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Kinase Fusion Gene:MAPK14_POP5 |
Kinase Fusion Protein Summary |
Kinase Fusion gene summary |
Kinase Fusion partner gene information | Kinase Fusion gene name: MAPK14_POP5 | KinaseFusionDB ID: KFG3541 | FusionGDB2.0 ID: KFG3541 | Hgene | Tgene | Gene symbol | MAPK14 | POP5 | Gene ID | 1432 | 51367 | |
Gene name | mitogen-activated protein kinase 14 | POP5 homolog, ribonuclease P/MRP subunit | ||||||||||
Synonyms | CSBP|CSBP1|CSBP2|CSPB1|EXIP|Mxi2|PRKM14|PRKM15|RK|SAPK2A|p38|p38ALPHA | HSPC004|RPP2|RPP20|hPop5 | ||||||||||
Cytomap | 6p21.31 | 12q24.31 | ||||||||||
Type of gene | protein-coding | protein-coding | ||||||||||
Description | mitogen-activated protein kinase 14CSAID-binding proteinMAP kinase 14MAP kinase Mxi2MAP kinase p38 alphaMAX-interacting protein 2cytokine suppressive anti-inflammatory drug binding proteinmitogen-activated protein kinase p38 alphap38 MAP kinasep3 | ribonuclease P/MRP protein subunit POP5processing of precursor 5, ribonuclease P/MRP subunit | ||||||||||
Modification date | 20240411 | 20240305 | ||||||||||
UniProtAcc | Q16539 | Q969H6 | ||||||||||
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000229794, ENST00000229795, ENST00000310795, ENST00000468133, | ENST00000341039, ENST00000357500, ENST00000542776, | |||||||||
Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: MAPK14 [Title/Abstract] AND POP5 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | MAPK14(36038835)-POP5(121017812), # samples:1 |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MAPK14 | GO:0031098 | stress-activated protein kinase signaling cascade | 35857590 |
Hgene | MAPK14 | GO:0035556 | intracellular signal transduction | 10838079 |
Hgene | MAPK14 | GO:0038066 | p38MAPK cascade | 10330143 |
Hgene | MAPK14 | GO:0051403 | stress-activated MAPK cascade | 35857590 |
Hgene | MAPK14 | GO:0071222 | cellular response to lipopolysaccharide | 23776175 |
Hgene | MAPK14 | GO:0071493 | cellular response to UV-B | 35857590 |
Hgene | MAPK14 | GO:1900015 | regulation of cytokine production involved in inflammatory response | 15251176 |
Tgene | POP5 | GO:0001682 | tRNA 5'-leader removal | 16723659|30454648 |
Kinase Fusion gene breakpoints across MAPK14 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Kinase Fusion gene breakpoints across POP5 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
Kinase Fusion gene information. |
Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
ChiTaRS5.0 | BM826654 | MAPK14 | chr6 | 36038835 | POP5 | chr12 | 121017812 |
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Kinase Fusion ORF Analysis |
Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:36038835/:121017812) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
MAPK14 | POP5 |
FUNCTION: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1 (PubMed:9687510, PubMed:9792677). RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery (PubMed:9687510, PubMed:9792677). On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2 (PubMed:11154262). MAPK14 interacts also with casein kinase II, leading to its activation through autophosphorylation and further phosphorylation of TP53/p53 (PubMed:10747897). In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. In a similar way, MAPK14 phosphorylates the ubiquitin ligase SIAH2, regulating its activity towards EGLN3 (PubMed:17003045). MAPK14 may also inhibit the lysosomal degradation pathway of autophagy by interfering with the intracellular trafficking of the transmembrane protein ATG9 (PubMed:19893488). Another function of MAPK14 is to regulate the endocytosis of membrane receptors by different mechanisms that impinge on the small GTPase RAB5A. In addition, clathrin-mediated EGFR internalization induced by inflammatory cytokines and UV irradiation depends on MAPK14-mediated phosphorylation of EGFR itself as well as of RAB5A effectors (PubMed:16932740). Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17 (PubMed:20188673). Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Another p38 MAPK substrate is FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A (PubMed:9430721, PubMed:9858528, PubMed:10330143). The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment. Phosphorylates CDC25B and CDC25C which is required for binding to 14-3-3 proteins and leads to initiation of a G2 delay after ultraviolet radiation (PubMed:11333986). Phosphorylates TIAR following DNA damage, releasing TIAR from GADD45A mRNA and preventing mRNA degradation (PubMed:20932473). The p38 MAPKs may also have kinase-independent roles, which are thought to be due to the binding to targets in the absence of phosphorylation. Protein O-Glc-N-acylation catalyzed by the OGT is regulated by MAPK14, and, although OGT does not seem to be phosphorylated by MAPK14, their interaction increases upon MAPK14 activation induced by glucose deprivation. This interaction may regulate OGT activity by recruiting it to specific targets such as neurofilament H, stimulating its O-Glc-N-acylation. Required in mid-fetal development for the growth of embryo-derived blood vessels in the labyrinth layer of the placenta. Also plays an essential role in developmental and stress-induced erythropoiesis, through regulation of EPO gene expression (PubMed:10943842). Isoform MXI2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform EXIP may play a role in the early onset of apoptosis. Phosphorylates S100A9 at 'Thr-113' (PubMed:15905572). Phosphorylates NLRP1 downstream of MAP3K20/ZAK in response to UV-B irradiation and ribosome collisions, promoting activation of the NLRP1 inflammasome and pyroptosis (PubMed:35857590). {ECO:0000269|PubMed:10330143, ECO:0000269|PubMed:10747897, ECO:0000269|PubMed:10943842, ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:11333986, ECO:0000269|PubMed:15905572, ECO:0000269|PubMed:16932740, ECO:0000269|PubMed:17003045, ECO:0000269|PubMed:17724032, ECO:0000269|PubMed:19893488, ECO:0000269|PubMed:20188673, ECO:0000269|PubMed:20932473, ECO:0000269|PubMed:35857590, ECO:0000269|PubMed:9430721, ECO:0000269|PubMed:9687510, ECO:0000269|PubMed:9792677, ECO:0000269|PubMed:9858528}.; FUNCTION: (Microbial infection) Activated by phosphorylation by M.tuberculosis EsxA in T-cells leading to inhibition of IFN-gamma production; phosphorylation is apparent within 15 minutes and is inhibited by kinase-specific inhibitors SB203580 and siRNA (PubMed:21586573). {ECO:0000269|PubMed:21586573}. | FUNCTION: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:11413139, PubMed:30454648). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465). {ECO:0000269|PubMed:11413139, ECO:0000269|PubMed:28115465, ECO:0000269|PubMed:30454648}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of MAPK14_POP5 |
Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
MAPK14 | Q16539 | human | MAPT | P10636-8 | T231 | KKVAVVRtPPKsPss | |
MAPK14 | Q16539 | human | AIMP2 | Q13155 | S156 | LSTVHtHssVkSVPE | Thioredoxin_16 |
MAPK14 | Q16539 | human | SLC9A1 | P19634 | S726 | IDPAsPQsPEsVDLV | |
