UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine
leaf

Kinase Fusion Gene Summary

leaf

Kinase Fusion Gene Sample Information

leaf

Kinase Fusion ORF Analysis

leaf

Kinase Fusion Amino Acid Sequences

leaf

Multiple Sequence Alignment of All Fusion Protein Isoforms

leaf

Kinase Fusion Protein Functional Features

leaf

Kinase Fusion Protein Structures

leaf

Comparison of Fusion Protein Isoforms

leaf

Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

leaf

pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

leaf

Ramachandran Plot of Kinase Fusion Protein Structure

leaf

Potential Active Site Information

leaf

Virtual Screening Results

leaf

Kinase-Substrate Information

leaf

Related Drugs with This Kinase Fusion Protein

leaf

Related Disease with This Kinase Fusion Protein

leaf

Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:ANKRD11_RPS6KA1

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: ANKRD11_RPS6KA1
KinaseFusionDB ID: KFG355
FusionGDB2.0 ID: KFG355
HgeneTgene
Gene symbol

ANKRD11

RPS6KA1

Gene ID

29123

6195

Gene nameankyrin repeat domain containing 11ribosomal protein S6 kinase A1
SynonymsANCO-1|ANCO1|LZ16|T13HU-1|MAPKAPK1|MAPKAPK1A|RSK|RSK1|p90Rsk
Cytomap

16q24.3

1p36.11

Type of geneprotein-codingprotein-coding
Descriptionankyrin repeat domain-containing protein 11ankyrin repeat domain 11ankyrin repeat-containing cofactor 1ankyrin repeats containing cofactor 1nasopharyngeal carcinoma susceptibility proteinribosomal protein S6 kinase alpha-190 kDa ribosomal protein S6 kinase 1MAP kinase-activated protein kinase 1aMAPK-activated protein kinase 1aMAPKAP kinase 1aMAPKAPK-1aRSK-1S6K-alpha 1dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1)p9
Modification date2024040720240403
UniProtAcc

Q6UB99

Q15418

Ensembl transtripts involved in fusion geneENST idsENST00000378330, ENST00000301030, 
ENST00000563291, ENST00000567736, 
ENST00000374168, ENST00000374166, 
ENST00000526792, ENST00000374162, 
ENST00000530003, ENST00000531382, 
ENST00000488985, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: ANKRD11 [Title/Abstract] AND RPS6KA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRPS6KA1

GO:0043154

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

18402937


check buttonKinase Fusion gene breakpoints across ANKRD11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonKinase Fusion gene breakpoints across RPS6KA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


Top

Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
CCLESW 156ANKRD11chr16

89484692

RPS6KA1chr1

26863416



Top

Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)

Top

Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

Multiple Sequence Alignment of All Fusion Protein Isoforms



Top

Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:/:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANKRD11

Q6UB99

RPS6KA1

Q15418

FUNCTION: Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). {ECO:0000250|UniProtKB:E9Q4F7, ECO:0000269|PubMed:15184363, ECO:0000269|PubMed:25556659}.FUNCTION: Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:10679322, PubMed:16223362, PubMed:15117958, PubMed:12213813, PubMed:9430688, PubMed:17360704, PubMed:26158630, PubMed:18722121, PubMed:35772404). In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:18508509, PubMed:18813292). In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed:12213813, PubMed:16223362). Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:18508509, PubMed:18813292). Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complex (PubMed:17360704). In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:16763566). Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed:15342917). Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR (PubMed:22017876). Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed:10679322, PubMed:16213824). Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:11684016). Mediates induction of hepatocyte prolifration by TGFA through phosphorylation of CEBPB (PubMed:18508509, PubMed:18813292). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (PubMed:18508509, PubMed:18813292). Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630). In response to mTORC1 activation, phosphorylates EIF4B at 'Ser-406' and 'Ser-422' which stimulates bicarbonate cotransporter SLC4A7 mRNA translation, increasing SLC4A7 protein abundance and function (PubMed:35772404). {ECO:0000269|PubMed:10679322, ECO:0000269|PubMed:11684016, ECO:0000269|PubMed:12213813, ECO:0000269|PubMed:15117958, ECO:0000269|PubMed:15342917, ECO:0000269|PubMed:16213824, ECO:0000269|PubMed:16223362, ECO:0000269|PubMed:16763566, ECO:0000269|PubMed:17360704, ECO:0000269|PubMed:18722121, ECO:0000269|PubMed:22017876, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:35772404, ECO:0000269|PubMed:9430688, ECO:0000303|PubMed:18508509, ECO:0000303|PubMed:18813292}.; FUNCTION: (Microbial infection) Promotes the late transcription and translation of viral lytic genes during Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, when constitutively activated. {ECO:0000269|PubMed:30842327}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


Top

Kinase-Substrate Information of ANKRD11_RPS6KA1


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
RPS6KA1Q15418humanTERF2IPQ9NYB0S205GDAPVsPssQkLKRK
RPS6KA1Q15418humanTBC1D4O60343S318EFRsRCssVtGVQRRPID
RPS6KA1Q15418humanSLC9A1P19634S703MsRARIGsDPLAyEP
RPS6KA1Q15418humanWWC1Q8IX03S947CRLNRsDsDSSTLSK
RPS6KA1Q15418humanNDRG2Q9UN36S350RsRsRtLsQssEsGt
RPS6KA1Q15418humanVASPP50552T278LARRRKAtQVGEktP
RPS6KA1Q15418humanRPS6KA1Q15418K335KLYRREIkPPFKPAV
RPS6KA1Q15418humanCDC25BP30305T355NkRRRsVtPPEEQQEM-inducer_phosp
RPS6KA1Q15418humanREPS1Q96D71S709PVRRRLksEDELRPE
RPS6KA1Q15418humanCDC25CP30307S247kVKKkYFsGQGkLRKM-inducer_phosp
RPS6KA1Q15418humanRIOK2Q9BVS4S483QYRTRtLsItssGsA
RPS6KA1Q15418humanRPTORQ8N122S721tPrLrsVssyGNIRA
RPS6KA1Q15418humanEEF2KO00418S366sPQVRtLsGSRPPLL
RPS6KA1Q15418humanMXD1Q05195S145IERIRMDsIGSTVSS
RPS6KA1Q15418humanYBX1P67809S102NPRKyLrsVGDGEtVCSD
RPS6KA1Q15418humanRPS6KA1Q15418S380HQLFRGFsFVAtGLMPkinase_C
RPS6KA1Q15418humanPDCD4Q53EL6S457RGRKRFVsEGDGGRL
RPS6KA1Q15418humanSOS1Q07889S1134PHGPRsAsVssISLT
RPS6KA1Q15418humanLCP1P13796S5___MARGsVsDEEMM
RPS6KA1Q15418humanSOS1Q07889S1161PPRRRPEsAPAEssP
RPS6KA1Q15418humanDAPK1P53355S289QALSRKAsAVNMEkF
RPS6KA1Q15418humanMETTL1Q9UBP6S27YYRQrAHsNPMADHT
RPS6KA1Q15418humanOSTF1Q92882S202TDAVRtLsNAEDyLD
RPS6KA1Q15418humanRPS6KA1Q15418K110VRDRVRTkMERDILA
RPS6KA1Q15418humanCDC25AP30304S295TKrRKsMsGASPkESM-inducer_phosp
RPS6KA1Q15418humanTBC1D4O60343S570AKRsLtssLENIFsr
RPS6KA1Q15418humanEPHA2P29317S897RVsIRLPstsGsEGV
RPS6KA1Q15418humanEIF4BP23588S425sRtGsEssQtGtstt
RPS6KA1Q15418humanITGB4P16144S1364PSGsQRPsVSDDTGC
RPS6KA1Q15418humanFOSP01100S362AAAHRKGssSNEPSS
RPS6KA1Q15418humanWWC1Q8IX03T929stIIRsKtFsPGPQS
RPS6KA1Q15418humanNFKBIAP25963S32LLDDRHDsGLDsMkD
RPS6KA1Q15418humanAPAF1O14727S268LLTTRDksVTDsVMGNB-ARC
RPS6KA1Q15418humanCDC25BP30305S353VQNkRRRsVtPPEEQM-inducer_phosp
RPS6KA1Q15418humanUBR5O95071S2483ENRKRHGssRsVVDM
RPS6KA1Q15418humanMAPK7Q13164S496SRLRDGPsAPLEAPE
RPS6KA1Q15418humanBADQ92934S75EIRsRHssyPAGtEDBcl-2_BAD
RPS6KA1Q15418humanRPS6KA1Q15418K421FSDGYVVkETIGVGS
RPS6KA1Q15418humanRPTORQ8N122S719PCtPrLrsVssyGNI
RPS6KA1Q15418humanCREB1P16220S119EILsRRPsyRkILNDpKID
RPS6KA1Q15418humanARHGAP31Q2M1Z3S1106KGKNRPSsLNLDPAI
RPS6KA1Q15418humanGSK3BP49841S9SGRPRttsFAEsCkP
RPS6KA1Q15418humanNDRG2Q9UN36S332LsRsRtAsLtsAAsV
RPS6KA1Q15418humanRANBP3Q9H6Z4S126VKRERtssLtQFPPs
RPS6KA1Q15418humanTBC1D4O60343S751EGRKRtsstCsNEsL
RPS6KA1Q15418humanCICQ96RK0S301EtRERsMsEtGtAAA
RPS6KA1Q15418humanDEPTORQ8TB45S287sMssCGssGyFsssP
RPS6KA1Q15418humanUBR5O95071T637PYKRRRstPAPKEEE
RPS6KA1Q15418humanTBC1D4O60343S341QPRRRHAsAPsHVQPPID
RPS6KA1Q15418humanTSC2P49815S1798GQRKRLIssVEDFTE
RPS6KA1Q15418humanESR1P03372S167GGRERLAsTNDkGSMOest_recep
RPS6KA1Q15418humanCARHSP1Q9Y2V2S52tRRtrtFsAtVRAsQ
RPS6KA1Q15418humanNHERF1O14745T156ELRPRLCtMKKGPsGPDZ
RPS6KA1Q15418humanRPS6P62753S236AKRRRLssLRAstsK
RPS6KA1Q15418humanCHEK1O14757S280AKRPRVtsGGVsEsP
RPS6KA1Q15418humanMITFO75030-9S409KTSsRRSsMSMEETEDUF3371
RPS6KA1Q15418humanRELAQ04206S276sMQLRRPsDRELsEPRHD_dimer
RPS6KA1Q15418humanDEPTORQ8TB45S286ssMssCGssGyFsss
RPS6KA1Q15418humanFLNAP21333S2152tRRRRAPsVANVGsHFilamin
RPS6KA1Q15418humanTBC1D4O60343T642QFRRRAHtFsHPPss
RPS6KA1Q15418humanCCT2P78371S260GsRVRVDstAkVAEICpn60_TCP1
RPS6KA1Q15418humanTBC1D4O60343T568NKAKRsLtssLENIF
RPS6KA1Q15418humanAPAF1O14727S357FKRIRKSsSYDYEALNB-ARC
RPS6KA1Q15418humanTBC1D4O60343S588RMRGRLGsVDsFERs
RPS6KA1Q15418humanUBR5O95071S1227DCKLKRTsPTAYCDC
RPS6KA1Q15418humanTBC1D4O60343S666GRAQGVRsPLLRQSS
RPS6KA1Q15418humanPDCD4Q53EL6S76RDsGrGDsVsDsGsD
RPS6KA1Q15418humanGMFBP60983T27KFRFRKEtNNAAIIMCofilin_ADF
RPS6KA1Q15418humanCDC34P49427T162KGkDREYtDIIrkQVUQ_con
RPS6KA1Q15418humanMAGI1Q96QZ7S741QPLERKDsQNSSQHsMAGI_u5
RPS6KA1Q15418humanEIF4BP23588S422RERsRtGsEssQtGt
RPS6KA1Q15418humanRPS6P62753S235IAKRRRLssLRAsts
RPS6KA1Q15418humanSENP2Q9HC62T369TDDLLELtEDMEKEI
RPS6KA1Q15418humanDEPTORQ8TB45S291CGssGyFsssPtLss
RPS6KA1Q15418humanARHGAP31Q2M1Z3S1178ALTGRRNsAPVsVsA
RPS6KA1Q15418humanCICQ96RK0S173PGKRRtQsLsALPKE
RPS6KA1Q15418humanCDC25AP30304S293GSTKrRKsMsGASPkM-inducer_phosp
RPS6KA1Q15418humanRPTORQ8N122S722PrLrsVssyGNIRAV


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
RPS6KA1IDDescription0.00e+00
RPS6KA1GO:0035994response to muscle stretch5.21e-04
RPS6KA1GO:0032868response to insulin5.21e-04
RPS6KA1GO:0032869cellular response to insulin stimulus6.65e-04
RPS6KA1GO:0071375cellular response to peptide hormone stimulus6.65e-04
RPS6KA1GO:0043434response to peptide hormone6.65e-04
RPS6KA1GO:1901993regulation of meiotic cell cycle phase transition6.65e-04
RPS6KA1GO:0044771meiotic cell cycle phase transition1.35e-03
RPS6KA1GO:1901653cellular response to peptide1.51e-03
RPS6KA1GO:0030316osteoclast differentiation1.96e-03
RPS6KA1GO:0030011maintenance of cell polarity2.67e-03
RPS6KA1GO:0030099myeloid cell differentiation3.03e-03
RPS6KA1GO:0009612response to mechanical stimulus3.28e-03
RPS6KA1GO:0046824positive regulation of nucleocytoplasmic transport3.28e-03
RPS6KA1GO:0006913nucleocytoplasmic transport3.39e-03
RPS6KA1GO:0051169nuclear transport3.39e-03
RPS6KA1GO:0097191extrinsic apoptotic signaling pathway3.62e-03
RPS6KA1GO:0044772mitotic cell cycle phase transition3.62e-03
RPS6KA1GO:0045670regulation of osteoclast differentiation3.62e-03
RPS6KA1GO:0014074response to purine-containing compound3.94e-03
RPS6KA1GO:0010508positive regulation of autophagy4.28e-03
RPS6KA1GO:0045672positive regulation of osteoclast differentiation4.28e-03
RPS6KA1GO:0051446positive regulation of meiotic cell cycle4.28e-03
RPS6KA1GO:0010971positive regulation of G2/M transition of mitotic cell cycle5.02e-03
RPS6KA1GO:0036294cellular response to decreased oxygen levels5.02e-03
RPS6KA1GO:0031929TOR signaling5.53e-03
RPS6KA1GO:1902751positive regulation of cell cycle G2/M phase transition5.53e-03
RPS6KA1GO:0031331positive regulation of cellular catabolic process5.53e-03
RPS6KA1GO:0071868cellular response to monoamine stimulus5.53e-03
RPS6KA1GO:0071870cellular response to catecholamine stimulus5.53e-03
RPS6KA1GO:2001233regulation of apoptotic signaling pathway5.53e-03
RPS6KA1GO:0071867response to monoamine5.76e-03
RPS6KA1GO:0071869response to catecholamine5.76e-03
RPS6KA1GO:0071453cellular response to oxygen levels5.76e-03
RPS6KA1GO:1903706regulation of hemopoiesis6.52e-03
RPS6KA1GO:1901992positive regulation of mitotic cell cycle phase transition7.20e-03
RPS6KA1GO:0007212dopamine receptor signaling pathway7.20e-03
RPS6KA1GO:0008361regulation of cell size7.20e-03
RPS6KA1GO:0043620regulation of DNA-templated transcription in response to stress7.56e-03
RPS6KA1GO:0031400negative regulation of protein modification process7.59e-03
RPS6KA1GO:0070884regulation of calcineurin-NFAT signaling cascade7.75e-03
RPS6KA1GO:0010389regulation of G2/M transition of mitotic cell cycle7.77e-03
RPS6KA1GO:0034504protein localization to nucleus7.77e-03
RPS6KA1GO:0106056regulation of calcineurin-mediated signaling7.77e-03
RPS6KA1GO:0036293response to decreased oxygen levels8.13e-03
RPS6KA1GO:0062197cellular response to chemical stress8.22e-03
RPS6KA1GO:0046822regulation of nucleocytoplasmic transport8.34e-03
RPS6KA1GO:1902105regulation of leukocyte differentiation8.34e-03
RPS6KA1GO:0016055Wnt signaling pathway8.34e-03
RPS6KA1GO:0198738cell-cell signaling by wnt8.38e-03

Top

Related Drugs to ANKRD11_RPS6KA1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning ANKRD11-RPS6KA1 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

Top

Related Diseases to ANKRD11_RPS6KA1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


Top

Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate