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Kinase Fusion Gene:MCF2L_GRK1 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: MCF2L_GRK1 | KinaseFusionDB ID: KFG3728 | FusionGDB2.0 ID: KFG3728 | Hgene | Tgene | Gene symbol | MCF2L | GRK1 | Gene ID | 23263 | 6011 | |
| Gene name | MCF.2 cell line derived transforming sequence like | G protein-coupled receptor kinase 1 | ||||||||||
| Synonyms | ARHGEF14|DBS|OST | GPRK1|RHOK|RK | ||||||||||
| Cytomap | 13q34 | 13q34 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | guanine nucleotide exchange factor DBSDBL's big sisterMCF2 transforming sequence-like protein | rhodopsin kinase GRK1 | ||||||||||
| Modification date | 20240403 | 20240411 | ||||||||||
| UniProtAcc | O15068 | Q15835 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000375608, ENST00000397036, ENST00000442652, ENST00000375597, ENST00000375601, ENST00000375604, ENST00000397021, ENST00000397024, ENST00000397030, ENST00000421756, ENST00000423482, ENST00000434480, ENST00000480321, ENST00000535094, | ENST00000545304, ENST00000335678, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: MCF2L [Title/Abstract] AND GRK1 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | MCF2L(113556685)-GRK1(114435857), # samples:2 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | GRK1 | GO:0022400 | regulation of opsin-mediated signaling pathway | 15946941 |
| Kinase Fusion gene breakpoints across MCF2L (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across GRK1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChimerDB4 | TCGA-09-0364-01A | MCF2L | chr13 | 113556685 | GRK1 | chr13 | 114435857 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:113556685/:114435857) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MCF2L | GRK1 |
| FUNCTION: Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways (By similarity). Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42 (PubMed:15157669). {ECO:0000250|UniProtKB:Q63406, ECO:0000269|PubMed:15157669}.; FUNCTION: [Isoform 3]: Does not catalyze guanine nucleotide exchange on CDC42 (PubMed:15157669). {ECO:0000269|PubMed:15157669}. | FUNCTION: Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade (PubMed:15946941). This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination (By similarity). May play a role in the maintenance of the outer nuclear layer in the retina (By similarity). {ECO:0000250|UniProtKB:Q9WVL4, ECO:0000269|PubMed:15946941}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of MCF2L_GRK1 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| GRK1 | Q15835 | human | FFAR4 | Q5NUL3-1 | S366 | GAILtDtsVKRNDLs | |
| GRK1 | Q15835 | human | OPRK1 | P41145 | S358 | RMERQSTsRVRNTVQ | |
| GRK1 | Q15835 | human | FFAR4 | Q5NUL3-1 | T363 | PEKGAILtDtsVKRN | |
| GRK1 | Q15835 | human | FFAR4 | Q5NUL3-1 | S373 | sVKRNDLsIIsG___ |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| GRK1 | ID | Description | 0.00e+00 |
| GRK1 | GO:0046888 | negative regulation of hormone secretion | 2.09e-03 |
| GRK1 | GO:0007200 | phospholipase C-activating G protein-coupled receptor signaling pathway | 2.99e-03 |
| GRK1 | GO:1903531 | negative regulation of secretion by cell | 3.47e-03 |
| GRK1 | GO:0051048 | negative regulation of secretion | 3.47e-03 |
| GRK1 | GO:0046883 | regulation of hormone secretion | 5.32e-03 |
| GRK1 | GO:1903532 | positive regulation of secretion by cell | 5.32e-03 |
| GRK1 | GO:0046879 | hormone secretion | 5.32e-03 |
| GRK1 | GO:0051047 | positive regulation of secretion | 5.32e-03 |
| GRK1 | GO:0009914 | hormone transport | 5.32e-03 |
| GRK1 | GO:0051051 | negative regulation of transport | 9.19e-03 |
| GRK1 | GO:0043410 | positive regulation of MAPK cascade | 9.19e-03 |
| GRK1 | GO:0023061 | signal release | 9.19e-03 |
| GRK1 | GO:0032275 | luteinizing hormone secretion | 1.09e-02 |
| GRK1 | GO:0042711 | maternal behavior | 1.09e-02 |
| GRK1 | GO:2000253 | positive regulation of feeding behavior | 1.09e-02 |
| GRK1 | GO:0032276 | regulation of gonadotropin secretion | 1.09e-02 |
| GRK1 | GO:0038003 | G protein-coupled opioid receptor signaling pathway | 1.09e-02 |
| GRK1 | GO:0060746 | parental behavior | 1.09e-02 |
| GRK1 | GO:0033605 | positive regulation of catecholamine secretion | 1.12e-02 |
| GRK1 | GO:0046541 | saliva secretion | 1.16e-02 |
| GRK1 | GO:0048148 | behavioral response to cocaine | 1.16e-02 |
| GRK1 | GO:0043950 | positive regulation of cAMP-mediated signaling | 1.16e-02 |
| GRK1 | GO:0044849 | estrous cycle | 1.16e-02 |
| GRK1 | GO:0090336 | positive regulation of brown fat cell differentiation | 1.16e-02 |
| GRK1 | GO:0032274 | gonadotropin secretion | 1.16e-02 |
| GRK1 | GO:0050872 | white fat cell differentiation | 1.16e-02 |
| GRK1 | GO:0048520 | positive regulation of behavior | 1.59e-02 |
| GRK1 | GO:0090335 | regulation of brown fat cell differentiation | 1.59e-02 |
| GRK1 | GO:0060259 | regulation of feeding behavior | 1.60e-02 |
| GRK1 | GO:0050951 | sensory perception of temperature stimulus | 1.60e-02 |
| GRK1 | GO:0043949 | regulation of cAMP-mediated signaling | 1.66e-02 |
| GRK1 | GO:1900745 | positive regulation of p38MAPK cascade | 1.72e-02 |
| GRK1 | GO:0014059 | regulation of dopamine secretion | 1.74e-02 |
| GRK1 | GO:0042755 | eating behavior | 1.74e-02 |
| GRK1 | GO:0044058 | regulation of digestive system process | 1.74e-02 |
| GRK1 | GO:1901381 | positive regulation of potassium ion transmembrane transport | 1.74e-02 |
| GRK1 | GO:0044060 | regulation of endocrine process | 1.74e-02 |
| GRK1 | GO:0014046 | dopamine secretion | 1.74e-02 |
| GRK1 | GO:0051954 | positive regulation of amine transport | 1.74e-02 |
| GRK1 | GO:0032941 | secretion by tissue | 1.74e-02 |
| GRK1 | GO:0019098 | reproductive behavior | 1.74e-02 |
| GRK1 | GO:0032691 | negative regulation of interleukin-1 beta production | 1.74e-02 |
| GRK1 | GO:0043268 | positive regulation of potassium ion transport | 1.74e-02 |
| GRK1 | GO:0050912 | detection of chemical stimulus involved in sensory perception of taste | 1.74e-02 |
| GRK1 | GO:0090278 | negative regulation of peptide hormone secretion | 1.74e-02 |
| GRK1 | GO:1900744 | regulation of p38MAPK cascade | 1.74e-02 |
| GRK1 | GO:0002792 | negative regulation of peptide secretion | 1.74e-02 |
| GRK1 | GO:0042220 | response to cocaine | 1.82e-02 |
| GRK1 | GO:0032692 | negative regulation of interleukin-1 production | 1.84e-02 |
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Related Drugs to MCF2L_GRK1 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning MCF2L-GRK1 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to MCF2L_GRK1 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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