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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:MAPKAPK2_IKBKE

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: MAPKAPK2_IKBKE
KinaseFusionDB ID: KFG3589
FusionGDB2.0 ID: KFG3589
HgeneTgene
Gene symbol

MAPKAPK2

IKBKE

Gene ID

9261

9641

Gene nameMAPK activated protein kinase 2inhibitor of nuclear factor kappa B kinase subunit epsilon
SynonymsMAPKAP-K2|MK-2|MK2IKK-E|IKK-i|IKKE|IKKI
Cytomap

1q32.1

1q32.1

Type of geneprotein-codingprotein-coding
DescriptionMAP kinase-activated protein kinase 2MAPKAP kinase 2mitogen-activated protein kinase-activated protein kinase 2inhibitor of nuclear factor kappa-B kinase subunit epsilonI-kappa-B kinase epsilonIKK-epsilonIKK-related kinase epsiloninducible I kappa-B kinaseinducible IkappaB kinaseinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
Modification date2024030520240407
UniProtAcc

P49137

Q14164

Ensembl transtripts involved in fusion geneENST idsENST00000294981, ENST00000367103, 
ENST00000479009, 		ENST00000367120, 
ENST00000537984, ENST00000463979, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: MAPKAPK2 [Title/Abstract] AND IKBKE [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAPKAPK2

GO:0018105

peptidyl-serine phosphorylation

15850461

HgeneMAPKAPK2

GO:0032680

regulation of tumor necrosis factor production

15014438

HgeneMAPKAPK2

GO:0034097

response to cytokine

8774846

HgeneMAPKAPK2

GO:0070935

3'-UTR-mediated mRNA stabilization

14517288|15014438|20932473

TgeneIKBKE

GO:0032481

positive regulation of type I interferon production

12692549

TgeneIKBKE

GO:0043123

positive regulation of canonical NF-kappaB signal transduction

10882136

TgeneIKBKE

GO:0060340

positive regulation of type I interferon-mediated signaling pathway

24882218


check buttonKinase Fusion gene breakpoints across MAPKAPK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonKinase Fusion gene breakpoints across IKBKE (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
CCLERERF-LC-Sq1MAPKAPK2chr1

206858853

IKBKEchr1

206664152



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:/:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAPKAPK2

P49137

IKBKE

Q14164

FUNCTION: Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Phosphorylates HSF1; leading to the interaction with HSP90 proteins and inhibiting HSF1 homotrimerization, DNA-binding and transactivation activities (PubMed:16278218). Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to the dissociation of HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impairment of their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins ELAVL1, HNRNPA0, PABPC1 and TTP/ZFP36, leading to the regulation of the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity, leading to inhibition of dependent degradation of ARE-containing transcripts. Phosphorylates CEP131 in response to cellular stress induced by ultraviolet irradiation which promotes binding of CEP131 to 14-3-3 proteins and inhibits formation of novel centriolar satellites (PubMed:26616734). Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and phosphorylates HNRNPA0 and PARN, leading to stabilization of GADD45A mRNA. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. {ECO:0000269|PubMed:10383393, ECO:0000269|PubMed:11844797, ECO:0000269|PubMed:12456657, ECO:0000269|PubMed:12565831, ECO:0000269|PubMed:14499342, ECO:0000269|PubMed:14517288, ECO:0000269|PubMed:15014438, ECO:0000269|PubMed:15629715, ECO:0000269|PubMed:16278218, ECO:0000269|PubMed:16456544, ECO:0000269|PubMed:17481585, ECO:0000269|PubMed:18021073, ECO:0000269|PubMed:20932473, ECO:0000269|PubMed:26616734, ECO:0000269|PubMed:8093612, ECO:0000269|PubMed:8280084, ECO:0000269|PubMed:8774846}.FUNCTION: Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at 'Ser-708'. Phosphorylation of STAT1 at 'Ser-708' seems also to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Phosphorylates AKT1. {ECO:0000269|PubMed:17568778, ECO:0000269|PubMed:18583960, ECO:0000269|PubMed:19153231, ECO:0000269|PubMed:20188669, ECO:0000269|PubMed:21138416, ECO:0000269|PubMed:21464307, ECO:0000269|PubMed:22532683, ECO:0000269|PubMed:23453969, ECO:0000269|PubMed:23478265}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


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Kinase-Substrate Information of MAPKAPK2_IKBKE


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
IKBKEQ14164humanPELI1Q96FA3T80DQHsIsYtLsRAQtVPellino
IKBKEQ14164humanNFATC1O95644S324NALTTDSsLDLGDGV
IKBKEQ14164humanIRF3Q14653S386ARVGGAssLENtVDL
IKBKEQ14164humanIRF1P10914S219FQVsPMPsTsEATTD
IKBKEQ14164humanPELI1Q96FA3T288QCPVGFNtLAFPsMkPellino
IKBKEQ14164humanIRF7Q92985S477VssLDSSsLsLCLsS
IKBKEQ14164humanAKT1P31749S473RPHFPQFsysAsGtAPkinase_C
IKBKEQ14164humanIRF1P10914S215DLYNFQVsPMPsTsE
IKBKEQ14164humanNFATC1O95644S151VLPSSKRsPstATLs
IKBKEQ14164humanIRF3Q14653S398VDLHIsNsHPLsLts
IKBKEQ14164humanCDK2AP1O14519S46LSDYGPPsLGYTQGTCDK2AP
IKBKEQ14164humanIRF1P10914S221VsPMPsTsEATTDED
IKBKEQ14164humanYAP1P46937S419tPDDFLNsVDEMDTG
IKBKEQ14164humanDDX3XO00571S102rFDDrGrsDyDGIGs
IKBKEQ14164humanPBXIP1Q96AQ6S147REEGRCsssDDDtDV
IKBKEQ14164humanRELAQ04206S536sGDEDFSsIADMDFS
IKBKEQ14164humanIRF7Q92985S479sLDSSsLsLCLsSAN
IKBKEQ14164humanRELAQ04206S468AVFTDLAsVDNsEFQ
IKBKEQ14164humanIKBKEQ14164T501ELRSRLRtLAEVLSRTBK1_CCD1
IKBKEQ14164humanIRF3Q14653S402IsNsHPLsLtsDQYK
IKBKEQ14164humanNFKBIAP25963S32LLDDRHDsGLDsMkD
IKBKEQ14164humanFOXO3O43524S644GLDFNFDsLISTQNVFOXO-TAD
IKBKEQ14164humanGSK3AP49840S21sGrARtssFAEPGGG
IKBKEQ14164humanASB8Q9H765S17QSIQSKYsLSERLIR
IKBKEQ14164humanNFKBIAP25963S36RHDsGLDsMkDEEyE
IKBKEQ14164humanHTTP42858S13kLMkAFEsLksFQQQ
IKBKEQ14164humanIRF3Q14653S396NtVDLHIsNsHPLsL
IKBKEQ14164humanTRAF2Q12933S11AsVtPPGsLELLQPG
IKBKEQ14164humanIRF7Q92985S471GTQREGVssLDSSsL
IKBKEQ14164humanRIGIO95786S855PKPkQFssFEkRAKIRIG-I_C-RD
IKBKEQ14164humanNFATC1O95644S161tATLsLPsLEAYRDP
IKBKEQ14164humanFERMT2Q96AC1S159KkkLDDQsEDEALEL
IKBKEQ14164humanESR1P03372S167GGRERLAsTNDkGSMOest_recep
IKBKEQ14164humanNFATC1O95644S117DGAPALEsPRIEITS
IKBKEQ14164humanIRF7Q92985S472TQREGVssLDSSsLs
IKBKEQ14164humanPELI1Q96FA3S293FNtLAFPsMkRkDVVPellino
IKBKEQ14164humanXIAPP98170S430QDESSQtsLQkEIst
IKBKEQ14164humanPELI1Q96FA3S76IsNKDQHsIsYtLsRPellino
IKBKEQ14164humanSTAT2P52630T404IWDFGYLtLVEQRSGSTAT_bind
IKBKEQ14164humanAKT1P31749T308kDGAtMKtFCGtPEyPkinase
IKBKEQ14164humanFAF1Q9UNN5S556EREAIRLsLEQALPP
MAPKAPK2P49137humanTAB3Q8N5C8S506HKYQRsSsSGSDDyA
MAPKAPK2P49137humanCDC25BP30305S169VLRNItNsQAPDGRRM-inducer_phosp
MAPKAPK2P49137humanPOU5F1Q01860S93PQGGLEtsQPEGEAG
MAPKAPK2P49137humanHNRNPA0Q13151S84VELkRAVsREDsARP
MAPKAPK2P49137humanGJA1P17302S255HAtsGALsPAkDCGs
MAPKAPK2P49137humanHSPB1P04792S78PAysRALsRQLssGV
MAPKAPK2P49137humanLIMK1P53667S323KDLGrSEsLRVVCRP
MAPKAPK2P49137humanWNK4Q96J92S575PFLFRHAsYSSTTSD
MAPKAPK2P49137humanCREB1P16220S119EILsRRPsyRkILNDpKID
MAPKAPK2P49137humanRCSD1Q6JBY9S179RRFRRsQsDCGELGDCAP-ZIP_m
MAPKAPK2P49137humanMRTFAQ969V6S333CGLARQNstsLtGKP
MAPKAPK2P49137humanYWHAZP63104S58VVGARRssWRVVssI14-3-3
MAPKAPK2P49137humanAGO2Q9UKV8S387SkLMRsAsFNtDPyVArgoL2
MAPKAPK2P49137humanBAG2O95816S20GRFCRSSsMADRSSR
MAPKAPK2P49137humanPOU5F1Q01860S111EsNsDGAsPEPCtVt
MAPKAPK2P49137humanMDM2Q00987S157SHLVSRPstSsRRRA
MAPKAPK2P49137humanRBM7Q9Y580S204QrkVrMNsyPYLADr
MAPKAPK2P49137humanMDM2Q00987S166SsRRRAIsEtEENsD
MAPKAPK2P49137humanEEF2KO00418S377PPLLRPLsENsGDEN
MAPKAPK2P49137humanTHP07101-4S44RFIGRRQsLIEDARKTOH_N
MAPKAPK2P49137humanKRT18P05783S53IsVsrstsFrGGMGs
MAPKAPK2P49137humanNELFEP18615S51GGVkRsLsEQPVMDt
MAPKAPK2P49137humanRBM7Q9Y580S136QIIQRsFssPENFQr
MAPKAPK2P49137humanMAPKAPK2P49137T338VPQtPLHtsRVLKED
MAPKAPK2P49137humanZFP36L1Q07352S92RFRDRsFsEGGERLLTis11B_N
MAPKAPK2P49137humanRTN4Q9NQC3-2S107VAPERQPsWDPSPVS
MAPKAPK2P49137humanPLK1P53350S326LTIPPRFsIAPssLD
MAPKAPK2P49137humanCEP131Q9UPN4S47kPIVRsVsVVTGsEQ
MAPKAPK2P49137humanRCSD1Q6JBY9S244PPLRRsPsRTEKQEERCSD
MAPKAPK2P49137humanAKT1P31749S473RPHFPQFsysAsGtAPkinase_C
MAPKAPK2P49137humanARPC5O15511S77AVKDrAGsIVLKVLIP16-Arc
MAPKAPK2P49137humanTP53P04637S20PLsQEtFsDLWkLLPP53_TAD
MAPKAPK2P49137humanTRIM29Q14134S550GyPsLMRsQsPkAQP
MAPKAPK2P49137humanHSPA1LP34931S241DFDNRLVsHFVEEFKHSP70
MAPKAPK2P49137humanRPS6KA3P51812S386HQLFRGFsFVAItsDPkinase_C
MAPKAPK2P49137humanCDC25BP30305S323QRLFRsPsMPCsVIRM-inducer_phosp
MAPKAPK2P49137humanZFP36L1Q07352S203PRLQHsFsFAGFPSA
MAPKAPK2P49137humanTHP07101-3S19KGFRRAVsELDAKQATOH_N
MAPKAPK2P49137humanPLK1P53350S383DMLQQLHsVNAskPS
MAPKAPK2P49137humanPARNO95453S557NHyYRNNsFTAPsTV
MAPKAPK2P49137humanDDX5P17844S198CRACRLkstCIyGGADEAD
MAPKAPK2P49137humanTHP07101-2S19KGFRRAVsELDAKQATOH_N
MAPKAPK2P49137humanTHP07101-2S67RFIGRRQsLIEDARKTOH_N
MAPKAPK2P49137humanRPS6KA1Q15418S380HQLFRGFsFVAtGLMPkinase_C
MAPKAPK2P49137humanGJA1P17302S279sSPtAPLsPMsPPGy
MAPKAPK2P49137humanCEP131Q9UPN4S78NNLRRsNsttQVSQP
MAPKAPK2P49137humanDAZLQ92904S65SFFARYGsVkEVKIIRRM_1
MAPKAPK2P49137humanRIPK1Q13546S320AVVkRMQsLQLdCVA
MAPKAPK2P49137humanZFP36L1Q07352S54GGFPRRHsVtLPSSkTis11B_N
MAPKAPK2P49137humanNELFEP18615S251GPFRRsDsFPERRAP
MAPKAPK2P49137humanCOPS5Q92905S177IDPTRTIsAGkVNLG
MAPKAPK2P49137humanTHP07101-4S19KGFRRAVsELDAKQATOH_N
MAPKAPK2P49137humanSRFP11831S103RGLKRsLsEMEIGMV
MAPKAPK2P49137humanTRIM28Q13263S473sGVkRsRsGEGEVsG
MAPKAPK2P49137humanGJA1P17302S282tAPLsPMsPPGykLV
MAPKAPK2P49137humanTHP07101S71RFIGRRQsLIEDARKTOH_N
MAPKAPK2P49137humanNELFEP18615S115QPFQRsIsADDDLQE
MAPKAPK2P49137humanLSP1P33241S252PKLARQAsIELPsMACaldesmon
MAPKAPK2P49137humanPDE4DQ08499-6S133sFLYRSDsDYDLSPk
MAPKAPK2P49137humanPIAS1O75925S522DTSYINTsLIQDYRH
MAPKAPK2P49137humanTHP07101-3S404GELLHCLsEEPEIRABiopterin_H
MAPKAPK2P49137humanALOX5P09917S272CsLERQLsLEQEVQQLipoxygenase
MAPKAPK2P49137humanMRTFAQ969V6S312tPPVRsLstTNSsSS
MAPKAPK2P49137humanAATFQ9NY61T366FTVYRNRtLQkWHDKAATF-Che1
MAPKAPK2P49137humanHSPB1P04792S15FsLLrGPsWDPFrDW
MAPKAPK2P49137humanCDC25BP30305S375ARVLRsksLCHDEIEM-inducer_phosp
MAPKAPK2P49137humanTRIM29Q14134S552PsLMRsQsPkAQPQT
MAPKAPK2P49137humanHSF1Q00613S121NIkRkVtsVSTLksE
MAPKAPK2P49137humanBCL2L1Q07817S62PSWHLADsPAVNGAT
MAPKAPK2P49137humanPFKFB3Q16875S461NPLMRRNsVtPLAsP
MAPKAPK2P49137humanTSC2P49815S1254TALyksLsVPAASTA
MAPKAPK2P49137humanTHP07101S19KGFRRAVsELDAKQATOH_N
MAPKAPK2P49137humanCDC25CP30307S216sGLyRsPsMPENLNRM-inducer_phosp
MAPKAPK2P49137humanTHP07101-3S40RFIGRRQsLIEDARKTOH_N
MAPKAPK2P49137humanBECN1Q14457S90IPPARMMstEsANsF
MAPKAPK2P49137humanKRT20P35900S13RSFHRsLsSSLQAPV
MAPKAPK2P49137humanHSPB1P04792S82RALsRQLssGVsEIr
MAPKAPK2P49137humanCDC25BP30305S353VQNkRRRsVtPPEEQM-inducer_phosp


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
IKBKEIDDescription0.00e+00
IKBKEGO:0045088regulation of innate immune response9.57e-13
IKBKEGO:0045089positive regulation of innate immune response6.51e-11
IKBKEGO:0002221pattern recognition receptor signaling pathway6.51e-11
IKBKEGO:0002833positive regulation of response to biotic stimulus8.49e-11
IKBKEGO:0002758innate immune response-activating signaling pathway8.49e-11
IKBKEGO:0002218activation of innate immune response1.56e-10
IKBKEGO:0032481positive regulation of type I interferon production6.15e-10
IKBKEGO:0031349positive regulation of defense response8.95e-10
IKBKEGO:0002753cytosolic pattern recognition receptor signaling pathway1.08e-09
IKBKEGO:0030522intracellular receptor signaling pathway1.08e-09
IKBKEGO:0007249canonical NF-kappaB signal transduction8.33e-09
IKBKEGO:0002757immune response-activating signaling pathway1.42e-08
IKBKEGO:0032479regulation of type I interferon production1.42e-08
IKBKEGO:0032606type I interferon production1.42e-08
IKBKEGO:0001819positive regulation of cytokine production2.06e-08
IKBKEGO:0002764immune response-regulating signaling pathway2.06e-08
IKBKEGO:0097191extrinsic apoptotic signaling pathway2.29e-08
IKBKEGO:2001236regulation of extrinsic apoptotic signaling pathway6.47e-08
IKBKEGO:0032728positive regulation of interferon-beta production1.08e-07
IKBKEGO:0060759regulation of response to cytokine stimulus1.63e-07
IKBKEGO:0032608interferon-beta production6.96e-07
IKBKEGO:0032648regulation of interferon-beta production6.96e-07
IKBKEGO:0071356cellular response to tumor necrosis factor8.75e-07
IKBKEGO:0060760positive regulation of response to cytokine stimulus1.22e-06
IKBKEGO:0032727positive regulation of interferon-alpha production1.26e-06
IKBKEGO:0062207regulation of pattern recognition receptor signaling pathway1.29e-06
IKBKEGO:0051090regulation of DNA-binding transcription factor activity1.29e-06
IKBKEGO:0034612response to tumor necrosis factor1.29e-06
IKBKEGO:0038061non-canonical NF-kappaB signal transduction1.30e-06
IKBKEGO:0043122regulation of canonical NF-kappaB signal transduction1.41e-06
IKBKEGO:0009615response to virus1.96e-06
IKBKEGO:0032607interferon-alpha production2.45e-06
IKBKEGO:0032647regulation of interferon-alpha production2.45e-06
IKBKEGO:0001959regulation of cytokine-mediated signaling pathway2.63e-06
IKBKEGO:0043123positive regulation of canonical NF-kappaB signal transduction5.57e-06
IKBKEGO:0051607defense response to virus5.57e-06
IKBKEGO:0140546defense response to symbiont5.57e-06
IKBKEGO:2001237negative regulation of extrinsic apoptotic signaling pathway5.57e-06
IKBKEGO:0140888interferon-mediated signaling pathway8.01e-06
IKBKEGO:0033209tumor necrosis factor-mediated signaling pathway9.38e-06
IKBKEGO:0060338regulation of type I interferon-mediated signaling pathway9.67e-06
IKBKEGO:2001233regulation of apoptotic signaling pathway1.60e-05
IKBKEGO:1903320regulation of protein modification by small protein conjugation or removal1.66e-05
IKBKEGO:0051091positive regulation of DNA-binding transcription factor activity1.66e-05
IKBKEGO:0043331response to dsRNA2.53e-05
IKBKEGO:0070534protein K63-linked ubiquitination2.66e-05
IKBKEGO:0001961positive regulation of cytokine-mediated signaling pathway2.99e-05
IKBKEGO:1901873regulation of post-translational protein modification3.69e-05
IKBKEGO:0070431nucleotide-binding oligomerization domain containing 2 signaling pathway5.29e-05

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Related Drugs to MAPKAPK2_IKBKE


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning MAPKAPK2-IKBKE and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

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Related Diseases to MAPKAPK2_IKBKE


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate