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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:MAPK9_UBL7

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: MAPK9_UBL7
KinaseFusionDB ID: KFG3583
FusionGDB2.0 ID: KFG3583
HgeneTgene
Gene symbol

MAPK9

UBL7

Gene ID

5601

84993

Gene namemitogen-activated protein kinase 9ubiquitin like 7
SynonymsJNK-55|JNK2|JNK2A|JNK2ALPHA|JNK2B|JNK2BETA|PRKM9|SAPK|SAPK1a|p54a|p54aSAPKBMSC-UbP|TCBA1
Cytomap

5q35.3

15q24.1

Type of geneprotein-codingprotein-coding
Descriptionmitogen-activated protein kinase 9Jun kinaseMAP kinase 9MAPK 9c-Jun N-terminal kinase 2c-Jun kinase 2stress-activated protein kinase 1astress-activated protein kinase JNK2ubiquitin-like protein 7ubiquitin-like 7 (bone marrow stromal cell-derived)ubiquitin-like protein SB132
Modification date2024041120240305
UniProtAcc

P45984

Q96S82

Ensembl transtripts involved in fusion geneENST idsENST00000343111, ENST00000347470, 
ENST00000393360, ENST00000425491, 
ENST00000452135, ENST00000455781, 
ENST00000397072, ENST00000524170, 
ENST00000539014, 		ENST00000361351, 
ENST00000395081, ENST00000564488, 
ENST00000565335, ENST00000567435, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: MAPK9 [Title/Abstract] AND UBL7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MAPK9(179718848)-UBL7(74749012), # samples:3
UBL7(74751025)-MAPK9(179707608), # samples:2
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAPK9

GO:0007254

JNK cascade

8654373

HgeneMAPK9

GO:0034614

cellular response to reactive oxygen species

34048572

HgeneMAPK9

GO:0090594

inflammatory response to wounding

27830702

HgeneMAPK9

GO:1900017

positive regulation of cytokine production involved in inflammatory response

8654373


check buttonKinase Fusion gene breakpoints across MAPK9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonKinase Fusion gene breakpoints across UBL7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChimerDB4TCGA-25-1314-01AMAPK9chr5

179718848

UBL7chr15

74749012



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:179718848/:74749012)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAPK9

P45984

UBL7

Q96S82

FUNCTION: Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels. Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption. When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692). Phosphorylates POU5F1, which results in the inhibition of POU5F1's transcriptional activity and enhances its proteasomal degradation (By similarity). {ECO:0000250|UniProtKB:Q9WTU6, ECO:0000269|PubMed:22441692}.; FUNCTION: MAPK9 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to JUN, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.FUNCTION: Interferon-stimulated protein that positively regulates RNA virus-triggered innate immune signaling. Mechanistically, promotes 'Lys-27'-linked polyubiquitination of MAVS through TRIM21 leading to enhanced the IFN signaling pathway. {ECO:0000269|PubMed:19690332}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


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Kinase-Substrate Information of MAPK9_UBL7


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
MAPK9P45984-2humanMFN2O95140S27HMAEVNAsPLkHFVT
MAPK9P45984-2humanSTAT3P40763S727NtIDLPMsPrTLDSL
MAPK9P45984humanYAP1P46937-3T154VVSGPAAtPTAQHLR
MAPK9P45984humanMAPTP10636-8T231KKVAVVRtPPKsPss
MAPK9P45984humanATF2P15336T69sVIVADQtPtPtRFL
MAPK9P45984humanAPPP05067-4T668VEVDAAVtPEERHLsAPP_amyloid
MAPK9P45984humanATF2P15336T71IVADQtPtPtRFLkN
MAPK9P45984humanJDP2Q8WYK2T148VRtDsVKtPEsEGNP
MAPK9P45984humanKLF13Q9Y2Y9S119GAAAAPPsPAWsEPE
MAPK9P45984humanTOB1P50616S154SSVSSsPsPPFGHSA
MAPK9P45984humanYAP1P46937-3T119AGTAGALtPQHVRAH
MAPK9P45984humanNFATC4Q14934S217GLGsPLPsPRAsPRP
MAPK9P45984humanKLF13Q9Y2Y9S123APPsPAWsEPEPEAG
MAPK9P45984humanPDX1P52945S66QGsPPDIsPYEVPPL
MAPK9P45984humanLIMD1Q9UGP4S277RVsPGLPsPNLENGA
MAPK9P45984humanLIMD1Q9UGP4S272TASsQRVsPGLPsPN
MAPK9P45984humanBCL2L1Q07817T115LTSQLHItPGTAYQSBcl-2
MAPK9P45984humanATF2P15336S90GLFNELAsPFENEFk
MAPK9P45984humanTP53P04637S46AMDDLMLsPDDIEQWTAD2
MAPK9P45984humanBAZ1BQ9UIG0S158ksDGACDsPssDKEN
MAPK9P45984humanCDC25CP30307S168SEMKyLGsPIttVPK
MAPK9P45984humanSLC6A4P31645T616IKsItPEtPTEIPCG
MAPK9P45984humanYAP1P46937-3S317GTQNPVSsPGMSQEL
MAPK9P45984humanBIDP55957T59EGyDELQtDGNRsSHBID
MAPK9P45984humanLIMD1Q9UGP4S421LGSVLLDsPssPRVr
MAPK9P45984humanPIN1Q13526S115sQFSDCssAkARGDLRotamase
MAPK9P45984humanPSEN1P49768S319NskyNAEstEREsQDPresenilin
MAPK9P45984humanDCXO43602-2T321TSSSQLStPKSKQsP
MAPK9P45984humanNFATC3Q12968S163SYRESSLsPsPASSI
MAPK9P45984humanBCL2L1Q07817S62PSWHLADsPAVNGAT
MAPK9P45984humanDCXO43602-2S334sPIStPTsPGSLRkH
MAPK9P45984humanCDKN1AP38936S98GGRRPGTsPALLQGT
MAPK9P45984humanFOXO4P98177T451PIPKALGtPVLtPPt
MAPK9P45984humanSREBF1P36956S117YPSMPAFsPGPGIkE
MAPK9P45984humanGORASP1Q9BQQ3S274DPLPGPGsPSHsAPD
MAPK9P45984humanDCXO43602-2T331SKQsPIStPTsPGSL
MAPK9P45984humanMAPTP10636-8S202sGyssPGsPGtPGsR
MAPK9P45984humanMYCP01106S86sRRsGLCsPSyVAVtMyc_N
MAPK9P45984humanPSEN1P49768T320skyNAEstEREsQDTPresenilin
MAPK9P45984humanCDKN1AP38936S130sGEQAEGsPGGPGDs
MAPK9P45984humanRXRAP19793S260NMGLNPssPNDPVtNHormone_recep
MAPK9P45984humanYAP1P46937-3S138SLQLGAVsPGTLTPT
MAPK9P45984humanBCL2L1Q07817T47GTESEMEtPsAINGN
MAPK9P45984humanTOB1P50616S152PASSVSSsPsPPFGH
MAPK9P45984humanMAPTP10636-8T217sRtPsLPtPPtREPK
MAPK9P45984humanNFATC4Q14934S213ASRFGLGsPLPsPRA
MAPK9P45984humanNFATC3Q12968S165RESSLsPsPASSISs
MAPK9P45984humanJUNP05412S73VGLLkLAsPELERLIJun
MAPK9P45984humanTP53P04637S20PLsQEtFsDLWkLLPP53_TAD
MAPK9P45984humanMAPTP10636-8T181ktPPAPktPPssGEP
MAPK9P45984humanMAPKAPK5Q8IW41T182IDQGDLMtPQFtPyYPkinase
MAPK9P45984humanMARCKSP29966S46VKVNGDAsPAAAEsGMARCKS
MAPK9P45984humanJUNP05412S63kNsDLLtsPDVGLLkJun
MAPK9P45984humanMYCP01106S77LLPtPPLsPsRRsGLMyc_N
MAPK9P45984humanCDK4P11802T172YSYQMALtPVVVTLWPkinase
MAPK9P45984humanPDX1P52945S61LGALEQGsPPDIsPY
MAPK9P45984humanMAPTP10636-8T212tPGsRsRtPsLPtPP
MAPK9P45984humanTAB1Q15750S438tPTLTNQsPTLtLQS
MAPK9P45984humanMAPK8IP1Q9UQF2T103LIDAtGDtPGAEDDE
MAPK9P45984humanLIMD1Q9UGP4S424VLLDsPssPRVrLPC
MAPK9P45984humanTOB1P50616S164FGHSAAVsPTFMPRS
MAPK9P45984humanFOXO4P98177T455ALGtPVLtPPtEAAS
MAPK9P45984humanRRN3Q9NYV6T200IARYVPstPWFLMPIRRN3
MAPK9P45984humanCDKN1AP38936T57NFDFVtEtPLEGDFACDI
MAPK9P45984humanYAP1P46937-3T362SSySVPRtPDDFLNS
MAPK9P45984humanAPLP2Q06481T736VEVDPMLtPEERHLNAPP_amyloid


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
MAPK9IDDescription0.00e+00
MAPK9GO:1902893regulation of miRNA transcription5.24e-08
MAPK9GO:0061614miRNA transcription5.24e-08
MAPK9GO:2000628regulation of miRNA metabolic process1.24e-07
MAPK9GO:0097193intrinsic apoptotic signaling pathway1.24e-07
MAPK9GO:0140747regulation of ncRNA transcription1.34e-07
MAPK9GO:0010586miRNA metabolic process2.85e-07
MAPK9GO:2001233regulation of apoptotic signaling pathway6.02e-07
MAPK9GO:0098781ncRNA transcription1.32e-06
MAPK9GO:0009299mRNA transcription7.25e-06
MAPK9GO:0010332response to gamma radiation7.25e-06
MAPK9GO:1902895positive regulation of miRNA transcription7.28e-06
MAPK9GO:0006839mitochondrial transport8.18e-06
MAPK9GO:2001242regulation of intrinsic apoptotic signaling pathway8.18e-06
MAPK9GO:1902749regulation of cell cycle G2/M phase transition9.85e-06
MAPK9GO:2000630positive regulation of miRNA metabolic process1.54e-05
MAPK9GO:0072594establishment of protein localization to organelle1.57e-05
MAPK9GO:0071480cellular response to gamma radiation1.94e-05
MAPK9GO:0050673epithelial cell proliferation2.04e-05
MAPK9GO:2001234negative regulation of apoptotic signaling pathway2.99e-05
MAPK9GO:0044839cell cycle G2/M phase transition3.85e-05
MAPK9GO:0051402neuron apoptotic process6.69e-05
MAPK9GO:0071478cellular response to radiation8.68e-05
MAPK9GO:0008630intrinsic apoptotic signaling pathway in response to DNA damage1.04e-04
MAPK9GO:0010389regulation of G2/M transition of mitotic cell cycle1.10e-04
MAPK9GO:0034504protein localization to nucleus1.13e-04
MAPK9GO:0042789mRNA transcription by RNA polymerase II1.13e-04
MAPK9GO:0048144fibroblast proliferation1.13e-04
MAPK9GO:1901987regulation of cell cycle phase transition1.13e-04
MAPK9GO:0044772mitotic cell cycle phase transition1.37e-04
MAPK9GO:2001243negative regulation of intrinsic apoptotic signaling pathway1.38e-04
MAPK9GO:0007006mitochondrial membrane organization1.73e-04
MAPK9GO:0070482response to oxygen levels1.77e-04
MAPK9GO:0031667response to nutrient levels1.77e-04
MAPK9GO:1901990regulation of mitotic cell cycle phase transition2.10e-04
MAPK9GO:0046902regulation of mitochondrial membrane permeability2.67e-04
MAPK9GO:0010212response to ionizing radiation2.88e-04
MAPK9GO:0043470regulation of carbohydrate catabolic process2.88e-04
MAPK9GO:0000086G2/M transition of mitotic cell cycle3.00e-04
MAPK9GO:1904019epithelial cell apoptotic process3.35e-04
MAPK9GO:0001701in utero embryonic development3.41e-04
MAPK9GO:0097284hepatocyte apoptotic process3.51e-04
MAPK9GO:0006979response to oxidative stress3.71e-04
MAPK9GO:0071479cellular response to ionizing radiation3.78e-04
MAPK9GO:0010821regulation of mitochondrion organization3.86e-04
MAPK9GO:0007178transmembrane receptor protein serine/threonine kinase signaling pathway4.06e-04
MAPK9GO:0090559regulation of membrane permeability4.65e-04
MAPK9GO:0006606protein import into nucleus4.78e-04
MAPK9GO:0009314response to radiation5.03e-04
MAPK9GO:0048143astrocyte activation5.05e-04

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Related Drugs to MAPK9_UBL7


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning MAPK9-UBL7 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

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Related Diseases to MAPK9_UBL7


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate