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	Kinase Fusion Gene Summary
	Kinase Fusion Gene Sample Information
	Kinase Fusion ORF Analysis
	Kinase Fusion Amino Acid Sequences
	Multiple Sequence Alignment of All Fusion Protein Isoforms
	Kinase Fusion Protein Functional Features
	Kinase Fusion Protein Structures
	Comparison of Fusion Protein Isoforms
	Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB
	pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.
	Ramachandran Plot of Kinase Fusion Protein Structure
	Potential Active Site Information
	Virtual Screening Results
	Kinase-Substrate Information
	Related Drugs with This Kinase Fusion Protein
	Related Disease with This Kinase Fusion Protein
	Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:MED24_ERBB2

Kinase Fusion Protein Summary

Kinase Fusion gene summary

Kinase Fusion partner gene information	Kinase Fusion gene name: MED24_ERBB2
	KinaseFusionDB ID: KFG3755
	FusionGDB2.0 ID: KFG3755
		Hgene	Tgene
	Gene symbol	MED24	ERBB2
	Gene ID	9862	2064
	Gene name	mediator complex subunit 24	erb-b2 receptor tyrosine kinase 2
	Synonyms	ARC100\|CRSP100\|CRSP4\|DRIP100\|MED5\|THRAP4\|TRAP100	CD340\|HER-2\|HER-2/neu\|HER2\|MLN 19\|MLN-19\|NEU\|NGL\|TKR1\|VSCN2\|c-ERB-2\|c-ERB2\|p185(erbB2)
	Cytomap	17q21.1	17q12
	Type of gene	protein-coding	protein-coding
	Description	mediator of RNA polymerase II transcription subunit 24CRSP complex subunit 4activator-recruited cofactor 100 kDa componentcofactor required for Sp1 transcriptional activation subunit 4cofactor required for Sp1 transcriptional activation, subunit 4, 10	receptor tyrosine-protein kinase erbB-2c-erb B2/neu proteinherstatinhuman epidermal growth factor receptor 2metastatic lymph node gene 19 proteinneuro/glioblastoma derived oncogene homologneuroblastoma/glioblastoma derived oncogene homologproto-onc
	Modification date	20240407	20240416
	UniProtAcc	O75448	Q96RT1
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000356271, ENST00000394126, ENST00000394127, ENST00000394128, ENST00000501516, ENST00000479829,	ENST00000269571, ENST00000445658, ENST00000540042, ENST00000540147, ENST00000578199, ENST00000584450, ENST00000584888, ENST00000406381, ENST00000541774, ENST00000584601,
Context (manual curation of fusion genes in KinaseFusionDB)	PubMed: MED24 [Title/Abstract] AND ERBB2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	MED24(38188901)-ERBB2(37868574), # samples:1 MED24(38185078)-ERBB2(37865570), # samples:1

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MED24	GO:0045893	positive regulation of DNA-templated transcription	10198638
Hgene	MED24	GO:0060261	positive regulation of transcription initiation by RNA polymerase II	12218053
Tgene	ERBB2	GO:0007165	signal transduction	10572067
Tgene	ERBB2	GO:0007166	cell surface receptor signaling pathway	9685399
Tgene	ERBB2	GO:0007169	cell surface receptor protein tyrosine kinase signaling pathway	7514177\|7556068
Tgene	ERBB2	GO:0018108	peptidyl-tyrosine phosphorylation	12000754
Tgene	ERBB2	GO:0032886	regulation of microtubule-based process	20937854
Tgene	ERBB2	GO:0035556	intracellular signal transduction	19372587
Tgene	ERBB2	GO:0038134	ERBB2-EGFR signaling pathway	8702723
Tgene	ERBB2	GO:0042060	wound healing	12646923
Tgene	ERBB2	GO:0043406	positive regulation of MAP kinase activity	10572067
Tgene	ERBB2	GO:0043491	phosphatidylinositol 3-kinase/protein kinase B signal transduction	7556068
Tgene	ERBB2	GO:0045785	positive regulation of cell adhesion	7556068
Tgene	ERBB2	GO:0050679	positive regulation of epithelial cell proliferation	10572067
Tgene	ERBB2	GO:0071363	cellular response to growth factor stimulus	20010870
Tgene	ERBB2	GO:0090314	positive regulation of protein targeting to membrane	20010870

Kinase Fusion gene breakpoints across MED24 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Kinase Fusion gene breakpoints across ERBB2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Kinase Fusion Gene Sample Information

Kinase Fusion gene information.

Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Sample	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
ChimerDB4	TCGA-HU-A4G6	MED24	chr17	38185078	ERBB2	chr17	37865570
ChimerDB4	TCGA-BH-A1EV	MED24	chr17	38188901	ERBB2	chr17	37868574

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Kinase Fusion ORF Analysis

Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (amino acids)
ENST00000356271	ENST00000584601	MED24	chr17	38188901	ERBB2	chr17	37868574	4045	911
ENST00000394127	ENST00000584601	MED24	chr17	38185078	ERBB2	chr17	37865570	5120	1107

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Kinase Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

>ENST00000356271_ENST00000584601_MED24_chr17_38188901_ERBB2_chr17_37868574_length(amino acids)=911
MGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGR
ILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPG
PTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIW
KFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSG
AMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTV
QLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKV
PIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVS
EFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLE
PSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPRE
GPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAE

--------------------------------------------------------------

>ENST00000394127_ENST00000584601_MED24_chr17_38185078_ERBB2_chr17_37865570_length(amino acids)=1107
MKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHE
QCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGT
QRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDS
LPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEG
LACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVA
RCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMR
RLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVG
SPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLAR
LLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKC
WMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHR
SSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPE
YVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPP

--------------------------------------------------------------

Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:38188901/chr17:37868574)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MED24 O75448	ERBB2 Q96RT1
FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269\|PubMed:12218053, ECO:0000269\|PubMed:16595664}.	FUNCTION: Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). {ECO:0000269\|PubMed:10878805, ECO:0000269\|PubMed:16203728}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).

Partner

Hgeneene

Hbp

Tgeneene

Tbp

ENST

BPexon

TotalExon

Protein feature loci

BPloci

TotalLen

Feature

Note

- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).

Partner

Hgeneene

Hbp

Tgeneene

Tbp

ENST

BPexon

TotalExon

Protein feature loci

BPloci

TotalLen

Feature

Note

Tgene

MED24

38185078

ERBB2

37865570

ENST00000394127

720_987

131

1241

Domain

Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159

Tgene

MED24

38185078

ERBB2

37865570

ENST00000394127

720_987

146

1256

Domain

Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159

Tgene

MED24

38188901

ERBB2

37868574

ENST00000356271

720_987

325

1241

Domain

Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159

Tgene

MED24

38188901

ERBB2

37868574

ENST00000356271

720_987

340

1256

Domain

Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159

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Kinase Fusion Protein Structures

CIF files of the predicted kinase fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Kinase Fusion protein CIF link (fusion AA seq ID in KinaseFusionDB)	Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	AA seq	Len(AA seq)
PDB file >>>305_MED24_ERBB2	ENST00000394127	ENST00000584601	MED24	chr17	38185078	ERBB2	chr17	37865570	MKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHE QCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGT QRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDS LPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEG LACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVA RCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMR RLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVG SPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLAR LLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKC WMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHR SSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPE YVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPP	1107
3D view using mol* of 305_MED24_ERBB2

PDB file >>>TKFP_529_MED24_ERBB2	ENST00000356271	ENST00000584601	MED24	chr17	38188901	ERBB2	chr17	37868574	MGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGR ILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPG PTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIW KFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSG AMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTV QLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKV PIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVS EFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSSSTRSGGGDLTLGLE PSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPRE GPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAE	911_MED24_ERBB2
PDB file >>>TKFP_530_MED24_ERBB2	ENST00000394127	ENST00000584601	MED24	chr17	38185078	ERBB2	chr17	37865570	MKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHE QCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGT QRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDS LPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEG LACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVA RCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMR RLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVG SPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLAR LLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKC WMIDSECRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHR SSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPE YVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYWDQDPP	1107_MED24_ERBB2
3D view using mol* of TKFP_530_MED24_ERBB2

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Comparison of Fusion Protein Isoforms

Superimpose the 3D Structures Among All Fusion Protein Isoforms
* Download the pdb file and open it from the molstar online viewer.

3D view using mol* of viewer/superimpose_isoforms/TKFP_529_MED24_ERBB2_vs_TKFP_530_MED24_ERBB2_superimposed.pdb.html

Comparison of the Secondary Structures of Fusion Protein Isoforms

./secondary_str/TKFP_530_MED24_ERBB2_vs_TKFP_529_MED24_ERBB2.png

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

MED24_ERBB2 does not have any known PDB structures.

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pLDDT score distribution

all_data/KinaseFusionDB_T_Results/KinaseFusionDB_T_ViolinPlots/305_MED24_ERBB2.pngall_data/KinaseFusionDB_T_Results/KinaseFusionDB_T_ViolinPlots/TKFP_530_MED24_ERBB2_updated_violin_plot.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
* The blue color at the bottom marks the best active site residues.

305_MED24_ERBB2.png

TKFP_530_MED24_ERBB2.png

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Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Kinase Fusion AA seq ID in KinaseFusionDB	Site score	Size	Dscore	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
TKFP_530_MED24_ERBB2	1.014	747	1.019	2321.767	0.581	0.719	0.893	0.526	1.08	0.487	0.932	Chain A: 1,2,23,24,26,27,28,29,30,31,57,64,65,66,6 8,69,78,92,93,94,108,553,554,555,556,557,559,560,5 61,562,563,564,578,579,580,581,582,583,586,603,605 ,607,608,609,610,611,612,614,615,617,618,619,620,6 21,622,624,625,626,627,628,629,630,635,636,637,645 ,646,648,650,651,652,653,655,656,657,659,660,661,6 63,664,665,687,691,693,696,697,699,700,701,702,704 ,714,715,716,717,718,719,720,721,722,723,725,726,7 27,728,729,730,731,732,733,734,735,736,737,738,739 ,740,751,766,771,772,773,774,776,777,778,779,780,7 81,854,856,1091,1092,1093,1094,1095,1096,1097,1100 ,1101,1102

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Ramachandran Plot of Kinase Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

305_MED24_ERBB2_ramachandran.png

TKFP_530_MED24_ERBB2_ramachandran.png

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Virtual Screening Results

Distribution of the average docking score across all approved kinase inhibitors.
Distribution of the number of occurrence across all approved kinase inhibitors.

5'-kinase fusion protein case

3'-kinase fusion protein case

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Drug information from DrugBank of the top 20 interacting small molecules.
* The detailed information of individual kinase inhibitors are available in the download page.

Fusion gene name info

Drug

Docking score

Glide g score

Glide energy

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Kinase-Substrate Information of MED24_ERBB2

Phosphorylation target of the kinase
(phosphosite, 03-17-2024)

Kinase	Kinase UniProt Acc	Kinase species	Substrate	Substrate UniProt Acc	Substrate phosphorylated residues	Substrate phosphorylated sites (+/-7AA)	Domain
ERBB2	P04626	human	BBC3	Q9BXH1	Y172	PsPWRVLyNLIMGLL	PUMA
ERBB2	P04626	human	ERBB2	P04626	Y1222	PAFDNLyyWDQDPPE
ERBB2	P04626	human	DOCK7	Q96N67	Y1257	METVPQLyDFTETHN
ERBB2	P04626	human	BBC3	Q9BXH1	Y58	PTLLPAAyLCAPTAP	PUMA
ERBB2	P04626	human	ERBB2	P04626	Y1023	DLVDAEEyLVPQQGF
ERBB2	P04626	human	PLXNB1	O43157	Y1708	DSVGEPLyMLFRGIK	Plexin_cytopl
ERBB2	P04626	human	BBC3	Q9BXH1	Y152	ADDLNAQyERRRQEE	PUMA
ERBB2	P04626	human	PLXNB1	O43157	Y1732	SVtGKAKyTLNDNRL	Plexin_cytopl
ERBB2	P04626	human	ERBB2	P04626	Y877	LDIDEtEyHADGGkV	PK_Tyr_Ser-Thr
ERBB2	P04626	human	CTNNB1	P35222	Y654	RNEGVAtyAAAVLFR
ERBB2	P04626	human	ERBB2	P04626	Y1112	DPsPLQRySEDPTVP
ERBB2	P04626	human	ERBB2	P04626	Y1221	sPAFDNLyyWDQDPP
ERBB2	P04626	human	ERBB2	P04626	Y1248	PtAENPEyLGLDVPV
ERBB2	P04626	human	ERBB2	P04626	Y1139	tCsPQPEyVNQPDVR
ERBB2	P04626	human	CDK1	P06493	Y15	EkIGEGtyGVVykGR	Pkinase
ERBB2	P04626	human	LDHA	P00338	Y10	tLkDQLIyNLLkEEQ
ERBB2	P04626	human	ERBB2	P04626	Y1196	GAVENPEyLtPQGGA

Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

Enriched GO biological processes of the phosphorylation target genes of the kinase

Kinase	GOID	GO term	P.adjust
ERBB2	ID	Description	0.00e+00
ERBB2	GO:0090316	positive regulation of intracellular protein transport	1.24e-02
ERBB2	GO:0032388	positive regulation of intracellular transport	1.24e-02
ERBB2	GO:0033157	regulation of intracellular protein transport	1.24e-02
ERBB2	GO:0043547	positive regulation of GTPase activity	1.24e-02
ERBB2	GO:0010001	glial cell differentiation	1.24e-02
ERBB2	GO:0043087	regulation of GTPase activity	1.48e-02
ERBB2	GO:0051222	positive regulation of protein transport	1.48e-02
ERBB2	GO:1904951	positive regulation of establishment of protein localization	1.48e-02
ERBB2	GO:0032386	regulation of intracellular transport	1.48e-02
ERBB2	GO:0042063	gliogenesis	1.48e-02
ERBB2	GO:0050767	regulation of neurogenesis	2.05e-02
ERBB2	GO:0045685	regulation of glial cell differentiation	2.10e-02
ERBB2	GO:0007405	neuroblast proliferation	2.10e-02
ERBB2	GO:0007422	peripheral nervous system development	2.10e-02
ERBB2	GO:0007409	axonogenesis	2.11e-02
ERBB2	GO:0033077	T cell differentiation in thymus	2.11e-02
ERBB2	GO:0051960	regulation of nervous system development	2.11e-02
ERBB2	GO:0045995	regulation of embryonic development	2.11e-02
ERBB2	GO:1903829	positive regulation of protein localization	2.11e-02
ERBB2	GO:0050808	synapse organization	2.11e-02
ERBB2	GO:1905477	positive regulation of protein localization to membrane	2.21e-02
ERBB2	GO:0048709	oligodendrocyte differentiation	2.21e-02
ERBB2	GO:0048144	fibroblast proliferation	2.21e-02
ERBB2	GO:2001252	positive regulation of chromosome organization	2.21e-02
ERBB2	GO:1902106	negative regulation of leukocyte differentiation	2.21e-02
ERBB2	GO:1903707	negative regulation of hemopoiesis	2.40e-02
ERBB2	GO:0007098	centrosome cycle	3.15e-02
ERBB2	GO:0042552	myelination	3.21e-02
ERBB2	GO:0007272	ensheathment of neurons	3.21e-02
ERBB2	GO:0008366	axon ensheathment	3.21e-02
ERBB2	GO:0031023	microtubule organizing center organization	3.41e-02
ERBB2	GO:0061351	neural precursor cell proliferation	3.67e-02
ERBB2	GO:1905475	regulation of protein localization to membrane	3.67e-02
ERBB2	GO:0042129	regulation of T cell proliferation	3.67e-02
ERBB2	GO:2001242	regulation of intrinsic apoptotic signaling pathway	3.67e-02
ERBB2	GO:0007416	synapse assembly	3.67e-02
ERBB2	GO:0042098	T cell proliferation	3.67e-02
ERBB2	GO:0050679	positive regulation of epithelial cell proliferation	3.67e-02
ERBB2	GO:0007411	axon guidance	3.67e-02
ERBB2	GO:0097485	neuron projection guidance	3.67e-02
ERBB2	GO:0050670	regulation of lymphocyte proliferation	3.67e-02
ERBB2	GO:0032944	regulation of mononuclear cell proliferation	3.67e-02
ERBB2	GO:0050769	positive regulation of neurogenesis	3.67e-02
ERBB2	GO:0033002	muscle cell proliferation	3.67e-02
ERBB2	GO:0033044	regulation of chromosome organization	3.67e-02
ERBB2	GO:0045930	negative regulation of mitotic cell cycle	3.67e-02
ERBB2	GO:0097305	response to alcohol	3.67e-02
ERBB2	GO:0045927	positive regulation of growth	3.67e-02
ERBB2	GO:0007440	foregut morphogenesis	3.67e-02

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Related Drugs to MED24_ERBB2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Distribution of the number of studies mentioning MED24-ERBB2 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1

Fusion gene - drug pair 2

PMID

Publication date

DOI

Study title

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Related Diseases to MED24_ERBB2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)

MeSH ID

MeSH term

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Clinical Trials of the Found Drugs/Small Molecules

Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion Gene

Kinase Inhibitor

NCT ID

Study Status

Phases

Disease

# Enrolment

Date