP3K5.png |
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| 298_MAP7_MAP3K5.png |
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Potential Active Site Information |
| The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite. |
| Kinase Fusion AA seq ID in KinaseFusionDB | Site score | Size | Dscore | Volume | Exposure | Enclosure | Contact | Phobic | Philic | Balance | Don/Acc | Residues |
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Ramachandran Plot of Kinase Fusion Protein Structure |
| Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide. |
| 298_MAP7_MAP3K5_ramachandran.png |
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Virtual Screening Results |
| Distribution of the average docking score across all approved kinase inhibitors. Distribution of the number of occurrence across all approved kinase inhibitors. |
| 5'-kinase fusion protein case |
| 3'-kinase fusion protein case |
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| Drug information from DrugBank of the top 20 interacting small molecules. * The detailed information of individual kinase inhibitors are available in the download page. |
| Fusion gene name info | Drug | Docking score | Glide g score | Glide energy |
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Kinase-Substrate Information of MAP7_MAP3K5 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| MAP3K5 | Q99683 | human | SIAH1 | Q8IUQ4 | T74 | PKLtCCPtCRGPLGS | |
| MAP3K5 | Q99683 | human | MAP3K5 | Q99683 | T838 | GINPCTEtFTGtLQY | Pkinase |
| MAP3K5 | Q99683 | human | STRAP | Q9Y3F4 | T175 | LWDHAtMtEVKsLNF | |
| MAP3K5 | Q99683 | human | SIAH1 | Q8IUQ4 | T239 | RRLtWEAtPRSIHEG | Sina |
| MAP3K5 | Q99683 | human | SIAH1 | Q8IUQ4 | T70 | SNCRPKLtCCPtCRG | |
| MAP3K5 | Q99683 | human | MAPK8 | P45983 | Y185 | tsFMMtPyVVtRYYR | Pkinase |
| MAP3K5 | Q99683 | human | MAP3K5 | Q99683 | T842 | CTEtFTGtLQYMAPE | Pkinase |
| MAP3K5 | Q99683 | human | ZNF622 | Q969S3 | S314 | WCNEkGksFYStEAV | zf-C2H2_2 |
| MAP3K5 | Q99683 | human | MAPRE1 | Q15691 | S40 | TKIEQLCsGAAYCQF | CH |
| MAP3K5 | Q99683 | human | PDPK1 | O15530 | S398 | SSssHsLsASDTGLP | |
| MAP3K5 | Q99683 | human | CDKN1A | P38936 | S98 | GGRRPGTsPALLQGT | |
| MAP3K5 | Q99683 | human | SIAH1 | Q8IUQ4 | T235 | NGHRRRLtWEAtPRS | Sina |
| MAP3K5 | Q99683 | human | DAXX | Q9UER7 | S176 | TNAENTAsQsPRTRG | |
| MAP3K5 | Q99683 | human | MAP2K3 | P46734 | S218 | IsGyLVDsVAKtMDA | Pkinase |
| MAP3K5 | Q99683 | human | MAPK8 | P45983 | T183 | AGtsFMMtPyVVtRY | Pkinase |
| MAP3K5 | Q99683 | human | MAP2K6 | P52564 | S207 | IsGyLVDsVAKtIDA | Pkinase |
| MAP3K5 | Q99683 | human | MAPK14 | Q16539 | T180 | RHtDDEMtGyVAtRW | Pkinase |
| MAP3K5 | Q99683 | human | STRAP | Q9Y3F4 | S179 | AtMtEVKsLNFNMSV | |
| MAP3K5 | Q99683 | human | ZNF622 | Q969S3 | T318 | kGksFYStEAVQAHM | zf-C2H2_2 |
| MAP3K5 | Q99683 | human | DAXX | Q9UER7 | S184 | QsPRTRGsRRQIQRL | |
| MAP3K5 | Q99683 | human | MAPRE1 | Q15691 | T206 | QVNVLKLtVEDLEkE | |
| MAP3K5 | Q99683 | human | MAPRE1 | Q15691 | T154 | NkPkkPLtssSAAPQ | |
| MAP3K5 | Q99683 | human | MAP3K5 | Q99683 | T813 | GDNVLINtySGVLKI | Pkinase |
| MAP3K5 | Q99683 | human | MAP2K4 | P45985 | T261 | LVDsIAKtRDAGCRP | Pkinase |
| MAP3K5 | Q99683 | human | PDPK1 | O15530 | S394 | QVSSSSssHsLsASD | |
| MAP3K5 | Q99683 | human | MAPK14 | Q16539 | Y182 | tDDEMtGyVAtRWYR | Pkinase |
| MAP3K5 | Q99683 | human | MAP3K5 | Q99683 | S966 | NEYLRsIsLPVPVLV |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| MAP3K5 | ID | Description | 0.00e+00 |
| MAP3K5 | GO:0090398 | cellular senescence | 1.84e-10 |
| MAP3K5 | GO:0051403 | stress-activated MAPK cascade | 1.84e-10 |
| MAP3K5 | GO:0031098 | stress-activated protein kinase signaling cascade | 1.84e-10 |
| MAP3K5 | GO:0097193 | intrinsic apoptotic signaling pathway | 6.26e-06 |
| MAP3K5 | GO:0033674 | positive regulation of kinase activity | 6.26e-06 |
| MAP3K5 | GO:0038066 | p38MAPK cascade | 6.26e-06 |
| MAP3K5 | GO:0007254 | JNK cascade | 6.26e-06 |
| MAP3K5 | GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress | 7.85e-06 |
| MAP3K5 | GO:0051770 | positive regulation of nitric-oxide synthase biosynthetic process | 1.26e-05 |
| MAP3K5 | GO:0051347 | positive regulation of transferase activity | 1.29e-05 |
| MAP3K5 | GO:0051767 | nitric-oxide synthase biosynthetic process | 1.92e-05 |
| MAP3K5 | GO:0051769 | regulation of nitric-oxide synthase biosynthetic process | 1.92e-05 |
| MAP3K5 | GO:0045860 | positive regulation of protein kinase activity | 5.14e-05 |
| MAP3K5 | GO:0034198 | cellular response to amino acid starvation | 2.97e-04 |
| MAP3K5 | GO:1990928 | response to amino acid starvation | 3.29e-04 |
| MAP3K5 | GO:0002931 | response to ischemia | 4.93e-04 |
| MAP3K5 | GO:0043410 | positive regulation of MAPK cascade | 4.99e-04 |
| MAP3K5 | GO:0046330 | positive regulation of JNK cascade | 1.13e-03 |
| MAP3K5 | GO:0071493 | cellular response to UV-B | 1.13e-03 |
| MAP3K5 | GO:0010657 | muscle cell apoptotic process | 1.13e-03 |
| MAP3K5 | GO:0051402 | neuron apoptotic process | 1.13e-03 |
| MAP3K5 | GO:0035331 | negative regulation of hippo signaling | 1.23e-03 |
| MAP3K5 | GO:0071214 | cellular response to abiotic stimulus | 2.01e-03 |
| MAP3K5 | GO:0104004 | cellular response to environmental stimulus | 2.01e-03 |
| MAP3K5 | GO:0071496 | cellular response to external stimulus | 2.20e-03 |
| MAP3K5 | GO:0032874 | positive regulation of stress-activated MAPK cascade | 2.20e-03 |
| MAP3K5 | GO:0070304 | positive regulation of stress-activated protein kinase signaling cascade | 2.23e-03 |
| MAP3K5 | GO:0046328 | regulation of JNK cascade | 2.42e-03 |
| MAP3K5 | GO:0010224 | response to UV-B | 2.42e-03 |
| MAP3K5 | GO:0036480 | neuron intrinsic apoptotic signaling pathway in response to oxidative stress | 2.42e-03 |
| MAP3K5 | GO:0038095 | Fc-epsilon receptor signaling pathway | 3.27e-03 |
| MAP3K5 | GO:0071322 | cellular response to carbohydrate stimulus | 3.27e-03 |
| MAP3K5 | GO:0009411 | response to UV | 3.27e-03 |
| MAP3K5 | GO:0035330 | regulation of hippo signaling | 3.27e-03 |
| MAP3K5 | GO:0034614 | cellular response to reactive oxygen species | 3.27e-03 |
| MAP3K5 | GO:0046685 | response to arsenic-containing substance | 4.75e-03 |
| MAP3K5 | GO:0009267 | cellular response to starvation | 4.82e-03 |
| MAP3K5 | GO:0032872 | regulation of stress-activated MAPK cascade | 5.23e-03 |
| MAP3K5 | GO:0042770 | signal transduction in response to DNA damage | 5.23e-03 |
| MAP3K5 | GO:0070302 | regulation of stress-activated protein kinase signaling cascade | 5.23e-03 |
| MAP3K5 | GO:0031667 | response to nutrient levels | 5.33e-03 |
| MAP3K5 | GO:0071276 | cellular response to cadmium ion | 5.33e-03 |
| MAP3K5 | GO:0002764 | immune response-regulating signaling pathway | 5.33e-03 |
| MAP3K5 | GO:0031281 | positive regulation of cyclase activity | 5.79e-03 |
| MAP3K5 | GO:0000302 | response to reactive oxygen species | 5.90e-03 |
| MAP3K5 | GO:0009612 | response to mechanical stimulus | 6.46e-03 |
| MAP3K5 | GO:0045663 | positive regulation of myoblast differentiation | 6.59e-03 |
| MAP3K5 | GO:0042594 | response to starvation | 6.62e-03 |
| MAP3K5 | GO:0035329 | hippo signaling | 6.62e-03 |
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Related Drugs to MAP7_MAP3K5 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning MAP7-MAP3K5 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to MAP7_MAP3K5 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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