MAPK14 | Q16539 | human | MEF2D | Q14814 | S180 | LTDPRLLsPQQPALQ | |
MAPK14 | Q16539 | human | ATF2 | P15336 | T69 | sVIVADQtPtPtRFL | |
MAPK14 | Q16539 | human | STAT1 | P42224 | S727 | TDNLLPMsPEEFDEV | STAT1_TAZ2bind |
MAPK14 | Q16539 | human | MAPT | P10636-8 | S199 | GDRsGyssPGsPGtP | |
MAPK14 | Q16539 | human | DDIT3 | P35638 | S79 | EVTSTSQsPHsPDSS | |
MAPK14 | Q16539 | human | NCF1 | P14598 | S348 | PGPQsPGsPLEEERQ | |
MAPK14 | Q16539 | human | SLC6A2 | P23975 | T30 | QPLRARKtAELLVVK | |
MAPK14 | Q16539 | human | ATF2 | P15336 | T71 | IVADQtPtPtRFLkN | |
MAPK14 | Q16539 | human | JDP2 | Q8WYK2 | T148 | VRtDsVKtPEsEGNP | |
MAPK14 | Q16539 | human | ADAM17 | P78536 | T735 | kPFPAPQtPGRLQPA | |
MAPK14 | Q16539 | human | ELK4 | P28324 | S387 | LsPVAPLsPARLQGA | |
MAPK14 | Q16539 | human | TP63 | Q9H3D4-2 | S361 | QKQtsIQsPSSYGNs | |
MAPK14 | Q16539 | human | SHC1 | P29353 | S54 | PPLPGDDsPTTLCSF | |
MAPK14 | Q16539 | human | NOXA1 | Q86UR1 | S239 | ARsLIMDsPRAGTHQ | |
MAPK14 | Q16539 | human | ETV6 | P41212 | S257 | ESHPKPSsPRQESTR | |
MAPK14 | Q16539 | human | RBM17 | Q96I25 | S222 | EEQDRPRsPtGPsNs | |
MAPK14 | Q16539 | human | ELK1 | P19419 | S389 | LsPIAPRsPAKLSFQ | |
MAPK14 | Q16539 | human | FPR1 | P21462 | S342 | AtNstLPsAEVELQA | |
MAPK14 | Q16539 | human | PPARGC1A | Q9UBK2 | T263 | TTLSLPLtPEsPNDP | |
MAPK14 | Q16539 | human | MYLK | Q15746 | T978 | VPPPKPAtPDFRSVL | |
MAPK14 | Q16539 | human | KCNQ2 | O43526-4 | S436 | QAQTVRRsPsADQSL | KCNQ_channel |
MAPK14 | Q16539 | human | SHC1 | P29353 | T386 | PTAPNAQtPSHLGAT | |
MAPK14 | Q16539 | human | FOXC1 | Q12948 | S241 | PsPPQPLsPAAALGS | |
MAPK14 | Q16539 | human | MEF2D | Q14814 | S98 | KGFNGCDsPEPDGED | HJURP_C |
MAPK14 | Q16539 | human | PPARGC1A | Q9UBK2 | T299 | AGLtPPTtPPHKANQ | |
MAPK14 | Q16539 | human | PDX1 | P52945 | S66 | QGsPPDIsPYEVPPL | |
MAPK14 | Q16539 | human | EIF2AK2 | P19525 | T451 | kRtRSKGtLRyMsPE | Pkinase |
MAPK14 | Q16539 | human | TP63 | Q9H3D4 | S160 | SSTFDALsPsPAIPS | |
MAPK14 | Q16539 | human | NOS3 | P29474 | S600 | MSGPYNSsPRPEQHK | Flavodoxin_1 |
MAPK14 | Q16539 | human | MAP4 | P27816 | S696 | PNKELPPsPEKKTkP | |
MAPK14 | Q16539 | human | CASP8 | Q14790 | S347 | FTGLkCPsLAGkPkV | Peptidase_C14 |
MAPK14 | Q16539 | human | CDT1 | Q9H211 | S391 | LRSAAPssPGsPrPA | |
MAPK14 | Q16539 | human | DDX5 | P17844 | T446 | GtAyTFFtPNNIkQV | |
MAPK14 | Q16539 | human | USP21 | Q9UK80 | S538 | VYNDSRVsPVSENQV | UCH |
MAPK14 | Q16539 | human | MKNK1 | Q9BUB5-2 | T214 | ITtPELTtPCGSAEY | Pkinase |
MAPK14 | Q16539 | human | TP53 | P04637 | S46 | AMDDLMLsPDDIEQW | TAD2 |
MAPK14 | Q16539 | human | KCNB1 | Q14721 | S805 | ESsPLPtsPKFLRQN | |
MAPK14 | Q16539 | human | BAZ1B | Q9UIG0 | S158 | ksDGACDsPssDKEN | |
MAPK14 | Q16539 | human | MKNK1 | Q9BUB5 | T250 | NSCTPITtPELTtPC | Pkinase |
MAPK14 | Q16539 | human | MEF2A | Q02078 | T319 | tPVVSVTtPSLPPQG | |
MAPK14 | Q16539 | human | ELAVL1 | Q15717 | T118 | sGLPRTMtQkDVEDM | RRM_1 |
MAPK14 | Q16539 | human | MAPT | P10636-8 | S396 | GAEIVyKsPVVsGDt | |
MAPK14 | Q16539 | human | SLC6A4 | P31645 | T616 | IKsItPEtPTEIPCG | |
MAPK14 | Q16539 | human | MAPT | P10636-8 | S404 | PVVsGDtsPRHLsNV | |
MAPK14 | Q16539 | human | TAB1 | Q15750 | T431 | ASTLDEAtPTLTNQs | |
MAPK14 | Q16539 | human | MAPKAPK2 | P49137 | S272 | SNHGLAIsPGMKTRI | Pkinase |
MAPK14 | Q16539 | human | POU3F2 | P20265 | S96 | DGsPWSTsPLGQPDI | |
MAPK14 | Q16539 | human | S100A9 | P06702 | T113 | KPGLGEGtP______ | |
MAPK14 | Q16539 | human | MAFA | Q8NHW3 | T57 | LSStPLStPCSsVPS | |
MAPK14 | Q16539 | human | CDT1 | Q9H211 | T402 | PrPALPAtPPAtPPA | |
MAPK14 | Q16539 | human | NFATC4 | Q14934 | S168 | QGGGAFFsPsPGsSS | |
MAPK14 | Q16539 | human | PTPN7 | P35236 | S93 | ALQRQPPsPKQLEEE | |
MAPK14 | Q16539 | human | FOXO3 | O43524 | S7 | _MAEAPAsPAPLsPL | |
MAPK14 | Q16539 | human | EPS15 | P42566 | S796 | RsINkLDsPDPFkLN | |
MAPK14 | Q16539 | human | NCOA3 | Q9Y6Q9 | S860 | NRAVsLDsPVsVGss | |
MAPK14 | Q16539 | human | HBP1 | O60381 | S402 | GFSkNCGsPGSSQLS | |
MAPK14 | Q16539 | human | RB1 | P06400 | T841 | sIGEsFGtsEkFQkI | Rb_C |
MAPK14 | Q16539 | human | RPS27 | P42677 | S27 | KKkRLVQsPNsyFMD | |
MAPK14 | Q16539 | human | TAB1 | Q15750 | S452 | STNTHTQssSSssDG | |
MAPK14 | Q16539 | human | FOXO3 | O43524 | S294 | QLskWPGsPtsRsSD | |
MAPK14 | Q16539 | human | KARS1 | Q15046 | S49 | ELsEKQLsQAtAAAT | |
MAPK14 | Q16539 | human | MEF2D | Q14814 | S251 | NkVIPAksPPPPtHS | |
MAPK14 | Q16539 | human | HTRA2 | O43464 | S142 | VPSPPPAsPRSQYNF | Peptidase_M50 |
MAPK14 | Q16539 | human | KRT8 | P05787 | S74 | tVNQsLLsPLVLEVD | Keratin_2_head |
MAPK14 | Q16539 | human | ISL1 | P61371 | S269 | GTPMVAAsPERHDGG | |
MAPK14 | Q16539 | human | FGFR1 | P11362 | S777 | SMPLDQysPsFPDTR | |
MAPK14 | Q16539 | human | TP63 | Q9H3D4-2 | S68 | TFDALsPsPAIPSNT | |
MAPK14 | Q16539 | human | GSK3B | P49841 | T43 | kVTTVVAtPGQGPDR | |
MAPK14 | Q16539 | human | FH | P07954 | T90 | GVtERMPtPVIkAFG | Lyase_1 |
MAPK14 | Q16539 | human | EGFR | P00533 | T1041 | LLSsLsAtsNNstVA | |
MAPK14 | Q16539 | human | CDX2 | Q99626 | S283 | RsVPEPLsPVSSLQA | |
MAPK14 | Q16539 | human | MYLK | Q15746 | S947 | EEERKVHsPQQVDFR | |
MAPK14 | Q16539 | human | POU3F2 | P20265 | T440 | PPHHGVQtPVQ____ | |
MAPK14 | Q16539 | human | TAB1 | Q15750 | S456 | HTQssSSssDGGLFR | |
MAPK14 | Q16539 | human | NFATC4 | Q14934 | S170 | GGAFFsPsPGsSSLS | |
MAPK14 | Q16539 | human | CBX4 | O00257 | T497 | SLQVkPEtPASAAVA | |
MAPK14 | Q16539 | human | USF1 | P22415 | T153 | EALLGQAtPPGTGQF | |
MAPK14 | Q16539 | human | MEF2C | Q06413-3 | T300 | tPVVSVAtPTLPGQG | |
MAPK14 | Q16539 | human | RAB7A | P51149 | S72 | AGQERFQsLGVAFYR | Ras |
MAPK14 | Q16539 | human | TP53 | P04637 | S33 | LPENNVLsPLPsQAM | |
MAPK14 | Q16539 | human | NCOA3 | Q9Y6Q9 | S543 | SLLSTLSsPGPKLDN | NCOA_u2 |
MAPK14 | Q16539 | human | AR | P10275 | S651 | GEASSTTsPTEETTQ | |
MAPK14 | Q16539 | human | TP63 | Q9H3D4 | S162 | TFDALsPsPAIPSNT | |
MAPK14 | Q16539 | human | RB1 | P06400 | T252 | PINGsPRtPRRGQNR | |
MAPK14 | Q16539 | human | MEF2A | Q02078 | S223 | VPNGAGSsPVGNGFV | |
MAPK14 | Q16539 | human | STAT3 | P40763 | S727 | NtIDLPMsPrTLDSL | |
MAPK14 | Q16539 | human | BUB3 | O43684 | S211 | AVEyLDPsPEVQkkk | |
MAPK14 | Q16539 | human | FOXO3 | O43524 | S425 | TKGsGLGsPtSSFNS | |
MAPK14 | Q16539 | human | CDT1 | Q9H211 | S411 | PAtPPAAsPsALkGV | |
MAPK14 | Q16539 | human | MEF2A | Q02078 | S408 | SIkSEPIsPPRDRMT | |
MAPK14 | Q16539 | human | CDKN2D | P55273 | S66 | ELLKQGAsPNVQDTS | Ank_2 |
MAPK14 | Q16539 | human | ETV6 | P41212 | S22 | IsytPPEsPVPsyAs | |
MAPK14 | Q16539 | human | SOX9 | P48436 | S211 | FKALQADsPHsSSGM | |
MAPK14 | Q16539 | human | GRHL3 | Q8TE85 | T454 | RPETDLEtPPVLFIP | |
MAPK14 | Q16539 | human | DROSHA | Q9NRR4 | T274 | sDyDrGRtPsRHRSY | |
MAPK14 | Q16539 | human | RBPJ | Q06330 | T339 | STDKAEYtFYEGMGP | |
MAPK14 | Q16539 | human | TP63 | Q9H3D4-2 | S66 | SSTFDALsPsPAIPS | |
MAPK14 | Q16539 | human | SLC9A1 | P19634 | T718 | KEDLPVItIDPAsPQ | |
MAPK14 | Q16539 | human | BCL2L1 | Q07817 | S62 | PSWHLADsPAVNGAT | |
MAPK14 | Q16539 | human | GATA2 | P23769 | S192 | PsTTGAAsPASSSAG | |
MAPK14 | Q16539 | human | SREBF1 | P36956 | S63 | AGGtDPAsPDTSSPG | |
MAPK14 | Q16539 | human | CRYAB | P02511 | S59 | PsFLRAPsWFDTGLS | |
MAPK14 | Q16539 | human | NOS3 | P29474 | S114 | RKLQGRPsPGPPAPE | |
MAPK14 | Q16539 | human | DDX5 | P17844 | T564 | SFRTGNPtGTYQNGY | P68HR |
MAPK14 | Q16539 | human | RB1 | P06400 | S567 | SLAWLSDsPLFDLIk | RB_A |
MAPK14 | Q16539 | human | CDKN1A | P38936 | S98 | GGRRPGTsPALLQGT | |
MAPK14 | Q16539 | human | LAMP2 | P13473 | T213 | PSPtttPtPKEKPEA | |
MAPK14 | Q16539 | human | RB1 | P06400 | S249 | AVIPINGsPRtPRRG | |
MAPK14 | Q16539 | human | MEF2D | Q14814 | S192 | ALQRNSVsPGLPQRP | |
MAPK14 | Q16539 | human | TRIM9 | Q9C026-5 | S80 | EADsGYGsYGGFASA | |
MAPK14 | Q16539 | human | SREBF1 | P36956 | T426 | TEVEDTLtPPPsDAG | |
MAPK14 | Q16539 | human | SMAD9 | O15198 | T136 | YHYRRVEtPVLPPVL | |
MAPK14 | Q16539 | human | SNAI1 | O95863 | S107 | sQPPsPPsPAPssFS | |
MAPK14 | Q16539 | human | DDIT3 | P35638 | S82 | STSQsPHsPDSSQSS | |
MAPK14 | Q16539 | human | KHSRP | Q92945 | T692 | QAAyYGQtPGPGGPQ | |
MAPK14 | Q16539 | human | DROSHA | Q9NRR4 | S300 | RHRDNRRsPsLERSY | |
MAPK14 | Q16539 | human | ZNHIT1 | O43257 | T103 | AEGPNYLtACAGPPS | |
MAPK14 | Q16539 | human | FOXO3 | O43524 | S12 | PAsPAPLsPLEVELD | |
MAPK14 | Q16539 | human | TP63 | Q9H3D4-2 | S301 | TSIKKRRsPDDELLY | P53_tetramer |
MAPK14 | Q16539 | human | NR3C1 | P04150 | S226 | IDENCLLsPLAGEDD | GCR |
MAPK14 | Q16539 | human | SKP2 | Q13309 | S64 | sNLGHPEsPPRkRLk | |
MAPK14 | Q16539 | human | BCL2 | P10415 | S87 | AAAGPALsPVPPVVH | |
MAPK14 | Q16539 | human | RBM17 | Q96I25 | T71 | DDrQIVDtPPHVAAG | |
MAPK14 | Q16539 | human | ATF6 | P18850 | T166 | NKTENGLtPKKKIQV | |
MAPK14 | Q16539 | human | PXN | P49023 | S85 | HQQPQsssPVyGsSA | Paxillin |
MAPK14 | Q16539 | human | MEF2A | Q02078 | S192 | TTLHRNVsPGAPQRP | |
MAPK14 | Q16539 | human | NR3C1 | P04150 | S203 | DLEFSSGsPGkEtNE | GCR |
MAPK14 | Q16539 | human | MEF2A | Q02078 | S98 | KEHRGCDsPDPDtsy | HJURP_C |
MAPK14 | Q16539 | human | MAPT | P10636-8 | S202 | sGyssPGsPGtPGsR | |
MAPK14 | Q16539 | human | DROSHA | Q9NRR4 | S255 | DRRERGRsPDRRRQD | |
MAPK14 | Q16539 | human | FOXC2 | Q99958 | S367 | DHPSGPTsPLSALNL | |
MAPK14 | Q16539 | human | SREBF1 | P36956-3 | S39 | AGGTDPAsPDTSSPG | |
MAPK14 | Q16539 | human | CDKN1A | P38936 | S130 | sGEQAEGsPGGPGDs | |
MAPK14 | Q16539 | human | TAB1 | Q15750 | S423 | QMVNGAHsASTLDEA | |
MAPK14 | Q16539 | human | KARS1 | Q15046 | T52 | EKQLsQAtAAATNHT | |
MAPK14 | Q16539 | human | PIP4K2B | P78356 | S326 | SYGtPPDsPGNLLsF | PIP5K |
MAPK14 | Q16539 | human | SUCLA2 | Q9P2R7 | S79 | PKGyVAksPDEAyAI | ATP-grasp_2 |
MAPK14 | Q16539 | human | FOXN3 | O00409 | S83 | FGESVLRsVsPVQDL | |
MAPK14 | Q16539 | human | KCNB1 | Q14721 | S800 | EKNHFESsPLPtsPK | |
MAPK14 | Q16539 | human | TP63 | Q9H3D4 | S395 | TSIKKRRsPDDELLY | P53_tetramer |
MAPK14 | Q16539 | human | SLC9A1 | P19634 | S723 | VItIDPAsPQsPEsV | |
MAPK14 | Q16539 | human | HSPB1 | P04792 | S176 | MPkLAtQsNEItIPV | HSP20 |
MAPK14 | Q16539 | human | ESR1 | P03372 | S118 | LHPPPQLsPFLQPHG | Oest_recep |
MAPK14 | Q16539 | human | SNX27 | Q96L92 | S51 | VRIVksEsGYGFNVR | PDZ |
MAPK14 | Q16539 | human | MRTFA | Q969V6 | S333 | CGLARQNstsLtGKP | |
MAPK14 | Q16539 | human | AGO2 | Q9UKV8 | S387 | SkLMRsAsFNtDPyV | ArgoL2 |
MAPK14 | Q16539 | human | NCF1 | P14598 | S345 | QARPGPQsPGsPLEE | |
MAPK14 | Q16539 | human | GSK3B | P49841 | T390 | RIQAAAstPtNAtAA | |
MAPK14 | Q16539 | human | FOXN3 | O00409 | S85 | ESVLRsVsPVQDLDD | |
MAPK14 | Q16539 | human | MKNK1 | Q9BUB5 | T255 | ITtPELTtPCGSAEY | Pkinase |
MAPK14 | Q16539 | human | ESR1 | P03372 | S294 | RAANLWPsPLMIkRS | |
MAPK14 | Q16539 | human | SLC9A1 | P19634 | S729 | AsPQsPEsVDLVNEE | |
MAPK14 | Q16539 | human | DROSHA | Q9NRR4 | S221 | KAPSERRsPERLKHy | |
MAPK14 | Q16539 | human | NCOA3 | Q9Y6Q9 | S867 | sPVsVGssPPVKNIS | |
MAPK14 | Q16539 | human | LIMK1 | P53667 | S310 | PGAGsLGsPAsQRKD | |
MAPK14 | Q16539 | human | TWIST1 | Q15672 | S68 | GGGDEPGsPAQGkRG | |
MAPK14 | Q16539 | human | MEF2A | Q02078 | T312 | QATQPLAtPVVSVTt | |
MAPK14 | Q16539 | human | MAPKAPK2 | P49137 | T222 | tSHNsLttPCytPYY | Pkinase |
MAPK14 | Q16539 | human | RPS6KA5 | O75582 | S360 | TEMDPTYsPAALPQS | Pkinase_C |
MAPK14 | Q16539 | human | MAOA | P21397 | S209 | GGTTRIFsVTNGGQE | Amino_oxidase |
MAPK14 | Q16539 | human | ZAP70 | P43403 | T293 | tLNsDGytPEPARIt | |
MAPK14 | Q16539 | human | PTPN7 | P35236 | T66 | EPICsVNtPREVTLH | |
MAPK14 | Q16539 | human | HSF1 | Q00613 | S307 | EPPsPPQsPRVEEAs | Vert_HS_TF |
MAPK14 | Q16539 | human | DROSHA | Q9NRR4 | S355 | LEIVNHRsPsREKKR | |
MAPK14 | Q16539 | human | TAB1 | Q15750 | S457 | TQssSSssDGGLFRS | |
MAPK14 | Q16539 | human | MEF2A | Q02078 | S479 | DPRGDFHsPIVLGRP | |
MAPK14 | Q16539 | human | PAK6 | Q9NQU5 | S165 | MPWPEPQsPRVLPNG | |
MAPK14 | Q16539 | human | EGFR | P00533 | S1039 | tPLLSsLsAtsNNst | |
MAPK14 | Q16539 | human | MEF2C | Q06413-3 | S387 | TRHEAGRsPVDSLSS | |
MAPK14 | Q16539 | human | CASP3 | P42574 | S150 | FRGDRCRsLtGKPKL | Peptidase_C14 |
MAPK14 | Q16539 | human | ESR1 | P03372 | T311 | NsLALSLtADQMVSA | |
MAPK14 | Q16539 | human | MAPT | P10636-8 | T181 | ktPPAPktPPssGEP | |
MAPK14 | Q16539 | human | CORO1B | Q9BR76 | S2 | ______MsFRKVVRQ | |
MAPK14 | Q16539 | human | EGFR | P00533 | T693 | RELVEPLtPsGEAPN | |
MAPK14 | Q16539 | human | MKNK1 | Q9BUB5-2 | T209 | NSCTPITtPELTtPC | Pkinase |
MAPK14 | Q16539 | human | RB1 | P06400 | S838 | ILVsIGEsFGtsEkF | Rb_C |
MAPK14 | Q16539 | human | MAPKAPK5 | Q8IW41 | T182 | IDQGDLMtPQFtPyY | Pkinase |
MAPK14 | Q16539 | human | GSK3B | P49841 | S389 | ARIQAAAstPtNAtA | |
MAPK14 | Q16539 | human | FOXO3 | O43524 | S344 | QDDDAPLsPMLYSSS | |
MAPK14 | Q16539 | human | ELK4 | P28324 | S381 | IHFWSTLsPVAPLsP | |
MAPK14 | Q16539 | human | NLRP1 | Q9C000 | S107 | PSEPHLGsPSQPTST | |
MAPK14 | Q16539 | human | GJA1 | P17302 | S279 | sSPtAPLsPMsPPGy | |
MAPK14 | Q16539 | human | HSF1 | Q00613 | S303 | RVkEEPPsPPQsPRV | Vert_HS_TF |
MAPK14 | Q16539 | human | CDT1 | Q9H211 | S491 | GSCCTIMsPGEMEKH | CDT1_C |
MAPK14 | Q16539 | human | KAT5 | Q92993-2 | T106 | VEVVsPAtPVPSETA | |
MAPK14 | Q16539 | human | MAFA | Q8NHW3 | T134 | NPEALNLtPEDAVEA | Maf_N |
MAPK14 | Q16539 | human | MEF2A | Q02078 | T108 | PDtsyVLtPHtEEKy | HJURP_C |
MAPK14 | Q16539 | human | HNF4A | P41235 | S167 | VLSRQItsPVsGING | |
MAPK14 | Q16539 | human | PRKN | O60260 | S131 | HTDsRkDsPPAGsPA | |
MAPK14 | Q16539 | human | MDM4 | O15151 | S314 | TECKKFNsPSKRYCF | zf-RanBP |
MAPK14 | Q16539 | human | NFATC1 | O95644 | S172 | YRDPsCLsPASSLSS | |
MAPK14 | Q16539 | human | PDX1 | P52945 | S61 | LGALEQGsPPDIsPY | |
MAPK14 | Q16539 | human | EEA1 | Q15075 | T1392 | CSAKNALtPSSKKPV | FYVE |
MAPK14 | Q16539 | human | TRIM28 | Q13263 | S473 | sGVkRsRsGEGEVsG | |
MAPK14 | Q16539 | human | F3 | P13726 | S290 | GQsWkENsPLNVs__ | |
MAPK14 | Q16539 | human | RPS6KA4 | O75676 | S196 | EEkERtFsFCGTIEY | Pkinase |
MAPK14 | Q16539 | human | GJA1 | P17302 | S282 | tAPLsPMsPPGykLV | |
MAPK14 | Q16539 | human | TAB1 | Q15750 | S453 | TNTHTQssSSssDGG | |
MAPK14 | Q16539 | human | MAPKAPK2 | P49137 | T25 | APPPQPPtPALPHPP | |
MAPK14 | Q16539 | human | MEF2D | Q14814 | S231 | GYVsARAsPGLLPVA | |
MAPK14 | Q16539 | human | HSF1 | Q00613 | S326 | ssVDtLLsPTALIDs | Vert_HS_TF |
MAPK14 | Q16539 | human | TAB1 | Q15750 | S438 | tPTLTNQsPTLtLQS | |
MAPK14 | Q16539 | human | MAPKAPK2 | P49137 | T334 | QstKVPQtPLHtsRV | |
MAPK14 | Q16539 | human | RPS6KA5 | O75582 | T581 | PDNQPLKtPCFTLHY | Pkinase |
MAPK14 | Q16539 | human | IFNAR1 | P17181 | S532 | KKySSQTsQDsGNys | |
MAPK14 | Q16539 | human | MRTFA | Q969V6 | S312 | tPPVRsLstTNSsSS | |
MAPK14 | Q16539 | human | NOXA1 | Q86UR1 | S282 | VGKQAPLsPGLPAMG | |
MAPK14 | Q16539 | human | BCL2 | P10415 | T56 | FSSQPGHtPHPAASR | |
MAPK14 | Q16539 | human | CCND2 | P30279 | T280 | DELDQAstPtDVRDI | Cyclin_C |
MAPK14 | Q16539 | human | LAMP2 | P13473 | T211 | tVPSPtttPtPKEKP | |
MAPK14 | Q16539 | human | MEF2D | Q14814 | S450 | VsPsRERsPAPPPPA | |
MAPK14 | Q16539 | human | ELK1 | P19419 | S383 | IHFWSTLsPIAPRsP | |
MAPK14 | Q16539 | human | TP53 | P04637 | S15 | PsVEPPLsQEtFsDL | P53_TAD |
MAPK14 | Q16539 | human | TRIM9 | Q9C026-5 | S76 | SLYSEADsGYGsYGG | |
MAPK14 | Q16539 | human | RBSN | Q9H1K0 | S215 | EsLSTHtsPsQsPNs | FYVE |
MAPK14 | Q16539 | human | PRKCE | Q02156 | S350 | RsKsAPtsPCDQEIK | |
MAPK14 | Q16539 | human | F3 | P13726 | S285 | RKAGVGQsWkENsPL | |
MAPK14 | Q16539 | human | POU3F2 | P20265 | S91 | GGGGGDGsPWSTSPL | |
MAPK14 | Q16539 | human | FOXC1 | Q12948 | S272 | SSLSSGSsPPGSLPS | |
MAPK14 | Q16539 | human | MFF | Q9GZY8 | S155 | GRLkRERsMsENAVR | Miff |
MAPK14 | Q16539 | human | EZH2 | Q15910 | T367 | NNssRPstPtINVLE | |
MAPK14 | Q16539 | human | MAPT | P10636-8 | T205 | ssPGsPGtPGsRsRt | |
MAPK14 | Q16539 | human | SREBF1 | P36956-3 | T402 | TEVEDTLtPPPSDAG | |
MAPK14 | Q16539 | human | KCNQ2 | O43526-4 | S427 | VAAKGKGsPQAQTVR | |
MAPK14 | Q16539 | human | EWSR1 | Q01844 | T79 | QPPTGYTtPTAPQAY | |
MAPK14 | Q16539 | human | PPARGC1A | Q9UBK2 | S266 | SLPLtPEsPNDPKGs | |
MAPK14 | Q16539 | human | BACE1 | P56817 | S83 | YVEMTVGsPPQTLNI | Asp |
MAPK14 | Q16539 | human | CDT1 | Q9H211 | T406 | LPAtPPAtPPAAsPs | |
MAPK14 | Q16539 | human | MAPT | P10636-8 | S422 | GsIDMVDsPQLAtLA | |
MAPK14 | Q16539 | human | CDKN1A | P38936 | T57 | NFDFVtEtPLEGDFA | CDI |
MAPK14 | Q16539 | human | ELAVL1 | Q15717 | S88 | LNGLRLQskTIkVSY | RRM_1 |
MAPK14 | Q16539 | human | EIF2S1 | P05198 | S52 | MILLsELsRRRIRsI | S1 |
MAPK14 | Q16539 | human | KAT5 | Q92993 | T158 | VEVVsPAtPVPSETA | |
MAPK14 | Q16539 | human | NCOA3 | Q9Y6Q9 | S505 | SPVAGVHsPMAsSGN | NCOA_u2 |
MAPK14 | Q16539 | human | NR3C1 | P04150 | S211 | PGkEtNEsPWRSDLL | GCR |
MAPK14 | Q16539 | human | MAP4 | P27816 | S787 | KAPEkRAsPsKPAsA | |
MAPK14 | Q16539 | human | TXNIP | Q9H3M7 | S361 | DMDGsQDsPIFMYAP | |
MAPK14 | Q16539 | human | MEF2A | Q02078 | S494 | PNTEDREsPsVKRMR | |
MAPK14 | Q16539 | human | MEF2C | Q06413-3 | T293 | QSAQSLAtPVVSVAt | |
MAPK14 | Q16539 | human | TP63 | Q9H3D4 | S455 | QKQtSIQsPSSYGNs |
Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
Enriched GO biological processes of the phosphorylation target genes of the kinase |
Kinase | GOID | GO term | P.adjust |
MAPK14 | ID | Description | 0.00e+00 |
MAPK14 | GO:0010586 | miRNA metabolic process | 1.55e-15 |
MAPK14 | GO:0061614 | miRNA transcription | 6.25e-14 |
MAPK14 | GO:0051402 | neuron apoptotic process | 2.74e-13 |
MAPK14 | GO:2000628 | regulation of miRNA metabolic process | 5.41e-13 |
MAPK14 | GO:1902893 | regulation of miRNA transcription | 8.07e-13 |
MAPK14 | GO:0048863 | stem cell differentiation | 2.72e-12 |
MAPK14 | GO:0140747 | regulation of ncRNA transcription | 2.39e-11 |
MAPK14 | GO:0098781 | ncRNA transcription | 1.91e-10 |
MAPK14 | GO:0043523 | regulation of neuron apoptotic process | 1.70e-09 |
MAPK14 | GO:0032355 | response to estradiol | 5.31e-09 |
MAPK14 | GO:0006979 | response to oxidative stress | 8.53e-09 |
MAPK14 | GO:0062197 | cellular response to chemical stress | 1.43e-08 |
MAPK14 | GO:0097193 | intrinsic apoptotic signaling pathway | 1.46e-08 |
MAPK14 | GO:1902895 | positive regulation of miRNA transcription | 1.61e-08 |
MAPK14 | GO:0060485 | mesenchyme development | 1.86e-08 |
MAPK14 | GO:0072132 | mesenchyme morphogenesis | 3.34e-08 |
MAPK14 | GO:2001233 | regulation of apoptotic signaling pathway | 4.26e-08 |
MAPK14 | GO:0048762 | mesenchymal cell differentiation | 5.70e-08 |
MAPK14 | GO:2000630 | positive regulation of miRNA metabolic process | 8.27e-08 |
MAPK14 | GO:0031667 | response to nutrient levels | 1.72e-07 |
MAPK14 | GO:0003170 | heart valve development | 2.51e-07 |
MAPK14 | GO:0009408 | response to heat | 3.11e-07 |
MAPK14 | GO:0034599 | cellular response to oxidative stress | 3.11e-07 |
MAPK14 | GO:0010212 | response to ionizing radiation | 3.53e-07 |
MAPK14 | GO:0072331 | signal transduction by p53 class mediator | 3.53e-07 |
MAPK14 | GO:0010038 | response to metal ion | 3.75e-07 |
MAPK14 | GO:0043525 | positive regulation of neuron apoptotic process | 4.92e-07 |
MAPK14 | GO:0050673 | epithelial cell proliferation | 5.08e-07 |
MAPK14 | GO:0009314 | response to radiation | 5.86e-07 |
MAPK14 | GO:0048638 | regulation of developmental growth | 7.43e-07 |
MAPK14 | GO:0016049 | cell growth | 7.89e-07 |
MAPK14 | GO:0003179 | heart valve morphogenesis | 8.36e-07 |
MAPK14 | GO:0071214 | cellular response to abiotic stimulus | 8.37e-07 |
MAPK14 | GO:0104004 | cellular response to environmental stimulus | 8.37e-07 |
MAPK14 | GO:0001701 | in utero embryonic development | 9.71e-07 |
MAPK14 | GO:0003203 | endocardial cushion morphogenesis | 9.86e-07 |
MAPK14 | GO:0070482 | response to oxygen levels | 1.10e-06 |
MAPK14 | GO:0071496 | cellular response to external stimulus | 1.20e-06 |
MAPK14 | GO:0003176 | aortic valve development | 1.28e-06 |
MAPK14 | GO:0001666 | response to hypoxia | 1.28e-06 |
MAPK14 | GO:0000302 | response to reactive oxygen species | 1.28e-06 |
MAPK14 | GO:0010506 | regulation of autophagy | 1.53e-06 |
MAPK14 | GO:0071480 | cellular response to gamma radiation | 1.81e-06 |
MAPK14 | GO:0001558 | regulation of cell growth | 1.81e-06 |
MAPK14 | GO:0009266 | response to temperature stimulus | 1.81e-06 |
MAPK14 | GO:1905314 | semi-lunar valve development | 2.02e-06 |
MAPK14 | GO:0042060 | wound healing | 2.02e-06 |
MAPK14 | GO:0003007 | heart morphogenesis | 2.02e-06 |
MAPK14 | GO:0042594 | response to starvation | 2.02e-06 |
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Related Drugs to MAPK14_POP5 |
Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
Distribution of the number of studies mentioning MAPK14-POP5 and kinase inhibitors the PubMed Abstract (04-01-2024) |
Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to MAPK14_POP5 |
Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
MeSH ID | MeSH term |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
Clinical Trials from clinicaltrials.gov (06-17-2024) |
Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |