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Kinase Fusion Gene:MAPK6_SCAMP2 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: MAPK6_SCAMP2 | KinaseFusionDB ID: KFG3566 | FusionGDB2.0 ID: KFG3566 | Hgene | Tgene | Gene symbol | MAPK6 | SCAMP2 | Gene ID | 5597 | 10066 | |
| Gene name | mitogen-activated protein kinase 6 | secretory carrier membrane protein 2 | ||||||||||
| Synonyms | ERK3|HsT17250|PRKM6|p97MAPK | - | ||||||||||
| Cytomap | 15q21.2 | 15q24.1 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | mitogen-activated protein kinase 6ERK-3MAP kinase 6MAPK 6extracellular signal-regulated kinase 3extracellular signal-regulated kinase, p97p97-MAPKprotein kinase, mitogen-activated 5protein kinase, mitogen-activated 6 | secretory carrier-associated membrane protein 2testis secretory sperm-binding protein Li 219p | ||||||||||
| Modification date | 20240305 | 20240305 | ||||||||||
| UniProtAcc | Q16659 | O15127 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000261845, ENST00000558841, | ENST00000268099, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: MAPK6 [Title/Abstract] AND SCAMP2 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | MAPK6(52311573)-SCAMP2(75146990), # samples:2 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SCAMP2 | GO:0015031 | protein transport | 15840657 |
| Kinase Fusion gene breakpoints across MAPK6 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across SCAMP2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChimerDB4 | TCGA-HT-A614-01A | MAPK6 | chr15 | 52311573 | SCAMP2 | chr15 | 75146990 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:52311573/:75146990) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAPK6 | SCAMP2 |
| FUNCTION: Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity). {ECO:0000250}. | FUNCTION: Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of MAPK6_SCAMP2 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| MAPK6 | Q16659 | human | NCOA3 | Q9Y6Q9 | S857 | PPYNRAVsLDsPVsV | |
| MAPK6 | Q16659 | human | SVIL | O95425 | S245 | sFtEVPRsPKHAHSS | |
| MAPK6 | Q16659 | human | MAPK6 | Q16659 | S189 | ySHKGHLsEGLVTkW | Pkinase |
| MAPK6 | Q16659 | human | TDP2 | O95551 | S60 | EMERALNsyFEPPVE | UBA_4 |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| MAPK6 | ID | Description | 0.00e+00 |
| MAPK6 | GO:0051302 | regulation of cell division | 4.11e-02 |
| MAPK6 | GO:0043696 | dedifferentiation | 4.11e-02 |
| MAPK6 | GO:0043697 | cell dedifferentiation | 4.11e-02 |
| MAPK6 | GO:2000035 | regulation of stem cell division | 4.11e-02 |
| MAPK6 | GO:0051014 | actin filament severing | 4.11e-02 |
| MAPK6 | GO:0045618 | positive regulation of keratinocyte differentiation | 4.11e-02 |
| MAPK6 | GO:0051016 | barbed-end actin filament capping | 4.11e-02 |
| MAPK6 | GO:0045606 | positive regulation of epidermal cell differentiation | 4.11e-02 |
| MAPK6 | GO:0017145 | stem cell division | 4.11e-02 |
| MAPK6 | GO:2000273 | positive regulation of signaling receptor activity | 4.11e-02 |
| MAPK6 | GO:0045684 | positive regulation of epidermis development | 4.11e-02 |
| MAPK6 | GO:0071392 | cellular response to estradiol stimulus | 4.11e-02 |
| MAPK6 | GO:0060999 | positive regulation of dendritic spine development | 4.11e-02 |
| MAPK6 | GO:0045616 | regulation of keratinocyte differentiation | 4.11e-02 |
| MAPK6 | GO:0051693 | actin filament capping | 4.11e-02 |
| MAPK6 | GO:0030835 | negative regulation of actin filament depolymerization | 4.20e-02 |
| MAPK6 | GO:0032467 | positive regulation of cytokinesis | 4.20e-02 |
| MAPK6 | GO:1902459 | positive regulation of stem cell population maintenance | 4.20e-02 |
| MAPK6 | GO:0030834 | regulation of actin filament depolymerization | 4.20e-02 |
| MAPK6 | GO:0060998 | regulation of dendritic spine development | 4.20e-02 |
| MAPK6 | GO:0030042 | actin filament depolymerization | 4.20e-02 |
| MAPK6 | GO:0045604 | regulation of epidermal cell differentiation | 4.20e-02 |
| MAPK6 | GO:0030837 | negative regulation of actin filament polymerization | 4.22e-02 |
| MAPK6 | GO:0045682 | regulation of epidermis development | 4.22e-02 |
| MAPK6 | GO:1901880 | negative regulation of protein depolymerization | 4.22e-02 |
| MAPK6 | GO:0030858 | positive regulation of epithelial cell differentiation | 4.22e-02 |
| MAPK6 | GO:2000036 | regulation of stem cell population maintenance | 4.22e-02 |
| MAPK6 | GO:0032272 | negative regulation of protein polymerization | 4.24e-02 |
| MAPK6 | GO:0043242 | negative regulation of protein-containing complex disassembly | 4.24e-02 |
| MAPK6 | GO:1901879 | regulation of protein depolymerization | 4.41e-02 |
| MAPK6 | GO:0032465 | regulation of cytokinesis | 4.42e-02 |
| MAPK6 | GO:0051781 | positive regulation of cell division | 4.42e-02 |
| MAPK6 | GO:0060996 | dendritic spine development | 4.42e-02 |
| MAPK6 | GO:0010469 | regulation of signaling receptor activity | 4.90e-02 |
| MAPK6 | GO:0032355 | response to estradiol | 4.90e-02 |
| MAPK6 | GO:0051261 | protein depolymerization | 4.90e-02 |
| MAPK6 | GO:0043244 | regulation of protein-containing complex disassembly | 5.09e-02 |
| MAPK6 | GO:0030833 | regulation of actin filament polymerization | 5.48e-02 |
| MAPK6 | GO:0031333 | negative regulation of protein-containing complex assembly | 5.62e-02 |
| MAPK6 | GO:0008064 | regulation of actin polymerization or depolymerization | 5.62e-02 |
| MAPK6 | GO:0030832 | regulation of actin filament length | 5.62e-02 |
| MAPK6 | GO:0051494 | negative regulation of cytoskeleton organization | 5.62e-02 |
| MAPK6 | GO:0007519 | skeletal muscle tissue development | 5.62e-02 |
| MAPK6 | GO:0030041 | actin filament polymerization | 5.62e-02 |
| MAPK6 | GO:1902904 | negative regulation of supramolecular fiber organization | 5.62e-02 |
| MAPK6 | GO:0030856 | regulation of epithelial cell differentiation | 5.62e-02 |
| MAPK6 | GO:0030216 | keratinocyte differentiation | 5.62e-02 |
| MAPK6 | GO:0060538 | skeletal muscle organ development | 5.62e-02 |
| MAPK6 | GO:0019827 | stem cell population maintenance | 5.62e-02 |
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Related Drugs to MAPK6_SCAMP2 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning MAPK6-SCAMP2 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to MAPK6_SCAMP2 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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