Ensembl transtripts involved in fusion gene | ENST ids | ENST00000261845, ENST00000558841,
| ENST00000316623, ENST00000561429, ENST00000560355, |
Hgene | Tgene |
MAPK6
Q16659 | FBN1
P35555 |
FUNCTION: Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity). {ECO:0000250}. | FUNCTION: [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues (PubMed:1860873, PubMed:15062093). Fibrillin-1-containing microfibrils provide long-term force bearing structural support (PubMed:27026396). In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin (PubMed:27026396). In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus where they provide tensile strength and have anchoring roles (PubMed:27026396). Fibrillin-1 also plays a key role in tissue homeostasis through specific interactions with growth factors, such as the bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and latent transforming growth factor-beta-binding proteins (LTBPs), cell-surface integrins and other extracellular matrix protein and proteoglycan components (PubMed:27026396). Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively (By similarity). Negatively regulates osteoclastogenesis by binding and sequestering an osteoclast differentiation and activation factor TNFSF11 (PubMed:24039232). This leads to disruption of TNFSF11-induced Ca(2+) signaling and impairment of TNFSF11-mediated nuclear translocation and activation of transcription factor NFATC1 which regulates genes important for osteoclast differentiation and function (PubMed:24039232). Mediates cell adhesion via its binding to cell surface receptors integrins ITGAV:ITGB3 and ITGA5:ITGB1 (PubMed:12807887, PubMed:17158881). Binds heparin and this interaction has an important role in the assembly of microfibrils (PubMed:11461921). {ECO:0000250|UniProtKB:Q61554, ECO:0000269|PubMed:11461921, ECO:0000269|PubMed:12807887, ECO:0000269|PubMed:15062093, ECO:0000269|PubMed:17158881, ECO:0000269|PubMed:1860873, ECO:0000269|PubMed:24039232, ECO:0000303|PubMed:27026396}.; FUNCTION: [Asprosin]: Adipokine secreted by white adipose tissue that plays an important regulatory role in the glucose metabolism of liver, muscle and pancreas (PubMed:27087445, PubMed:30853600). Hormone that targets the liver in response to fasting to increase plasma glucose levels (PubMed:27087445). Binds the olfactory receptor OR4M1 at the surface of hepatocytes and promotes hepatocyte glucose release by activating the protein kinase A activity in the liver, resulting in rapid glucose release into the circulation (PubMed:27087445, PubMed:31230984). May act as a regulator of adaptive thermogenesis by inhibiting browning and energy consumption, while increasing lipid deposition in white adipose tissue (By similarity). Also acts as an orexigenic hormone that increases appetite: crosses the blood brain barrier and exerts effects on the hypothalamus (By similarity). In the arcuate nucleus of the hypothalamus, asprosin directly activates orexigenic AgRP neurons and indirectly inhibits anorexigenic POMC neurons, resulting in appetite stimulation (By similarity). Activates orexigenic AgRP neurons via binding to the olfactory receptor OR4M1 (By similarity). May also play a role in sperm motility in testis via interaction with OR4M1 receptor (By similarity). {ECO:0000250|UniProtKB:Q61554, ECO:0000269|PubMed:27087445, ECO:0000269|PubMed:30853600, ECO:0000269|PubMed:31230984}. |
Kinase | GOID | GO term | P.adjust |
MAPK6 | ID | Description | 0.00e+00 |
MAPK6 | GO:0051302 | regulation of cell division | 4.11e-02 |
MAPK6 | GO:0043696 | dedifferentiation | 4.11e-02 |
MAPK6 | GO:0043697 | cell dedifferentiation | 4.11e-02 |
MAPK6 | GO:2000035 | regulation of stem cell division | 4.11e-02 |
MAPK6 | GO:0051014 | actin filament severing | 4.11e-02 |
MAPK6 | GO:0045618 | positive regulation of keratinocyte differentiation | 4.11e-02 |
MAPK6 | GO:0051016 | barbed-end actin filament capping | 4.11e-02 |
MAPK6 | GO:0045606 | positive regulation of epidermal cell differentiation | 4.11e-02 |
MAPK6 | GO:0017145 | stem cell division | 4.11e-02 |
MAPK6 | GO:2000273 | positive regulation of signaling receptor activity | 4.11e-02 |
MAPK6 | GO:0045684 | positive regulation of epidermis development | 4.11e-02 |
MAPK6 | GO:0071392 | cellular response to estradiol stimulus | 4.11e-02 |
MAPK6 | GO:0060999 | positive regulation of dendritic spine development | 4.11e-02 |
MAPK6 | GO:0045616 | regulation of keratinocyte differentiation | 4.11e-02 |
MAPK6 | GO:0051693 | actin filament capping | 4.11e-02 |
MAPK6 | GO:0030835 | negative regulation of actin filament depolymerization | 4.20e-02 |
MAPK6 | GO:0032467 | positive regulation of cytokinesis | 4.20e-02 |
MAPK6 | GO:1902459 | positive regulation of stem cell population maintenance | 4.20e-02 |
MAPK6 | GO:0030834 | regulation of actin filament depolymerization | 4.20e-02 |
MAPK6 | GO:0060998 | regulation of dendritic spine development | 4.20e-02 |
MAPK6 | GO:0030042 | actin filament depolymerization | 4.20e-02 |
MAPK6 | GO:0045604 | regulation of epidermal cell differentiation | 4.20e-02 |
MAPK6 | GO:0030837 | negative regulation of actin filament polymerization | 4.22e-02 |
MAPK6 | GO:0045682 | regulation of epidermis development | 4.22e-02 |
MAPK6 | GO:1901880 | negative regulation of protein depolymerization | 4.22e-02 |
MAPK6 | GO:0030858 | positive regulation of epithelial cell differentiation | 4.22e-02 |
MAPK6 | GO:2000036 | regulation of stem cell population maintenance | 4.22e-02 |
MAPK6 | GO:0032272 | negative regulation of protein polymerization | 4.24e-02 |
MAPK6 | GO:0043242 | negative regulation of protein-containing complex disassembly | 4.24e-02 |
MAPK6 | GO:1901879 | regulation of protein depolymerization | 4.41e-02 |
MAPK6 | GO:0032465 | regulation of cytokinesis | 4.42e-02 |
MAPK6 | GO:0051781 | positive regulation of cell division | 4.42e-02 |
MAPK6 | GO:0060996 | dendritic spine development | 4.42e-02 |
MAPK6 | GO:0010469 | regulation of signaling receptor activity | 4.90e-02 |
MAPK6 | GO:0032355 | response to estradiol | 4.90e-02 |
MAPK6 | GO:0051261 | protein depolymerization | 4.90e-02 |
MAPK6 | GO:0043244 | regulation of protein-containing complex disassembly | 5.09e-02 |
MAPK6 | GO:0030833 | regulation of actin filament polymerization | 5.48e-02 |
MAPK6 | GO:0031333 | negative regulation of protein-containing complex assembly | 5.62e-02 |
MAPK6 | GO:0008064 | regulation of actin polymerization or depolymerization | 5.62e-02 |
MAPK6 | GO:0030832 | regulation of actin filament length | 5.62e-02 |
MAPK6 | GO:0051494 | negative regulation of cytoskeleton organization | 5.62e-02 |
MAPK6 | GO:0007519 | skeletal muscle tissue development | 5.62e-02 |
MAPK6 | GO:0030041 | actin filament polymerization | 5.62e-02 |
MAPK6 | GO:1902904 | negative regulation of supramolecular fiber organization | 5.62e-02 |
MAPK6 | GO:0030856 | regulation of epithelial cell differentiation | 5.62e-02 |
MAPK6 | GO:0030216 | keratinocyte differentiation | 5.62e-02 |
MAPK6 | GO:0060538 | skeletal muscle organ development | 5.62e-02 |
MAPK6 | GO:0019827 | stem cell population maintenance | 5.62e-02 |