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Kinase Fusion Gene:MKNK1_EFCAB14 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: MKNK1_EFCAB14 | KinaseFusionDB ID: KFG3878 | FusionGDB2.0 ID: KFG3878 | Hgene | Tgene | Gene symbol | MKNK1 | EFCAB14 | Gene ID | 8569 | 9813 | |
| Gene name | MAPK interacting serine/threonine kinase 1 | EF-hand calcium binding domain 14 | ||||||||||
| Synonyms | MNK1 | KIAA0494 | ||||||||||
| Cytomap | 1p33 | 1p33 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | MAP kinase-interacting serine/threonine-protein kinase 1MAP kinase interacting serine/threonine kinase 1MAP kinase signal-integrating kinase 1MAPK signal-integrating kinase 1 | EF-hand calcium-binding domain-containing protein 14 | ||||||||||
| Modification date | 20240403 | 20240305 | ||||||||||
| UniProtAcc | Q9BUB5 | O75071 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000545730, ENST00000341183, ENST00000371944, ENST00000371945, ENST00000371946, ENST00000428112, ENST00000465783, ENST00000525888, | ENST00000371933, ENST00000544071, ENST00000484461, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: MKNK1 [Title/Abstract] AND EFCAB14 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | MKNK1(47082383)-EFCAB14(47182115), # samples:2 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MKNK1 | GO:0006468 | protein phosphorylation | 9155018 |
| Hgene | MKNK1 | GO:0018105 | peptidyl-serine phosphorylation | 17130135 |
| Hgene | MKNK1 | GO:0035556 | intracellular signal transduction | 9155018 |
| Kinase Fusion gene breakpoints across MKNK1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across EFCAB14 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChimerDB4 | TCGA-KP-A3W4-01A | MKNK1 | chr1 | 47082383 | EFCAB14 | chr1 | 47182115 |
| ChimerDB4 | TCGA-13-0893-01B | MKNK1 | chr1 | 47082383 | EFCAB14 | chr1 | 47131036 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:47082383/:47182115) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MKNK1 | EFCAB14 |
| FUNCTION: May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. {ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:15350534, ECO:0000269|PubMed:9155018, ECO:0000269|PubMed:9878069}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of MKNK1_EFCAB14 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| MKNK1 | Q9BUB5-2 | human | EIF4E | P06730 | S209 | DtATksGsttKNRFV | |
| MKNK1 | Q9BUB5 | human | PNPLA8 | Q9NP80 | S511 | ELYRKLGsDVFsQNV | Patatin |
| MKNK1 | Q9BUB5 | human | SFPQ | P23246 | S283 | EGFkANLsLLRRPGE | |
| MKNK1 | Q9BUB5 | human | SFPQ | P23246 | S8 | MSRDRFrsrGGGGGG | |
| MKNK1 | Q9BUB5 | human | HNRNPA1 | P09651 | S192 | EMASAsssQrGrsGs | |
| MKNK1 | Q9BUB5 | human | HNRNPA1 | P09651 | S364 | yGGssssssyGsGrr | |
| MKNK1 | Q9BUB5 | human | SPRY2 | O43597 | S112 | APLSRSIsTVssGsR | |
| MKNK1 | Q9BUB5 | human | EIF4E | P06730 | S209 | DtATksGsttKNRFV | |
| MKNK1 | Q9BUB5 | human | HNRNPA1 | P09651 | S363 | GyGGssssssyGsGr | |
| MKNK1 | Q9BUB5 | human | HNRNPA1 | P09651 | S362 | GGyGGssssssyGsG | |
| MKNK1 | Q9BUB5 | human | SPRY2 | O43597 | S121 | VssGsRSsTRtSTSs |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| MKNK1 | ID | Description | 0.00e+00 |
| MKNK1 | GO:0000380 | alternative mRNA splicin | 1.39e-04 |
| MKNK1 | GO:0051386 | regulation of neurotrophin TRK receptor signaling pathway | 5.50e-02 |
| MKNK1 | GO:0006913 | nucleocytoplasmic transport | 5.50e-02 |
| MKNK1 | GO:0051169 | nuclear transport | 5.50e-02 |
| MKNK1 | GO:0000377 | RNA splicin | 2.98e-03 |
| MKNK1 | GO:0032048 | cardiolipin metabolic process | 5.50e-02 |
| MKNK1 | GO:0034638 | phosphatidylcholine catabolic process | 5.50e-02 |
| MKNK1 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway | 5.50e-02 |
| MKNK1 | GO:0071243 | cellular response to arsenic-containing substance | 5.50e-02 |
| MKNK1 | GO:0010801 | negative regulation of peptidyl-threonine phosphorylation | 5.50e-02 |
| MKNK1 | GO:0060602 | branch elongation of an epithelium | 5.50e-02 |
| MKNK1 | GO:1902548 | negative regulation of cellular response to vascular endothelial growth factor stimulus | 5.50e-02 |
| MKNK1 | GO:0032211 | negative regulation of telomere maintenance via telomerase | 5.50e-02 |
| MKNK1 | GO:0043651 | linoleic acid metabolic process | 5.50e-02 |
| MKNK1 | GO:0008380 | RNA splicing | 5.50e-02 |
| MKNK1 | GO:0040037 | negative regulation of fibroblast growth factor receptor signaling pathway | 5.50e-02 |
| MKNK1 | GO:0071549 | cellular response to dexamethasone stimulus | 5.50e-02 |
| MKNK1 | GO:0048011 | neurotrophin TRK receptor signaling pathway | 5.50e-02 |
| MKNK1 | GO:1900407 | regulation of cellular response to oxidative stress | 5.50e-02 |
| MKNK1 | GO:0045742 | positive regulation of epidermal growth factor receptor signaling pathway | 5.50e-02 |
| MKNK1 | GO:0099170 | postsynaptic modulation of chemical synaptic transmission | 5.50e-02 |
| MKNK1 | GO:1904357 | negative regulation of telomere maintenance via telomere lengthening | 5.50e-02 |
| MKNK1 | GO:0046337 | phosphatidylethanolamine metabolic process | 5.50e-02 |
| MKNK1 | GO:0003401 | axis elongation | 5.50e-02 |
| MKNK1 | GO:1900746 | regulation of vascular endothelial growth factor signaling pathway | 5.50e-02 |
| MKNK1 | GO:1901186 | positive regulation of ERBB signaling pathway | 5.50e-02 |
| MKNK1 | GO:0060441 | epithelial tube branching involved in lung morphogenesis | 5.50e-02 |
| MKNK1 | GO:0050482 | arachidonic acid secretion | 5.50e-02 |
| MKNK1 | GO:1902547 | regulation of cellular response to vascular endothelial growth factor stimulus | 5.50e-02 |
| MKNK1 | GO:1903963 | arachidonate transport | 5.50e-02 |
| MKNK1 | GO:0001516 | prostaglandin biosynthetic process | 5.50e-02 |
| MKNK1 | GO:0046457 | prostanoid biosynthetic process | 5.50e-02 |
| MKNK1 | GO:0046685 | response to arsenic-containing substance | 5.50e-02 |
| MKNK1 | GO:0032212 | positive regulation of telomere maintenance via telomerase | 5.50e-02 |
| MKNK1 | GO:0046475 | glycerophospholipid catabolic process | 5.50e-02 |
| MKNK1 | GO:0000132 | establishment of mitotic spindle orientation | 5.50e-02 |
| MKNK1 | GO:0032205 | negative regulation of telomere maintenance | 5.50e-02 |
| MKNK1 | GO:0046471 | phosphatidylglycerol metabolic process | 5.50e-02 |
| MKNK1 | GO:1902882 | regulation of response to oxidative stress | 5.50e-02 |
| MKNK1 | GO:0070306 | lens fiber cell differentiation | 5.50e-02 |
| MKNK1 | GO:1904358 | positive regulation of telomere maintenance via telomere lengthening | 5.50e-02 |
| MKNK1 | GO:2000279 | negative regulation of DNA biosynthetic process | 5.50e-02 |
| MKNK1 | GO:0040036 | regulation of fibroblast growth factor receptor signaling pathway | 5.50e-02 |
| MKNK1 | GO:0001662 | behavioral fear response | 5.50e-02 |
| MKNK1 | GO:0038179 | neurotrophin signaling pathway | 5.50e-02 |
| MKNK1 | GO:0071548 | response to dexamethasone | 5.50e-02 |
| MKNK1 | GO:0002209 | behavioral defense response | 5.50e-02 |
| MKNK1 | GO:0040001 | establishment of mitotic spindle localization | 5.50e-02 |
| MKNK1 | GO:0051294 | establishment of spindle orientation | 5.50e-02 |
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Related Drugs to MKNK1_EFCAB14 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning MKNK1-EFCAB14 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to MKNK1_EFCAB14 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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