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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:METRN_TRPM7

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: METRN_TRPM7
KinaseFusionDB ID: KFG3818
FusionGDB2.0 ID: KFG3818
HgeneTgene
Gene symbol

METRN

TRPM7

Gene ID

79006

54822

Gene namemeteorin, glial cell differentiation regulatortransient receptor potential cation channel subfamily M member 7
SynonymsC16orf23|c380A1.2ALSPDC|CHAK|CHAK1|LTRPC7|LTrpC-7|TRP-PLIK
Cytomap

16p13.3

15q21.2

Type of geneprotein-codingprotein-coding
Descriptionmeteorintransient receptor potential cation channel subfamily M member 7LTRPC ion channel family member 7channel-kinase 1long transient receptor potential channel 7transient receptor potential-phospholipase C-interacting kinase
Modification date2024030520240411
UniProtAcc

Q9UJH8

Q96QT4

Ensembl transtripts involved in fusion geneENST idsENST00000568223, ENST00000568415, 
ENST00000313478, ENST00000560955, 
ENST00000561443, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: METRN [Title/Abstract] AND TRPM7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)METRN(769655)-TRPM7(50910540), # samples:1
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonKinase Fusion gene breakpoints across METRN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonKinase Fusion gene breakpoints across TRPM7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChiTaRS5.0BF526337METRNchr16

769655

TRPM7chr15

50910540



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:769655/:50910540)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
METRN

Q9UJH8

TRPM7

Q96QT4

FUNCTION: Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. Also induces axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia (By similarity). {ECO:0000250}.FUNCTION: Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium (PubMed:35561741). Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1). {ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:24316671, ECO:0000269|PubMed:35561741}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


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Kinase-Substrate Information of METRN_TRPM7


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
TRPM7Q96QT4humanMYH9P35579S1808VKskykAsItALEAkMyosin_tail_1
TRPM7Q96QT4humanTRPM7Q96QT4T1482VssLAGFtDCHRTsI
TRPM7Q96QT4humanTRPM7Q96QT4S1258AQkAsEAsKVHNEIt
TRPM7Q96QT4humanTRPM7Q96QT4S1287DDGPVRPsVWKKHGV
TRPM7Q96QT4humanTRPM7Q96QT4T1537EMPsEEGtLNGLtsP
TRPM7Q96QT4humanTRPM7Q96QT4S1404PPTKFFVstPsQPsC
TRPM7Q96QT4humanTRPM7Q96QT4S1387KNQKLGssSTsIPHL
TRPM7Q96QT4humanTRPM7Q96QT4T1405PTKFFVstPsQPsCK
TRPM7Q96QT4humanPLCG2P16885T1045LQPESMRtEkyDPMP
TRPM7Q96QT4humanANXA1P04083S5___MAMVsEFLKQAW
TRPM7Q96QT4humanPLCG2P16885S1164AVKSGFRsVPLKNGYC2
TRPM7Q96QT4humanTRPM7Q96QT4S1390KLGssSTsIPHLssP
TRPM7Q96QT4humanTRPM7Q96QT4T1435KATEGDNtEFGAFVG
TRPM7Q96QT4humanTRPM7Q96QT4T1265sKVHNEItRELsIsK
TRPM7Q96QT4humanTRPM7Q96QT4T1542EGtLNGLtsPFKPAM
TRPM7Q96QT4humanTRPM7Q96QT4S1463sNKIKILsNNNTsEN
TRPM7Q96QT4humanEEF2KO00418S78ssGsPANsFHFkEAW
TRPM7Q96QT4humanTRPM7Q96QT4T1685QRAAQKLtFAFNQMKAlpha_kinase
TRPM7Q96QT4humanTMOD1P28289S2______MsyRRELEK
TRPM7Q96QT4humanTRPM7Q96QT4S1851LNLQPGNsTKESEST
TRPM7Q96QT4humanTRPM7Q96QT4S1358SSGALFPsAVsPPEL
TRPM7Q96QT4humanTMOD1P28289T54GLRQKDQtTKAPTGPTropomodulin
TRPM7Q96QT4humanTRPM7Q96QT4S1695FNQMKPKsIPYSPRFAlpha_kinase
TRPM7Q96QT4humanTRPM7Q96QT4S1468ILsNNNTsENtLkRV
TRPM7Q96QT4humanTRPM7Q96QT4S1543GtLNGLtsPFKPAMD
TRPM7Q96QT4humanTRPM7Q96QT4S1660EVVNTWSsIYKEDTVAlpha_kinase
TRPM7Q96QT4humanTRPM7Q96QT4S1193DDKFHsGsEERIRVT
TRPM7Q96QT4humanTRPM7Q96QT4S1477NtLkRVssLAGFtDC
TRPM7Q96QT4humanTRPM7Q96QT4S1860KESESTNsVRLML__
TRPM7Q96QT4humanTRPM7Q96QT4T1471NNNTsENtLkRVssL
TRPM7Q96QT4humanTRPM7Q96QT4S1569NLMRLsQsIPFTPVP
TRPM7Q96QT4humanTRPM7Q96QT4T1583PPRGEPVtVYRLEES
TRPM7Q96QT4humanTRPM7Q96QT4T1830DLKRNDYtPDkIIFP
TRPM7Q96QT4humanTRPM7Q96QT4S1615CAKIEFLsKEEMGGG
TRPM7Q96QT4humanTRPM7Q96QT4S1446AFVGHRDsMDLQRFK
TRPM7Q96QT4humanMYH9P35579S1803EMEGtVKskykAsItMyosin_tail_1
TRPM7Q96QT4humanTRPM7Q96QT4S1456LQRFKEtsNKIKILs
TRPM7Q96QT4humanTRPM7Q96QT4S1255TLTAQkAsEAsKVHN
TRPM7Q96QT4humanTRPM7Q96QT4T1455DLQRFKEtsNKIKIL
TRPM7Q96QT4humanTRPM7Q96QT4S1779GENLTDPsVIKAEEKAlpha_kinase
TRPM7Q96QT4humanTRPM7Q96QT4T1163DGPkLFLtEEDQkKL
TRPM7Q96QT4humanTRPM7Q96QT4S1476ENtLkRVssLAGFtD
TRPM7Q96QT4humanTRPM7Q96QT4S1598SPNILNNsMSSWSQL
TRPM7Q96QT4humanTRPM7Q96QT4S1567RNNLMRLsQsIPFTP
TRPM7Q96QT4humanTRPM7Q96QT4S1191EKDDKFHsGsEERIR
TRPM7Q96QT4humanTRPM7Q96QT4T1551PFKPAMDtNYYYSAV
TRPM7Q96QT4humanTRPM7Q96QT4S1493RTsIPVHsKQAEKIs
TRPM7Q96QT4humanTRPM7Q96QT4S1533PsNREMPsEEGtLNG
TRPM7Q96QT4humanTRPM7Q96QT4T1505KIsRRPstEDtHEVD
TRPM7Q96QT4humanTRPM7Q96QT4S1271ItRELsIsKHLAQNL
TRPM7Q96QT4humanMYH9P35579T1800kLQEMEGtVKskykAMyosin_tail_1
TRPM7Q96QT4humanTRPM7Q96QT4T1508RRPstEDtHEVDsKA
TRPM7Q96QT4humanTRPM7Q96QT4S1407KFFVstPsQPsCKsH
TRPM7Q96QT4humanTRPM7Q96QT4S1513EDtHEVDsKAALIPD
TRPM7Q96QT4humanTRPM7Q96QT4S1527DWLQDRPsNREMPsE


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
TRPM7IDDescription0.00e+00
TRPM7GO:0031032actomyosin structure organization7.27e-03
TRPM7GO:0006909phagocytosis7.27e-03
TRPM7GO:0022604regulation of cell morphogenesis7.27e-03
TRPM7GO:0032743positive regulation of interleukin-2 production7.27e-03
TRPM7GO:0006911phagocytosi9.84e-05
TRPM7GO:0010631epithelial cell migration8.26e-03
TRPM7GO:0090132epithelium migration8.26e-03
TRPM7GO:0090130tissue migration8.26e-03
TRPM7GO:0032623interleukin-2 production8.26e-03
TRPM7GO:0032663regulation of interleukin-2 production8.26e-03
TRPM7GO:0010324membrane invagination8.26e-03
TRPM7GO:1902808positive regulation of cell cycle G1/S phase transition8.26e-03
TRPM7GO:0042060wound healing9.39e-03
TRPM7GO:1903131mononuclear cell differentiation1.20e-02
TRPM7GO:0071277cellular response to calcium ion1.20e-02
TRPM7GO:0001667ameboidal-type cell migration1.24e-02
TRPM7GO:1901989positive regulation of cell cycle phase transition2.00e-02
TRPM7GO:0030168platelet activation2.36e-02
TRPM7GO:0008360regulation of cell shape2.48e-02
TRPM7GO:0051592response to calcium ion2.50e-02
TRPM7GO:0045807positive regulation of endocytosis2.76e-02
TRPM7GO:0010634positive regulation of epithelial cell migration3.40e-02
TRPM7GO:0043534blood vessel endothelial cell migration3.45e-02
TRPM7GO:1902075cellular response to salt3.88e-02
TRPM7GO:0071248cellular response to metal ion3.88e-02
TRPM7GO:1902806regulation of cell cycle G1/S phase transition4.07e-02
TRPM7GO:0002285lymphocyte activation involved in immune response4.08e-02
TRPM7GO:0007596blood coagulation4.18e-02
TRPM7GO:0050817coagulation4.18e-02
TRPM7GO:0071241cellular response to inorganic substance4.18e-02
TRPM7GO:0007599hemostasis4.18e-02
TRPM7GO:0002274myeloid leukocyte activation4.33e-02
TRPM7GO:0032984protein-containing complex disassembly4.33e-02
TRPM7GO:0090068positive regulation of cell cycle process4.33e-02
TRPM7GO:0002699positive regulation of immune effector process4.33e-02
TRPM7GO:0044843cell cycle G1/S phase transition4.33e-02
TRPM7GO:0032429regulation of phospholipase A2 activity4.33e-02
TRPM7GO:0033034positive regulation of myeloid cell apoptotic process4.33e-02
TRPM7GO:0043542endothelial cell migration4.33e-02
TRPM7GO:0030100regulation of endocytosis4.33e-02
TRPM7GO:0007343egg activation4.33e-02
TRPM7GO:0031340positive regulation of vesicle fusion4.33e-02
TRPM7GO:0045625regulation of T-helper 1 cell differentiation4.33e-02
TRPM7GO:0010632regulation of epithelial cell migration4.33e-02
TRPM7GO:0002366leukocyte activation involved in immune response4.33e-02
TRPM7GO:0002263cell activation involved in immune response4.33e-02
TRPM7GO:0051146striated muscle cell differentiation4.33e-02
TRPM7GO:0002732positive regulation of dendritic cell cytokine production4.33e-02
TRPM7GO:0032957inositol trisphosphate metabolic process4.33e-02

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Related Drugs to METRN_TRPM7


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning METRN-TRPM7 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

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Related Diseases to METRN_TRPM7


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate