| Kinase Fusion partner gene information | Kinase Fusion gene name: MARK3_ENTPD5 |
KinaseFusionDB ID: KFG3644 | FusionGDB2.0 ID: KFG3644 | | Hgene | Tgene | Gene symbol | MARK3 | ENTPD5 | Gene ID | 4140 | 957 | | Gene name | microtubule affinity regulating kinase 3 | ectonucleoside triphosphate diphosphohydrolase 5 (inactive) |
| Synonyms | CTAK1|KP78|PAR1A|Par-1a|VIPB | CD39L4|NTPDase-5|PCPH |
| Cytomap | 14q32.32-q32.33 | 14q24.3 |
| Type of gene | protein-coding | protein-coding |
| Description | MAP/microtubule affinity-regulating kinase 3C-TAK1ELKL motif kinase 2EMK-2cdc25C-associated protein kinase 1protein kinase STK10ser/Thr protein kinase PAR-1serine/threonine-protein kinase p78 | nucleoside diphosphate phosphatase ENTPD5CD39 antigen-like 4CD39-like 4ER-UDPaseGDPase ENTPD5NTPDase 5Pcph proto-oncogene proteinUDPase ENTPD5guanosine-diphosphatase ENTPD5inosine diphosphate phosphatase ENTPD5nucleoside diphosphataseproto-onco |
| Modification date | 20240407 | 20240305 |
| UniProtAcc | P27448 | O75356 |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000216288, ENST00000303622,
ENST00000335102, ENST00000416682,
ENST00000429436, ENST00000440884,
ENST00000553942, ENST00000561071,
| ENST00000334696, ENST00000554664,
ENST00000556242, ENST00000557325,
|
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: MARK3 [Title/Abstract] AND ENTPD5 [Title/Abstract] AND fusion [Title/Abstract] |
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | MARK3(103946827)-ENTPD5(74482633), # samples:2
|
 Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Kinase Fusion gene breakpoints across MARK3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Kinase Fusion gene breakpoints across ENTPD5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene information. |
Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChimerDB4 | TCGA-18-3411-01A | MARK3 | chr14 | 103946827 | ENTPD5 | chr14 | 74482633 |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length
(transcript) | Seq length
(amino acids) |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq
|
Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:103946827/:74482633)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene. |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
MARK3
P27448 | ENTPD5
O75356 |
| FUNCTION: Serine/threonine-protein kinase (PubMed:16822840, PubMed:16980613, PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216' (PubMed:12941695). Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol (PubMed:16822840). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714). Phosphorylates PKP2 and KSR1 (PubMed:12941695). {ECO:0000269|PubMed:12941695, ECO:0000269|PubMed:16822840, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:28087714}. | FUNCTION: Hydrolyzes nucleoside diphosphates with a preference for GDP, IDP and UDP compared to ADP and CDP (PubMed:15698960, PubMed:10400613). In the lumen of the endoplasmic reticulum, hydrolyzes UDP that acts as an end-product feedback inhibitor of the UDP-Glc:glycoprotein glucosyltransferases. UMP can be transported back by an UDP-sugar antiporter to the cytosol where it is consumed to regenerate UDP-glucose. Therefore, it positively regulates protein reglucosylation by clearing UDP from the ER lumen and by promoting the regeneration of UDP-glucose. Protein reglucosylation is essential to proper glycoprotein folding and quality control in the ER (By similarity). {ECO:0000250|UniProtKB:Q9WUZ9, ECO:0000269|PubMed:10400613, ECO:0000269|PubMed:15698960}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at download page * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
Phosphorylation target of the kinase
(phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| MARK3 | P27448-3 | human | MARK3 | P27448-3 | S601 | SQTRsRGstNLFsKL | |
| MARK3 | P27448-3 | human | MARK3 | P27448-3 | S598 | TPLSQTRsRGstNLF | |
| MARK3 | P27448-3 | human | MARK3 | P27448-3 | S606 | RGstNLFsKLTSKLT | |
| MARK3 | P27448-3 | human | MARK3 | P27448-3 | T602 | QTRsRGstNLFsKLT | |
| MARK3 | P27448 | human | MEF2C | Q06413 | S222 | GYGNPRNsPGLLVsP | |
| MARK3 | P27448 | human | PPP1R2 | P41236 | S72 | LMKIDEPstPyHSMM | IPP-2 |
| MARK3 | P27448 | human | CDC25C | P30307 | S216 | sGLyRsPsMPENLNR | M-inducer_phosp |
| MARK3 | P27448 | human | TNK1 | Q13470 | S502 | RMKGIsRsLEsVLsL | |
| MARK3 | P27448 | human | FEZ1 | Q99689 | S58 | SEIISFKsMEDLVNE | FEZ |
| MARK3 | P27448 | human | ARHGEF2 | Q92974 | S151 | LsLAksVsttNIAGH | |
Biological Network Integration of This Kinase and Substrates
(GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Distribution of the number of studies mentioning MARK3-ENTPD5 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024) |
Diseases associated with fusion partners.
(DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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