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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:MAPK12_MORN5

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: MAPK12_MORN5
KinaseFusionDB ID: KFG3531
FusionGDB2.0 ID: KFG3531
HgeneTgene
Gene symbol

MAPK12

MORN5

Gene ID

6300

254956

Gene namemitogen-activated protein kinase 12MORN repeat containing 5
SynonymsERK-6|ERK3|ERK6|MAPK 12|P38GAMMA|PRKM12|SAPK-3|SAPK3C9orf113|C9orf18
Cytomap

22q13.33

9q33.2

Type of geneprotein-codingprotein-coding
Descriptionmitogen-activated protein kinase 12MAP kinase 12MAP kinase p38 gammaextracellular signal-regulated kinase 6mitogen-activated protein kinase 3mitogen-activated protein kinase p38 gammastress-activated protein kinase 3MORN repeat-containing protein 5
Modification date2024030520240305
UniProtAcc

P53778

Q5VZ52

Ensembl transtripts involved in fusion geneENST idsENST00000497036, ENST00000215659, 
ENST00000395778, ENST00000395780, 
ENST00000373764, ENST00000486801, 
ENST00000536616, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: MAPK12 [Title/Abstract] AND MORN5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MAPK12(50685108)-MORN5(124962164), # samples:1
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAPK12

GO:0018105

peptidyl-serine phosphorylation

15850461

HgeneMAPK12

GO:0045445

myoblast differentiation

8633070


check buttonKinase Fusion gene breakpoints across MAPK12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonKinase Fusion gene breakpoints across MORN5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChimerDB4TCGA-V1-A8WV-01AMAPK12chr22

50685108

MORN5chr9

124962164



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:50685108/:124962164)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAPK12

P53778

MORN5

Q5VZ52

FUNCTION: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1, thereby causing dissociation of DLG1-SFPQ complexes. This function is independent of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to osmolarity changes in the environment. Regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage and G2 arrest after gamma-radiation exposure. MAPK12 is involved in the regulation of SLC2A1 expression and basal glucose uptake in L6 myotubes; and negatively regulates SLC2A4 expression and contraction-mediated glucose uptake in adult skeletal muscle. C-Jun (JUN) phosphorylation is stimulated by MAPK14 and inhibited by MAPK12, leading to a distinct AP-1 regulation. MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration. {ECO:0000269|PubMed:10848581, ECO:0000269|PubMed:14592936, ECO:0000269|PubMed:17724032, ECO:0000269|PubMed:20605917, ECO:0000269|PubMed:21172807, ECO:0000269|PubMed:8633070, ECO:0000269|PubMed:9430721}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


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Kinase-Substrate Information of MAPK12_MORN5


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
MAPK12P53778humanMYOD1P15172S201SGDSDAssPRsNCsDMyf5
MAPK12P53778humanATF2P15336T71IVADQtPtPtRFLkN
MAPK12P53778humanNUP62P37198T269GAASGTStTTsTAAT
MAPK12P53778humanDLG1Q12959S443FLGQtPAsPARysPVPDZ_assoc
MAPK12P53778humanMAPTP10636-8S396GAEIVyKsPVVsGDt
MAPK12P53778humanMAPTP10636-8S404PVVsGDtsPRHLsNV
MAPK12P53778humanDLG1Q12959T209VNTDSLEtPTYVNGTMAGUK_N_PEST
MAPK12P53778humanSTAT2P52630Y690NLQERRKyLKHRLIV
MAPK12P53778humanPTPN3P26045S459QKSsSSVsPSSNAPG
MAPK12P53778humanHTRA2O43464S142VPSPPPAsPRSQYNFPeptidase_M50
MAPK12P53778humanHSP90AA1P07900S595VsNRLVTsPCCIVtsHSP90
MAPK12P53778humanNUP62P37198S272SGTStTTsTAATATA
MAPK12P53778humanTP53P04637S33LPENNVLsPLPsQAM
MAPK12P53778humanMAPK12P53778S3_____MSsPPPARSG
MAPK12P53778humanSQSTM1Q13501T269GGkRsRLtPVsPEss
MAPK12P53778humanSREBF1P36956S63AGGtDPAsPDTSSPG
MAPK12P53778humanSREBF1P36956T426TEVEDTLtPPPsDAG
MAPK12P53778humanCCND3P30281T283QGPsQtstPtDVtAI
MAPK12P53778humanGYS1P13807S723sssLStPsEPLsPts
MAPK12P53778humanHSF1Q00613S307EPPsPPQsPRVEEAsVert_HS_TF
MAPK12P53778humanCTNNB1P35222S605LFVQLLYsPIENIQRArm
MAPK12P53778humanMYOD1P15172S200YSGDSDAssPRsNCsMyf5
MAPK12P53778humanDLG1Q12959S158FVsHsHIsPIKPTEAMAGUK_N_PEST
MAPK12P53778humanNLRP1Q9C000S107PSEPHLGsPSQPTST
MAPK12P53778humanMEF2DQ14814S444SIkSEPVsPsRERsP
MAPK12P53778humanHSF1Q00613S303RVkEEPPsPPQsPRVVert_HS_TF
MAPK12P53778humanKAT5Q92993-2T106VEVVsPAtPVPSETA
MAPK12P53778humanGYS1P13807S727StPsEPLsPtssLGE
MAPK12P53778humanHSF1Q00613S326ssVDtLLsPTALIDsVert_HS_TF
MAPK12P53778humanGYS1P13807T278kRkPDIVtPNGLNVkGlycogen_syn
MAPK12P53778humanSQSTM1Q13501S272RsRLtPVsPEssstE
MAPK12P53778humanKAT5Q92993T158VEVVsPAtPVPSETA


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
MAPK12IDDescription0.00e+00
MAPK12GO:0010821regulation of mitochondrion organization9.30e-06
MAPK12GO:0072594establishment of protein localization to organelle9.30e-06
MAPK12GO:0045786negative regulation of cell cycle6.92e-05
MAPK12GO:0034599cellular response to oxidative stress7.85e-05
MAPK12GO:1903008organelle disassembly1.21e-04
MAPK12GO:0006606protein import into nucleus1.27e-04
MAPK12GO:0034605cellular response to heat1.27e-04
MAPK12GO:0062197cellular response to chemical stress1.27e-04
MAPK12GO:0051170import into nucleus1.27e-04
MAPK12GO:0009267cellular response to starvation1.66e-04
MAPK12GO:0010506regulation of autophagy1.86e-04
MAPK12GO:0006839mitochondrial transport1.86e-04
MAPK12GO:2000291regulation of myoblast proliferation2.92e-04
MAPK12GO:0006979response to oxidative stress2.92e-04
MAPK12GO:0042594response to starvation2.92e-04
MAPK12GO:0000422autophagy of mitochondrion3.02e-04
MAPK12GO:0061726mitochondrion disassembly3.02e-04
MAPK12GO:0009408response to heat3.48e-04
MAPK12GO:0045930negative regulation of mitotic cell cycle4.32e-04
MAPK12GO:0031669cellular response to nutrient levels4.32e-04
MAPK12GO:0032355response to estradiol4.32e-04
MAPK12GO:0051450myoblast proliferation4.49e-04
MAPK12GO:1903829positive regulation of protein localization5.05e-04
MAPK12GO:0072655establishment of protein localization to mitochondrion5.05e-04
MAPK12GO:0071392cellular response to estradiol stimulus5.05e-04
MAPK12GO:0051402neuron apoptotic process5.05e-04
MAPK12GO:0031667response to nutrient levels5.05e-04
MAPK12GO:0000423mitophagy5.05e-04
MAPK12GO:0031668cellular response to extracellular stimulus5.05e-04
MAPK12GO:0022411cellular component disassembly5.05e-04
MAPK12GO:1903146regulation of autophagy of mitochondrion5.10e-04
MAPK12GO:0070585protein localization to mitochondrion5.10e-04
MAPK12GO:0034504protein localization to nucleus7.30e-04
MAPK12GO:0051972regulation of telomerase activity7.30e-04
MAPK12GO:0009299mRNA transcription8.86e-04
MAPK12GO:0006913nucleocytoplasmic transport8.86e-04
MAPK12GO:0051169nuclear transport8.86e-04
MAPK12GO:1903747regulation of establishment of protein localization to mitochondrion8.93e-04
MAPK12GO:0010659cardiac muscle cell apoptotic process1.03e-03
MAPK12GO:0071496cellular response to external stimulus1.03e-03
MAPK12GO:0010658striated muscle cell apoptotic process1.08e-03
MAPK12GO:0010952positive regulation of peptidase activity1.08e-03
MAPK12GO:0009266response to temperature stimulus1.08e-03
MAPK12GO:0042770signal transduction in response to DNA damage1.57e-03
MAPK12GO:0031334positive regulation of protein-containing complex assembly1.84e-03
MAPK12GO:0043254regulation of protein-containing complex assembly2.23e-03
MAPK12GO:0042098T cell proliferation2.34e-03
MAPK12GO:0009410response to xenobiotic stimulus2.53e-03
MAPK12GO:0010720positive regulation of cell development2.73e-03

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Related Drugs to MAPK12_MORN5


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning MAPK12-MORN5 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

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Related Diseases to MAPK12_MORN5


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate