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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:MAPK1_RFT1

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: MAPK1_RFT1
KinaseFusionDB ID: KFG3558
FusionGDB2.0 ID: KFG3558
HgeneTgene
Gene symbol

MAPK1

RFT1

Gene ID

5594

91869

Gene namemitogen-activated protein kinase 1RFT1 homolog
SynonymsERK|ERK-2|ERK2|ERT1|MAPK2|NS13|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|p42-MAPKCDG1N
Cytomap

22q11.22

3p21.1

Type of geneprotein-codingprotein-coding
Descriptionmitogen-activated protein kinase 1MAP kinase 1MAP kinase 2MAPK 2extracellular signal-regulated kinase 2mitogen-activated protein kinase 2protein tyrosine kinase ERK2protein RFT1 homologRFT1, requiring fifty three 1 homologcongenital disorder of glycosylation 1Nputative endoplasmic reticulum multispan transmembrane protein
Modification date2024032320240411
UniProtAcc

Q8NDC0

Q9NWF4

Ensembl transtripts involved in fusion geneENST idsENST00000215832, ENST00000398822, 
ENST00000491588, ENST00000544786, 
ENST00000296292, ENST00000394738, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: MAPK1 [Title/Abstract] AND RFT1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MAPK1(22116989)-RFT1(53133502), # samples:2
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAPK1

GO:0006468

protein phosphorylation

23184662

HgeneMAPK1

GO:0010800

positive regulation of peptidyl-threonine phosphorylation

16314496

HgeneMAPK1

GO:0018105

peptidyl-serine phosphorylation

15850461

HgeneMAPK1

GO:0034198

cellular response to amino acid starvation

11096076

HgeneMAPK1

GO:0038127

ERBB signaling pathway

15133037

HgeneMAPK1

GO:0051403

stress-activated MAPK cascade

11096076

HgeneMAPK1

GO:0070371

ERK1 and ERK2 cascade

16314496|22031296

HgeneMAPK1

GO:0070849

response to epidermal growth factor

18794356


check buttonKinase Fusion gene breakpoints across MAPK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonKinase Fusion gene breakpoints across RFT1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChiTaRS5.0AW376334MAPK1chr22

22116989

RFT1chr3

53133502

ChiTaRS5.0AW752527MAPK1chr22

22116994

RFT1chr3

53133502



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:22116989/:53133502)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAPK1

Q8NDC0

RFT1

Q9NWF4

FUNCTION: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism (PubMed:18632736, PubMed:20463145). Humans are unable to synthesize vitamin B2/riboflavin and must obtain it via intestinal absorption (PubMed:20463145). {ECO:0000269|PubMed:18632736, ECO:0000269|PubMed:20463145, ECO:0000303|PubMed:20463145}.; FUNCTION: (Microbial infection) May function as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A). {ECO:0000305|PubMed:12740431}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


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Kinase-Substrate Information of MAPK1_RFT1


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
MAPK1P28482humanHELLSQ9NRZ9S503EKEtIELsPtGRPKRSNF2-rel_dom
MAPK1P28482humanBRAFP15056T401sTtGLsAtPPAsLPG
MAPK1P28482humanMAPTP10636-8T231KKVAVVRtPPKsPss
MAPK1P28482humanWTAPQ15007S341AGYESVDsPtGsENs
MAPK1P28482humanSLC9A1P19634S726IDPAsPQsPEsVDLV
MAPK1P28482humanNUP153P49790T388VyFkPsLtPsGEFRKNup153
MAPK1P28482humanIRS1P35568S636sGDyMPMsPKsVSAP
MAPK1P28482humanAPBB1O00213T709PKRLGAHtP______
MAPK1P28482humanPXNP49023-2S83FIHQQPQsssPVyGsPaxillin
MAPK1P28482humanRPS6KA1Q15418T573AENGLLMtPCytANFPkinase
MAPK1P28482humanMAPTP10636-8S199GDRsGyssPGsPGtP
MAPK1P28482humanFGFR2P21802S780SQPLEQYsPsYPDTR
MAPK1P28482humanSHARPINQ9H0F6S146ACPVsLPsPPEAStL
MAPK1P28482humanTHP07101-2S58SYTPTPRsPRFIGRRTOH_N
MAPK1P28482humanSPHK1Q9NYA1S225VGSKTPAsPVVVQQG
MAPK1P28482humanATF2P15336T71IVADQtPtPtRFLkN
MAPK1P28482humanRPS6KB1P23443S447GsPRtPVsPVkFsPG
MAPK1P28482humanPDE4BQ07343S659YQSMIPQsPSPPLDE
MAPK1P28482humanGORASP2Q9H8Y8T222LPGQMAGtPItPLKD
MAPK1P28482humanPARVAQ9NVD7S4____MAtsPQKsPsV
MAPK1P28482humanADAM17P78536T735kPFPAPQtPGRLQPA
MAPK1P28482humanSMAD1Q15797S195PNSSYPNsPGSSSSt
MAPK1P28482humanRESTQ13127S861sVsTEDLsPPsPPLP
MAPK1P28482humanSMAD1Q15797S187NSHPFPHsPNSSYPN
MAPK1P28482humanSTIM1Q13586S608PsAPPGGsPHLDSSR
MAPK1P28482humanTOB1P50616S154SSVSSsPsPPFGHSA
MAPK1P28482humanTSC2P49815S664KkTSGPLsPPTGPPGTuberin
MAPK1P28482humanBCL2P10415T74ARtsPLQtPAAPGAA
MAPK1P28482humanASLP04424S417LQELQTIsPLFSGDV
MAPK1P28482humanPXNP49023-2S126sFPNKQKsAEPsPtVPaxillin
MAPK1P28482humanDUSP16Q9BY84S446TNKLCQFsPVQELSE
MAPK1P28482humanMITFO75030-9S73PGSSAPNsPMAMLTLMITF_TFEB_C_3_N
MAPK1P28482humanPARP1P09874S372VAAtPPPstAsAPAA
MAPK1P28482humanMTMR2Q13614S58StSADNFsPDLRVLR
MAPK1P28482humanKLF8O95600S48EYRSNMTsPTLLDAN
MAPK1P28482humanCRTC3Q6UUV7S391RRRQPPVsPLtLsPG
MAPK1P28482humanWTAPQ15007S306tEDDFPssPGNGNKs
MAPK1P28482humanEP300Q09472T1960QHQMPPMtPMAPMGM
MAPK1P28482humanSTMN3Q9NZ72S68PSDLsPEsPMLssPPStathmin
MAPK1P28482humanRBM17Q96I25S222EEQDRPRsPtGPsNs
MAPK1P28482humanLYL1P12980S36APPPKPAsPGPPQVE
MAPK1P28482humanSP1P08047S59GGQEsQPsPLALLAA
MAPK1P28482humanDUSP5Q16690S346IGHLQTLsPDMQGAY
MAPK1P28482humanCASP9P55211T125PEVLRPEtPRPVDIG
MAPK1P28482humanDUSP6Q16828S159DGSCSSSsPPLPVLG
MAPK1P28482humanWASF2Q9Y6W5S308PPAPPLGsPPGPKPG
MAPK1P28482humanNCOA1Q15788T1179NYGTNPGtPPASTsPDUF1518
MAPK1P28482humanESR1P03372S104FPPLNsVsPsPLMLLOest_recep
MAPK1P28482humanNCAM1P13591-1T803HTEPNETtPLTEPEK
MAPK1P28482humanSTIM1Q13586S575LVEKLPDsPALAKkA
MAPK1P28482humanCENPEQ02224S2654sRsKsLPsPHPVRYF
MAPK1P28482humanCTNND1O60716T906sLDNNystPNERGDH
MAPK1P28482humanCREBBPQ92793S93IGNVSASsPVQQGLG
MAPK1P28482humanARRB2P32121S14TRVFKKssPNCKLtV
MAPK1P28482humanRUNX1Q01196-8S276DTRQIQPsPPWSYDQ
MAPK1P28482humanPOU5F1Q01860T118sPEPCtVtPGAVkLE
MAPK1P28482humanRGS19P49795S151EDyVsILsPkEVSLDRGS
MAPK1P28482humanMAFAQ8NHW3S14MGAELPSsPLAIEYV
MAPK1P28482humanFOSP01100S374PSSDSLSsPtLLAL_
MAPK1P28482humanNR3C2P08235S196EKSPSVCsPLNMTSS
MAPK1P28482humanABI1Q8IZP0S410DIPMFDDsPPPPPPP
MAPK1P28482humanNUP214P35658S1809NAPAFGQsPGFGQGG
MAPK1P28482humanSMAD2Q15796S255ELsPTTLsPVNHsLD
MAPK1P28482humanTOP2AP11388S1247kNENtEGsPQEDGVE
MAPK1P28482humanFOSP01100T232GGLPEVAtPESEEAF
MAPK1P28482humanNCF2P19878T233EPPPRPKtPEIFRAL
MAPK1P28482humanPDX1P52945S66QGsPPDIsPYEVPPL
MAPK1P28482humanDUSP1P28562S323HCSAEAGsPAMAVLD
MAPK1P28482humanEIF2AK2P19525T451kRtRSKGtLRyMsPEPkinase
MAPK1P28482humanTAGLN2P37802S145ArDDGLFsGDPNWFP
MAPK1P28482humanPMLP29590-4T28PTMPPPEtPSEGRQP
MAPK1P28482humanNOS3P29474S600MSGPYNSsPRPEQHKFlavodoxin_1
MAPK1P28482humanPITPNM1O00562T1223AEREGPGtPPTTLAr
MAPK1P28482humanGLE1Q53GS7S99ssAFsPAsPAtPNGT
MAPK1P28482humanGLI1P08151S116FINSRCTsPGGSYGH
MAPK1P28482humanRORCP51449S205ASCHLEYsPERGKAE
MAPK1P28482humanAPBB1O00213S175EEEEDLSsPPGLPEP
MAPK1P28482humanAPBB1O00213S347TFPAQSLsPEPLPQE
MAPK1P28482humanFHOD1Q9Y613S498PAARtPQsPAPCVLL
MAPK1P28482humanRUNX1Q01196-8T300sPSVHPAtPIsPGRA
MAPK1P28482humanRPTORQ8N122S696EKNyALPsPAttEGG
MAPK1P28482humanMAPTP10636-8S396GAEIVyKsPVVsGDt
MAPK1P28482humanARRB1P49407S412EEEDGtGsPQLNNR_
MAPK1P28482humanDUSP6Q16828S197SATDSDGsPLSNSQP
MAPK1P28482humanSLC6A4P31645T616IKsItPEtPTEIPCG
MAPK1P28482humanCIITAP33076S280TVHGLPTsPDRPGsT
MAPK1P28482humanMAPTP10636-8S404PVVsGDtsPRHLsNV
MAPK1P28482humanMAPKAPK2P49137S272SNHGLAIsPGMKTRIPkinase
MAPK1P28482humanNCOA1Q15788S1185GtPPASTsPFSQLAADUF1518
MAPK1P28482humanTPD52P55327S40GNssPPGsPTLQKFG
MAPK1P28482humanPPARGP37231S112AIkVEPAsPPYYSEK
MAPK1P28482humanBCL2L11O43521S69GPLAPPAsPGPFATR
MAPK1P28482humanMCTS1Q9ULC4T81REGPFYPtLRLLHkYPre-PUA
MAPK1P28482humanPCBP2Q15366S272FsGIEsssPEVkGyW
MAPK1P28482humanPDE4DQ08499-5S413YQSTIPQsPSPAPDD
MAPK1P28482humanPTPN7P35236S93ALQRQPPsPKQLEEE
MAPK1P28482humanBANPQ8N9N5T337VkSFSRRtPNSSSYC
MAPK1P28482humanL1CAMP32004S1204GDIKPLGsDDSLADyBravo_FIGEY
MAPK1P28482humanMAPTP10636-8S262NVKskIGstENLkHQTubulin-binding
MAPK1P28482humanCCNB1P14635S126PILVDTAsPsPMETs
MAPK1P28482humanEP300Q09472S2279PVQPNPMsPQQHMLP
MAPK1P28482humanNANOGQ9H9S0S52MPHTEtVsPLPssMD
MAPK1P28482humanMED14O60244S986NEDDNPPsPIGGDMM
MAPK1P28482humanHNRNPKP61978S284rrDyDDMsPrrGPPP
MAPK1P28482humanTPPPO94811S18ANRtPPKsPGDPskD
MAPK1P28482humanNEFLP07196T21ykRRYVEtPrVHISSFilament_head
MAPK1P28482humanFOXO3O43524S294QLskWPGsPtsRsSD
MAPK1P28482humanSHARPINQ9H0F6T309APREAPAtGPsPQHP
MAPK1P28482humanCRTC2Q53ET0S238DAkKLSSsSSRPRsCTORC_M
MAPK1P28482humanMAP2K1Q02750T292EtPPRPRtPGRPLssPkinase
MAPK1P28482humanTHP07101S62SYTPTPRsPRFIGRRTOH_N
MAPK1P28482humanASB2Q96Q27S371RIRRSGVsPLHLAAEAnk_2
MAPK1P28482humanFOSL2P15408T322SDsLNsPtLLAL___
MAPK1P28482humanCSNK2A1P68400S362ISSVPtPsPLGPLAG
MAPK1P28482humanNUP50Q9UKX7S315TQSkPVSsPFPTkPL
MAPK1P28482humanBRAFP15056T753yACAsPKtPIQAGGy
MAPK1P28482humanPDE4CQ08493-2S535YQSKIPRsPSDLTNP
MAPK1P28482humanPMLP29590-4S527PHLDGPPsPRsPVIGDUF3583
MAPK1P28482humanNDEL1Q9GZM8T219AsLsLPAtPVGKGTENUDE_C
MAPK1P28482humanMYLKQ15746S1779sstGsPtsPLNAEKL
MAPK1P28482humanCICQ96RK0S1389sPRAILGsYRKKRKN
MAPK1P28482humanSP3Q02447S73CsKIGPPsPGDDEEE
MAPK1P28482humanWWC1Q8IX03S548SsPSPPCsPLMADPL
MAPK1P28482humanFGFR1P11362S777SMPLDQysPsFPDTR
MAPK1P28482humanGSK3BP49841T43kVTTVVAtPGQGPDR
MAPK1P28482humanLCKP06239S59EGSNPPAsPLQDNLV
MAPK1P28482humanLIFRP42702S1044WNLVsPDsPRsIDSN
MAPK1P28482humanCTTNQ14247S405KtQtPPVsPAPQPtE
MAPK1P28482humanRRAS2P62070S186QEQECPPsPEPtRkE
MAPK1P28482humanPDE4DQ08499-2S579YQSTIPQsPSPAPDD
MAPK1P28482humanSHARPINQ9H0F6S165PEADLPRsPGNLtER
MAPK1P28482humanTFAMQ00059S177FQEAKGDsPQEKLKTHMG_box_2
MAPK1P28482humanCALD1Q05682-4S534QSVDKVTsPTKV___
MAPK1P28482humanMYCP01106T73kkFELLPtPPLsPsRMyc_N
MAPK1P28482humanAPBB1O00213S287WEPPGRAsPsQGSSP
MAPK1P28482humanSMAD1Q15797S206SSStYPHsPTSSDPG
MAPK1P28482humanADD1P35611S358AKsRsPGsPVGEGtG
MAPK1P28482humanNR3C2P08235S263NVGsPLssPLSSMKS
MAPK1P28482humanNR3C2P08235S227FGSFPVHsPITQGTP
MAPK1P28482humanSMAD2Q15796S250TGsPAELsPTTLsPV
MAPK1P28482humanMCRIP1C9JLW8T30PsSsEIFtPAHEENVFAM195
MAPK1P28482humanGTF2IP78347-2S633QsPKRPRsPGSNSKV
MAPK1P28482humanDHPSP49366S233KNHIPVFsPALTDGSDS
MAPK1P28482humanSPHK2Q9NRA0T614AFRLEPLtPRGVLTVYegS_C
MAPK1P28482humanMAPTP10636-8T153DGKtKIAtPRGAAPP
MAPK1P28482humanTCF3P15923-2S359sPStPVGsPQGLAGT
MAPK1P28482humanNCOA1Q15788S395PsVNPsIsPAHGVAR
MAPK1P28482humanDNMT3AQ9Y6K1S255QQPTDPAsPTVATtP
MAPK1P28482humanWASF2Q9Y6W5S296PKRssVVsPsHPPPA
MAPK1P28482humanCIITAP33076S288PDRPGsTsPFAPsAT
MAPK1P28482humanTTKP33981S821GQLVGLNsPNsILkA
MAPK1P28482humanNUP50Q9UKX7S221kVAAEtQsPsLFGst
MAPK1P28482humanSTAT3P40763S727NtIDLPMsPrTLDSL
MAPK1P28482humanGRB10Q13322S476MNILGsQsPLHPSTL
MAPK1P28482humanMAPTP10636-8S191ssGEPPKsGDRsGys
MAPK1P28482humanFOXO3O43524S425TKGsGLGsPtSSFNS
MAPK1P28482humanPLA2G4AP47712S505LNTSYPLsPLSDFATPLA2_B
MAPK1P28482humanTRAP1Q12931S511NrHLAEHsPyyEAMkHSP90
MAPK1P28482humanEP300Q09472T317VQQPGLVtPVAQGMG
MAPK1P28482humanSP1P08047T739sEGSGtAtPSALITT
MAPK1P28482humanPCBP2Q15366T213SASFPHTtPSMCLNP
MAPK1P28482humanDMTNQ08495S96KstsPPPsPEVWADsAbLIM_anchor
MAPK1P28482humanNCOA6Q14686S884NKDVTLTsPLLVNLL
MAPK1P28482humanCSNK2A1P68400T360SGISSVPtPsPLGPL
MAPK1P28482humanTHRBP10828S142IQKNLHPsYSCkYEGzf-C4
MAPK1P28482humanCITED2Q99967T166KHSGGSStPGGSGGSCITED
MAPK1P28482humanMITFO75030S180PGSSAPNsPMAMLTLMITF_TFEB_C_3_N
MAPK1P28482humanETS1P14921T38CADVPLLtPSSkEMM
MAPK1P28482humanTHP07101-3S31KQAEAIMsPRFIGRRTOH_N
MAPK1P28482humanSTIM1Q13586S621SRsHsPssPDPDtPs
MAPK1P28482humanSMAD2Q15796S245NQsMDTGsPAELsPT
MAPK1P28482humanNUP153P49790T369PPVQRLMtPKPVsIANup153
MAPK1P28482humanBCL6P41182S333KGLVsPQsPQKsDCQ
MAPK1P28482humanSOS1Q07889S1178IMSKHLDsPPAIPPR
MAPK1P28482humanABI1Q8IZP0S183PPtQKPPsPPMsGRG
MAPK1P28482humanCDKN1AP38936S98GGRRPGTsPALLQGT
MAPK1P28482humanCTNND1O60716T310GtARRtGtPsDPRRR
MAPK1P28482humanMAPK7Q13164T733LPPVFsGtPKGSGAG
MAPK1P28482humanABI1Q8IZP0S225ARLGsQHsPGRtAsL
MAPK1P28482humanDUSP5Q16690T321ESEILPStPNPQPPS
MAPK1P28482humanEP300Q09472S2366MEQGHFAsPDQNSML
MAPK1P28482humanYTHDF2Q9Y5A9S39DDFEPyLsPQARPNN
MAPK1P28482humanSMAD1Q15797S214PTSSDPGsPFQMPAD
MAPK1P28482humanSMAD3P84022T179PQSNIPEtPPPGYLS
MAPK1P28482humanSMAD3P84022S213NLsPNPMsPAHNNLD
MAPK1P28482humanEP300Q09472T938LLPPQPAtPLSQPAV
MAPK1P28482humanSHC4Q6S5L8T159GHRATALtPDSCPLP
MAPK1P28482humanPMLP29590-4S530DGPPsPRsPVIGsEVDUF3583
MAPK1P28482humanSREBF2Q12772S432NQNVLLMsPPASDSG
MAPK1P28482humanCENPEQ02224S2608tCENsPKsPKVtGTA
MAPK1P28482humanGLE1Q53GS7T102FsPAsPAtPNGTKGk
MAPK1P28482humanNCOA2Q15596S736tIkQEPVsPkkKENADUF4927
MAPK1P28482humanSREBF1P36956S117YPSMPAFsPGPGIkE
MAPK1P28482humanFOXO3O43524S12PAsPAPLsPLEVELD
MAPK1P28482humanGAB1Q13480T476EANyVPMtPGTFDFS
MAPK1P28482humanABI1Q8IZP0S267PIAVPtPsPPTIGPE
MAPK1P28482humanMYCNP04198S62LLPtPPLsPsrGFAEMyc_N
MAPK1P28482humanPARP1P09874T373AAtPPPstAsAPAAV
MAPK1P28482humanRUNX1Q01196-8S303VHPAtPIsPGRASGM
MAPK1P28482humanSLC9A1P19634S693VPAHKLDsPtMsRARNEXCaM_BD
MAPK1P28482humanSLC9A1P19634S770MMRsKETssPGtDDV
MAPK1P28482humanBCL2P10415S87AAAGPALsPVPPVVH
MAPK1P28482humanCDKN1BP46527T187NAGsVEQtPKKPGLR
MAPK1P28482humanRBM17Q96I25T71DDrQIVDtPPHVAAG
MAPK1P28482humanMAPTP10636-8S46tDAGLkEsPLQtPtE
MAPK1P28482humanNFATC4Q14934S676SNGRRKRsPTQSFRFRHD_dimer
MAPK1P28482humanNR3C2P08235S361TLRDVVPsPDTQEKG
MAPK1P28482humanMBPP02686T232KNIVTPRtPPPSQGKMyelin_MBP
MAPK1P28482humanKDM4BO94953S566PTWkEPVsPMELTGP
MAPK1P28482humanSLC9A1P19634T779PGtDDVFtPAPsDsP
MAPK1P28482humanTOP2AP11388S1361sPPKTKtsPKLsNkE
MAPK1P28482humanPITPNM1O00562T794LEMLVPStPTSTSGADDHD
MAPK1P28482humanERBB2P04626T701TELVEPLtPsGAMPN
MAPK1P28482humanSREBF1P36956-3T81SPPQPAPtPLKMYPS
MAPK1P28482humanEIF4EBP1Q13541S65FLMECrNsPVtktPPeIF_4EBP
MAPK1P28482humanCEBPAP49715S21PMsSHLQsPPHAPSS
MAPK1P28482humanNOX5Q96PH1-4S498RSVtMRKsQRSsKGSFAD_binding_8
MAPK1P28482humanERFP50548T526GEAGGPLtPRRVssD
MAPK1P28482humanNUP153P49790S516TNKVQMtsPsstGsPNup153
MAPK1P28482humanMAPTP10636-8S202sGyssPGsPGtPGsR
MAPK1P28482humanDUSP5Q16690S376TVSELSRsPVATATS
MAPK1P28482humanSNAI1O95863S104GkGsQPPsPPsPAPs
MAPK1P28482humanNUP153P49790S257ktsQLGDsPFyPGkTNup153
MAPK1P28482humanPKMP14618S37MCRLDIDsPPItARN
MAPK1P28482humanMETTL3Q86U44S43rNPEAALsPTFRsDs
MAPK1P28482humanPXNP49023-2S130KQKsAEPsPtVMStsPaxillin
MAPK1P28482humanEP300Q09472S2315RsPQPVPsPrPQsQP
MAPK1P28482humanEPAS1Q99814S672APLGPPVsPPHVSTF
MAPK1P28482humanCDKN1AP38936S130sGEQAEGsPGGPGDs
MAPK1P28482humanCDC73Q6P1J9S465PWLLPDGsPVDIFAK
MAPK1P28482humanFOSL2P15408S320QSSDsLNsPtLLAL_
MAPK1P28482humanBADQ92934S75EIRsRHssyPAGtEDBcl-2_BAD
MAPK1P28482humanNDEL1Q9GZM8T245GFGtsPLtPSARISANUDE_C
MAPK1P28482humanCITED2Q99967S85VNGGHPPsALAPAARCITED
MAPK1P28482humanRXRAP19793S260NMGLNPssPNDPVtNHormone_recep
MAPK1P28482humanNUP153P49790S338IVssPLNsPLDrsGINup153
MAPK1P28482humanSNAI2O43623S87SSSLGRVsPPPPsDT
MAPK1P28482humanEIF4G1Q04637-8S1232EAALPPVsPLKAALs
MAPK1P28482humanCENPEQ02224S2639QDPVPKEsPkSCFFD
MAPK1P28482humanPLCB1Q9NQ66S982KkKsEPssPDHGssT
MAPK1P28482humanTERF2Q15554S365PTQALPAsPALKNKR
MAPK1P28482humanSLC9A1P19634S771MRsKETssPGtDDVF
MAPK1P28482humanCAPN2P17655S50GTLFQDPsFPAIPSAPeptidase_C2
MAPK1P28482humanSLC9A1P19634S723VItIDPAsPQsPEsV
MAPK1P28482humanPRDX6P30041T177TAEKRVAtPVDWkDG1-cysPrx_C
MAPK1P28482humanESR1P03372S118LHPPPQLsPFLQPHGOest_recep
MAPK1P28482humanMRTFAQ969V6S454tGstPPVsPtPsERS
MAPK1P28482humanSOS1Q07889S1197kAYsPrysISDRTSI
MAPK1P28482humanDAZAP1Q96EP5T315GVPPPPAtPGAAPLA
MAPK1P28482humanGRB10Q13322S150PELCGPGsPPVLtPG
MAPK1P28482humanSLC9A1P19634S785FtPAPsDsPssQRIQ
MAPK1P28482humanMETTL3Q86U44S525YGMIERLsPGTRKIEMT-A70
MAPK1P28482humanSMAD3P84022S208DAGsPNLsPNPMsPA
MAPK1P28482humanRPS6KA3P51812Y529TITKTVEyLHAQGVVPkinase
MAPK1P28482humanNUP153P49790S320QsLEkMssPLADAkRNup153
MAPK1P28482humanESR1P03372S106PLNsVsPsPLMLLHPOest_recep
MAPK1P28482humanADD2P35612S600PAksAPAsPVQsPAK
MAPK1P28482humanKDM4BO94953S352tRPTALTsPELSSWS
MAPK1P28482humanSOS1Q07889S1193QPTSkAYsPrysISD
MAPK1P28482humanALOX5P09917S664QLPYYYLsPDRIPNs
MAPK1P28482humanKDM4BO94953T1065AKRPRVGtPLAtEDS
MAPK1P28482humanTCF3P15923-2S352SSNNFSSsPStPVGs
MAPK1P28482humanCICQ96RK0S1409sAPEDPtsPKRKMRR
MAPK1P28482humanNCF1P14598S345QARPGPQsPGsPLEE
MAPK1P28482humanWTAPQ15007T148ELSAWkFtPDSQTGKWtap
MAPK1P28482humanTGS1Q96RS0S298DLVsFPssPIMVDND
MAPK1P28482humanPOU5F1Q01860S111EsNsDGAsPEPCtVt
MAPK1P28482humanMKNK1Q9BUB5T255ITtPELTtPCGSAEYPkinase
MAPK1P28482humanTOB1P50616S152PASSVSSsPsPPFGH
MAPK1P28482humanADD1P35611S669EEAHRPPsPtEAPTE
MAPK1P28482humanMAPTP10636-8T217sRtPsLPtPPtREPK
MAPK1P28482humanCDCA5Q96FF9S209DMtLPGIsPPPEKQKSororin
MAPK1P28482humanTP53BP2Q13625S827NSDMPAPsPGLDYEP
MAPK1P28482humanMAPKAPK2P49137S9LSNSQGQsPPVPFPA
MAPK1P28482humanRPS3P23396T42sGVEVRVtPTRtEIIKH_2
MAPK1P28482humanAKAP4Q5JQC9T265KERISPRtPAsKIAsAKAP_110
MAPK1P28482humanMDM2Q00987S166SsRRRAIsEtEENsD
MAPK1P28482humanTWIST1Q15672S68GGGDEPGsPAQGkRG
MAPK1P28482humanCTNND1O60716T308DyGtARRtGtPsDPR
MAPK1P28482humanMAPKAPK2P49137T222tSHNsLttPCytPYYPkinase
MAPK1P28482humanESPL1Q14674S1126IAPStNSsPVLKTKP
MAPK1P28482humanMAPTP10636-8T50LkEsPLQtPtEDGsE
MAPK1P28482humanRUNX1Q01196-8S462AEGSHSNsPTNMAPSRunxI
MAPK1P28482humanMED1Q15648T1457HsKsPAytPQNLDsE
MAPK1P28482humanARHGEF2Q92974T679PGVELLLtPREPALP
MAPK1P28482humanTPPPO94811S160GVtKAIssPtVSRLTp25-alpha
MAPK1P28482humanRPS6KA5O75582S360TEMDPTYsPAALPQSPkinase_C
MAPK1P28482humanDLG2Q15700S323KtsLPPIsPGRySPIPDZ_assoc
MAPK1P28482humanEIF4EBP1Q13541T70rNsPVtktPPRDLPteIF_4EBP
MAPK1P28482humanSPHK2Q9NRA0S387PATVEPAsPTPAHSL
MAPK1P28482humanPBKQ96KB5S32PtINIPAsPFMQKLG
MAPK1P28482humanPTPN7P35236T66EPICsVNtPREVTLH
MAPK1P28482humanJUNP05412S73VGLLkLAsPELERLIJun
MAPK1P28482humanSNAI2O43623S104KDHsGSEsPISDEEE
MAPK1P28482humanSREBF1P36956-3S93YPSMPAFsPGPGIKE
MAPK1P28482humanMAP2K1Q02750T286VEGdAAEtPPRPRtPPkinase
MAPK1P28482humanTXNIPQ9H3M7T349HRLEsPttPLLDDMD
MAPK1P28482humanL1CAMP32004S1248NDssGAtsPINPAVA
MAPK1P28482humanHIF1AQ16665S643kILIAsPsPTHIHkE
MAPK1P28482humanFBXW7Q969H0S176KRKLDHGsEVRSFSL
MAPK1P28482humanSMAD3P84022S204NHSMDAGsPNLsPNP
MAPK1P28482humanPDE4DQ08499-4S490YQSTIPQsPSPAPDD
MAPK1P28482humanCCDC88AQ3V6T2S233HASSSAQsPCGsPGM
MAPK1P28482humanCITED2Q99967T175GGSGGSStPGGSGSSCITED
MAPK1P28482humanHSF4Q9ULV5S298LLkEEPAsPGGDGEA
MAPK1P28482humanDYRK1BQ9Y463S421YEPAARIsPLGALQHPkinase
MAPK1P28482humanSOX10P56693T244GPPtPPTtPkTELQS
MAPK1P28482humanMETTL3Q86U44S50sPTFRsDsPVPtAPt
MAPK1P28482humanUSP11P51784S948GssGAPAsPACssPP
MAPK1P28482humanABI1Q8IZP0T394ENIADsPtPPPPPPP
MAPK1P28482humanMCRIP1C9JLW8S21kRtssPRsPPsSsEIFAM195
MAPK1P28482humanNUP153P49790S529sPMFKFSsPIVKsTENup153
MAPK1P28482humanCEP55Q53EZ4S425NREKVAAsPksPtAA
MAPK1P28482humanSNAI1O95863S82ASLRLQEsPRVAELT
MAPK1P28482humanGTF2IP78347-2S627INTKALQsPKRPRsP
MAPK1P28482humanCASP8Q14790S387yLEMDLSsPQTRYIPPeptidase_C14
MAPK1P28482humanPTPRCAPQ14761S163EGDLVLGsPGPASAGPTPRCAP
MAPK1P28482humanDMTNQ08495S90ERsLSPKstsPPPsPAbLIM_anchor
MAPK1P28482humanMAPK1P28482S246HILGILGsPsQEDLNPkinase
MAPK1P28482humanKDM4BO94953S622LGRPPTRsPLsVVKQ
MAPK1P28482humanRORAP35398-4T128PGEAEPLtPTYNISA
MAPK1P28482humanRPTORQ8N122S863LtQsAPAsPtNkGVH
MAPK1P28482humanSTAT5AP42229S780DsLDsRLsPPAGLFT
MAPK1P28482humanMAPTP10636-8T181ktPPAPktPPssGEP
MAPK1P28482humanNR3C2P08235S287SVKsPVSsPNNVTLR
MAPK1P28482humanDNM1LO00429S616PIPIMPAsPQKGHAV
MAPK1P28482humanPOU5F1Q01860S355VSVTtLGsPMHsN__
MAPK1P28482humanRESTQ13127S864TEDLsPPsPPLPKEN
MAPK1P28482humanHECTD3Q5T447T157ARLVPIDtPNHLQRQ
MAPK1P28482humanEGFRP00533T693RELVEPLtPsGEAPN
MAPK1P28482humanMAPKAPK5Q8IW41T182IDQGDLMtPQFtPyYPkinase
MAPK1P28482humanCCDC88AQ3V6T2S237SAQsPCGsPGMKRTE
MAPK1P28482humanMARCKSP29966S46VKVNGDAsPAAAEsGMARCKS
MAPK1P28482humanJUNP05412S63kNsDLLtsPDVGLLkJun
MAPK1P28482humanPMLP29590-4S38EGRQPsPsPsPTERA
MAPK1P28482humanCDK2P24941T160GVPVRtytHEVVtLWPkinase
MAPK1P28482humanFOXO3O43524S344QDDDAPLsPMLYSSS
MAPK1P28482humanPTPN12Q05209S571KtVsLtPsPtTQVEt
MAPK1P28482humanSHOC2Q9UQ13T507GLGENLLtHLPEEIGLRR_8
MAPK1P28482humanABI1Q8IZP0S392VQENIADsPtPPPPP
MAPK1P28482humanGLRA1P23415S408PPPAPSKsPEEMRKL
MAPK1P28482humanMCL1Q07820T163tDGsLPstPPPAEEE
MAPK1P28482humanIRS1P35568S639yMPMsPKsVSAPQQI
MAPK1P28482humanEIF4EBP1Q13541T37PPGDysttPGGtLFseIF_4EBP
MAPK1P28482humanMAPTP10636-8T175AtRIPAktPPAPktP
MAPK1P28482humanRAMACQ9BTL3S36yLKRPPEsPPIVEEWRAM
MAPK1P28482humanABI1Q8IZP0S216VPNDyMtsPARLGsQ
MAPK1P28482humanABI1Q8IZP0T265GIPIAVPtPsPPTIG
MAPK1P28482humanNR3C2P08235S238QGTPLTCsPNVENRG
MAPK1P28482humanDAZAP1Q96EP5T269FTSYIVStPPGGFPP
MAPK1P28482humanBMFQ96LC9S74DKATQTLsPAsPSQGBMF
MAPK1P28482humanRPS6KB1P23443T444RFIGsPRtPVsPVkF
MAPK1P28482humanTOP2AP11388S1354DFVPsDAsPPKTKts
MAPK1P28482humanRPS6KB1P23443S434sFEPKIRsPRRFIGs
MAPK1P28482humanADD1P35611S707GAAADPGsDGsPGKs
MAPK1P28482humanMYCP01106S77LLPtPPLsPsRRsGLMyc_N
MAPK1P28482humanCEP55Q53EZ4S428KVAAsPksPtAALNE
MAPK1P28482humanIL2RBP14784T476PQPLGPPtPGVPDLV
MAPK1P28482humanPCBP2Q15366S173MLETLSQsPPKGVtI
MAPK1P28482humanPGK1P00558S203yFAkALEsPERPFLAPGK
MAPK1P28482humanGORASP2Q9H8Y8T225QMAGtPItPLKDGFT
MAPK1P28482humanMED1Q15648T1032SSSNRPFtPPTsTGG
MAPK1P28482humanARRB2P32121T276FCKVYTItPLLSDNRArrestin_C
MAPK1P28482humanCDKN1BP46527S10NVRVSNGsPsLErMD
MAPK1P28482humanPDX1P52945S61LGALEQGsPPDIsPY
MAPK1P28482humanPARVAQ9NVD7S8MAtsPQKsPsVPKsP
MAPK1P28482humanMAPTP10636-8T212tPGsRsRtPsLPtPP
MAPK1P28482humanMAFAQ8NHW3S65PCSsVPSsPSFCAPS
MAPK1P28482humanPMLP29590-4S36PSEGRQPsPsPsPTE
MAPK1P28482humanERGP11308S96kGGkMVGsPDTVGMN
MAPK1P28482humanCDKN1BP46527S178EENVsDGsPNAGsVE
MAPK1P28482humanERFP50548S161sPtEDPRsPPACssS
MAPK1P28482humanCCNB1P14635S128LVDTAsPsPMETsGC
MAPK1P28482humanMAPKAPK2P49137T25APPPQPPtPALPHPP
MAPK1P28482humanGLI1P08151S130HLSIGTMsPSLGFPA
MAPK1P28482humanRPTORQ8N122S8MESEMLQsPLLGLGE
MAPK1P28482humanNR4A1P22736S431IPGFAELsPADQDLLHormone_recep
MAPK1P28482humanCADP27708T456KVYFLPItPHYVTQV
MAPK1P28482humanSP1P08047T453SGPIIIRtPTVGPNG
MAPK1P28482humanERFP50548S251PLsPFPVsPLAGPGS
MAPK1P28482humanHSF1Q00613S326ssVDtLLsPTALIDsVert_HS_TF
MAPK1P28482humanFBXW7Q969H0T205GLVPCSAtPTTFGDL
MAPK1P28482humanTAB1Q15750S438tPTLTNQsPTLtLQS
MAPK1P28482humanNUP153P49790S334RIPsIVssPLNsPLDNup153
MAPK1P28482humanSOS1Q07889S1132TLPHGPRsAsVssIS
MAPK1P28482humanHDAC6Q9UBN7T1031ASStDHQtPPtsPVQ
MAPK1P28482humanMAPKAPK2P49137T334QstKVPQtPLHtsRV
MAPK1P28482humanNUP214P35658S1710VSSSGFSsPAFGTTA
MAPK1P28482humanCTTNQ14247S418tEErLPssPVyEDAA
MAPK1P28482humanRPS6KA5O75582T581PDNQPLKtPCFTLHYPkinase
MAPK1P28482humanNOXA1Q86UR1S282VGKQAPLsPGLPAMG
MAPK1P28482humanBANPQ8N9N5T352PSEPMMStPPPASEL
MAPK1P28482humanBCL2P10415T56FSSQPGHtPHPAASR
MAPK1P28482humanNUP153P49790T413TGYEkNMtPGQNREQNup153
MAPK1P28482humanPCBP2Q15366S189yRPkPsssPVIFAGG
MAPK1P28482humanWWC1Q8IX03S542sPRSsLSsPSPPCsP
MAPK1P28482humanELK1P19419S383IHFWSTLsPIAPRsP
MAPK1P28482humanGATA6Q92908S266VSARFPYsPsPPMANGATA-N
MAPK1P28482humanTP53P04637S15PsVEPPLsQEtFsDLP53_TAD
MAPK1P28482humanCOPS6Q7L5N1S148QVCEIIEsPLFLkLNJAB
MAPK1P28482humanGLE1Q53GS7S93PKsPDAssAFsPAsP
MAPK1P28482humanTOB1P50616S164FGHSAAVsPTFMPRS
MAPK1P28482humanPMLP29590-4S40RQPsPsPsPTERAPA
MAPK1P28482humanGLI1P08151S102LQTVIRTsPSSLVAF
MAPK1P28482humanADD2P35612S596EPGsPAksAPAsPVQ
MAPK1P28482humanGAB2Q9UQC2S623ALDFQPssPsPHRKP
MAPK1P28482humanEIF4EBP1Q13541T46GGtLFsttPGGtRIIeIF_4EBP
MAPK1P28482humanRPS6KA3P51812Y488DVyDDGKyVYVVTELPkinase
MAPK1P28482humanSH2B1Q9NRF2S96PPILAPLsPGAEIsP
MAPK1P28482humanHIF1AQ16665S641DIkILIAsPsPTHIH
MAPK1P28482humanDAPK1P53355S734NsSRFPPsPLASKPT
MAPK1P28482humanCENPEQ02224S2605KQVtCENsPKsPKVt
MAPK1P28482humanRUNX1Q01196-8S293QYLGSIAsPSVHPAt
MAPK1P28482humanPDE4BQ07343-2S487YQSMIPQsPSPPLDE
MAPK1P28482humanGLE1Q53GS7S92VPKsPDAssAFsPAs
MAPK1P28482humanMAPTP10636-8T205ssPGsPGtPGsRsRt
MAPK1P28482humanMAP2K1Q02750T386IGLNQPstPtHAAGV
MAPK1P28482humanTOP2AP11388S1393GsVPLsssPPAtHFP
MAPK1P28482humanTCF3P15923-2T355NFSSsPStPVGsPQG
MAPK1P28482humanKDM4BO94953T305IDYGkVAtQCTCRKD
MAPK1P28482humanEWSR1Q01844T79QPPTGYTtPTAPQAY
MAPK1P28482humanSOX10P56693T240GQSHGPPtPPTtPkT
MAPK1P28482humanLIN28AQ9H9Z2S200EEEEEIHsPtLLPEA
MAPK1P28482humanERFP50548S246RGGPEPLsPFPVsPL
MAPK1P28482humanMAPTP10636-8S422GsIDMVDsPQLAtLA
MAPK1P28482humanBMFQ96LC9S77TQTLsPAsPSQGVMLBMF
MAPK1P28482humanNUP153P49790S522tsPsstGsPMFKFSsNup153
MAPK1P28482humanEP300Q09472S2039GLGQVGIsPLKPGTVCreb_binding
MAPK1P28482humanMAPTP10636-8S235VVRtPPKsPssAKsR
MAPK1P28482humanYTHDF2Q9Y5A9T381SQAGSGstPsEPHPV
MAPK1P28482humanGLE1Q53GS7S88QPSFVPKsPDAssAF
MAPK1P28482humanSREBF2Q12772S455SIDSEPGsPLLDDAK
MAPK1P28482humanKRT8P05787S432sAyGGLtsPGLsysL
MAPK1P28482humanPGRP06401S294APMAPGRsPLATTVMProg_receptor
MAPK1P28482humanADD1P35611S355kYKAKsRsPGsPVGE
MAPK1P28482humanCDKN1AP38936T57NFDFVtEtPLEGDFACDI
MAPK1P28482humanSMAD2Q15796T220QSNYIPEtPPPGYIS
MAPK1P28482humanEP300Q09472S1038STSATQssPAPGQsk
MAPK1P28482humanTOP2AP11388S1213QMAEVLPsPRGQRVI
MAPK1P28482humanTP53P04637T55DDIEQWFtEDPGPDETAD2
MAPK1P28482humanIER3P46695T18MTILQAPtPAPSTIP
MAPK1P28482humanCEBPBP17676T235SsssPPGtPSPADAK
MAPK1P28482humanBCL6P41182S343KsDCQPNsPTESCSS
MAPK1P28482humanEIF2S1P05198S52MILLsELsRRRIRsIS1
MAPK1P28482humanSORBS3O60504-2S188DGPQLPTsPRLTAAA
MAPK1P28482humanCDCA5Q96FF9S79AVQsPRRsPRIsFFL
MAPK1P28482humanADD2P35612S592tAPEEPGsPAksAPA
MAPK1P28482humanERGP11308S215VDKALQNsPRLMHAR
MAPK1P28482humanDUSP1P28562S296kQRRSIIsPNFSFMGDSPc
MAPK1P28482humanSOS1Q07889S1167EsAPAEssPsKIMSK
MAPK1P28482humanEPAS1Q99814S484SSCSTPNsPEDYYTS
MAPK1P28482humanARP10275S516VSRVPYPsPTCVkSE
MAPK1P28482humanNR5A1Q13285S203EYPEPYAsPPQPGLP
MAPK1P28482humanNANOGQ9H9S0S65MDLLIQDsPDsStsP
MAPK1P28482humanEXOC7Q9UPT5S250sSSGVPysPAIPNKR


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
MAPK1IDDescription0.00e+00
MAPK1GO:1902893regulation of miRNA transcription2.20e-23
MAPK1GO:0061614miRNA transcription2.20e-23
MAPK1GO:2000628regulation of miRNA metabolic process2.22e-21
MAPK1GO:0140747regulation of ncRNA transcription7.94e-21
MAPK1GO:0010586miRNA metabolic process7.94e-21
MAPK1GO:0001666response to hypoxia7.59e-18
MAPK1GO:1902895positive regulation of miRNA transcription2.47e-17
MAPK1GO:0036293response to decreased oxygen levels3.08e-17
MAPK1GO:0070482response to oxygen levels3.74e-17
MAPK1GO:0098781ncRNA transcription5.15e-17
MAPK1GO:2000630positive regulation of miRNA metabolic process8.63e-16
MAPK1GO:0097193intrinsic apoptotic signaling pathway2.83e-15
MAPK1GO:0001701in utero embryonic development1.26e-14
MAPK1GO:0048732gland development5.49e-14
MAPK1GO:0050673epithelial cell proliferation7.86e-14
MAPK1GO:2001233regulation of apoptotic signaling pathway1.23e-13
MAPK1GO:0062197cellular response to chemical stress1.24e-13
MAPK1GO:0030099myeloid cell differentiation1.24e-13
MAPK1GO:0043434response to peptide hormone1.24e-13
MAPK1GO:0048545response to steroid hormone3.24e-13
MAPK1GO:0071456cellular response to hypoxia5.06e-13
MAPK1GO:0036294cellular response to decreased oxygen levels2.00e-12
MAPK1GO:0034599cellular response to oxidative stress3.32e-12
MAPK1GO:0071375cellular response to peptide hormone stimulus3.86e-12
MAPK1GO:0006979response to oxidative stress4.75e-12
MAPK1GO:2001242regulation of intrinsic apoptotic signaling pathway5.61e-12
MAPK1GO:1901653cellular response to peptide5.68e-12
MAPK1GO:0001890placenta development8.30e-12
MAPK1GO:0048511rhythmic process8.84e-12
MAPK1GO:0071453cellular response to oxygen levels9.53e-12
MAPK1GO:0010038response to metal ion1.30e-11
MAPK1GO:0031669cellular response to nutrient levels1.52e-11
MAPK1GO:0031667response to nutrient levels2.27e-11
MAPK1GO:0001892embryonic placenta development3.45e-11
MAPK1GO:0071496cellular response to external stimulus3.48e-11
MAPK1GO:0048863stem cell differentiation7.73e-11
MAPK1GO:0031668cellular response to extracellular stimulus1.42e-10
MAPK1GO:0009410response to xenobiotic stimulus1.56e-10
MAPK1GO:0050678regulation of epithelial cell proliferation2.04e-10
MAPK1GO:1901654response to ketone2.11e-10
MAPK1GO:0008630intrinsic apoptotic signaling pathway in response to DNA damage2.69e-10
MAPK1GO:0030324lung development3.00e-10
MAPK1GO:0030522intracellular receptor signaling pathway3.09e-10
MAPK1GO:0030323respiratory tube development4.17e-10
MAPK1GO:0010821regulation of mitochondrion organization7.86e-10
MAPK1GO:1902894negative regulation of miRNA transcription1.04e-09
MAPK1GO:0000302response to reactive oxygen species1.25e-09
MAPK1GO:2000629negative regulation of miRNA metabolic process1.50e-09
MAPK1GO:0009299mRNA transcription2.02e-09

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Related Drugs to MAPK1_RFT1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning MAPK1-RFT1 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

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Related Diseases to MAPK1_RFT1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate